Upregulation of gap junctional intercellular communication and connexin 43 expression by cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells

Cancer Chemotherapy and Pharmacology

Volumn 47, Issue 2, 2001, Pages 126-132

  Carystinos, G D ^a   Alaoui Jamali, M A ^a   Phipps, J ^a   Yen, L ^a   Batist, G ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Chemosensitivity; Connexin 43; Glutathione; Intercellular communication

Indexed keywords

BUCLADESINE; CARMUSTINE; CONNEXIN 43; CYCLIC AMP; DOXORUBICIN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; MELPHALAN; RETINOIC ACID;

ARTICLE; CARCINOGENESIS; CELL COMMUNICATION; CELL SURVIVAL; CHEMOSENSITIVITY; CONTROLLED STUDY; DOWN REGULATION; DRUG POTENCY; ENZYME ACTIVITY; GAP JUNCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

BUCLADESINE; CELL COMMUNICATION; CONNEXIN 43; GAP JUNCTIONS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; NEUROBLASTOMA; TRETINOIN; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0034925106     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800000231     Document Type: Article

References (49)

1. Effect of DNA-repair-enzyme modulators on cytotoxicity of L-phenylalanine mustard and cis-diamminedichloroplatinum (II) in mammary carcinoma cells resistant to alkylating drugs
2. Phase I clinical trial of intravenous L-buthionine sulfoximine and melphalan: An attempt at modulation of glutathione
3. Enhancement of gap junctional intercellular communication by dibutyryl cyclic AMP in lung epithelial cells
4. In vivo selective modulation of tissue glutathione in a rat mammary carcinoma model
5. Expression of a drug resistance gene in human neuroblastoma cell lines: Modulation by retinoic acid-induced differentiation
6. The glutathione system and drug resistance
7. Multidrug resistance associated with alterations in topoisomerase II
8. Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules
9. The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction protein
10. Connections with connexins: The molecular basis of direct intercellular signaling
11. Effect of tumor promoting stimuli on gap junction permeability and connexin43 expression in ARL 18 rat liver cell line
12. Cyclic-AMP induction of gap junctional intercellular communication increases bystander effect in suicide gene therapy
13. Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas
14. Overexpression of a transporter gone in a multidrug-resistant human lung cancer cell line
15. Pilot trial of the safety, tolerability, and retinoid levels of N-(4-hydroxyphenyl) retinamide in combination with tamoxifen in patients at high risk for developing invasive breast cancer
16. Characterization of a cAMP-dependent protein kinase mutant resistant to cisplatin
17. Gap junctions promote the bystander effect of herpes simplex thymidine kinase in vivo
18. The extent of heterocellular communication mediated gap junctions is predictive of bystander tumor cytotoxicity in vitro
19. Connexins, connexons, and intercellular communication
20. Gap junction function and cancer
21. Retinoids suppress proliferation, induce cell spreading, and up-regulate connexin 43 expression only in postconfluent 10T1/2 cells: Implications for the role of gap junctional communication
22. Measurement of gap junctional communication by fluorescence activated cell sorting
23. Biology of disease: Role of inhibition of intercellular communication in carcinogenesis
24. Acquired multicellular-mediated resistance to alkylating agents in cancer
25. Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes
26. Intercellular communication and tissue growth
27. Junctional intercellular communication and the control of growth
28. Junctional intercellular communication: The cell-to-cell membrane channel
29. Cell-cell communication and the control of growth
30. Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth
31. Intercellular communication of transformed and non-transformed rat live epithelial cells modulation by 12-O-tetradecanoylphorbol-13-acetate
32. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins
33. Multidrug resistance
34. Continuous treatment with all-trans retinoic acid causes a progressive reduction in plasma drug concentrations: Implications for relapse and retinoid "resistance" in patients with acute promyelocytic leukemia
35. Selective permeability of different connexin channels to the second messenger inositol 1,4,5-trisphosphate
36. Phase I study of the novel cyclic AMP (cAMP) analogue 8-chloro-cAMP in patients with cancer: Toxicity, hormonal, and immunological effects
37. Transfection of rhabdomyosarcoma cells with connexin43 induces myogenic differentiation
38. Gap-junction protein gene suppresses tumorigenicity
39. In vivo and in vitro mechanisms of drug resistance in a rat mammary carcinoma model
40. Expression of a rat glutathione-S-transferase complementary DNA in rat mammary carcinoma cells: Impact upon alkylator-induced toxicity
41. Synergistic effects of 8-Cl-cAMP and retinoic acids in the inhibition of growth and induction of apoptosis in ovarian cancer cells: Induction of retinoic acid receptor beta
42. Effect of cell-cell interactions on drug sensitivity and growth of drug-sensitive and -resistant tumor cells in spheroids
43. Synergistic effect between doxorubicin and a low dose of all-trans-retinoic acid in MCF-7 breast cancer cell line
44. Acute promyelocytic leukemia
45. Structure-function relationships in gap junctions
46. Gap junctional intercellular communication and carcinogenesis
47. Non-genotoxic mechanisms of carcinogenesis: Studies of cell transformation and gap junctional intercellular communication
48. Intercellular communication and carcinogenesis