Up-regulation of gap junctional intercellular communication and connexin43 expression by retinoic acid in human endometrial stromal cells

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 7, 2005, Pages 4151-4156

  Tanmahasamut, Prasong ^a   Sidell, Neil ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 43; GAP JUNCTION PROTEIN; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C ACTIVATOR; RETINOIC ACID; RETINOID;

ARTICLE; CELL COMMUNICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOMETRIUM CELL; FEMALE; FEMALE INFERTILITY; GAP JUNCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STROMA CELL; UPREGULATION;

CELL COMMUNICATION; CELLS, CULTURED; CONNEXIN 43; ENDOMETRIUM; FEMALE; GAP JUNCTIONS; HUMANS; PHOSPHORYLATION; RNA, MESSENGER; STROMAL CELLS; TETRADECANOYLPHORBOL ACETATE; TRETINOIN; UP-REGULATION;

EID: 23044451132     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0663     Document Type: Article

References (51)

1. Eiberger J, Degen J, Romualdi A, Deutsch U, Willecke K, Sohl G 2001 Connexin genes in the mouse and human genome. Cell Adhes Commun 8:163-165
2. Yamasaki H, Naus CCG 1996 Role of connexin genes in growth control. Carcinogenesis 17:1199-1213
3. Hirschi KK, Xu CE, Tsukamoto T, Sager R 1996 Gap junction gene Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ 7:861-870
4. King TJ, Fukushima LH, Hieber AD, Shimabukuro KA, Sakr WA, Bertram JS 2000 Reduced levels of connexin43 in cervical dysplasia: inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. Carcinogenesis 21:1097-1109
5. Proulx AA, Lin ZX, Naus CC 1997 Transfection of rhabdomyosarcoma cells with connexin43 induces myogenic differentiation. Cell Growth Differ 8:533-540
6. Lau AF, Kanemitsu MY, Kurata WE, Danesh S, Boynton AL 1992 Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine. Mol Biol Cell 3:865-874
7. Guo H, Acevedo P, Parsa FD, Bertram JS 1992 Gap junctional protein connexin43 is expressed in dermis and epidermis of human skin: Differential modulation by retinoids. J Invest Dermatol 99:460-467
8. Bertram JS 1999 Carotenoids and gene regulation. Nutr Rev 57:182-191
9. Clairmont A, Tessman D, Stock A, Nicolai S, Stahl W, Sies H 1996 Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor. Carcinogenesis 17:1389-1391
10. Oh SY, Grupen CG, Murray AW 1991 Phorbol ester induces phosphorylation and down-regulation of connexin 43 in WB cells. Biochim Biophys Acta 1094:243-245
11. Warn-Cramer BJ, Lampe PD, Durata WE, Kanemitsu MY, Loo LWM, Eckhart W, Lau AF 1996 Characterization of the mitogen-activated protein kinase phosphorylation sites on the connexin-43 gap junction protein. J Biol Chem 271:3779-3786
12. Jahn E, Classen-Linke I, Kusche M, Beier HM, Traub O, Grummer R, Winterhager E 1995 Expression of gap junction connexins in the human endometrium throughout the menstrual cycle. Hum Reprod 10:2666-2670
13. Schlemmer SR, Kaufman DG 2000 Endometrial stromal cells regulate gapjunction function in normal human endometrial epithelial cells but not in endometrial carcinoma cells. Mol Carcinog 28:70-75
14. Granot I, Dekel N, Bechor E, Segal I, Fieldust S, Barash A 2000 Temporal analysis of connexin 43 protein and gene expression throughout the menstrual cycle in human endometrium. Fertil Steril 73:381-386
15. Berg PA, Navot D 1992 The impact of embryonic development and endometrial maturity on the timing of implantation. Fertil Steril 58:537-542
16. Vestweber D 2000 Molecular mechanisms that control endothelial cell contacts. J Pathol 190:281-291
17. Zhu D, Caveney S, Kidder GM, Naus CC 1991 Transfection of C6 glioma cells with connexin 43 cDNA: analysis of expression, intercellular coupling, and cell proliferation. Proc Natl Acad Sci USA 88:1883-1887
18. Stahl W, Sies H 1998 The role of carotenoids and retinoids in gap junctional communication. Int J Vitam Nutr Res 68:354-359
19. Ross SA, McCaffery PJ, Drager UC, De LucaLM2000 Retinoids in embryonal development. Physiol Rev 80:1021-1054
20. Ryan IP, Schriock ED, Taylor RN 1994 Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro. J Clin Endocrinol Metab 78:642-649
21. Hornung D, Ryan IP, Chao VA, Vigne JL, Schriock ED, Taylor RN 1997 Immunolocalization and regulation of the chemokine RANTES in human endometrial and endometriosis tissues and cells. J Clin Endocrinol Metab 82:1621-1628
22. Spinella F, Rosano L, Di Castro V, Nicotra MR, Natali PG, Bagnato A 2003 Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. J Biol Chem 278:41294-41301
23. Berthoud VM, Ledbetter MLS, Hertzberg EL, Saez JC 1992 Connexin 43 in MDCK cells: regulation by a tumor-promoting phorbol ester and calcium. Eur J Cell Biol 57:40-50
24. Brissette JL, Kumar NM, Gilula NB, Dotto GP 1991 The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins. Mol Cell Biol 11:5364-5371
25. Lampe PD 1994 Analyzing phorbol ester effects on gap junction communication: a dramatic inhibition of assembly. J Cell Biol 127:1895-1905
26. Holder JW, Elmore E, Barrett JC 1993 Gap junction function and cancer. Cancer Res 53:3475-3485
27. Goodenough DA, Golinger JA, Paul DL 1996 Connexins, connexons, and intercellular communication. Ann Rev Biochem 65:475-502
28. Regidor P-A, Regidor M, Schindler AE, Winterhager E 1997 Aberrant expression pattern of gap junction connexins in endometriotic tissues. Mol Hum Reprod 3:375-381
29. Gabriel S, Winterhager E, Pfarrer C, Traub O, Leiser R 2004 Modulation of connexin expression in sheep endometrium in response to pregnancy. Placenta 25:287-296
30. Heikaus S, Winterhager E, Traub O, Grummer R 2002 Responsiveness of endometrial genes Connexin26, Connexin43, C3 and clusterin to primary estrogen, selective estrogen receptor modulators, phyto- and xenoestrogens. J Mol Endocrinol 29:239-249
31. Hossain MZ, Wilkins LR, Mehta PP, Loewenstein WR, Bertram JS 1989 Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation. Carcinogenesis 10:1743-1748
32. Belliveau DJ, Bechberger JF, Rogers KA, Naus CC 1997 Differential expression of gap junctions in neurons and astrocytes derived from P19 embryonal carcinoma cells. Dev Genet 21:187-200
33. Bani-Yaghoub M, Bechberger JF, Naus CC 1997 Reduction of connexin 43 expression and dye-coupling during neuronal differentiation of human NTera2/clone D1 cells. J Neurosci Res 49:19-31
34. Rogers M, Berestecky JM, Hossain MZ, Go HM, Kadle R, Nicolson BJ, Bertram JS 1990 Retinoid-enhanced gap junctional communication is achieved by increased levels of connexin 43mRNAand protein. Mol Carcinog 3:335-343
35. Siddiqui NA, Loughney A, Thomas EJ, Dunlop W, Redfern CP 1994 Cellular retinoid binding proteins and nuclear retinoic acid receptors in endometrial epithelial cells. Hum Reprod 9:1410-1416
36. Prentice A, Matthews CJ, Thomas EJ, Redfern CP 1992 The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid. Hum Reprod 7:692-700
37. Sawatsri S, Desai N, Rock JA, Sidell N 2000 Retinoic acid suppresses interleukin-6 production in human endometrial cells. Fertil Steril 73:1012-1019
38. Carystinos GD, Alaoui-Jamali MA, Phipps J, Yen L, Batist G 2001 Upregulation of gap junctional intercellular communication and connexin 43 expression by cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells. Cancer Chemother Pharmacol 47:126-132
39. Mayaguchi T, Nomata K, Noguchi M, Watanabe J, Satoh H, KanetakeH2001 TAC-101, a novel retinobenzoic-acid derivative, enhances gap junctional intercellular communication among renal epithelial cells treated with renal carcinogens. Anticancer Res 21:4025-4030
40. Watanabe J, Nomata K, Noguchi M, Satoh H, Kanda S, Kanetake H, Saito Y 1999 All-trans retinoic acid enhances gap junctional intercellular communication among renal epithelial cells in vitro treated with renal carcinogens. Eur J Cancer 35:1003-1008
41. Cruciani V, Mikalsen S-O 1999 Stimulated phosphorylation of intracellular connexin43. Exp Cell Res 251:285-298
42. Verma AK 1988 Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13- acetate-induced synthesis of epidermal ornithine decarboxylase messenger RNA and diacylglycerol-promoted mouse skin tumor formation by retinoic acid. Cancer Res 48:2168-2173
43. Cope FO 1986 The in vivo inhibition of mouse brain protein kinase-C by retinoic acid. Cancer Lett 30:275-288
44. Nakagawa S, Fujii T, Yokoyama G, Kazanietz MG, Yamana H, Shirouzu K 2003 Cell growth inhibition by all-trans retinoic acid in SKBR-3 breast cancer cells: involvement of protein kinase Cα and extracellular signal-regulated kinase mitogen-activated protein kinase. Mol Carcinog 38:106-116
45. Kambhampati S, Li Y, Verma A, Sassano A, Majchrzak B, Deb DK, Parmar S, Giafis N, Kalvakolanu DV, Rahman A, Uddin S, Minucci S, Tallman MS, Fish EN, Platanias LC 2003 Activation of protein kinase C Δ by all-transretinoic acid. J Biol Chem 278:32544-32551
46. Parrow V, Horton C, Maden M, Laurie S, Notarianni E 1998 Retinoids are endogenous to the porcine blastocyst and secreted by trophectoderm cells at functionally-active levels. Int J Dev Biol 42:629-632
47. Tarrade A, Rochette-Egly C, Guibourdenche J, Evain-Brion D 2000 The expression of nuclear retinoid receptors in human implantation. Placenta 21:703-710
48. Brar AK, Kessler CA, Meyer AJ, Cedars MI, Jikihara H 1996 Retinoic acid suppresses in-vitro decidualization of human endometrial stromal cells. Mol Hum Reprod 2:185-193
49. Goldman-Wohl D, Yagel S 2002 Regulation of trophoblast invasion: from normal implantation to pre-eclampsia. Mol Cell Endocrinol 187:233-238
50. Huang F-J,WuT-CJ, Tsai M-Y 2001 Effect of retinoic acid on implantation and postimplantation development of mouse embryos in vitro. Hum Reprod 16:2171-2176
51. Coberly S, Lammer E, AlashariM1996 Retinoic acid embryopathy: case report and review of literature. Pediatr Pathol Lab Med 16:823-836