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Volumn 5, Issue 2, 2005, Pages 172-182

Homocysteine and endothelial function in human studies

Author keywords

Endothelium; Flow mediated dilation; Nitric oxide; Tetrahydrobiopterin

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BETAINE; CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; FOLIC ACID; GLYCERYL TRINITRATE; HOMOCYSTEINE; METHIONINE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PYRIDOXINE; TETRAHYDROBIOPTERIN;

EID: 21744440729     PISSN: 15289648     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-872402     Document Type: Review
Times cited : (33)

References (66)
  • 1
    • 0029885126 scopus 로고    scopus 로고
    • Endothelial dysfunction in atherosclerosis
    • Busse R, Fleming I. Endothelial dysfunction in atherosclerosis. J Vasc Res 1996;33:181-194
    • (1996) J Vasc Res , vol.33 , pp. 181-194
    • Busse, R.1    Fleming, I.2
  • 2
    • 0032990560 scopus 로고    scopus 로고
    • Endothelial dysfunction in human disease
    • Drexler H, Hornig B. Endothelial dysfunction in human disease. J Mol Cell Cardiol 1999;31:51-60
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 51-60
    • Drexler, H.1    Hornig, B.2
  • 3
    • 0037116573 scopus 로고    scopus 로고
    • Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force
    • Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002;39:257-265
    • (2002) J Am Coll Cardiol , vol.39 , pp. 257-265
    • Corretti, M.C.1    Anderson, T.J.2    Benjamin, E.J.3
  • 4
    • 0342424181 scopus 로고    scopus 로고
    • Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    • Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000;101:1899-1906
    • (2000) Circulation , vol.101 , pp. 1899-1906
    • Schachinger, V.1    Britten, M.B.2    Zeiher, A.M.3
  • 6
    • 0037799889 scopus 로고    scopus 로고
    • Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease
    • Gokce N, Keaney JF Jr, Hunter LM. Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol 2003;41:1769-1775
    • (2003) J Am Coll Cardiol , vol.41 , pp. 1769-1775
    • Gokce, N.1    Keaney Jr., J.F.2    Hunter, L.M.3
  • 7
    • 0037031266 scopus 로고    scopus 로고
    • Prognostic value of coronary vascular endothelial dysfunction
    • Halcox JP, Schenke WH, Zalos G. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002;106:653-658
    • (2002) Circulation , vol.106 , pp. 653-658
    • Halcox, J.P.1    Schenke, W.H.2    Zalos, G.3
  • 8
    • 0033814542 scopus 로고    scopus 로고
    • Endothelium-dependent responses in patients with hypercholesterolemic coronary artery disease under the effects of simvastatin and enalapril, either separately or combined
    • Esper RJ, Machado R, Vilarino J, et al. Endothelium-dependent responses in patients with hypercholesterolemic coronary artery disease under the effects of simvastatin and enalapril, either separately or combined. Am Heart J 2000;140:684-689
    • (2000) Am Heart J , vol.140 , pp. 684-689
    • Esper, R.J.1    Machado, R.2    Vilarino, J.3
  • 9
    • 0027266865 scopus 로고
    • Ramipril prevents impaired endothelium-dependent relaxation in arteries from rabbits fed an atherogenic diet
    • Finta KM, Fischer MJ, Lee L, Gordon D, Pitt B, Webb RC. Ramipril prevents impaired endothelium-dependent relaxation in arteries from rabbits fed an atherogenic diet. Atherosclerosis 1993;100:149-156
    • (1993) Atherosclerosis , vol.100 , pp. 149-156
    • Finta, K.M.1    Fischer, M.J.2    Lee, L.3    Gordon, D.4    Pitt, B.5    Webb, R.C.6
  • 10
    • 0034651798 scopus 로고    scopus 로고
    • Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure
    • Farquharson CA, Struthers AD. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure. Circulation 2000;101:594-597
    • (2000) Circulation , vol.101 , pp. 594-597
    • Farquharson, C.A.1    Struthers, A.D.2
  • 11
    • 0034006247 scopus 로고    scopus 로고
    • Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia
    • Goodfellow J, Bellamy MF, Ramsey MW, Jones CJ, Lewis MJ. Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol 2000;35:265-270
    • (2000) J Am Coll Cardiol , vol.35 , pp. 265-270
    • Goodfellow, J.1    Bellamy, M.F.2    Ramsey, M.W.3    Jones, C.J.4    Lewis, M.J.5
  • 12
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383-1389
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 13
    • 0027423378 scopus 로고
    • Effect of ramipril on martality and morvidity of survivors of acute myocardial infarction with clinical evidence of heart failure
    • The Acute Infarction Ramipril Efficacy (AIRE) Study investigators
    • Effect of ramipril on martality and morvidity of survivors of acute myocardial infarction with clinical evidence of heart failure. The Acute Infarction Ramipril Efficacy (AIRE) Study investigators. Lancet 1993;342:821-828
    • (1993) Lancet , vol.342 , pp. 821-828
  • 14
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999;341:709-717
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 15
    • 0345109256 scopus 로고    scopus 로고
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin e after myocardial infarction: Results of the GISSI-Prevenzione trial
    • Gruppo Italiano per lo Studio della Sopravvivenza nell Infarto miocardico
    • Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell Infarto miocardico. Lancet 1999;354:447-455
    • (1999) Lancet , vol.354 , pp. 447-455
  • 16
    • 0014545138 scopus 로고
    • Vascular pathology of homocysteinemia: Implications for the pathogenesis of arteriosclerosis
    • McCully KS. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am J Pathol 1969;56:111-128
    • (1969) Am J Pathol , vol.56 , pp. 111-128
    • McCully, K.S.1
  • 17
    • 0027255291 scopus 로고
    • Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents
    • Celermajer DS, Sorensen K, Ryalls M, et al. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol 1993;22:854-8S8
    • (1993) J Am Coll Cardiol , vol.22
    • Celermajer, D.S.1    Sorensen, K.2    Ryalls, M.3
  • 18
    • 0035987991 scopus 로고    scopus 로고
    • Vitamin C therapy ameliorates vascular endothelial dysfunction in treated patients with homocystinuria
    • Pullin CH, Bonham JR, McDowell IF, et al. Vitamin C therapy ameliorates vascular endothelial dysfunction in treated patients with homocystinuria. J Inherit Metab Dis 2002;25:107-118
    • (2002) J Inherit Metab Dis , vol.25 , pp. 107-118
    • Pullin, C.H.1    Bonham, J.R.2    McDowell, I.F.3
  • 19
    • 0035570015 scopus 로고    scopus 로고
    • Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: A multicenter observational study
    • Yap S, Boers GH, Wilcken B, et al. Vascular outcome in patients with homocystinuria due to cystathionine beta-synthase deficiency treated chronically: a multicenter observational study. Arterioscler Thromb Vasc Biol 2001;21:2080-2085
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 2080-2085
    • Yap, S.1    Boers, G.H.2    Wilcken, B.3
  • 20
    • 0031018333 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans
    • Tawakol A, Omland T, Gerhard M, Wu JT, Creager MA. Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 1997;95:1119-1121
    • (1997) Circulation , vol.95 , pp. 1119-1121
    • Tawakol, A.1    Omland, T.2    Gerhard, M.3    Wu, J.T.4    Creager, M.A.5
  • 21
    • 0030876147 scopus 로고    scopus 로고
    • Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans
    • Woo KS, Chook P, Lolin YI, et al. Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation 1997;6:2542-2544
    • (1997) Circulation , vol.6 , pp. 2542-2544
    • Woo, K.S.1    Chook, P.2    Lolin, Y.I.3
  • 23
    • 2142646462 scopus 로고    scopus 로고
    • Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects
    • Woodman RJ, Celermajer DE, Thompson PL, Hung J. Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects. Clin Sci 2004;106:353-358
    • (2004) Clin Sci , vol.106 , pp. 353-358
    • Woodman, R.J.1    Celermajer, D.E.2    Thompson, P.L.3    Hung, J.4
  • 24
    • 0037163849 scopus 로고    scopus 로고
    • MTHFR 677C → T polymorphism and risk of coronary heart disease: A meta-analysis
    • Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG. MTHFR 677C → T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 2002;288:2023-2031
    • (2002) JAMA , vol.288 , pp. 2023-2031
    • Klerk, M.1    Verhoef, P.2    Clarke, R.3    Blom, H.J.4    Kok, F.J.5    Schouten, E.G.6
  • 25
    • 0035195610 scopus 로고    scopus 로고
    • Optimization of dietary folate or low-dose folk acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype
    • Puffin CH, Ashfield-Watt PA, Burr ML, et al. Optimization of dietary folate or low-dose folk acid supplements lower homocysteine but do not enhance endothelial function in healthy adults, irrespective of the methylenetetrahydrofolate reductase (C677T) genotype. J Am Coll Cardiol 2001;38:1799-1805
    • (2001) J Am Coll Cardiol , vol.38 , pp. 1799-1805
    • Puffin, C.H.1    Ashfield-Watt, P.A.2    Burr, M.L.3
  • 26
    • 0036143431 scopus 로고    scopus 로고
    • The T allele of the C (677)T 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism may protect endothelial function in young, normal subjects
    • Butler R, Morris AD, Struthers AD. The T allele of the C (677)T 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism may protect endothelial function in young, normal subjects. Arterioscler Thromb Vasc Biol 2002;22:193-194
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 193-194
    • Butler, R.1    Morris, A.D.2    Struthers, A.D.3
  • 27
    • 0032480790 scopus 로고    scopus 로고
    • Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults
    • Bellamy MF, McDowell IF, Ramsey MW, et al. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation 1998;98:1848-1852
    • (1998) Circulation , vol.98 , pp. 1848-1852
    • Bellamy, M.F.1    McDowell, I.F.2    Ramsey, M.W.3
  • 28
    • 0033537653 scopus 로고    scopus 로고
    • Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: An effect reversible with vitamin C therapy
    • Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 1999;99:1156-1160
    • (1999) Circulation , vol.99 , pp. 1156-1160
    • Chambers, J.C.1    McGregor, A.2    Jean-Marie, J.3    Obeid, O.A.4    Kooner, J.S.5
  • 29
    • 0033052019 scopus 로고    scopus 로고
    • Endothelial dysfunction by acute hyperhomocyst (e)inaemia: Restoration by folic acid
    • Usui M, Matsuoka H, Miyazaki H, Ueda S, Okuda S, Imaizumi T. Endothelial dysfunction by acute hyperhomocyst (e)inaemia: restoration by folic acid. Clin Sci 1999;96:235-239
    • (1999) Clin Sci , vol.96 , pp. 235-239
    • Usui, M.1    Matsuoka, H.2    Miyazaki, H.3    Ueda, S.4    Okuda, S.5    Imaizumi, T.6
  • 30
    • 0033554459 scopus 로고    scopus 로고
    • Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans
    • Kanani PM, Sinkey CA, Browning RL, Allaman M, Knapp HR, Haynes WG. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans. Circulation 1999;100:1161-1168
    • (1999) Circulation , vol.100 , pp. 1161-1168
    • Kanani, P.M.1    Sinkey, C.A.2    Browning, R.L.3    Allaman, M.4    Knapp, H.R.5    Haynes, W.G.6
  • 31
    • 0034620573 scopus 로고    scopus 로고
    • Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults
    • Chao CL, Kuo TL, Lee YT. Effects of methionine-induced hyperhomocysteinemia on endothelium-dependent vasodilation and oxidative status in healthy adults. Circulation 2000;101:485-490
    • (2000) Circulation , vol.101 , pp. 485-490
    • Chao, C.L.1    Kuo, T.L.2    Lee, Y.T.3
  • 32
    • 0033538267 scopus 로고    scopus 로고
    • Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins
    • Nappo F, De Rosa N, Marfella R, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA 1999;281:2113-2118
    • (1999) JAMA , vol.281 , pp. 2113-2118
    • Nappo, F.1    De Rosa, N.2    Marfella, R.3
  • 34
    • 0035920267 scopus 로고    scopus 로고
    • Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects
    • Chambers JC, Ueland PM, Wright M, Dore CJ, Refsum H, Kooner JS. Investigation of relationship between reduced, oxidized, and protein-bound homocysteine and vascular endothelial function in healthy human subjects. Circ Res 2001;89:187-192
    • (2001) Circ Res , vol.89 , pp. 187-192
    • Chambers, J.C.1    Ueland, P.M.2    Wright, M.3    Dore, C.J.4    Refsum, H.5    Kooner, J.S.6
  • 35
    • 0035109723 scopus 로고    scopus 로고
    • Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans
    • Boger RH, Lentz SR, Bode-Boger SM, Knapp HR, Haynes WG. Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocyst(e)inaemia in humans. Clin Sci 2001;100:161-167
    • (2001) Clin Sci , vol.100 , pp. 161-167
    • Boger, R.H.1    Lentz, S.R.2    Bode-Boger, S.M.3    Knapp, H.R.4    Haynes, W.G.5
  • 36
    • 0041357001 scopus 로고    scopus 로고
    • Endothelial dysfunction induced by hyperhomocyst(e)inemia: Role of asymmetric dimethylarginine
    • Stuhlinger MC, Oka RK, Graf EE, et al. Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Circulation 2003;108:933-938
    • (2003) Circulation , vol.108 , pp. 933-938
    • Stuhlinger, M.C.1    Oka, R.K.2    Graf, E.E.3
  • 37
    • 0142062109 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading
    • Wanby P, Brattstrom L, Brudin L, Hultberg B, Teerlink T. Asymmetric dimethylarginine and total homocysteine in plasma after oral methionine loading. Scand J Clin Lab Invest 2003;63:347-353
    • (2003) Scand J Clin Lab Invest , vol.63 , pp. 347-353
    • Wanby, P.1    Brattstrom, L.2    Brudin, L.3    Hultberg, B.4    Teerlink, T.5
  • 38
    • 13844294309 scopus 로고    scopus 로고
    • Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine and endothelial function in healthy human subjects during experimental hyper and hypohomocysteinaemia
    • Doshi SN, McDowell IF, Goodfellow J, et al. Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine and endothelial function in healthy human subjects during experimental hyper and hypohomocysteinaemia. Metabolism 2005;54:351-360
    • (2005) Metabolism , vol.54 , pp. 351-360
    • Doshi, S.N.1    McDowell, I.F.2    Goodfellow, J.3
  • 39
    • 0345455362 scopus 로고    scopus 로고
    • The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia
    • 1 Epub
    • Hanratty C, McGrath L, McAuley D, Young I, Johnston D. The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia. BMC Cardiovasc Disord 2001;1:1 Epub
    • (2001) BMC Cardiovasc Disord , vol.1
    • Hanratty, C.1    McGrath, L.2    McAuley, D.3    Young, I.4    Johnston, D.5
  • 40
    • 0032703860 scopus 로고    scopus 로고
    • Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia
    • Chao CL, Chien KL, Lee YT. Effect of short-term vitamin (folic acid, vitamins B6 and B12) administration on endothelial dysfunction induced by post-methionine load hyperhomocysteinemia. Am J Cardiol 1999;84:1359-1361
    • (1999) Am J Cardiol , vol.84 , pp. 1359-1361
    • Chao, C.L.1    Chien, K.L.2    Lee, Y.T.3
  • 41
    • 0036636392 scopus 로고    scopus 로고
    • Effect of dexrazoxane on homocysteine-induced endothelial dysfunction in normal subjects
    • Zheng H, Dimayuga C, Hudailhed A, Katz S. Effect of dexrazoxane on homocysteine-induced endothelial dysfunction in normal subjects. Aterioscler Thromb Vasc Biol 2002;22:E15-E18
    • (2002) Aterioscler Thromb Vasc Biol , vol.22
    • Zheng, H.1    Dimayuga, C.2    Hudailhed, A.3    Katz, S.4
  • 42
    • 1242306238 scopus 로고    scopus 로고
    • Folate, endothelial fonction and cardiovascular disease. Invited review
    • Moat SJ, Lang D, McDowell IFW, et al. Folate, endothelial fonction and cardiovascular disease. Invited review. J Nutr Biochem 2004;15:64-79
    • (2004) J Nutr Biochem , vol.15 , pp. 64-79
    • Moat, S.J.1    Lang, D.2    McDowell, I.F.W.3
  • 45
    • 0035806914 scopus 로고    scopus 로고
    • Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: A human in vivo study
    • Gori T, Burstein JM, Ahmed S, et al. Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: a human in vivo study. Circulation 2001;104:1119-1123
    • (2001) Circulation , vol.104 , pp. 1119-1123
    • Gori, T.1    Burstein, J.M.2    Ahmed, S.3
  • 47
    • 0031973361 scopus 로고    scopus 로고
    • No change in impaired endothelial function after long-term folic acid therapy of hyperhomocysteinaemia in haemodialysis patients
    • van Guldener C, Janssen MJ, Lambert J, et al. No change in impaired endothelial function after long-term folic acid therapy of hyperhomocysteinaemia in haemodialysis patients. Nephrol Dial Transplant 1998;13:106-112
    • (1998) Nephrol Dial Transplant , vol.13 , pp. 106-112
    • Van Guldener, C.1    Janssen, M.J.2    Lambert, J.3
  • 48
    • 0034702916 scopus 로고    scopus 로고
    • Does folic acid decrease plasma homocysteine and improve endothelial fonction in patients with predialysis renal failure?
    • Thambyrajah J, Landray MJ, McGlynn FJ, Jones HJ, Wheeler DC, Townend JN. Does folic acid decrease plasma homocysteine and improve endothelial fonction in patients with predialysis renal failure? Circulation 2000;102:871-875
    • (2000) Circulation , vol.102 , pp. 871-875
    • Thambyrajah, J.1    Landray, M.J.2    McGlynn, F.J.3    Jones, H.J.4    Wheeler, D.C.5    Townend, J.N.6
  • 49
    • 0035721992 scopus 로고    scopus 로고
    • Folate improves endothelial fonction in coronary artery disease: An effect mediated by reduction of intracellular superoxide?
    • Doshi SN, McDowell IF, Moat SJ, et al. Folate improves endothelial fonction in coronary artery disease: an effect mediated by reduction of intracellular superoxide? Arterioscler Thromb Vasc Biol 2001;21:1196-1202
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1196-1202
    • Doshi, S.N.1    McDowell, I.F.2    Moat, S.J.3
  • 50
    • 0036140785 scopus 로고    scopus 로고
    • Folic acid improves endothelial fonction in coronary artery disease via mechanisms largely independent of homocysteine lowering
    • Doshi SN, McDowell IF, Moat SJ, et al. Folic acid improves endothelial fonction in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 2002;105:22-26
    • (2002) Circulation , vol.105 , pp. 22-26
    • Doshi, S.N.1    McDowell, I.F.2    Moat, S.J.3
  • 51
    • 0033852888 scopus 로고    scopus 로고
    • Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease
    • Title LM, Cummings PM, Giddens K, Genest JJ Jr, Nassar BA. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease. J Am Coll Cardiol 2000;36:758-765
    • (2000) J Am Coll Cardiol , vol.36 , pp. 758-765
    • Title, L.M.1    Cummings, P.M.2    Giddens, K.3    Genest Jr., J.J.4    Nassar, B.A.5
  • 52
    • 0034649324 scopus 로고    scopus 로고
    • Improved vascular endothelial fonction after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine
    • Chambers JC, Ueland PM, Obeid OA, Wrigley J, Refsum H, Kooner JS. Improved vascular endothelial fonction after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000;102:2479-2483
    • (2000) Circulation , vol.102 , pp. 2479-2483
    • Chambers, J.C.1    Ueland, P.M.2    Obeid, O.A.3    Wrigley, J.4    Refsum, H.5    Kooner, J.S.6
  • 53
    • 32644461605 scopus 로고    scopus 로고
    • High- But not low-dose folic acid improves endothelial fonction in coronary artery disease
    • Madhavan A, Moat SJ, McDowell IFW, Lewis MJ, Goodfellow J, Lang D. High- but not low-dose folic acid improves endothelial fonction in coronary artery disease. J Am Coll Cardiol 2004;43(517A):159-1186
    • (2004) J Am Coll Cardiol , vol.43 , Issue.517 A , pp. 159-1186
    • Madhavan, A.1    Moat, S.J.2    McDowell, I.F.W.3    Lewis, M.J.4    Goodfellow, J.5    Lang, D.6
  • 54
    • 0032570254 scopus 로고    scopus 로고
    • 5-Methyltetrahydrofolate, the active form of folic acid restores endothelial dysfunction in familial hypercholesterolaemia
    • Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ. 5-methyltetrahydrofolate, the active form of folic acid restores endothelial dysfunction in familial hypercholesterolaemia. Circulation 1998;97:237-241
    • (1998) Circulation , vol.97 , pp. 237-241
    • Verhaar, M.C.1    Wever, R.M.2    Kastelein, J.J.3    Van Dam, T.4    Koomans, H.A.5    Rabelink, T.J.6
  • 55
    • 0035686888 scopus 로고    scopus 로고
    • Folate protects against oxidative modification of human LDL
    • Nakano E, Higgins JA, Powers HJ. Folate protects against oxidative modification of human LDL. Br J Nutr 2001;86:637-639
    • (2001) Br J Nutr , vol.86 , pp. 637-639
    • Nakano, E.1    Higgins, J.A.2    Powers, H.J.3
  • 56
    • 0037086565 scopus 로고    scopus 로고
    • The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: An EPR spin trapping study
    • Vasquez-Vivar J, Martasek P, Whitsett J, Joseph J, Kalyanaraman B. The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. Biochem J 2002;362:733-739
    • (2002) Biochem J , vol.362 , pp. 733-739
    • Vasquez-Vivar, J.1    Martasek, P.2    Whitsett, J.3    Joseph, J.4    Kalyanaraman, B.5
  • 57
    • 0031018510 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
    • Stroes E, Kastelein J, Cosentino F, et al. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest 1997;99:41-46
    • (1997) J Clin Invest , vol.99 , pp. 41-46
    • Stroes, E.1    Kastelein, J.2    Cosentino, F.3
  • 58
    • 0033967254 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease
    • Maier W, Cosentino F, Lutolf RB, et al. Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease. J Cardiovasc Pharmacol 2000;35:173-178
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 173-178
    • Maier, W.1    Cosentino, F.2    Lutolf, R.B.3
  • 59
    • 0034625532 scopus 로고    scopus 로고
    • Folic acid reverts dysfunction of endothelial nitric oxide synthase
    • Stroes ES, van Faassen EE, Yo M, et al. Folic acid reverts dysfunction of endothelial nitric oxide synthase. Circ Res 2000;86:1129-1134
    • (2000) Circ Res , vol.86 , pp. 1129-1134
    • Stroes, E.S.1    Van Faassen, E.E.2    Yo, M.3
  • 61
    • 0035808310 scopus 로고    scopus 로고
    • L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin
    • Heller R, Unbehaun A, Schellenberg B, Mayer B, Werner-Felmayer G, Werner E. L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin. J Biol Chem 2001;276:40-47
    • (2001) J Biol Chem , vol.276 , pp. 40-47
    • Heller, R.1    Unbehaun, A.2    Schellenberg, B.3    Mayer, B.4    Werner-Felmayer, G.5    Werner, E.6
  • 62
    • 1242278327 scopus 로고    scopus 로고
    • Blinded comparison of folic acid and placebo in patients with ischaemic heart disease: An outcome trial
    • Baker F, Picton D, Blackwood S, et al. Blinded comparison of folic acid and placebo in patients with ischaemic heart disease: an outcome trial. Circulation 2002;106(Supplement 1):741
    • (2002) Circulation , vol.106 , Issue.SUPPL. 1 , pp. 741
    • Baker, F.1    Picton, D.2    Blackwood, S.3
  • 64
    • 1342309318 scopus 로고    scopus 로고
    • Lowering homocysteine in patients with ischaemic stroke to prevent recurrent stroke, myocardial infarction, and death. The vitamin Intervention for Stroke Prevention (VISP) Randomised Controlled Study
    • Toole J, Malinow MR, Chambless LE, et al. Lowering homocysteine in patients with ischaemic stroke to prevent recurrent stroke, myocardial infarction, and death. The vitamin Intervention for Stroke Prevention (VISP) Randomised Controlled Study. JAMA 2004;291:565-575
    • (2004) JAMA , vol.291 , pp. 565-575
    • Toole, J.1    Malinow, M.R.2    Chambless, L.E.3
  • 65
    • 2242477014 scopus 로고    scopus 로고
    • Lowering blood homcysteine with folic acid based supplements: Meta-analysis of randomised trials
    • Homocysteine Lowering Trialists' Collaboration
    • Lowering blood homcysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ 1998;316:894-898
    • (1998) BMJ , vol.316 , pp. 894-898
  • 66
    • 0036839888 scopus 로고    scopus 로고
    • Lowering plasma homocysteine with folic acid in cardiovascular disease: What will the trials tell us?
    • Doshi SN, Moat SJ, McDowell IFW, Lewis MJ, Goodfellow J. Lowering plasma homocysteine with folic acid in cardiovascular disease: what will the trials tell us? Atherosclerosis 2002;165:1-3
    • (2002) Atherosclerosis , vol.165 , pp. 1-3
    • Doshi, S.N.1    Moat, S.J.2    McDowell, I.F.W.3    Lewis, M.J.4    Goodfellow, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.