-
1
-
-
0035543338
-
Cellular pathophysiology and therapy of pulmonary hypertension
-
Olschewski H, Rose F, Grunig E et al. (2001) Cellular pathophysiology and therapy of pulmonary hypertension. J Lab Clin Med 138: 367-377
-
(2001)
J Lab Clin Med
, vol.138
, pp. 367-377
-
-
Olschewski, H.1
Rose, F.2
Grunig, E.3
-
2
-
-
0031031440
-
Primary pulmonary hypertension
-
Rubin LJ (1997) Primary pulmonary hypertension. N Engl J Med 336: 111-117
-
(1997)
N Engl J Med
, vol.336
, pp. 111-117
-
-
Rubin, L.J.1
-
3
-
-
0032578279
-
Primary pulmonary hypertension
-
Gaine SP, Rubin LJ (1998) Primary pulmonary hypertension. Lancet 352: 719-725
-
(1998)
Lancet
, vol.352
, pp. 719-725
-
-
Gaine, S.P.1
Rubin, L.J.2
-
4
-
-
0036682273
-
Inhaled iloprost for severe pulmonary hypertension
-
Olschewski H, Simonneau G, Galie N et al. (2002) Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 347: 322-329
-
(2002)
N Engl J Med
, vol.347
, pp. 322-329
-
-
Olschewski, H.1
Simonneau, G.2
Galie, N.3
-
5
-
-
4644290657
-
Treatment of pulmonary arterial hypertension
-
Humbert M, Sitbon O, Simonneau G (2004) Treatment of pulmonary arterial hypertension. N Engl J Med 351: 1425-1436
-
(2004)
N Engl J Med
, vol.351
, pp. 1425-1436
-
-
Humbert, M.1
Sitbon, O.2
Simonneau, G.3
-
7
-
-
0037006966
-
Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension
-
Ghofrani HA, Wiedemann R, Rose F et al. (2002) Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann Intern Med 136: 515-522
-
(2002)
Ann Intern Med
, vol.136
, pp. 515-522
-
-
Ghofrani, H.A.1
Wiedemann, R.2
Rose, F.3
-
9
-
-
0033228518
-
Mechanisms of structural remodeling in chronic pulmonary hypertension
-
Durmowicz AG, Stenmark KR (1999) Mechanisms of structural remodeling in chronic pulmonary hypertension. Pediatr Rev 20: e91-e102
-
(1999)
Pediatr Rev
, vol.20
-
-
Durmowicz, A.G.1
Stenmark, K.R.2
-
10
-
-
0036773104
-
The structural basis of pulmonary hypertension in chronic lung disease: Remodelling, rarefaction or angiogenesis?
-
Hopkins N, McLoughlin P (2002) The structural basis of pulmonary hypertension in chronic lung disease: remodelling, rarefaction or angiogenesis? J Anat 201: 335-348
-
(2002)
J Anat
, vol.201
, pp. 335-348
-
-
Hopkins, N.1
McLoughlin, P.2
-
11
-
-
2942541475
-
Cellular and molecular pathobiology of pulmonary arterial hypertension
-
Humbert M, Morrell NW, Archer SL et al. (2004) Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol 43: 13S-24S
-
(2004)
J Am Coll Cardiol
, vol.43
-
-
Humbert, M.1
Morrell, N.W.2
Archer, S.L.3
-
12
-
-
2942574709
-
Pathologic assessment of vasculopathies in pulmonary hypertension
-
Pietra GG, Capron F, Stewart S et al. (2004) Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol 43: 25S-32S
-
(2004)
J Am Coll Cardiol
, vol.43
-
-
Pietra, G.G.1
Capron, F.2
Stewart, S.3
-
13
-
-
0345490694
-
The tantalizing triplet of pulmonary hypertension-BMP receptors, serotonin receptors, and angiopoietins
-
Eickelberg O, Yeager ME, Grimminger F (2003) The tantalizing triplet of pulmonary hypertension-BMP receptors, serotonin receptors, and angiopoietins. Cardiovasc Res 60: 465-467
-
(2003)
Cardiovasc Res
, vol.60
, pp. 465-467
-
-
Eickelberg, O.1
Yeager, M.E.2
Grimminger, F.3
-
14
-
-
70449671451
-
Recent studies in primary pulmonary hypertension, including pharmacodynamic observations on pulmonary vascular resistance
-
Dresdale DT, Michtom RJ, Schultz M (1954) Recent studies in primary pulmonary hypertension, including pharmacodynamic observations on pulmonary vascular resistance. Bull N Y Acad Med 30: 195-207
-
(1954)
Bull N Y Acad Med
, vol.30
, pp. 195-207
-
-
Dresdale, D.T.1
Michtom, R.J.2
Schultz, M.3
-
15
-
-
0021288730
-
Familial primary pulmonary hypertension: Clinical patterns
-
Loyd JE, Primm RK, Newman JH (1984) Familial primary pulmonary hypertension: clinical patterns. Am Rev Respir Dis 129: 194-197
-
(1984)
Am Rev Respir Dis
, vol.129
, pp. 194-197
-
-
Loyd, J.E.1
Primm, R.K.2
Newman, J.H.3
-
16
-
-
0030956055
-
Mapping of familial primary pulmonary hypertension locus (PPH1) to chromosome 2q31-q32
-
Morse JH, Jones AC, Barst RJ, Hodge SE, Wilhelmsen KC, Nygaard TG (1997) Mapping of familial primary pulmonary hypertension locus (PPH1) to chromosome 2q31-q32. Circulation 95: 2603-2606
-
(1997)
Circulation
, vol.95
, pp. 2603-2606
-
-
Morse, J.H.1
Jones, A.C.2
Barst, R.J.3
Hodge, S.E.4
Wilhelmsen, K.C.5
Nygaard, T.G.6
-
17
-
-
0034021107
-
Fine mapping of PPH1, a gene for familial primary pulmonary hypertension, to a 3-cM region on chromosome 2q33
-
Deng Z, Haghighi F, Helleby L et al. (2000) Fine mapping of PPH1, a gene for familial primary pulmonary hypertension, to a 3-cM region on chromosome 2q33. Am J Respir Crit Care Med 161: 1055-1059
-
(2000)
Am J Respir Crit Care Med
, vol.161
, pp. 1055-1059
-
-
Deng, Z.1
Haghighi, F.2
Helleby, L.3
-
18
-
-
0031019091
-
Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32
-
Nichols WC, Koller DL, Slovis B et al. (1997) Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32. Nat Genet 15: 277-280
-
(1997)
Nat Genet
, vol.15
, pp. 277-280
-
-
Nichols, W.C.1
Koller, D.L.2
Slovis, B.3
-
19
-
-
0033838125
-
Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
-
Deng Z, Morse JH, Slager SL et al. (2000) Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet 67: 737-744
-
(2000)
Am J Hum Genet
, vol.67
, pp. 737-744
-
-
Deng, Z.1
Morse, J.H.2
Slager, S.L.3
-
20
-
-
0033817459
-
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
-
The International PPH Consortium
-
Lane KB, Machado RD, Pauciulo MW et al. (2000) Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Nat Genet 26: 81-84
-
(2000)
Nat Genet
, vol.26
, pp. 81-84
-
-
Lane, K.B.1
Machado, R.D.2
Pauciulo, M.W.3
-
21
-
-
0033623296
-
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR II, a receptor member of the TGF-beta family
-
Thomson JR, Machado RD, Pauciulo MW P et al. (2000) Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR II, a receptor member of the TGF-beta family. J Med Genet 37: 741-745
-
(2000)
J Med Genet
, vol.37
, pp. 741-745
-
-
Thomson, J.R.1
Machado, R.D.2
Pauciulo, M.W.P.3
-
22
-
-
2942581061
-
Genetic basis of pulmonary arterial hypertension: Current understanding and future directions
-
Newman JH, Trembath RC, Morse JA et al. (2004) Genetic basis of pulmonary arterial hypertension: current understanding and future directions. J Am Coll Cardiol 43: 33S-39S
-
(2004)
J Am Coll Cardiol
, vol.43
-
-
Newman, J.H.1
Trembath, R.C.2
Morse, J.A.3
-
23
-
-
0001644329
-
Mutations in the TGF-beta type 1 receptor, ALK1, in combined primary pulmonary hypertension and hereditary haemorrhagic telangiectasia, implies pathway specificity
-
Trembath RC (2001) Mutations in the TGF-beta type 1 receptor, ALK1, in combined primary pulmonary hypertension and hereditary haemorrhagic telangiectasia, implies pathway specificity. J Heart Lung Transplant 20: 175
-
(2001)
J Heart Lung Transplant
, vol.20
, pp. 175
-
-
Trembath, R.C.1
-
24
-
-
0035797556
-
Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
-
Trembath RC, Thomson JR, Machado RD et al. (2001) Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia. N Engl J Med 345: 325-334
-
(2001)
N Engl J Med
, vol.345
, pp. 325-334
-
-
Trembath, R.C.1
Thomson, J.R.2
Machado, R.D.3
-
25
-
-
9144219585
-
Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia
-
Harrison RE, Flanagan JA, Sankelo M et al. (2003) Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia. J Med Genet 40: 865-871
-
(2003)
J Med Genet
, vol.40
, pp. 865-871
-
-
Harrison, R.E.1
Flanagan, J.A.2
Sankelo, M.3
-
26
-
-
0031933224
-
Molecular and cell biology of TGF-beta
-
Roberts AB (1998) Molecular and cell biology of TGF-beta. Miner Electrolyte Metab 24: 111-119
-
(1998)
Miner Electrolyte Metab
, vol.24
, pp. 111-119
-
-
Roberts, A.B.1
-
27
-
-
0034678908
-
Transcriptional control by the TGF-beta/Smad signaling system
-
Massague J, Wotton D (2000) Transcriptional control by the TGF-beta/Smad signaling system. Embo J 19: 1745-1754
-
(2000)
Embo J
, vol.19
, pp. 1745-1754
-
-
Massague, J.1
Wotton, D.2
-
28
-
-
2342488852
-
New insights into TGF-beta-Smad signalling
-
ten Dijke P, Hill CS (2004) New insights into TGF-beta-Smad signalling. Trends Biochem Sci 29: 265-273
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 265-273
-
-
Ten Dijke, P.1
Hill, C.S.2
-
29
-
-
0035964939
-
Endless healing: TGF-beta, SMADs, and fibrosis
-
Eickelberg O (2001) Endless healing: TGF-beta, SMADs, and fibrosis. FEBS Lett 506: 11-14
-
(2001)
FEBS Lett
, vol.506
, pp. 11-14
-
-
Eickelberg, O.1
-
30
-
-
0036904895
-
Genetic analysis of the mammalian transforming growth factor-beta superfamily
-
Chang H, Brown CW, Matzuk MM (2002) Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 23: 787-823
-
(2002)
Endocr Rev
, vol.23
, pp. 787-823
-
-
Chang, H.1
Brown, C.W.2
Matzuk, M.M.3
-
31
-
-
0034193390
-
BMP type II receptor is required for gastrulation and early development of mouse embryos
-
Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K (2000) BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol 221: 249-258
-
(2000)
Dev Biol
, vol.221
, pp. 249-258
-
-
Beppu, H.1
Kawabata, M.2
Hamamoto, T.3
Chytil, A.4
Minowa, O.5
Noda, T.6
Miyazono, K.7
-
32
-
-
0032908432
-
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
-
Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A (1999) Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development 126: 1631-1642
-
(1999)
Development
, vol.126
, pp. 1631-1642
-
-
Chang, H.1
Huylebroeck, D.2
Verschueren, K.3
Guo, Q.4
Matzuk, M.M.5
Zwijsen, A.6
-
33
-
-
0005515655
-
Smad5 is essential for left-right asymmetry in mice
-
Chang H, Zwijsen A, Vogel H, Huylebroeck D, Matzuk MM (2000) Smad5 is essential for left-right asymmetry in mice. Dev Biol 219: 71-78
-
(2000)
Dev Biol
, vol.219
, pp. 71-78
-
-
Chang, H.1
Zwijsen, A.2
Vogel, H.3
Huylebroeck, D.4
Matzuk, M.M.5
-
34
-
-
0037096836
-
Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension
-
Rudarakanchana N, Flanagan JA, Chen H et al. (2002) Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension. Hum Mol Genet 11: 1517-1525
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1517-1525
-
-
Rudarakanchana, N.1
Flanagan, J.A.2
Chen, H.3
-
35
-
-
0036735752
-
Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension
-
Nishihara A, WatabeT, Imamura T, Miyazono K (2002) Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol Biol Cell 13: 3055-3063
-
(2002)
Mol Biol Cell
, vol.13
, pp. 3055-3063
-
-
Nishihara, A.1
Watabe, T.2
Imamura, T.3
Miyazono, K.4
-
36
-
-
0000224471
-
Immunolocalisation of BMPR-II and TGF-ss type I and II receptors in primary plexogenic pulmonary hypertension
-
Atkinson C, Stewart S, Imamura T, Trembath RC, Morrell NW (2001) Immunolocalisation of BMPR-II and TGF-ss type I and II receptors in primary plexogenic pulmonary hypertension. J Heart Lung Transplant 20: 149
-
(2001)
J Heart Lung Transplant
, vol.20
, pp. 149
-
-
Atkinson, C.1
Stewart, S.2
Imamura, T.3
Trembath, R.C.4
Morrell, N.W.5
-
37
-
-
0035859940
-
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins
-
Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK, Trembath RC (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104: 790-795
-
(2001)
Circulation
, vol.104
, pp. 790-795
-
-
Morrell, N.W.1
Yang, X.2
Upton, P.D.3
Jourdan, K.B.4
Morgan, N.5
Sheares, K.K.6
Trembath, R.C.7
-
38
-
-
0037046175
-
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
-
Atkinson C, Stewart S, Upton PD, Machado R, Thomson JR, Trembath RC, Morrell NW (2002) Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor. Circulation 105: 1672-1678
-
(2002)
Circulation
, vol.105
, pp. 1672-1678
-
-
Atkinson, C.1
Stewart, S.2
Upton, P.D.3
Machado, R.4
Thomson, J.R.5
Trembath, R.C.6
Morrell, N.W.7
-
39
-
-
0348013127
-
Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension
-
Machado RD, Rudarakanchana N, Atkinson C, Flanagan JA, Harrison R, Morrell NW, Trembath RC (2003) Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. Hum Mol Genet 12: 3277-3286
-
(2003)
Hum Mol Genet
, vol.12
, pp. 3277-3286
-
-
Machado, R.D.1
Rudarakanchana, N.2
Atkinson, C.3
Flanagan, J.A.4
Harrison, R.5
Morrell, N.W.6
Trembath, R.C.7
-
40
-
-
0141656297
-
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1
-
Foletta VC, Lim MA, Soosairajah J et al. (2003) Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J Cell Biol 162: 1089-1098
-
(2003)
J Cell Biol
, vol.162
, pp. 1089-1098
-
-
Foletta, V.C.1
Lim, M.A.2
Soosairajah, J.3
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