High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation

American Journal of Physiology - Cell Physiology

Volumn 278, Issue 1 47-1, 2000, Pages

  Begum, Najma ^a,b   Ragolia, Louis ^a  

^a WINTHROP UNIVERSITY HOSPITAL   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Cell growth; Extracellular signal regulated kinase signaling; Hyperglycemia; Inducible nitric oxide synthase; Insulin resistance; Mitogen activated protein kinase; Mitogen activated protein phosphatase 1; Vascular smooth muscle cells

Indexed keywords

GLUCOSE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 1;

ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RESISTANCE; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALIA;

EID: 0033955680     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2000.278.1.c81     Document Type: Article

References (10)

1. Avena, R., M. E. Mitchell, R. E. Neville, and A. N. Sidway. The additive effects of glucose and insulin on the proliferation of infragenicular vascular smooth muscle cells. J. Vasc. Surg. 28: 1033-1039, 1998.
2. Begum, N., L. Ragolia, M. McCarthy, and N. Duddy. Regulation of mitogen-activated protein kinase phosphatase-1 induction by insulin in vascular smooth muscle cells. Evaluation of the role of the nitric oxide signaling pathway and potential defects in hypertension. J. Biol. Chem. 273: 25164-25170, 1998.
3. Begum, N., L. Ragolia, and M. Srinivasan. Effect of tumor necrosis factor-alpha on insulin-stimulated mitogen-activated protein kinase cascade in cultured rat skeletal muscle cells. Eur. Biochem. 238: 214-220, 1996.
4. Begum, N., Y. Song, J. Rienzie, and L. Ragolia. Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension. Am. J. Physiol. Cell Physiol. 275: C42-C49, 1998.
5. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
6. Brownlee, M., A. Cerami, and H. Vlassara. Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N. Engl. J. Med. 318: 1315-1321, 1988.
7. Cobb, M. H., T. G. Boulton, and D. J. Robbins. Extracellular signal-regulated kinases: ERKs in progress. Cell Regul. 2: 965-978, 1991.
8. 7a. Da Silva, J., B. Pierrat, J. L. Mary, and W. Lesslaur. Blockade of p38 mitogen-activated protein kinase pathway inhibits inducible nitric-oxide synthase expression in mouse astrocytes. J. Biol. Chem. 272: 28373-28380, 1997.
9. DeFranzo, R. A., and E. Ferrannini. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14: 173-194, 1991.
10. Goalstone, M. R., P. R. Natarajan, R. R. Standley, M. F. Walsh, J. W. Leitner, K. Carel, S. Scott, J. Nadler, J. R. Sowers, and B. Draznin. Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells. Endocrinology 139: 4067-4072, 1998.