Effect of the immunosupressant FK506 on excitation-contraction coupling and outward K+ currents in rat ventricular myocytes

Journal of Physiology

Volumn 501, Issue 3, 1997, Pages 509-516

  DuBell, William H ^a   Wright, Pamela A ^a   Lederer, W J ^a   Rogers, Terry B ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; INDO 1; POTASSIUM ION; RYANODINE RECEPTOR; TACROLIMUS; CALCIUM CHANNEL L TYPE; DELAYED RECTIFIER POTASSIUM CHANNEL; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; HEART MUSCLE CELL; HEART VENTRICLE; MEMBRANE CURRENT; MICROELECTRODE; MUSCLE ACTION POTENTIAL; MUSCLE CONTRACTION; MUSCLE EXCITATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM; VOLTAGE CLAMP; ACTION POTENTIAL; ANIMAL EXPERIMENT; CALCIUM CELL LEVEL; CURRENT DENSITY; EXCITATION CONTRACTION COUPLING; HEART REPOLARIZATION; SPONTANEOUS TRANSIENT OUTWARD CURRENT; STEADY STATE; VOLTAGE CLAMP TECHNIQUE; WAVEFORM; WHOLE CELL PATCH CLAMP;

ACTION POTENTIALS; ANILINE COMPOUNDS; ANIMALS; CALCIUM; FLUORESCENT DYES; HEART VENTRICLES; IMMUNOSUPPRESSIVE AGENTS; ION TRANSPORT; KINETICS; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; MYOCARDIAL CONTRACTION; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; POTASSIUM; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS; XANTHENES;

EID: 0030764499     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.509bm.x     Document Type: Article

References (16)

1. ABRAHAM, R. T. & WIEDERRECHT, G. J. (1996). Immunopharmacology of rapamycin. Annual Reviews of Immunology 14, 483-510.
2. + currents in rat ventricular myocytes. Proceedings of the National Academy of Sciences of the USA 85, 8756-8760.
3. + currents in isolated rat ventricular myocytes. Journal of General Physiology 97, 973-1011.
4. ARMITAGE, J. M., KORMOS, R. L., FUNG, J. & STARZL, T. E. (1991). The clinical trial of FK506 as primary and rescue immunosupression in adult cardiac transplantation. Transplant Proceedings 23, 3054-3057.
5. BRAM, R. J., HUNG, D. T., MARTIN, P. K., SCHREIBER, S. L. & CRABTREE, G. R. (1993). Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Molecular and Cellular Biology 13, 4760-4769.
6. BRILLANTES, A.-M. B., ONDRIAS, K., SCOTT, A., KOBRINSKY, E., ONDRIASOVA, E., MOSCHELLA, M. C., JAYARAMAN, T., LANDERS, M., EHRLICH, B. E. & MARKS, A. R. (1994). Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 77, 513-523.
7. CLIPSTONE, N. A. & CRABTREE, G. R. (1992). Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697.
8. DUBELL, W. H., LEDERER, W. J. & ROGERS, T. B. (1996). Dynamic modulation of cardiac excitation-contraction coupling by protein phosphatases. Journal of Physiology 493, 793-800.
9. DUBELL, W. H., LEWARTOWSKI, B., SPURGEON, H. A., SILVERMAN, H. S. & LAKATTA, E. G. (1993). Repletion of sarcoplasmic reticulum Ca after ryanodine in rat ventricular myocytes. American Journal of Physiology 265, H604-615.
10. 1-adrenoceptor stimulation in rat cardiac myocytes. Circulation Research 71, 673-688.
11. 1-Adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiological Reviews 73, 469-487.
12. GALAT, A. (1993). Peptidylproline cis-trans isomerases: immunophilins. European Journal of Biochemistry 216, 689-707.
13. LAM, E., MARTIN, M. M., TIMERMAN, A. P., SABERS, C., FLEISCHER, S., LUKAS, T., ABRAHAM, R. T., O'KEEFE, S. J., O'NEILL, E. A. & WIEDERRECHT, G. J. (1995). A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. Journal of Biological Chemistry 270, 26511-26522.
14. 2+ transients in rat cardiac myocytes. Circulation Research 79, 1110-1121.
15. SIGAL, N. & DUMONT, F. (1992). Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annual Reviews of Immunology 10, 519-560.
16. 2+ release channel closure in rat heart. Journal of Physiology 500, 343-354.