Thermolytic Properties of 3-(2-Pyridyl)-1-propyl and 2-[N-Methyl-N-(2-pyridyl)]aminoethyl Phosphate/Thiophosphate Protecting Groups in Solid-Phase Synthesis of Oligodeoxyribonucleotides

Journal of Organic Chemistry

Volumn 68, Issue 26, 2003, Pages 10123-10129

  Cieślak, Jacek ^a,b   Beaucage, Serge L ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; DNA; ESTERS; PH EFFECTS; PYROLYSIS;

PROTECTING GROUPS; SOLID PHASE SYNTHESIS;

AROMATIC COMPOUNDS;

2 [N METHYL N (2 PYRIDYL)]AMINOETHYL PHOSPHATE; 2 [N METHYL N (2 PYRIDYL)]AMINOETHYL THIOPHOSPHATE; 3 (2 PYRIDYL) 1 PROPYL PHOSPHATE; ACRYLONITRILE; DEOXYRIBONUCLEOSIDE; DNA BASE; OLIGODEOXYRIBONUCLEOTIDE; OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; PYRIDINE DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; DEPROTECTION REACTION; DNA ALKYLATION; HEATING; NUCLEOTIDE METABOLISM; SOLID;

BASE SEQUENCE; HEAT; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHATES; PHOSPHORIC ACID ESTERS; THIONUCLEOTIDES;

EID: 0346992398     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0354490     Document Type: Article

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