Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist

Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2001, Pages 1305-1311

  Rajeswaran, W G ^a   Hocart, S J ^a   Murphy, W A ^a   Taylor, J E ^b   Coy, D H ^a  

^a TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b Biomeasure Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 CHLOROPHENYL)ALANINE CYCLO[DEXTRO CYSTEINYL 3 (3 PYRIDYL)ALANINE DEXTRO TRYPTOPHYL 2,4 DIAMINOBUTYRIC ACID THREONYLCYSTEINE] 3 (2 NAPHTHYL)ALANINAMIDE; 3 (4 CHLOROPHENYL)ALANINE CYCLO[DEXTRO CYSTEINYL 3 (3 PYRIDYL)ALANINE DEXTRO TRYPTOPHYL N METHYLLYSYLTHREONYLCYSTEINE] 3 (2 NAPHTHYL)ALANINAMIDE; 3 (4 CHLOROPHENYL)ALANINE CYCLO[DEXTRO CYSTEINYL 3 (3 PYRIDYL)ALANINE DEXTRO TRYPTOPHYL N METHYLLYSYLTHREONYLCYSTEINE] DEXTRO TRYPTOPHANAMIDE; 3 (4 CHLOROPHENYL)ALANINE CYCLO[DEXTRO CYSTEINYL 3 (3 PYRIDYL)ALANINE DEXTRO TRYPTOPHYLLYSYLTHREONYLCYSTEINE] 3 (2 NAPHTHYL)ALANINAMIDE; CALCIUM; CYSTEINE; GROWTH HORMONE; IODINE 125; LYSINE; RECEPTOR SUBTYPE; SOMATOSTATIN; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR BLOCKING AGENT; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; GROWTH HORMONE RELEASE; HYPOPHYSIS CELL; IC 50; IN VITRO STUDY; MALE; METHYLATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CALCIUM; CELLS, CULTURED; CHO CELLS; CRICETINAE; GROWTH HORMONE; HUMANS; INTRACELLULAR FLUID; MALE; METHYLATION; MODELS, MOLECULAR; PITUITARY GLAND, ANTERIOR; RADIOLIGAND ASSAY; RATS; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; TRANSFECTION;

EID: 0035848569     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0005048     Document Type: Article

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