Leukemia-Related Transcription Factor TEL Is Negatively Regulated through Extracellular Signal-Regulated Kinase-Induced Phosphorylation

Molecular and Cellular Biology

Volumn 24, Issue 8, 2004, Pages 3227-3237

  Maki, Kazuhiro ^a   Arai, Honoka ^a   Waga, Kazuo ^a   Sasaki, Ko ^a   Nakamura, Fumihiko ^a   Imai, Yoichi ^b   Kurokawa, Mineo ^b   Hirai, Hisamaru ^b   Mitani, Kinuko ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; SERINE; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR ETV6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CELL TRANSFORMATION; DIMERIZATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; ERYTHROID CELL; GENE OVEREXPRESSION; LEUKEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; DNA-BINDING PROTEINS; ERYTHROID CELLS; GENE EXPRESSION REGULATION; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-ETS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SERINE;

ANIMALIA;

EID: 1842557715     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.8.3227-3237.2004     Document Type: Article

References (39)

1. Arai, H., K. Maki, K. Waga, K. Sasaki, Y. Nakamura, Y. Imai, M. Kurokawa, H. Hirai, and K. Mitani. 2002. Functional regulation of TEL by p38-induced phosphorylation. Biochem. Biophys. Res. Commun. 299:116-125.
2. Brunet, A., A. Bonni, M. J. Zigmond, M. Z. Lin, P. Juo, L. S. Hu, M. J. Anderson, K. C. Arden, J. Blenis, and M. E. Greenberg, 1999. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96:857-868.
3. Buijs, A., L. van Rompaey, A. C. Molijn, J. N. Davis, A. C. O. Vertegaal, M. D. Potter, C. Adams, S. van Baal, E. C. Zwarthoff, M. F. Roussel, and G. C. Grosveld. 2000. The MNI-TEL fusion protein, encoded by the translocation (12;22)(p13;q11) in myeloid leukemia, is a transcription factor with transforming activity. Mol. Cell. Biol. 20:9281-9293.
4. Chang, L., and M. Karin. 2001. Mammalian MAP kinase signalling cascades. Nature 410:37-40.
5. Fenrick, R., J. M. Amann, B. Lutterhach, L. Wang, J. J. Westendorf, J. R. Downing, and S. W. Hiebert. 1999. Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol. Cell. Biol. 19:6566-6574.
6. Fenrick, R., L. Wang, J. Nip, J. M. Amann, R. J. Rooney, J. Walker-Daniels, H. C. Crawford, D. L. Huiboy, M. S. Kinch, L. M. Matrisian, and S. W. Hiebert. 2000. TEL, a putative tumor suppressor, modulates cell growth and cell morphology of Ras-transformed cells while repressing the transcription of stromelysin-1. Mol. Cell. Biol. 20:5828-5839.
7. Goluh, T. R., G. F. Barker, M. Lovett, and D. G. Gilliland. 1994. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5:12) chromosomal translocation. Cell 77:307-316.
8. Golub, T. R., A. Goga, G. F. Barker, D. E. Afar, J. McLaughlin, S. K. Bohlander, J. D. Rowley, O. N. Witte, and D. G. Gilliland. 1996. Oligomerization of the ABL tyrosine kinase by the Ets protein. Mol. Cell. Biol. 16:4107-4116.
9. Gu, X., B. H. Shin, Y. Akbarali, A. Weiss, J. Boitax, P. Oettgen, and T. A. Libermann. 2001. Tel-2 is a novel transcriptional repressor related to the Ets factor Tel/ETV-6. J. Biol. Chem. 276:9421-9436.
10. Guidez, F., K. Petrie, A. M. Ford, H. Lu, C. A. Bennett, A. MacGregor, J. Hannemann, Y. Ito, J. Ghysdael, M. Greaves, L. M. Wiedemann, and A. Zelent. 2000. Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein. Blood 96:2557-2561.
11. Hiebert, S. W., W. Sun, J. N. Davis, T. Golub, S. Shurtleff, A. Buijs, J. Downing, G. Grosveld, M. F. Roussel, D. G. Gilliland, N. Lenny, and S. Meyers. 1996. The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Mol. Cell. Biol. 16:1349-1355.
12. Jousset, C., C. Carron, A. Boureux, C. T. Quang, C. Oury, I. Dusanter-Fourt, M. Charon, J. Levin, O. Bernard, and J. Ghysdael. 1997. A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFRβ oncoprotein. EMBO J. 16:69-82.
13. Kim, C. A., M. L. Phillips, W. Kim, M. Gingery, H. H. Tran, M. A. Robinson, S. Faham, and J. U. Bowie. 2001. Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression. EMBO J. 20:4173-4182.
14. Kolch, W. 2000. Meaningful relationship: the regulation of the Ras/Raf/MEK/ERK pathways by protein interactions. Biochem. J. 351:289-305.
15. Kops, G. J. P. L., N. D. de Ruiter, A. M. M. de Vries-Smils, D. R. Powell, J. L. Bos, and B. M. T. Burgering. 1999. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398:630-634.
16. Kuno, Y., A. Abe, N. Emi, M. Iida, T. Yokozawa, M. Towatari, M. Tanimoto, and H. Saito. 2001. Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p13). Blood 97:1050-1055.
17. Kurokawa, M., K. Mitani, T. Yamagata, T. Tanaka, K. Izutsu, S. Ogawa, T. Moriguchi, E. Nishida, Y. Yazaki, and H. Hirai. 2000. The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death. EMBO J. 19:2958-2968.
18. Kwiatkowski, B. A., L. S. Bastian, T. R. Bauer, Jr., S. Tsai, A. G. Zielinska-Kwiatkowska, and D. D. Hickstein. 1998. The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity. J. Biol. Chem. 273:17525-17530.
19. Lacronique, V., A. Boureux, V. D. Valle, H. Poirel, C. T. Quang, M. Mauchauffe, C. Berthou, M. Lessard, R. Berger, J. Ghysdael, and O. A. Bernard. 1997. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278:1309-1312.
20. Le Gallic, L., D. Sgouras, G. Beal, Jr., and G. Mavrothalassitis. 1999. Transcriptional repressor ERF is a Ras/mitogen-activated protein kinase target that regulates cellular proliferation. Mol. Cell. Biol. 19:4121-4133.
21. Lopez, R. G., C. Carron, C. Oury, P. Gardellin, O. Bernard, and J. Ghysdael. 1999. TEL is a sequence-specific transcriptional repressor. J. Biol. Chem. 274:30132-30138.
22. Maki, K., K. Mitani, T. Yamagata, M. Kurokawa, Y. Kanda, Y. Yazaki, and H. Hirai. 1999. Transcriptional inhibition of p53 by MLL/MEN chimeric protein found in myeloid leukemia. Blood 93:3216-3224.
23. Matsuzaki, T., K. Aisaki. Y. Yamamura, M. Noda, and Y. Ikawa. 2000. Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a Friend murine leukemia cell line. Oncogene 19:1500-1508.
24. Miyazaki, R., H. Ogata, and Y. Kobayashi. 2001. Requirement of thrombopoietin-induced activation of ERK for megakaryocyte differentiation and of p38 for erythroid differentiation. Ann. Hematol. 80:284-291.
25. Pearson, G., F. Robinson, T. B. Gibson, B. E. Xu, M. Karandikar, K. Berman, and M. H. Cobb. 2001. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22:153-183.
26. Poirel, H., C. Oury, C. Carron, E. Duprez, Y. Laabi, A. Tsapis, S. P. Romana, M. Mauchauffe, M. Le Coniat, R. Berger, J. Ghysdael, and O. A. Bernard. 1997. The TEL gene products: nuclear phosphoproteins with DNA binding properties. Oncogene 14:349-357.
27. Potter, M. D., A. Buijs, B. Kreider, L. van Rompaey, and G. Grosveld. 2000. Identification and characterization of a new human ETS-family transcription factor, TEL2, that is expressed in hematopoietic tissues and can associate with TEL1/ETV6. Blood 95:3341-3348.
28. Rabault, B., M. F. Roussel, C. T. Quang, and J. Gbysdael. 1996. Phosphorylation of Ets1 regulates the complementation of a CSF-1 receptor impaired in mitogenesis. Oncogene 13:877-881.
29. Slupsky, C. M., L. N. Gentile, L. W. Donaldson, C. D. Mackereth, J. J. Seidel, B. J. Graves, and L. P. McIntosh. 1998. Structure of the Ets-1 pointed domain and mitogen-activated protein kinase phosphorylation site. Proc. Natl. Acad. Sci. USA 95:12129-12134.
30. Tanaka, T., M. Kurokawa, K. Ueki, K. Tanaka, Y. Imai, K. Mitani, K. Okazaki, N. Sagata, Y. Yazaki, Y. Shihata, T. Kadowaki, and H. Hirai. 1996. The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation ability. Mol. Cell. Biol. 16:3967-3979.
31. Ueki, K., S. Matsuda, K. Tobe, Y. Gotoh, H. Tamemoto, M. Yachi, Y. Akanuma, Y. Yazaki, E. Nishida, and T. Kadowaki. 1994. Feedback regulation of mitogen-activated protein kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation. J. Biol. Chem. 269:15756-15761.
32. Van Rompaey, L., M. Potter, C. Adams, and G. Grosveld. 2000. Tel induces a G1 arrest and suppresses Ras-induced transformation. Oncogene 19:5244-5250.
33. Waga, K., Y. Nakamura, K. Maki, H. Arai, T. Yamagata, K. Sasaki, M. Kurokawa, H. Hirai, and K. Mitani. 2003. Leukemia-related transcription factor TEL accelerates differentiation of Friend erythroleukemia cells. Oncogene 22:59-68.
34. Wang, L., and S. W. Hiebert. 2001. TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3. Oncogene 20:3716-3725.
35. Wang, L. C., F. Kuo, Y. Fujiwara, D. G. Gilliland, T. R. Golub, and S. H. Orkin. 1997. Yolk sac angiogenesis defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL. EMBO J. 16:4374-4383.
36. Wang, L. C., W. Swat, Y. Fujiwara, L. Davidson, J. Visvader, F. Kuo, F. W. Alt, D. G. Gilliland, T. R. Golub, and S. H. Orkin. 1998. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev. 12:2392-2402.
37. Witt, O., K. Sand, and A. Pekrun. 2000. Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. Blood 95:2391-2396.
38. Yang, B. S., C. A. Hauser, G. Henkel, M. S. Colman, C. van Beveren, K. J. Stacey, D. A. Hume, R. A. Maki, and M. C. Ostrowski. 1996. Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol. Cell. Biol. 16:538-547.
39. Yang, S. H., A. Galanis, and A. D. Sharrocks. 1999. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol. Cell. Biol. 19:4028-4038.