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Volumn 2, Issue 2, 2005, Pages 253-262

The airway pathophysiology of COPD: Implications for treatment

Author keywords

Airway and systemic inflammation; Fixed combination; Inhaled glucocorticoids; Long acting bronchodilators; Obstructive airway diseases

Indexed keywords

AMINOPHYLLINE; BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CILOMILAST; CORTICOSTEROID; FLUTICASONE PROPIONATE; FORMOTEROL; IPRATROPIUM BROMIDE; OXITROPIUM BROMIDE; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; ROFLUMILAST; SALBUTAMOL; SALMETEROL; TERBUTALINE; THEOPHYLLINE DERIVATIVE; TIOTROPIUM BROMIDE;

EID: 22244468659     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.1081/COPD-57598     Document Type: Review
Times cited : (24)

References (100)
  • 1
    • 0031001720 scopus 로고    scopus 로고
    • Alternative projections of mortality and disability by cause 1990-2020: Global burden of disease study
    • Murray CJL, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Lancet 1997; 349:1498-1504.
    • (1997) Lancet , vol.349 , pp. 1498-1504
    • Murray, C.J.L.1    Lopez, A.D.2
  • 2
    • 0036798971 scopus 로고    scopus 로고
    • Impact of COPD in North America and Europe in 2000: Subjects' perspective of confronting COPD international survey
    • Rennard S, Decramer M, Calverley PM, Pride NB, Soriano JB, Vermeire PA, Vestbo J. Impact of COPD in North America and Europe in 2000: subjects' perspective of confronting COPD international survey. Eur Respir J 2002; 20:799-805.
    • (2002) Eur Respir J , vol.20 , pp. 799-805
    • Rennard, S.1    Decramer, M.2    Calverley, P.M.3    Pride, N.B.4    Soriano, J.B.5    Vermeire, P.A.6    Vestbo, J.7
  • 3
    • 0008564346 scopus 로고
    • Defining chronic obstructive pulmonary disease
    • Calverley P, Pride N, eds. London: Chapman and Hall
    • Snider GL. Defining chronic obstructive pulmonary disease. In: Calverley P, Pride N, eds. Chronic Obstructive Pulmonary Disease. London: Chapman and Hall, 1995.
    • (1995) Chronic Obstructive Pulmonary Disease
    • Snider, G.L.1
  • 5
    • 3142517968 scopus 로고    scopus 로고
    • Association between chronic obstructive pulmonary disease and systemic inflammation: A systematic review and a meta-analysis
    • Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004; 59(7):574-580.
    • (2004) Thorax , vol.59 , Issue.7 , pp. 574-580
    • Gan, W.Q.1    Man, S.F.2    Senthilselvan, A.3    Sin, D.D.4
  • 6
    • 0029936262 scopus 로고    scopus 로고
    • Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease
    • The Lung Health Study Research Group
    • Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, Wise RA. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Am J Respir Crit Care Med 1996; 153(6 pt 1):1802-1811.
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.6 PART 1 , pp. 1802-1811
    • Tashkin, D.P.1    Altose, M.D.2    Connett, J.E.3    Kanner, R.E.4    Lee, W.W.5    Wise, R.A.6
  • 7
    • 18844474823 scopus 로고    scopus 로고
    • Airway hyperresponsiveness and COPD mortality
    • Vestbo J, Hansen EF. Airway hyperresponsiveness and COPD mortality. Thorax 2001; 56(suppl 2):ii11-ii14.
    • (2001) Thorax , vol.56 , Issue.SUPPL. 2
    • Vestbo, J.1    Hansen, E.F.2
  • 8
    • 0034649053 scopus 로고    scopus 로고
    • Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: A cohort study
    • Hospers JJ, Postma DS, Rijcken B, Weiss ST, Schouten JP. Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study. Lancet 2000; 356(9238):1313-1317.
    • (2000) Lancet , vol.356 , Issue.9238 , pp. 1313-1317
    • Hospers, J.J.1    Postma, D.S.2    Rijcken, B.3    Weiss, S.T.4    Schouten, J.P.5
  • 10
    • 0029947193 scopus 로고    scopus 로고
    • Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity
    • Copenhagen City Heart Study Group
    • Vestbo J, Prescott E, Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group. Am J Respir Crit Care Med 1996; 153(5):1530-1535.
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.5 , pp. 1530-1535
    • Vestbo, J.1    Prescott, E.2    Lange, P.3
  • 11
    • 0036618095 scopus 로고    scopus 로고
    • Does muscus hypersecretion matter in airway disease?
    • Melton L. Does muscus hypersecretion matter in airway disease? Lancet 2002; 359:1924.
    • (2002) Lancet , vol.359 , pp. 1924
    • Melton, L.1
  • 12
    • 0033772671 scopus 로고    scopus 로고
    • Mucus pathophysiology in COPD: Differences to asthma, and pharmacotherapy
    • Rogers DF. Mucus pathophysiology in COPD: differences to asthma, and pharmacotherapy. Monaldi Arch Chest Dis 2000; 55(4):324-332.
    • (2000) Monaldi Arch Chest Dis , vol.55 , Issue.4 , pp. 324-332
    • Rogers, D.F.1
  • 14
    • 0034040183 scopus 로고    scopus 로고
    • Bacterial infection and the pathogenesis of COPD
    • Sethi S. Bacterial infection and the pathogenesis of COPD. Chest 2000; 117(5 suppl 1):286S-291S.
    • (2000) Chest , vol.117 , Issue.5 SUPPL. 1
    • Sethi, S.1
  • 16
    • 0024424752 scopus 로고
    • Intraepithelial T-lymphocyte subsets in the airways of normal subjects and of patients with chronic bronchitis
    • Fournier M, Lebargy F, Le Roy Ladurie F, Lenormand E, Pariente R. Intraepithelial T-lymphocyte subsets in the airways of normal subjects and of patients with chronic bronchitis. Am Rev Respir Dis 1989; 140(3):737-742.
    • (1989) Am Rev Respir Dis , vol.140 , Issue.3 , pp. 737-742
    • Fournier, M.1    Lebargy, F.2    Le Roy Ladurie, F.3    Lenormand, E.4    Pariente, R.5
  • 20
    • 0036347640 scopus 로고    scopus 로고
    • Sputum chemotactic activity in chronic obstructive pulmonary disease: Effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8
    • Woolhouse IS, Bayley DL, Stockley RA. Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8. Thorax 2002; 57(8):709-714.
    • (2002) Thorax , vol.57 , Issue.8 , pp. 709-714
    • Woolhouse, I.S.1    Bayley, D.L.2    Stockley, R.A.3
  • 21
    • 0030071687 scopus 로고    scopus 로고
    • Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma
    • Keatings VM, Collins PD, Scott DM, Barnes PJ. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996; 153(2):530-534.
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.2 , pp. 530-534
    • Keatings, V.M.1    Collins, P.D.2    Scott, D.M.3    Barnes, P.J.4
  • 23
    • 0037465734 scopus 로고    scopus 로고
    • Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? the potential role of systemic inflammation in chronic obstructive pulmonary disease
    • Sin DD, Man SF. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 2003; 107(11):1514-1519.
    • (2003) Circulation , vol.107 , Issue.11 , pp. 1514-1519
    • Sin, D.D.1    Man, S.F.2
  • 24
    • 0037447325 scopus 로고    scopus 로고
    • Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease
    • Wilkinson TM, Patel IS, Wilks M, Donaldson GC, Wedzicha JA. Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2003; 167(8):1090-1095.
    • (2003) Am J Respir Crit Care Med , vol.167 , Issue.8 , pp. 1090-1095
    • Wilkinson, T.M.1    Patel, I.S.2    Wilks, M.3    Donaldson, G.C.4    Wedzicha, J.A.5
  • 25
    • 0029935615 scopus 로고    scopus 로고
    • Oxidant/antioxidant imbalance in smokers and chronic obstructive pulmonary disease
    • Rahman I, MacNee W. Oxidant/antioxidant imbalance in smokers and chronic obstructive pulmonary disease. Thorax 1996; 51(4):348-350.
    • (1996) Thorax , vol.51 , Issue.4 , pp. 348-350
    • Rahman, I.1    MacNee, W.2
  • 26
    • 0003321298 scopus 로고    scopus 로고
    • Upregulation of the inducible form of the nitric oxide synthase and nitrotyrosine formation in skeletal muscle of COPD patients
    • Gari PG, Busquets X, Morla M, Sauleda J, Agusti A. Upregulation of the inducible form of the nitric oxide synthase and nitrotyrosine formation in skeletal muscle of COPD patients. Eur Respir J 2002; 20:S38.
    • (2002) Eur Respir J , vol.20
    • Gari, P.G.1    Busquets, X.2    Morla, M.3    Sauleda, J.4    Agusti, A.5
  • 28
    • 0035840849 scopus 로고    scopus 로고
    • Oxidative stress and lung inflammation in airways disease
    • MacNee W. Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol 2001; 429(1-3):195-207.
    • (2001) Eur J Pharmacol , vol.429 , Issue.1-3 , pp. 195-207
    • MacNee, W.1
  • 29
    • 0030987526 scopus 로고    scopus 로고
    • Comparative loss of activity of recombinant secretory leukoprotease inhibitor and alpha 1-protease inhibitor caused by different forms of oxidative stress
    • Vogelmeier C, Biedermann T, Maier K, Mazur G, Behr J, Krombach F, Buhl R. Comparative loss of activity of recombinant secretory leukoprotease inhibitor and alpha 1-protease inhibitor caused by different forms of oxidative stress. Eur Respir J 1997; 10(9):2114-2119.
    • (1997) Eur Respir J , vol.10 , Issue.9 , pp. 2114-2119
    • Vogelmeier, C.1    Biedermann, T.2    Maier, K.3    Mazur, G.4    Behr, J.5    Krombach, F.6    Buhl, R.7
  • 30
    • 0032880124 scopus 로고    scopus 로고
    • The interrelationship of sputum inflammatory markers in patients with chronic bronchitis
    • Hill AT, Bayley D, Stockley RA. The interrelationship of sputum inflammatory markers in patients with chronic bronchitis. Am J Respir Crit Care Med 1999; 160(3):893-898.
    • (1999) Am J Respir Crit Care Med , vol.160 , Issue.3 , pp. 893-898
    • Hill, A.T.1    Bayley, D.2    Stockley, R.A.3
  • 31
    • 0035218725 scopus 로고    scopus 로고
    • Mucus hypersecretion in chronic obstructive pulmonary disease
    • discussion 77-83
    • Rogers DF. Mucus hypersecretion in chronic obstructive pulmonary disease. Novartis Found Symp 2001; 234:65-77; discussion 77-83.
    • (2001) Novartis Found Symp , vol.234 , pp. 65-77
    • Rogers, D.F.1
  • 32
    • 0034032761 scopus 로고    scopus 로고
    • Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley lecture
    • Jeffery PK. Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley lecture. Chest 2000; 117(5 suppl 1):251S-260S.
    • (2000) Chest , vol.117 , Issue.5 SUPPL. 1
    • Jeffery, P.K.1
  • 34
    • 0028270358 scopus 로고
    • Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs
    • Lang MR, Fiaux GW, Gillooly M, Stewart JA, Hulmes DJ, Lamb D. Collagen content of alveolar wall tissue in emphysematous and non-emphysematous lungs. Thorax 1994; 49(4):319-326.
    • (1994) Thorax , vol.49 , Issue.4 , pp. 319-326
    • Lang, M.R.1    Fiaux, G.W.2    Gillooly, M.3    Stewart, J.A.4    Hulmes, D.J.5    Lamb, D.6
  • 35
    • 0027247516 scopus 로고
    • Anthropometric and pulmonary function test profiles of outpatients with stable chronic obstructive pulmonary disease
    • Sahebjami H, Doers JT, Render ML, Bond TL. Anthropometric and pulmonary function test profiles of outpatients with stable chronic obstructive pulmonary disease. Am J Med 1993; 94(5):469-474.
    • (1993) Am J Med , vol.94 , Issue.5 , pp. 469-474
    • Sahebjami, H.1    Doers, J.T.2    Render, M.L.3    Bond, T.L.4
  • 37
    • 0029924786 scopus 로고    scopus 로고
    • Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease
    • Decramer M, de Bock V, Dom R. Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1996; 153(6 pt 1):1958-1964.
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.6 PART 1 , pp. 1958-1964
    • Decramer, M.1    De Bock, V.2    Dom, R.3
  • 38
    • 0029670951 scopus 로고    scopus 로고
    • Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients
    • de Godoy I, Donahoe M, Calhoun WJ, Mancino J, Rogers RM. Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients. Am J Respir Crit Care Med 1996; 153(2):633-637.
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.2 , pp. 633-637
    • De Godoy, I.1    Donahoe, M.2    Calhoun, W.J.3    Mancino, J.4    Rogers, R.M.5
  • 39
    • 0034522805 scopus 로고    scopus 로고
    • Peripheral muscle dysfunction in chronic obstructive pulmonary disease
    • Maltais F, LeBlanc P, Jobin J, Casaburi R. Peripheral muscle dysfunction in chronic obstructive pulmonary disease. Clin Chest Med 2000; 21(4):665-677.
    • (2000) Clin Chest Med , vol.21 , Issue.4 , pp. 665-677
    • Maltais, F.1    Leblanc, P.2    Jobin, J.3    Casaburi, R.4
  • 40
    • 1842552109 scopus 로고    scopus 로고
    • Standards for the diagnosis and treatment of patients with COPD: A summary of the ATS/ERS position paper
    • Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004; 23(6):932-946.
    • (2004) Eur Respir J , vol.23 , Issue.6 , pp. 932-946
    • Celli, B.R.1    MacNee, W.2
  • 41
    • 0018885920 scopus 로고
    • Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial
    • Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med 1980; 93(3):391-398.
    • (1980) Ann Intern Med , vol.93 , Issue.3 , pp. 391-398
  • 42
    • 84921006141 scopus 로고
    • Report of the Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema
    • Report of the Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Lancet 1981; 1(8222):681-686.
    • (1981) Lancet , vol.1 , Issue.8222 , pp. 681-686
  • 44
    • 0028886394 scopus 로고
    • Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: A pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD)
    • Dutch Study Group
    • Maesen FP, Smeets JJ, Sledsens TJ, Wald FD, Cornelissen PJ. Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: a pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD). Dutch Study Group. Eur Respir J 1995; 8(9):1506-1513.
    • (1995) Eur Respir J , vol.8 , Issue.9 , pp. 1506-1513
    • Maesen, F.P.1    Smeets, J.J.2    Sledsens, T.J.3    Wald, F.D.4    Cornelissen, P.J.5
  • 49
    • 0030903442 scopus 로고    scopus 로고
    • Quality of life changes in COPD patients treated with salmeterol
    • Jones PW, Bosh TK. Quality of life changes in COPD patients treated with salmeterol. Am J Respir Crit Care Med 1997; 155(4):1283-1289.
    • (1997) Am J Respir Crit Care Med , vol.155 , Issue.4 , pp. 1283-1289
    • Jones, P.W.1    Bosh, T.K.2
  • 51
    • 0032822578 scopus 로고    scopus 로고
    • Formoterol and salmeterol in partially reversible chronic obstructive pulmonary disease: A crossover, placebo-controlled comparison of onset and duration of action
    • Celik G, Kayacan O, Beder S, Durmaz G. Formoterol and salmeterol in partially reversible chronic obstructive pulmonary disease: a crossover, placebo-controlled comparison of onset and duration of action. Respiration 1999; 66(5):434-439.
    • (1999) Respiration , vol.66 , Issue.5 , pp. 434-439
    • Celik, G.1    Kayacan, O.2    Beder, S.3    Durmaz, G.4
  • 52
    • 0034890383 scopus 로고    scopus 로고
    • Alternative mechanisms for long-acting beta(2)-adrenergic agonists in COPD
    • Johnson M, Rennard S. Alternative mechanisms for long-acting beta(2)-adrenergic agonists in COPD. Chest 2001; 120(1):258-270.
    • (2001) Chest , vol.120 , Issue.1 , pp. 258-270
    • Johnson, M.1    Rennard, S.2
  • 53
    • 0000930544 scopus 로고    scopus 로고
    • Salmeterol (S) speeds mucociliary transport (MCT) in healthy subjects
    • Chambers C, Corrigan B, Newhouse M. Salmeterol (S) speeds mucociliary transport (MCT) in healthy subjects. Am J Respir Crit Care Med 1999; 159:A636.
    • (1999) Am J Respir Crit Care Med , vol.159
    • Chambers, C.1    Corrigan, B.2    Newhouse, M.3
  • 54
    • 0026497752 scopus 로고
    • The influence of a new beta agonist: Formoterol on mucociliary function
    • Melloni B, Germouty J. The influence of a new beta agonist: formoterol on mucociliary function. Rev Mal Respir 1992; 9(5):503-507.
    • (1992) Rev Mal Respir , vol.9 , Issue.5 , pp. 503-507
    • Melloni, B.1    Germouty, J.2
  • 55
    • 0031915354 scopus 로고    scopus 로고
    • Effect of salmeterol on Haemophilus influenzae infection of respiratory mucosa in vitro
    • Dowling RB, Johnson M, Cole PJ, Wilson R. Effect of salmeterol on Haemophilus influenzae infection of respiratory mucosa in vitro. Eur Respir J 1998; 11(1):86-90.
    • (1998) Eur Respir J , vol.11 , Issue.1 , pp. 86-90
    • Dowling, R.B.1    Johnson, M.2    Cole, P.J.3    Wilson, R.4
  • 57
    • 4243946913 scopus 로고
    • Salbutamol and salmeterol modulate cytokine production by peripheral blood monocytes
    • Pennings HJ, Dentener MA, Buurman WA, Wouters EFM. Salbutamol and salmeterol modulate cytokine production by peripheral blood monocytes. Eur Respir J 1995; 8(suppl 19):1871.
    • (1995) Eur Respir J , vol.8 , Issue.SUPPL. 19 , pp. 1871
    • Pennings, H.J.1    Dentener, M.A.2    Buurman, W.A.3    Wouters, E.F.M.4
  • 58
    • 4243742342 scopus 로고
    • 2-agonists: A comparison of salbutamol and salmterol
    • 2-agonists: a comparison of salbutamol and salmterol. Eur Respir J 1995; 8(suppl 19):2692.
    • (1995) Eur Respir J , vol.8 , Issue.SUPPL. 19 , pp. 2692
    • Pantelidis, P.1    Hayes, K.L.2
  • 59
    • 0031075106 scopus 로고    scopus 로고
    • Salmeterol inhibits the allergen-induced mononuclear cell proliferation and downregulates GM-CSF release and HLA-DR expression by monocytes
    • Oddera S, Silvestri M, Scarso L, Testi R, Rossi GA. Salmeterol inhibits the allergen-induced mononuclear cell proliferation and downregulates GM-CSF release and HLA-DR expression by monocytes. Pulm Pharmacol Ther 1997; 10(1):43-49.
    • (1997) Pulm Pharmacol Ther , vol.10 , Issue.1 , pp. 43-49
    • Oddera, S.1    Silvestri, M.2    Scarso, L.3    Testi, R.4    Rossi, G.A.5
  • 61
    • 0003244374 scopus 로고    scopus 로고
    • Salmeterol modulates cell proliferation on thrombin stimulated human cultured airway smooth muscle via an action independent of the beta2-adrenoceptor
    • Harris T, Koutsoubos V, Guida E. Salmeterol modulates cell proliferation on thrombin stimulated human cultured airway smooth muscle via an action independent of the beta2-adrenoceptor. Am J Respir Crit Care Med 1999; 159:A530.
    • (1999) Am J Respir Crit Care Med , vol.159
    • Harris, T.1    Koutsoubos, V.2    Guida, E.3
  • 62
    • 0029953807 scopus 로고    scopus 로고
    • Beta-adrenergic agonists attenuate fibroblast-mediated contraction of released collagen gels
    • Mio T, Adachi Y, Carnevali S, Romberger D, Spurzem J, Rennard S. Beta-adrenergic agonists attenuate fibroblast-mediated contraction of released collagen gels. Am J Physiol 1996; 70:L829-L835.
    • (1996) Am J Physiol , vol.70
    • Mio, T.1    Adachi, Y.2    Carnevali, S.3    Romberger, D.4    Spurzem, J.5    Rennard, S.6
  • 64
    • 0037092557 scopus 로고    scopus 로고
    • Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease
    • Culpitt SV, De Matos C, Russell RE, Donnelly LE, Rogers DF, Barnes PJ. Effect of theophylline on induced sputum inflammatory indices and neutrophil chemotaxis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 165(10):1371-1376.
    • (2002) Am J Respir Crit Care Med , vol.165 , Issue.10 , pp. 1371-1376
    • Culpitt, S.V.1    De Matos, C.2    Russell, R.E.3    Donnelly, L.E.4    Rogers, D.F.5    Barnes, P.J.6
  • 65
    • 0037445151 scopus 로고    scopus 로고
    • Theophylline: New perspectives for an old drug
    • Barnes PJ. Theophylline: new perspectives for an old drug. Am J Respir Crit Care Med 2003; 167(6):813-818.
    • (2003) Am J Respir Crit Care Med , vol.167 , Issue.6 , pp. 813-818
    • Barnes, P.J.1
  • 66
    • 0037173056 scopus 로고    scopus 로고
    • A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression
    • Ito K, Lim S, Caramori G, Cosio B, Chung KF, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A 2002; 99(13):8921-8926.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.13 , pp. 8921-8926
    • Ito, K.1    Lim, S.2    Caramori, G.3    Cosio, B.4    Chung, K.F.5    Adcock, I.M.6    Barnes, P.J.7
  • 68
    • 0034004246 scopus 로고    scopus 로고
    • Inhaled corticosteroids may reduce neutrophilic inflammation in patients with stable chronic obstructive pulmonary disease
    • Yildiz F, Kaur AC, Ilgazli A, Celikoglu M, Kacar Ozkara S, Paksoy N, Ozkarakas O. Inhaled corticosteroids may reduce neutrophilic inflammation in patients with stable chronic obstructive pulmonary disease. Respiration 2000; 67(1):71-76.
    • (2000) Respiration , vol.67 , Issue.1 , pp. 71-76
    • Yildiz, F.1    Kaur, A.C.2    Ilgazli, A.3    Celikoglu, M.4    Kacar Ozkara, S.5    Paksoy, N.6    Ozkarakas, O.7
  • 69
    • 0034086565 scopus 로고    scopus 로고
    • Inhaled corticosteroids in stable COPD patients: Do they have effects on cells and molecular mediators of airway inflammation?
    • Balbi B, Majori M, Bertacco S, Convertino G, Cuomo A, Donner CF, Pesci A. Inhaled corticosteroids in stable COPD patients: do they have effects on cells and molecular mediators of airway inflammation? Chest 2000; 117(6):1633-1637.
    • (2000) Chest , vol.117 , Issue.6 , pp. 1633-1637
    • Balbi, B.1    Majori, M.2    Bertacco, S.3    Convertino, G.4    Cuomo, A.5    Donner, C.F.6    Pesci, A.7
  • 70
    • 0031841422 scopus 로고    scopus 로고
    • Inhaled corticosteroids reduce neutrophilic bronchial inflammation in patients with chronic obstructive pulmonary disease
    • Confalonieri M, Mainardi E, Della Porta R, Bernorio S, Gandola L, Beghe B, Spanevello A. Inhaled corticosteroids reduce neutrophilic bronchial inflammation in patients with chronic obstructive pulmonary disease. Thorax 1998; 53(7):583-585.
    • (1998) Thorax , vol.53 , Issue.7 , pp. 583-585
    • Confalonieri, M.1    Mainardi, E.2    Della Porta, R.3    Bernorio, S.4    Gandola, L.5    Beghe, B.6    Spanevello, A.7
  • 71
    • 0030052682 scopus 로고    scopus 로고
    • Effect of fluticasone propionate on sputum of patients with chronic bronchitis and emphysema
    • Llewellyn-Jones CG, Harris TA, Stockley RA. Effect of fluticasone propionate on sputum of patients with chronic bronchitis and emphysema. Am J Respir Crit Care Med 1996; 153(2):616-621.
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.2 , pp. 616-621
    • Llewellyn-Jones, C.G.1    Harris, T.A.2    Stockley, R.A.3
  • 72
    • 0037097883 scopus 로고    scopus 로고
    • The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: A double-blind, placebo-controlled biopsy study
    • Hattotuwa KL, Gizycki MJ, Ansari TW, Jeffery PK, Barnes NC. The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study. Am J Respir Crit Care Med 2002; 165(12):1592-1596.
    • (2002) Am J Respir Crit Care Med , vol.165 , Issue.12 , pp. 1592-1596
    • Hattotuwa, K.L.1    Gizycki, M.J.2    Ansari, T.W.3    Jeffery, P.K.4    Barnes, N.C.5
  • 73
    • 0036727142 scopus 로고    scopus 로고
    • Effects of fluticasone propionate on inflammatory cells in COPD: An ultrastructural examination of endobronchial biopsy tissue
    • Gizycki MJ, Hattotuwa KL, Barnes N, Jeffery PK. Effects of fluticasone propionate on inflammatory cells in COPD: an ultrastructural examination of endobronchial biopsy tissue. Thorax 2002; 57(9):799-803.
    • (2002) Thorax , vol.57 , Issue.9 , pp. 799-803
    • Gizycki, M.J.1    Hattotuwa, K.L.2    Barnes, N.3    Jeffery, P.K.4
  • 74
    • 0001397197 scopus 로고    scopus 로고
    • Effect of an inhaled glucocorticosteroid, fluticasone propionate (FP) on inflammation in bronchial biopsies of COPD patients with bronchial hyperresponsiveness (BHR)
    • Verhoeven GT, Hegmans JPJJ, Mulder PGH, Hoogsteden HC, Prins JB. Effect of an inhaled glucocorticosteroid, fluticasone propionate (FP) on inflammation in bronchial biopsies of COPD patients with bronchial hyperresponsiveness (BHR). Am J Respir Crit Care Med 1999; 159:A524.
    • (1999) Am J Respir Crit Care Med , vol.159
    • Verhoeven, G.T.1    Hegmans, J.P.J.J.2    Mulder, P.G.H.3    Hoogsteden, H.C.4    Prins, J.B.5
  • 75
    • 0034643610 scopus 로고    scopus 로고
    • Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: The ISOLDE trial
    • Burge PS, Calverley PM, Jones PW, Spencer S, Anderson JA, Maslen TK. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. Br Med J 2000; 320(7245):1297-1303.
    • (2000) Br Med J , vol.320 , Issue.7245 , pp. 1297-1303
    • Burge, P.S.1    Calverley, P.M.2    Jones, P.W.3    Spencer, S.4    Anderson, J.A.5    Maslen, T.K.6
  • 76
    • 0037425745 scopus 로고    scopus 로고
    • Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: A randomised controlled trial
    • Calverley P, Pauwels R, Vestbo J, Jones P, Pride N, Gulsvik A, Anderson J, Maden C. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003; 361(9356):449-456.
    • (2003) Lancet , vol.361 , Issue.9356 , pp. 449-456
    • Calverley, P.1    Pauwels, R.2    Vestbo, J.3    Jones, P.4    Pride, N.5    Gulsvik, A.6    Anderson, J.7    Maden, C.8
  • 78
    • 0033042619 scopus 로고    scopus 로고
    • The response to inhaled and oral steroids in patients with stable chronic obstructive pulmonary disease
    • Weiner P, Weiner M, Rabner M, Waizman J, Magadle R, Zamir D. The response to inhaled and oral steroids in patients with stable chronic obstructive pulmonary disease. J Intern Med 1999; 245(1):83-89.
    • (1999) J Intern Med , vol.245 , Issue.1 , pp. 83-89
    • Weiner, P.1    Weiner, M.2    Rabner, M.3    Waizman, J.4    Magadle, R.5    Zamir, D.6
  • 79
    • 0035880882 scopus 로고    scopus 로고
    • Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with chronic obstructive pulmonary disease
    • Sin DD, Tu JV. Inhaled corticosteroids and the risk of mortality and readmission in elderly patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164(4):580-584.
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.4 , pp. 580-584
    • Sin, D.D.1    Tu, J.V.2
  • 80
    • 0036798266 scopus 로고    scopus 로고
    • Survival in COPD patients after regular use of fluticasone propionate and salmeterol in general practice
    • Soriano JB, Vestbo J, Pride NB, Kiri V, Maden C, Maier WC. Survival in COPD patients after regular use of fluticasone propionate and salmeterol in general practice. Eur Respir J 2002; 20(4):819-825.
    • (2002) Eur Respir J , vol.20 , Issue.4 , pp. 819-825
    • Soriano, J.B.1    Vestbo, J.2    Pride, N.B.3    Kiri, V.4    Maden, C.5    Maier, W.C.6
  • 81
    • 0042007981 scopus 로고    scopus 로고
    • Inhaled corticosteroids with/without long-acting beta-agonists reduce the risk of rehospitalization and death in COPD patients
    • Soriano JB, Kiri VA, Pride NB, Vestbo J. Inhaled corticosteroids with/without long-acting beta-agonists reduce the risk of rehospitalization and death in COPD patients. Am J Respir Med 2003; 2(1):67-74.
    • (2003) Am J Respir Med , vol.2 , Issue.1 , pp. 67-74
    • Soriano, J.B.1    Kiri, V.A.2    Pride, N.B.3    Vestbo, J.4
  • 82
    • 22244444916 scopus 로고    scopus 로고
    • Effectiveness of inhaled corticosteroids in COPD: Immortal time bias in observational studies
    • Suissa S. Effectiveness of inhaled corticosteroids in COPD: immortal time bias in observational studies. Am J Respir Crit Care Med 2003.
    • (2003) Am J Respir Crit Care Med
    • Suissa, S.1
  • 83
    • 0042867245 scopus 로고    scopus 로고
    • Inhaled glucocorticosteroids in COPD: Immortal time bias
    • Letter to editor
    • Sin DD, Man SFP, Tu JV. Inhaled glucocorticosteroids in COPD: immortal time bias. Letter to editor. Am J Respir Crit Care Med 2003; 168:126.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 126
    • Sin, D.D.1    Man, S.F.P.2    Tu, J.V.3
  • 84
    • 0042366193 scopus 로고    scopus 로고
    • Inhaled glucocorticosteroids in COPD: Immortal time bias
    • Letter to editor
    • Pride NB, Vestbo J, Soriano JB, Kiri V. Inhaled glucocorticosteroids in COPD: immortal time bias. Letter to editor. Am J Respir Crit Care Med 2003; 168:127.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 127
    • Pride, N.B.1    Vestbo, J.2    Soriano, J.B.3    Kiri, V.4
  • 85
    • 0346101503 scopus 로고    scopus 로고
    • Inhaled corticosteroids in chronic obstructive pulmonary disease and risk of death and hospitalization: Time-dependent analysis
    • Fan VS, Bryson CL, Curtis JR, Fihn SD, Bridevaux PO, McDonell MB, Au DH. Inhaled corticosteroids in chronic obstructive pulmonary disease and risk of death and hospitalization: time-dependent analysis. Am J Respir Crit Care Med 2003; 168(12):1488-1494.
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.12 , pp. 1488-1494
    • Fan, V.S.1    Bryson, C.L.2    Curtis, J.R.3    Fihn, S.D.4    Bridevaux, P.O.5    McDonell, M.B.6    Au, D.H.7
  • 86
    • 0034023468 scopus 로고    scopus 로고
    • Transient effect of inhaled fluticasone on airway mucosal blood flow in subjects with and without asthma
    • Kumar SD, Brieva JL, Danta I, Wanner A. Transient effect of inhaled fluticasone on airway mucosal blood flow in subjects with and without asthma. Am J Respir Crit Care Med 2000; 161(3 pt 1):918-921.
    • (2000) Am J Respir Crit Care Med , vol.161 , Issue.3 PART 1 , pp. 918-921
    • Kumar, S.D.1    Brieva, J.L.2    Danta, I.3    Wanner, A.4
  • 87
    • 0034768594 scopus 로고    scopus 로고
    • Steroid sensitivity of norepinephrine uptake by human bronchial arterial and rabbit aortic smooth muscle cells
    • Horvath G, Lieb T, Conner GE, Salathe M, Wanner A. Steroid sensitivity of norepinephrine uptake by human bronchial arterial and rabbit aortic smooth muscle cells. Am J Respir Cell Mol Biol 2001; 25(4):500-506.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , Issue.4 , pp. 500-506
    • Horvath, G.1    Lieb, T.2    Conner, G.E.3    Salathe, M.4    Wanner, A.5
  • 89
    • 0037637614 scopus 로고    scopus 로고
    • Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids
    • Mendes ES, Pereira A, Danta I, Duncan RC, Wanner A. Comparative bronchial vasoconstrictive efficacy of inhaled glucocorticosteroids. Eur Respir J 2003; 21(6):989-993.
    • (2003) Eur Respir J , vol.21 , Issue.6 , pp. 989-993
    • Mendes, E.S.1    Pereira, A.2    Danta, I.3    Duncan, R.C.4    Wanner, A.5
  • 90
    • 0141558800 scopus 로고    scopus 로고
    • The efficacy and safety of fluticasone propionate 250 mcg/salmeterol 50 mcg combined in the discus inhaler for the treatment of chronic obstructive pulmonary disease
    • Hanania NA, Darken P, Horstman D, Reisner MD, Lee B, Davis S, Shah T. The efficacy and safety of fluticasone propionate 250 mcg/salmeterol 50 mcg combined in the discus inhaler for the treatment of chronic obstructive pulmonary disease. Chest 2003; 124:834-843.
    • (2003) Chest , vol.124 , pp. 834-843
    • Hanania, N.A.1    Darken, P.2    Horstman, D.3    Reisner, M.D.4    Lee, B.5    Davis, S.6    Shah, T.7
  • 91
    • 0037108632 scopus 로고    scopus 로고
    • Effectiveness of fluticasone propionate and salmeterol combination delivered via the diskus device in the treatment of chronic obstructive pulmonary disease
    • Mahler DA, Wire P, Horstman D, Chang CN, Yates J, Fischer T, Shah T. Effectiveness of fluticasone propionate and salmeterol combination delivered via the diskus device in the treatment of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 166(8):1084-1091.
    • (2002) Am J Respir Crit Care Med , vol.166 , Issue.8 , pp. 1084-1091
    • Mahler, D.A.1    Wire, P.2    Horstman, D.3    Chang, C.N.4    Yates, J.5    Fischer, T.6    Shah, T.7
  • 92
    • 0347473812 scopus 로고    scopus 로고
    • Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease
    • Calverley PM, Boonsawat W, Cseke Z, Zhong N, Peterson S, Olsson H. Maintenance therapy with budesonide and formoterol in chronic obstructive pulmonary disease. Eur Respir J 2003; 22(6):912-919.
    • (2003) Eur Respir J , vol.22 , Issue.6 , pp. 912-919
    • Calverley, P.M.1    Boonsawat, W.2    Cseke, Z.3    Zhong, N.4    Peterson, S.5    Olsson, H.6
  • 93
    • 0028318612 scopus 로고
    • In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone. An 85-day multicenter trial
    • COMBIVENT Inhalation Aerosol Study Group. In chronic obstructive pulmonary disease, a combination of ipratropium and albuterol is more effective than either agent alone. An 85-day multicenter trial. Chest 1994; 105(5):1411-1419.
    • (1994) Chest , vol.105 , Issue.5 , pp. 1411-1419
  • 94
    • 0031783283 scopus 로고    scopus 로고
    • Inhalation by nebulization of albuterol-ipratropium combination (Dey combination) is superior to either agent alone in the treatment of chronic obstructive pulmonary disease
    • Dey Combination Solution Study Group
    • Gross N, Tashkin D, Miller R, Oren J, Coleman W, Linberg S. Inhalation by nebulization of albuterol-ipratropium combination (Dey combination) is superior to either agent alone in the treatment of chronic obstructive pulmonary disease. Dey Combination Solution Study Group. Respiration 1998; 65(5):354-362.
    • (1998) Respiration , vol.65 , Issue.5 , pp. 354-362
    • Gross, N.1    Tashkin, D.2    Miller, R.3    Oren, J.4    Coleman, W.5    Linberg, S.6
  • 95
    • 0034037365 scopus 로고    scopus 로고
    • Long-term treatment of chronic obstructive pulmonary disease with salmeterol and the additive effect of ipratropium
    • van Noord JA, de Munck DR, Bantje TA, Hop WC, Akveld ML, Bommer AM. Long-term treatment of chronic obstructive pulmonary disease with salmeterol and the additive effect of ipratropium. Eur Respir J 2000; 15(5):878-885.
    • (2000) Eur Respir J , vol.15 , Issue.5 , pp. 878-885
    • Van Noord, J.A.1    De Munck, D.R.2    Bantje, T.A.3    Hop, W.C.4    Akveld, M.L.5    Bommer, A.M.6
  • 96
    • 0035084103 scopus 로고    scopus 로고
    • Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro
    • Hatzelmann A, Schudt C. Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro. J Pharmacol Exp Ther 2001; 297(1):267-279.
    • (2001) J Pharmacol Exp Ther , vol.297 , Issue.1 , pp. 267-279
    • Hatzelmann, A.1    Schudt, C.2
  • 100
    • 14244270585 scopus 로고    scopus 로고
    • Development status of second generation PDE4 inhibitors for asthma and COPD: The story so far
    • Giembycz MA. Development status of second generation PDE4 inhibitors for asthma and COPD: the story so far. Monaldi Arch Chest Dis 2002; 57(1):48-64.
    • (2002) Monaldi Arch Chest Dis , vol.57 , Issue.1 , pp. 48-64
    • Giembycz, M.A.1


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