Backbone-methylated analogues of the principle receptor binding region of human parathyroid hormone: Evidence for binding to both the N-terminal extracellular domain and extracellular loop region

Journal of Biological Chemistry

Volumn 280, Issue 25, 2005, Pages 23771-23777

  Barbier, Jean René ^a   Gardella, Thomas J ^b   Dean, Thomas ^b   MacLean, Susanne ^a   Potetinova, Zhanna ^a   Whitfield, James F ^a   Willick, Gordon E ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BONE; CELLS; CYTOLOGY; ENZYMES; MUTAGENESIS;

AFFINITY BINDING; CIRCULAR DICHROISM (CD); PARATHYROID HORMONE (PTH); RECEPTOR BINDING;

HORMONES;

ARGININE; ASPARTIC ACID; LEUCINE; LYSINE; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR 1; SERINE; TRYPTOPHAN; VALINE;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; HORMONE ACTION; HORMONE DETERMINATION; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; METHYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CIRCULAR DICHROISM; HUMANS; METHYLATION; MOLECULAR SEQUENCE DATA; PARATHYROID HORMONE; SWINE;

EID: 21244482622     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M500817200     Document Type: Article

References (54)

1. Whitfield, J. F., Morley, P., and Willick, G. E. (1998) The Parathyroid Hor-mone: An Unexpected Bone Builder for Treating Osteoporosis, R. G. Landes, Austin, TX
2. Rosenblatt, M., and Kronenberg, H. M. (1989) in Endocrinology (DeGroot, L. J., ed) pp. 848-891, W. B. Saunders, Philadelphia
3. Whitfield, J. F., Morley, P., Fraher, L., Hodsman, A. B., Holdsworth, D. W., Watson, P. H., Willick, G. E., Barbier, J. R., Gulam, M., Isaacs, R. J., MacLean, S., and Ross, V. (2000) Calcif. Tissue Int. 66, 307-312
4. Cosman, F., and Lindsay, R. (1998) Calcif. Tissue Int. 62, 475-480
5. Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J. Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., Wang, O., and Mitlak, B. H. (2001) N. Engl. J. Med. 344, 1434-1441
6. Jüppner, H., Abou Samra, A. B., Freeman, M., Kong, X. F., Schipani, E., Richards, J., Kolakowski, L. F., Jr., Hock, J., Potts, J. T., Jr., Kronenberg, H. M., and Segre, G. V. (1991) Science 254, 1024-1026
7. Chorev, M. (2002) Receptors Channels 8, 219-242
8. Gardella, T. J., and Juppner, H. (2001) Trends Endocrinol. Metab. 12, 210-217
9. Herrmann Erlee, M. P., Heersche, J. N., Hekkelman, J. W., Gaillard, P. J., Tregear, G. W., Parsons, J. A., and Potts, J. T., Jr. (1976) Endocr. Res. Commun. 3, 21-35
10. Azarani, A., Goltzman, D., and Orlowski, J. (1995) J. Biol. Chem. 270, 20004-20010
11. Jouishomme, H., Whitfield, J. F., Chakravarthy, B., Durkin, J. P., Gagnon, L., Isaacs, R. J., MacLean, S., Neugebauer, W., Willick, G., and Rixon, R. H. (1992) Endocrinology 130, 53-60
12. Rosenblatt, M., Segre, G. V., Tyler, G. A., Shepard, G. L., Nussbaum, S. R., and Potts, J. T., Jr. (1980) Endocrinology 107, 545-550
13. Klaus, W., Dieckmann, T., Wray, V., Schomburg, D., Wingender, E., and Mayer, H. (1991) Biochemistry 30, 6936-6942
14. Chen, Z., Xu, P., Barbier, J. R., Willick, G., and Ni, F. (2000) Biochemistry 39, 12766-12777
15. Grauschopf, U., Lilie, H., Honold, K., Wozny, M., Reusch, D., Esswein, A., Schafer, W., Rucknagel, K. P., and Rudolph, R. (2000) Biochemistry 39, 8878-8887
16. Tsomaia, N., Pellegrini, M., Hyde, K., Gardella, T. J., and Mierke, D. F. (2004) Biochemistry 43, 690-699
17. Shimizu, M., Potts, J. T., Jr., and Gardella, T. J. (2000) J. Biol. Chem. 275, 21836-21843
18. Greenberg, Z., Bisello, A., Mierke, D. F., Rosenblatt, M., and Chorev, M. (2000) Biochemistry 39, 8142-8152
19. Rixon, R. H., Whitfield, J. F., Gagnon, L., Isaacs, R. J., Maclean, S., Chakravarthy, B., Durkin, J. P., Neugebauer, W., Ross, V., Sung, W., and Willick, G. E. (1994) J. Bone Miner. Res. 9, 1179-1189
20. Whitfield, J. F., Isaacs, R. J., Chakravarthy, B., Maclean, S., Morley, P., Willick, G., Divieti, P., and Bringhurst, F. R. (2001) J. Bone Miner. Res. 16, 441-447
21. Barbier, J. R., MacLean, S., Morley, P., Whitfield, J. F., and Willick, G. E. (2000) Biochemistry 39, 14522-14530
22. Gardella, T. J., Wilson, A. K., Keutmann, H. T., Oberstein, R., Potts, J. T., Jr., Kronenberg, M., and Nussbaum, S. R. (1993) Endocrinology 132, 2024-2030
23. Surewicz, W. K., Neugebauer, W., Gagnon, L., MacLean, S., Whitfield, J. F., and Willick, G. E. (1993) Peptides: Chemistry, Structure, and Biology, pp. 556-558, ESCOM, Leiden, The Netherlands
24. Oldenburg, K. R., Epand, R. F., D'Orfani, A., Vo, K., Selick, H., and Epand, R. M. (1996) J. Biol. Chem. 271, 17582-17591
25. Sali, D., Bycroft, M., and Fersht, A. R. (1988) Nature 335, 740-743
26. Lu, W. Y., Randal, M., Kossiakoff, A., and Kent, S. B. H. (1999) Chem. Biol. 6, 419-427
27. Baker, E. N., and Hubbard, R. E. (1984) Prog. Biophys. Mol. Biol. 44, 97-179
28. Sagan, S., Karoyan, P., Lequin, O., Chassaing, G., and Lavielle, S. (2004) Curr. Med. Chem. 11, 2799-2822
29. Vogen, S. M., Paczkowski, N. J., Kirnarsky, L., Short, A., Whitmore, J. B., Sherman, S. A., Taylor, S. M., and Sanderson, S. D. (2001) Int. Immunopharmacol. 1, 2151-2162
30. Schumann, C., Seyfarth, L., Greiner, G., Paegelow, I., and Reissmann, S. (2002) J. Pept. Res. 60, 128-140
31. Rajeswaran, W. G., Hocart, S. J., Murphy, W. A., Taylor, J. E., and Coy, D. H. (2001) J. Med. Chem. 44, 1305-1311
32. Barbier, J. R., Neugebauer, W., Morley, P., Ross, V., Soska, M., Whitfield, J. F., and Willick, G. (1997) J. Med. Chem. 40, 1373-1380
33. Miller, S. C., and Scanlan, T. S. (1997) J. Am. Chem. Soc. 119, 2301-2302
34. Chin, D. H., Woody, R. W., Rohl, C. A., and Baldwin, R. L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 15416-15421
35. Yang, J. T., Wu, C. S., and Martinez, H. M. (1986) Methods Enzymol. 130, 208-269
36. Rohl, C. A., and Baldwin, R. L. (1997) Biochemistry 36, 8435-8442
37. Takasu, H., Guo, J., and Bringhurst, F. R. (1999) J. Bone Miner. Res. 14, 11-20
38. Shimizu, N., Guo, J., and Gardella, T. J. (2001) J. Biol. Chem. 276, 49003-49012
39. Neugebauer, W., Surewicz, W. K., Gordon, H. L., Somorjai, R. L., Sung, W., and Willick, G. E. (1992) Biochemistry 31, 2056-2063
40. Chang, C. F., and Zehfus, M. H. (1996) Biopolymers 40, 609-616
41. Manning, M. C., Illangasekare, M., and Woody, R. W. (1988) Biophys. Chem. 31, 77-86
42. Manning, M. C., and Woody, R. W. (1991) Biopolymers 31, 569-586
43. Hoare, S. R., and Usdin, T. B. (2000) J. Bone Miner. Res. 15, 605-608
44. Luck, M. D., Carter, P. H., and Gardella, T. J. (1999) Mol. Endocrinol. 13, 670-680
45. Kenakin, T. (2002) Annu. Rev. Pharmacol. Toxicol. 42, 349-379
46. Barbier, J. R., MacLean, S., Whitfield, J. F., Morley, P., and Willick, G. E. (2001) Biochemistry 40, 8955-8961
47. Neugebauer, W., Barbier, J. R., Sung, W. L., Whitfield, J. F., and Willick, G. E. (1995) Biochemistry 34, 8835-8842
48. Bergwitz, C., Gardella, T. J., Flannery, M. R., Potts, J. T., Jr., Kronenberg, H. M., Goldring, S. R., and Juppner, H. (1996) J. Biol. Chem. 271, 26469-26472
49. Simon, R. J., Kania, R. S., Zuckermann, R. N., Huebner, V. D., Jewell, D. A., Banville, S., Ng, S., Wang, L., Rosenberg, S., Marlowe, C. K., Spellmeyer, D. C., Tan, R., Frankel, A. D., Santi, D. V., Cohen, F. E., and Bartlett, P. A. (1992)) Proc. Natl. Acad. Sci. U. S. A. 89, 9367-9371
50. Ajay, and Murcko, M. A. (1995) J. Med. Chem. 38, 4953-4967
51. Inooka, H., Ohtaki, T., Kitahara, O., Ikegami, T., Endo, S., Kitada, C., Ogi, K., Onda, H., Fujino, M., and Shirakawa, M. (2001) Nat. Struct. Biol. 8, 161-165
52. Gensure, R. C., Gardella, T. J., and Juppner, H. (2001) J. Biol. Chem. 276, 28650-28658
53. Gensure, R. C., Shimizu, N., Tsang, J., and Gardella, T. J. (2003) Mol. Endocrinol. 17, 2647-2658
54. Shimizu, N., Petroni, B. D., Khatri, A., and Gardella, T. J. (2003) Biochemistry 42, 2282-2290