Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans

Circulation

Volumn 96, Issue 8, 1997, Pages 2542-2544

  Woo, K S ^a   Chook, P ^a   Lolin, Y I ^a   Cheung, A S P ^a   Chan, L T ^a   Sun, Y Y ^a   Sanderson, J E ^a   Metreweli, C ^a   Celermajer, D S ^b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

Atherosclerosis; Endothelium derived factors; Hyperhomocysteinemia; Risk factors; Ultrasonics

Indexed keywords

HOMOCYSTEINE;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; MALE; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; RISK FACTOR; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0030876147     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.96.8.2542     Document Type: Article

References (25)

1. Meleady RA, Mulcathy DA, Graham IM. Genes, greens, and homocysteine. Heart. 1996;76:103-104.
2. Lolin YL, Sanderson JE, Cheng SK, Chan CF, Pang CP, Woo KS, Masarei JRL. Hyperhomocysteinemia and premature coronary artery disease in the Chinese. Heart. 1996;76:117-122.
3. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324:1149-1155.
4. Brattstrom LE, Hardebo JE, Hultberg BL. Moderate hyperhomocysteinemia: a possible risk factor for arteriosclerotic cerebrovascular disease. Stroke. 1984;15:1012-1016.
5. Harker LA, Ross R, Slichter SJ, Scott CR. Homocysteine-induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis. J Clin Invest. 1976;58:731-741.
6. Wall RT, Harlan JM, Harker LA, Striker GE. Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury. Thromb Res. 1980;18:113-121.
7. Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M. Singel D, Loscalzo J. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993;91:308-318.
8. Lentz SR, Sobey CG, Piegors DJ, Bhopatkar MY, Faraci FM, Malinow MR, Heistad DD. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia. J Clin Invest. 1996;98:24-29.
9. Cooke JP, Tsao PS. Is NO an endogenous antiatherogenic molecule? Arterioscler Thromb. 1994;14:653-655.
10. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111-1115.
11. Celermajer DS, Adams MR, Clarkson P, Robinson J, McCredie R, Donald A, Deanfield JE. Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults. N Engl J Med. 1996;334:150-154.
12. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Luscher TF. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995;91:1314-1319.
13. Celermajer DS, Sorensen K, Ryalls M, Robinson J, Thomas O, Leonard JV, Deanfield JE. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol. 1993;22:854-858.
14. Mayer EL Jacobsen DW, Robinson K. Homocysteine and coronary atherosclerosis. J Am Coll Cardiol. 1996;27:517-527.
15. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, Deanfield JE. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88: 2149-2155.
16. Sorensen KE, Celermajer DS, Spiegelhalter DJ, Georgakopoulos D, Robinson JTC, Thomas O, Deanfield JE. Noninvasive measurement of human endothelium-dependent arterial responses: accuracy and reproducibility. Br Heart J. 1995;74:247-253.
17. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D, Lieberman EH, Ganz P, Creager MA, Yeung AC, Selwyn AP. Close relationship of endothelial cell function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995;26:1235-1241.
18. Hochberg Y. A sharper Bonferroni procedure for multiple tests of significance. Biometrika. 1988;75:800-802.
19. Tawakol A, Omland T, Wu JT, Gerhard M, Creager MA. Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation. 1997;95:1119-1121.
20. Bellamy MF, Ramsey MW, Goodfellow J, Brownlee M, German S, McDowell IF, Lewis MJ. Hyperhomocysteinemia and endothelial dysfunction with low vitamin B-12/folate status. Circulation. 1996; 94(suppl I):I-462. Abstract.
21. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
22. Ludmer PL, Selwyn AP, Shook TL, Wayne RR, Mudge GH, Alexander RW, Ganz P. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315:1046-1051.
23. Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest. 1986;77:1370-1376.
24. Landgren F, Israelsson B, Lindgren A, Hultberg B, Andersson A, Brattstrom L. Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. J Intern Med. 1995;237: 381-388.
25. Van den Berg M, Boers GH, Franken DG, Blom HJ, Van Kamp GJ, Jakobs C, Rauwerda JA, Kluft C, Stehouwert CD. Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. Eur J Clin Invest. 1995;25: 176-181.