Mutation of the C-terminal leucine residue of PP2Ac inhibits PR55/B subunit binding and confers supersensitivity to microtubule destabilization in Saccharomyces cerevisiae

Molecular and General Genetics

Volumn 264, Issue 4, 2000, Pages 425-432

  Evans, D R H ^a,b   Hemmings, B A ^b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

Cdc55; Checkpoint; Phosphatase; PP2A; Yeast

Indexed keywords

DNA; LEUCINE; NOCODAZOLE; PHOSPHOPROTEIN PHOSPHATASE 2A;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVE SITE; MICROTUBULE; MUTATION; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0033738776     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380000302     Document Type: Article

References (52)

1. Regulation of dimorphism in Saccharomyces cerevisiae: Involvement of the novel protein kinase homolog E1m1p and protein phosphatase 2A
2. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Bα subunit
3. Mutations of mitotic checkpoint genes in human cancers
4. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
5. Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts
6. Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2
7. Dephosphorylation of cdc25-C by a type-2A protein phosphatase: Specific regulation during the cell cycle in Xenopus egg extracts
8. Remarkable similarities between yeast and mammalian protein phosphatases
9. High complexity in the expression of the B' subunit of protein phosphatase 2A0. Evidence for the existence at least seven novel isoforms
10. Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue
11. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
12. Rox3 and Rts1 function in the global stress response pathway in baker's yeast
13. Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis
14. Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms
15. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo
16. Protein phosphatase 2A: Who shall regulate the regulator?
17. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
18. CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: Identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase
19. Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and Xenopus
20. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
21. Negative regulation of mitosis by the fission yeast protein phosphatase ppa2
22. The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis
23. Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase
24. INH, a negative regulator of MPF, is a form of protein phosphatase 2A
25. Feedback control of mitosis in budding yeast
26. The role of Saccharomyces cerevisiae type 2A phosphatase in the actin cytoskeleton and in entry into mitosis
27. Protein phosphatase 2A is required for the initiation of chromosomal DNA replication
28. Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: Evidence for a neuronal-specific isoform
29. Protein phosphatase 2A a 'menage a trois'
30. The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase
31. Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to substrates of p34cdc2
32. Identification of a new family of protein phosphatase 2A regulatory subunits
33. Regulation of protein kinase cascades by protein phosphatase 2A
34. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast
35. B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A
36. Protein phosphatase 2A subunit assembly: The catalytic carboxy terminus is important for binding cellular B subunit but not polyomavirus middle tumor antigen
37. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of phosphatase 2A
38. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A
39. An anchoring factor targets protein phosphatase 2A to brain microtubules
40. Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A
41. Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos
42. Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes
43. Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis
44. Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae
45. Cdc55p, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae
46. Alterations of the PPP2R1B gene in human lung and colon cancer
47. Serine/threonine protein phosphatases
48. Deregulation of translational control of the 65-kDa regulatory subunit (PR65 alpha) of protein phosphatase 2A leads to multinucleated cells
49. Protein phosphatase 2A is reversibly modified by methyl esterification its C-terminal leucine residue in bovine brain
50. An enzymatic activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2A
51. Saccharomyces cerevisiae homologs of mammalian B and B' subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions
52. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits