Transcription initiation and termination on Leishmania major chromosome 3

Eukaryotic Cell

Volumn 3, Issue 2, 2004, Pages 506-517

  Martínez Calvillo, Santiago ^a,b   Nguyen, Dan ^a   Stuart, Kenneth ^a,b   Myler, Peter J ^a,b  

^a SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMANITIN; DICARBOXYLIC ACID; DNA DIRECTED RNA POLYMERASE; LUCIFERASE; LYSINE TRANSFER RNA; MESSENGER RNA; ORGANOPHOSPHORUS COMPOUND; SINGLE STRANDED DNA; SPACER DNA; TAGETITOXIN;

ANIMAL; ARTICLE; CHROMOSOME; DRUG ANTAGONISM; DRUG EFFECT; GENE; GENE FUSION; GENETIC TRANSCRIPTION; GENETICS; LEISHMANIA; METHODOLOGY; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

AMANITINS; ANIMALS; ARTIFICIAL GENE FUSION; BASE SEQUENCE; CHROMOSOMES; DICARBOXYLIC ACIDS; DNA, INTERGENIC; DNA, SINGLE-STRANDED; DNA-DIRECTED RNA POLYMERASES; GENES, PROTOZOAN; LEISHMANIA; LUCIFERASES; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NUCLEIC ACID HYBRIDIZATION; ORGANOPHOSPHORUS COMPOUNDS; RNA, MESSENGER; RNA, TRANSFER, LYS; TRANSCRIPTION, GENETIC; ULTRAVIOLET RAYS;

EUKARYOTA; LEISHMANIA MAJOR; PROTOZOA;

EID: 6344234341     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.3.2.506-517.2004     Document Type: Article

References (46)

1. met gene. Nucleic Acids Res. 12:1101-1115.
2. Ben Amar, M. F., D. Jefferies, A. Pays, N. Bakalara, G. Kendall, and E. Pays. 1991. The actin gene promoter of Trypanosoma brucei. Nucleic Acids Res. 19:5857-5862.
3. Ben-Shlomo, H., A. Levitan, O. Beja, and S. Michaeli. 1997. The trypanosomatid Leptomonas collosoma 7SL RNA gene. Analysis of elements controlling its expression. Nucleic Acids Res. 25:4977-4984.
4. Berberof, M., A. Pays, S. Lips, P. Tebabi, and E. Pays. 1996. Characterization of a transcription terminator of the procyclin PARP A unit of Trypanosoma brucei. Mol. Cell. Biol. 16:914-924.
5. Clayton, C. E. 2002. Life without transcriptional control? From fly to man and back again. EMBO J. 21:1881-1888.
6. Coquelet, H., M. Steinert, and E. Pays. 1991. Ultraviolet irradiation inhibits RNA decay and modifies ribosomal RNA processing in Trypanosoma brucei. Mol. Biochem. Parasitol. 44:33-42.
7. Downey, N., and J. E. Donelson. 1999. Search for promoters for the GARP and rRNA genes of Trypanosoma congolense. Mol. Biochem. Parasitol. 104: 25-38.
8. Fantoni, A., A. O. Dare, and C. Tschudi. 1994. RNA polymerase III-mediated transcription of the trypanosome U2 small nuclear RNA gene is controlled by both intragenic and extragenic regulatory elements. Mol. Cell. Biol. 14:2021-2028.
9. Galli, G., H. Hofstetter, and M. L. Birnstiel. 1981. Two conserved sequence blocks within eukaryotic tRNA genes are major promoter elements. Nature 294:626-631.
10. Gilinger, G., and V. Bellofatto. 2001. Trypanosome spliced leader RNA genes contain the first identified RNA polymerase II gene promoter in these organisms. Nucleic Acids Res. 29:1556-1564.
11. Graham, S. V., D. Jeferies, and J. D. Barry. 1996. A promoter directing α-amanitin-sensitive transcription of GARP, the major surface antigen of insect stage Trypanosoma congolense. Nucleic Acids Res. 24:272-281.
12. Grondal, E. J. M., R. Evers, K. Kosubek, and A. W. C. A. Cornelissen. 1989. Characterization of the RNA polymerases of Trypanosoma brucei: trypanosomal mRNAs are composed of transcripts derived from both RNA polymerase II and III. EMBO J. 8:3383-3389.
13. Johnson, P. J., J. M. Kooter, and P. Borst. 1987. Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene. Cell 51:273-281.
14. Kapler, G. M., K. Zhang, and S. M. Beverley. 1990. Nuclease mapping and DNA sequence analysis of transcripts from the dihydrofolate reductase- thymidylate synthase (R) region of Leishmania major. Nucleic Acids Res. 18:6399-6408.
15. Lee, M. G. S. 1996. An RNA polymerase II promoter in the hsp70 locus of Trypanosoma brucei. Mol. Cell. Biol. 16:1220-1230.
16. Luo, H., G. Gilinger, D. Mukberjee, and V. Bellofatto. 1999. Transcription initiation at the TATA-less spliced leader RNA gene promoter requires at least two DNA-binding proteins and a tripartite architecture that includes an initiator element. J. Biol. Chem. 274:31947-31954.
17. Marchetti, M. A., C. Tschudi, E. Silva, and E. Ullu. 1998. Physical and transcriptional analysis of the Trypanosoma brucei genome reveals a typical eukaryotic arrangement with close interspersion of RNA polymerase II- and III-transcribed genes. Nucleic Acids Res. 26:3591-3598.
18. Martinez-Calvillo, S., S. M. Sunkin, S. Yan, M. Fox, K. Stuart, and P. J. Myler. 2001. Genomic organization and functional characterization of the Leishmania major Friedlin ribosomal RNA gene locus. Mol. Biochem. Parasitol. 116:147-157.
19. Martinez-Calvillo, S., S. Yan, D. Nguyen, M. Fox, K. D. Stuart, and P. J. Myler. 2003. Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region. Mol. Cell 11:1291-1299.
20. McAndrew, M., S. Graham, C. Hartmann, and C. Clayton. 1998. Testing promoter activity in the trypanosome genome: isolation of a metacyclic-type VSG promoter, and unexpected insights into RNA polymerase II transcription. Exp. Parasitol. 90:65-76.
21. Myler, P. J., L. Audleman, T. deVos, G. Hixson, P. Kiser, C. Lemley, C. Magness, E. Rickell, E. Sisk, S. Sunkin, S. Swartzell, T. Westlake, P. Bastien, G. Fu, A. Ivens, and K. Stuart. 1999. Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes. Proc. Natl. Acad. Sci. USA 96:2902-2906.
22. Myler, P. J., E. Sisk, P. D. McDonagh, S. Martinez-Calvillo, A. Schnaufer, S. M. Sunkin, S. Yan, R. Madhubala, Ivens, A., and K. Stuart. 2000. Genomic organization and gene function in Leishmania. Biochem. Soc. Trans. 28:527-531.
23. Myung, K. S., J. K. Beetham, M. E. Wilson, and J. E. Donelson. 2002. Comparison of the post-transcriptional regulation of the mRNAs for the surface proteins PSA (GP46) and MSP (GP63) of Leishmania chagasi. J. Biol. Chem. 277:16489-16497.
24. Nakaar, V., A. O. Dare, D. Hong, E. Ullu, and C. Tschudi. 1994. Upstream tRNA genes are essential for expression of small nuclear and cytoplasmic RNA genes in trypanosomes. Mol. Cell. Biol. 14:6736-6742.
25. Nakaar, V., A. Gunzl, E. Ullu, and C. Tschudi. 1997. Structure of the Trypanosoma brucei U6 snRNA gene promoter. Mol. Biochem. Parasitol. 88:13-23.
26. Nakaar, V., C. Tschudi, and E. Ullu. 1995. An unusual liaison: small nuclear and cytoplasmic RNA genes team up with tRNA genes in trypanosomatid protozoa. Parasitol. Today 11:225-228.
27. Parsons, M., R. G. Nelson, K. P. Watkins, and N. Agabian. 1984. Trypanosome mRNAs share a common 5′ spliced leader sequence. Cell 38:309-316.
28. Paule, M. R., and R. J. White. 2000. Survey and summary: transcription by RNA polymerases I and III. Nucleic Acids Res. 28:1283-1298.
29. Prescott, E. M., and N. J. Proudfoot. 2002. Transcriptional collision between convergent genes in budding yeast. Proc. Natl. Acad. Sci. USA 99:8796-8801.
30. Proudfoot, N. J., A. Furger, and M. J. Dye. 2002. Integrating mRNA processing with transcription. Cell 108:501-512.
31. Rudenko, G., P. A. Blundell, A. Dirks-Mulder, R. Kieft, and P. Borst 1995. A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. brucei. Cell 83:547-553.
32. Saito, R. M., M. G. Elgort, and D. A. Campbell. 1994. A conserved upstream element is essential for transcription of the Leishmania tarentolae mini-exon gene. EMBO J. 13:5460-5469.
33. Sauerbler, W., and K. Hercules. 1978. Gene and transcription unit mapping by radiation effects. Annu. Rev. Genet. 12:329-363.
34. Sharp, S., D. DeFranco, T. Dingermann, P. Farrell, and D. Soll. 1981. Internal control regions for transcription of eukaryotic tRNA genes. Proc. Natl. Acad. Sci. USA 78:6657-6661.
35. Shaw, J. J., and R. Lainson. 1987. Ecology and epidemiology: New World, p. 291-361. In W. Peters and R. Killick-Kendrick (ed.), The leishmaniases in biology and medicine, vol. I. Academic Press, London, United Kingdom.
36. Steinberg, T. H., D. E. Mathews, R. D. Durbin, and R. R. Burgess. 1990. Tagetitoxin: a new inhibitor of eukaryotic transcription by RNA polymerase III. J. Biol. Chem. 265:499-505.
37. Stuart, K., T. E. Allen, S. Heidmann, and S. D. Seiwert. 1997. RNA editing in kinetoplastid protozoa. Microbiol. Mol. Biol. Rev. 61:105-120.
38. Sturm, N. R., M. C. Yu, and D. A. Campbell. 1999. Transcription termination and 3′-end processing of the spliced leader RNA in kinetoplastids. Mol. Cell. Biol. 19:1595-1604.
39. Swindle, J., and A. Tait. 1996. Trypanosomatid genetics, p. 6-34. In D. F. Smith and M. Parsons (ed.), Molecular biology of parasitic protozoa. Oxford University Press, Oxford, United Kingdom.
40. Wincker, P., C. Ravel, C. Blaineau, M. Pages, Y. Jaufret, J. Dedet, P. Bastien, and J. P. Dedet. 1996. The Leishmania genome comprises 36 chromosomes conserved across widely divergent human pathogenic species. Nucleic Acids Res. 24:1688-1694.
41. Wong, A. K. C., M. A. Curotto de Lafaille, and D. F. Wirth. 1994. Identification of a cis-acting gene regulatory element from the lemdr1 locus of Leishmania enriettii. J. Biol. Chem. 269:26497-26502.
42. Worthey, E., S. Martinez-Calvillo, A. Schnaufer, G. Aggarwal, J. Cawthra, G. Fazelinia, G. Fu, M. Hassebrock, G. Hixson, A. C. Ivens, P. Kiser, F. Marsolini, E. Rickell, R. Salavati, E. Sisk, S. M. Sunkin, K. D. Stuart, and P. J. Myler. 2003. Leishmania major chromosome 3 contains two long "convergent" polycistronic gene clusters separated by a tRNA gene. Nucleic Acids Res. 31:4201-4210.
43. Xu, Y., L. Liu, C. Lopez-Estrano, and S. Michaeli. 2001. Expression studies on clustered trypanosomatid box C/D small nucleolar RNAs. J. Biol. Chem. 276:14289-14298.
44. Yan, S., M. J. Lodes, M. Fox, P. J. Myler, and K. Stuart. 1999. Characterization of the Leishmania donovani ribosomal RNA promoter. Mol. Biochem. Parasitol. 103:197-210.
45. Yan, S., S. Martinez-Calvillo, A. Schnaufer, P. J. Myler, and K. Stuart. 2002. A low background inducible promoter system in Leishmania donovani. Mol. Biochem. Parasitol. 119:217-223.
46. Zomerdijk, J. C. B. M., R. Kieft, P. G. Shiels, and P. Borst. 1991. Alpha-amanitin-resistant transcription units in trypanosomes: a comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genes. Nucleic Acids Res. 19:5153-5158.