-
1
-
-
0038726089
-
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
-
Allan LA, Morrice N, Brady S, Magee G, Pathak S, and Clarke PR (2003) Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 5:647-654.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 647-654
-
-
Allan, L.A.1
Morrice, N.2
Brady, S.3
Magee, G.4
Pathak, S.5
Clarke, P.R.6
-
2
-
-
0035853709
-
Characterization of a novel isoform of caspase-9 that inhibits apoptosis
-
Angelastro JM, Moon NY, Liu DX, Yang AS, Greene LA, and Franker T (2001) Characterization of a novel isoform of caspase-9 that inhibits apoptosis. J Biol Chem 276:12190-12200.
-
(2001)
J Biol Chem
, vol.276
, pp. 12190-12200
-
-
Angelastro, J.M.1
Moon, N.Y.2
Liu, D.X.3
Yang, A.S.4
Greene, L.A.5
Franker, T.6
-
3
-
-
0027377493
-
Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies
-
Bryson HM and Sorkin EM (1993) Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 46:872-894.
-
(1993)
Drugs
, vol.46
, pp. 872-894
-
-
Bryson, H.M.1
Sorkin, E.M.2
-
4
-
-
0031018518
-
Different pathways of apoptosis revealed by 2-chloro-adenosine and deoxy-D-ribose in mammalian astroglial cells
-
Ceruti S, Barbieri D, Veronese E, Cattabeni F, Cossarizza A, Giammarioli AM, Malorni W, Franceschi C, and Abbracchio MP (1997) Different pathways of apoptosis revealed by 2-chloro-adenosine and deoxy-D-ribose in mammalian astroglial cells. J Neurosci Res 47:372-383.
-
(1997)
J Neurosci Res
, vol.47
, pp. 372-383
-
-
Ceruti, S.1
Barbieri, D.2
Veronese, E.3
Cattabeni, F.4
Cossarizza, A.5
Giammarioli, A.M.6
Malorni, W.7
Franceschi, C.8
Abbracchio, M.P.9
-
5
-
-
0038576220
-
A key role of caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2′-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells
-
Ceruti S, Beltrami E, Matarrese P, Mazzola A, Cattabeni F, Malorni W, and Abbracchio MP (2003) A key role of caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2′-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. Mol Pharmacol 63:1437-1447.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 1437-1447
-
-
Ceruti, S.1
Beltrami, E.2
Matarrese, P.3
Mazzola, A.4
Cattabeni, F.5
Malorni, W.6
Abbracchio, M.P.7
-
6
-
-
0034193432
-
Apoptosis induced by 2-chloro-adenosine and 2-chloro-deoxy-adenosine in human astrocytoma cell line: Differential mechanisms and possible clinical relevance
-
Ceruti S, Franceschi C, Barbieri D, Malorni W, Camurri A, Giammarioli AM, Ambrosini A, Racagni G, Cattabeni F, and Abbracchio MP (2000) Apoptosis induced by 2-chloro-adenosine and 2-chloro-deoxy-adenosine in human astrocytoma cell line: differential mechanisms and possible clinical relevance. J Neurosci Res 60:388-400.
-
(2000)
J Neurosci Res
, vol.60
, pp. 388-400
-
-
Ceruti, S.1
Franceschi, C.2
Barbieri, D.3
Malorni, W.4
Camurri, A.5
Giammarioli, A.M.6
Ambrosini, A.7
Racagni, G.8
Cattabeni, F.9
Abbracchio, M.P.10
-
8
-
-
1542357606
-
Apoptosis pathways in cancer and cancer therapy
-
Debatin KM (2004) Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother 53:153-159.
-
(2004)
Cancer Immunol Immunother
, vol.53
, pp. 153-159
-
-
Debatin, K.M.1
-
9
-
-
0032885388
-
Mammalian caspases: Structures, activation, substrates and functions during apoptosis
-
Earnshaw WC, Martins LM, and Kaufmann SH (1999) Mammalian caspases: structures, activation, substrates and functions during apoptosis. Annu Rev Biochem 68:383-424.
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 383-424
-
-
Earnshaw, W.C.1
Martins, L.M.2
Kaufmann, S.H.3
-
10
-
-
3242810661
-
Betulinic acid: A promising anticancer candidate
-
Eiznhamer DA and Xu ZQ (2004) Betulinic acid: a promising anticancer candidate. Drugs 7:359-373.
-
(2004)
Drugs
, vol.7
, pp. 359-373
-
-
Eiznhamer, D.A.1
Xu, Z.Q.2
-
12
-
-
0033646961
-
Betulinic acid induced apoptosis through a direct effect on mitochondria
-
Fulda S and Debatin KM (2000) Betulinic acid induced apoptosis through a direct effect on mitochondria. Med Pediatr Oncol 35:616-618.
-
(2000)
Med Pediatr Oncol
, vol.35
, pp. 616-618
-
-
Fulda, S.1
Debatin, K.M.2
-
13
-
-
7044240646
-
Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells
-
Fulda S, Jeremias I, and Debatin KM (2004) Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells. Oncogene 23:7611-7620.
-
(2004)
Oncogene
, vol.23
, pp. 7611-7620
-
-
Fulda, S.1
Jeremias, I.2
Debatin, K.M.3
-
14
-
-
0032969291
-
Betulinic acid: A new cytotoxic agent against malignant brain-tumour cells
-
Fulda S, Jeremias I, Steiner HH, Pietsch T, and Debatin KM (1999) Betulinic acid: a new cytotoxic agent against malignant brain-tumour cells. Int J Cancer 82:435-441.
-
(1999)
Int J Cancer
, vol.82
, pp. 435-441
-
-
Fulda, S.1
Jeremias, I.2
Steiner, H.H.3
Pietsch, T.4
Debatin, K.M.5
-
15
-
-
0032545386
-
Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid
-
Fulda S, Scaffidi C, Susin SA, Krammer PH, Kroemer G, Peter E, and Debatin KM (1998) Activation of mitochondria and release of mitochondrial apoptogenic factors by betulinic acid. J Biol Chem 18:33942-33948.
-
(1998)
J Biol Chem
, vol.18
, pp. 33942-33948
-
-
Fulda, S.1
Scaffidi, C.2
Susin, S.A.3
Krammer, P.H.4
Kroemer, G.5
Peter, E.6
Debatin, K.M.7
-
16
-
-
2942529075
-
Cloning, pharmacological characterization and distribution of the rat G-proteincoupled P2Y(13) receptor
-
Fumagalli M, Trincavelli L, Lecca D, Martini C, Ciana P, and Abbracchio MP (2004) Cloning, pharmacological characterization and distribution of the rat G-proteincoupled P2Y(13) receptor. Biochem Pharmacol 68:113-124.
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 113-124
-
-
Fumagalli, M.1
Trincavelli, L.2
Lecca, D.3
Martini, C.4
Ciana, P.5
Abbracchio, M.P.6
-
17
-
-
0036547417
-
Death and anti-death: Tumour resistance to apoptosis
-
Igney FH and Krammer PH (2002) Death and anti-death: tumour resistance to apoptosis. Nat Rev 2:277-288.
-
(2002)
Nat Rev
, vol.2
, pp. 277-288
-
-
Igney, F.H.1
Krammer, P.H.2
-
18
-
-
18444413539
-
Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose
-
Ikeda R, Furukawa T, Kitazono M, Ishitsuka K, Okumura H, Tani A, Sumizawa T, Araguchi M, Komatsu M, Uchimiya H, et al. (2002) Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose. Biochem Biophys Res Commun 291:806-812.
-
(2002)
Biochem Biophys Res Commun
, vol.291
, pp. 806-812
-
-
Ikeda, R.1
Furukawa, T.2
Kitazono, M.3
Ishitsuka, K.4
Okumura, H.5
Tani, A.6
Sumizawa, T.7
Araguchi, M.8
Komatsu, M.9
Uchimiya, H.10
-
19
-
-
3042848683
-
Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells
-
Jeremias I, Steiner HH, Benner A, Debatin M, and Herold-Mende C (2004) Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells. Acta Neurochir 146:721-729.
-
(2004)
Acta Neurochir
, vol.146
, pp. 721-729
-
-
Jeremias, I.1
Steiner, H.H.2
Benner, A.3
Debatin, M.4
Herold-Mende, C.5
-
20
-
-
0029399506
-
Histopathology, classification and grading of gliomas
-
Kleihues P, Soylemezoglu F, Schauble B, Scheithauer BW, and Burger P (1995) Histopathology, classification and grading of gliomas. Glia 15:211-221.
-
(1995)
Glia
, vol.15
, pp. 211-221
-
-
Kleihues, P.1
Soylemezoglu, F.2
Schauble, B.3
Scheithauer, B.W.4
Burger, P.5
-
21
-
-
0032512553
-
The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption
-
Kletsas D, Barbieri D, Stathakos D, Botti B, Bergamini S, Tomasi A, Monti D, Malorni W, and Franceschi C (1998) The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption. Biochem Biophys Res Commun 243:416-425.
-
(1998)
Biochem Biophys Res Commun
, vol.243
, pp. 416-425
-
-
Kletsas, D.1
Barbieri, D.2
Stathakos, D.3
Botti, B.4
Bergamini, S.5
Tomasi, A.6
Monti, D.7
Malorni, W.8
Franceschi, C.9
-
22
-
-
3343013154
-
Phosphatidylserine exposure during early primary necrosis (oncosis) in JB6 cells as evidenced by immunogold labelling technique
-
Krysko O, de Ridder L, and Cornelissen M (2004) Phosphatidylserine exposure during early primary necrosis (oncosis) in JB6 cells as evidenced by immunogold labelling technique. Apoptosis 9:495-500.
-
(2004)
Apoptosis
, vol.9
, pp. 495-500
-
-
Krysko, O.1
De Ridder, L.2
Cornelissen, M.3
-
23
-
-
0036447440
-
Oxidative stress and cyclooxygenase-2 induction mediate cyanide-induced apoptosis of cortical cells
-
Li L, Prabhakaran K, Shou Y, Borowitz JL, and Isom GE (2002) Oxidative stress and cyclooxygenase-2 induction mediate cyanide-induced apoptosis of cortical cells. Toxicol Appl Pharmacol 15:55-63.
-
(2002)
Toxicol Appl Pharmacol
, vol.15
, pp. 55-63
-
-
Li, L.1
Prabhakaran, K.2
Shou, Y.3
Borowitz, J.L.4
Isom, G.E.5
-
24
-
-
0028577916
-
Different susceptibilities to cell death induced by t-butylhydroperoxide could depend upon cell histotypeassociated growth features
-
Malorni W, Rainaldi G, Rivabene R, and Santini MT (1994) Different susceptibilities to cell death induced by t-butylhydroperoxide could depend upon cell histotypeassociated growth features. Cell Biol Toxicol 10:207-218.
-
(1994)
Cell Biol Toxicol
, vol.10
, pp. 207-218
-
-
Malorni, W.1
Rainaldi, G.2
Rivabene, R.3
Santini, M.T.4
-
25
-
-
0035503898
-
Cladribine induces apoptosis in human leukemia cells by caspase-dependent and -independent pathway acting on mitochondria
-
Marzo I, Perez-Galan P, Giraldo P, Rubio-Felix D, Anel A, and Naval J (2001) Cladribine induces apoptosis in human leukemia cells by caspase-dependent and -independent pathway acting on mitochondria. Biochem J 359:537-546.
-
(2001)
Biochem J
, vol.359
, pp. 537-546
-
-
Marzo, I.1
Perez-Galan, P.2
Giraldo, P.3
Rubio-Felix, D.4
Anel, A.5
Naval, J.6
-
26
-
-
0030983260
-
Co-expression of MDR-associated markers, including P-170, MRP and LRP and cytoskeletal proteins, in three resistant variants of the human ovarian carcinoma cell line, OAW42
-
Moran E, Clearly I, Larkin AM, Nic Amhlaoibh R, Masterson A, Scheper RJ, Izquierdo MA, Center M, O'Sullivan F, and Clynes M (1997) Co-expression of MDR-associated markers, including P-170, MRP and LRP and cytoskeletal proteins, in three resistant variants of the human ovarian carcinoma cell line, OAW42. Eur J Cancer 33:652-660.
-
(1997)
Eur J Cancer
, vol.33
, pp. 652-660
-
-
Moran, E.1
Clearly, I.2
Larkin, A.M.3
Nic Amhlaoibh, R.4
Masterson, A.5
Scheper, R.J.6
Izquierdo, M.A.7
Center, M.8
O'Sullivan, F.9
Clynes, M.10
-
27
-
-
3242806104
-
Caspases and cancer: Mechanisms of inactivation and new treatment modalities
-
Philchenkov A, Zavelevich M, Kroczak TJ, and Los M (2004) Caspases and cancer: mechanisms of inactivation and new treatment modalities. Exp Oncol 26:82-97.
-
(2004)
Exp Oncol
, vol.26
, pp. 82-97
-
-
Philchenkov, A.1
Zavelevich, M.2
Kroczak, T.J.3
Los, M.4
-
28
-
-
1442274991
-
Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation
-
Prabhakaran K, Li L, Borowitz JL, and Isom GE (2004) Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation. Toxicol Appl Pharmacol 195:194-202.
-
(2004)
Toxicol Appl Pharmacol
, vol.195
, pp. 194-202
-
-
Prabhakaran, K.1
Li, L.2
Borowitz, J.L.3
Isom, G.E.4
-
29
-
-
14144251559
-
Apoptosis mechanisms: Implications for cancer drug discovery
-
Reed JC (2004) Apoptosis mechanisms: implications for cancer drug discovery. Oncology 18:11-20.
-
(2004)
Oncology
, vol.18
, pp. 11-20
-
-
Reed, J.C.1
-
30
-
-
16244393359
-
Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway
-
Scholz C, Wieder T, Stärck L, Essmann F, Schulze-Osthoff K, Dörken B, and Daniel PT (2005) Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway. Oncogene 24:1904-1913.
-
(2005)
Oncogene
, vol.24
, pp. 1904-1913
-
-
Scholz, C.1
Wieder, T.2
Stärck, L.3
Essmann, F.4
Schulze-Osthoff, K.5
Dörken, B.6
Daniel, P.T.7
-
31
-
-
0033593201
-
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
-
Seol DW and Billiar TR (1999) A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J Biol Chem 274:2072-2076.
-
(1999)
J Biol Chem
, vol.274
, pp. 2072-2076
-
-
Seol, D.W.1
Billiar, T.R.2
-
32
-
-
0037007101
-
Oligomerization of caspase-9 induced by Apaf-1 CARD
-
Shiozaki EN, Chai J, and Shi Y (2002) Oligomerization of caspase-9 induced by Apaf-1 CARD. Proc Natl Acad Sci USA 99:4197-4202.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4197-4202
-
-
Shiozaki, E.N.1
Chai, J.2
Shi, Y.3
-
33
-
-
0034655358
-
Cyanide-induced apoptosis involves oxidative-stress-activated NF-κB in cortical neurons
-
Shou Y, Gunassekar PG, Borowitz JL, and Isom GE (2000) Cyanide-induced apoptosis involves oxidative-stress-activated NF-κB in cortical neurons. Toxicol Appl Pharmacol 164:196-205.
-
(2000)
Toxicol Appl Pharmacol
, vol.164
, pp. 196-205
-
-
Shou, Y.1
Gunassekar, P.G.2
Borowitz, J.L.3
Isom, G.E.4
-
34
-
-
0025673684
-
Effect of tumor necrosis factor on human tumor cell lines sensitive and resistant to cytotoxic drugs and its interaction with chemotherapeutic agents
-
Soranzo C, Perego P, and Zunino F (1990) Effect of tumor necrosis factor on human tumor cell lines sensitive and resistant to cytotoxic drugs and its interaction with chemotherapeutic agents. Anticancer Drugs 1:157-163.
-
(1990)
Anticancer Drugs
, vol.1
, pp. 157-163
-
-
Soranzo, C.1
Perego, P.2
Zunino, F.3
-
35
-
-
0033104331
-
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis
-
Srinivasula SM, Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T, and Alnemri ES (1999) Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res 59:999-1002.
-
(1999)
Cancer Res
, vol.59
, pp. 999-1002
-
-
Srinivasula, S.M.1
Ahmad, M.2
Guo, Y.3
Zhan, Y.4
Lazebnik, Y.5
Fernandes-Alnemri, T.6
Alnemri, E.S.7
-
36
-
-
0037109158
-
The role of caspases 9 and 9-short (9S) in death ligand- and drug-induced apoptosis in human astrocytoma cells
-
Waltereit R and Weller M (2002) The role of caspases 9 and 9-short (9S) in death ligand- and drug-induced apoptosis in human astrocytoma cells. Mol Brain Res 106:42-49.
-
(2002)
Mol Brain Res
, vol.106
, pp. 42-49
-
-
Waltereit, R.1
Weller, M.2
-
37
-
-
0033023669
-
Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species and caspase processing
-
Wick W, Grimmel C, Wagenknecht B, Dichgans J, and Weller M (1999) Betulinic acid-induced apoptosis in glioma cells: a sequential requirement for new protein synthesis, formation of reactive oxygen species and caspase processing. J Pharmacol Exp Ther 289:1306-1312.
-
(1999)
J Pharmacol Exp Ther
, vol.289
, pp. 1306-1312
-
-
Wick, W.1
Grimmel, C.2
Wagenknecht, B.3
Dichgans, J.4
Weller, M.5
-
38
-
-
0037049876
-
Selective cytotoxicity of betulinic acid an tumor cell lines, but not on normal cells
-
Zuco V, Supino R, Righetti SC, Cleris L, Marchesi E, Gambacorti-Passerini C, and Formelli F (2002) Selective cytotoxicity of betulinic acid an tumor cell lines, but not on normal cells. Cancer Lett 175:17-25.
-
(2002)
Cancer Lett
, vol.175
, pp. 17-25
-
-
Zuco, V.1
Supino, R.2
Righetti, S.C.3
Cleris, L.4
Marchesi, E.5
Gambacorti-Passerini, C.6
Formelli, F.7
|