2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 360, Issue 2, 1999, Pages 103-108

  Klotz, Karl Norbert ^a   Camaioni, Emidio ^b   Volpini, Rosaria ^b   Kachler, Sonja ^a   Vittori, Sauro ^b   Cristalli, Gloria ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

A(2A); A(2B); A1; A3; Adenosine; Adenosine receptors; Agonist; High affinity; Human; Ligand; Selectivity

Indexed keywords

2 (3 HYDROXY 3 PHENYL)PROPYN 1 YL ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR STIMULATING AGENT; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; NONHUMAN; RECEPTOR AFFINITY;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ADENYLATE CYCLASE; ANIMALS; ANTINEOPLASTIC AGENTS; CELLS, CULTURED; CHO CELLS; CRICETINAE; HUMANS; RADIOLIGAND ASSAY; RECEPTORS, PURINERGIC P1; TRANSFECTION;

EID: 0032863120     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900044     Document Type: Article

References (21)

1. 3 receptors in rat brain. Mol Pharmacol 48 : 1038-1045
2. 3 adenosine receptors. J Med Chem 39 : 802-806
3. Calker D van, Müller M, Hamprecht B (1979) Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J Neurochem 33 : 999-1005
4. Camaioni E, Di Francesco E, Vittori S, Volpini R, Cristalli G (1997) Adenosine receptor agonists: synthesis and biological evaluation of the diastereoisomers of 2-(3-hydroxy-3-phenyl-1-propyn-1-yl)NECA. Bioorg Med Chem 5 : 2267-2275
5. 2 adenosine receptors. J Med Chem 35 : 2363-2368
6. 2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation. J Med Chem 37 : 1720-1726
7. 2a adenosine receptor agonists. J Med Chem 38: 1462-1472
8. De Lean A, Hancock AA, Lefkowitz RJ (1982) Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes. Mol Pharmacol 21 : 5-16
9. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden K, Jacobson KA, Leff P, Williams M (1994) VI: Nomenclature and classification of purinoceptors. Physiol Rev 46: 143-156
10. 3-selective adenosine agonists. J Med Chem 37 : 636-646
11. 3-adenosine receptors: design of selective ligands and therapeutic prospects. Drugs Future 20 : 689-699
12. 3 adenosine receptors. J Med Chem 37 : 3614-3621
13. 1-adenosine receptors. J Biol Chem 260 : 14659-14664
14. Klotz K-N, Hessling J, Hegler J, Owman C, Kull B, Fredholm BB, Lohse MJ (1998) Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells. Naunyn-Schmiedeberg's Arch Pharmacol 357 : 1-9
15. 1 adenosine receptors. Naunyn-Schmiedeberg's Arch Pharmacol 336 : 204-210
16. Londos C, Cooper DMF, Wolff J (1980) Subclasses of external adenosine receptors. Proc Natl Acad Sci USA 77 : 2551-2554
17. Müller CE, Stein B (1996) Adenosine receptor antagonists: structure and potential therapeutic applications. Curr Pharmaceut Design 2 : 501-530
18. Pierce KD, Furlong TJ, Selbie L-A, Shine J (1992) Molecular cloning and expression of an adenosine A2b receptor from human brain. Biochem Biophys Res Commun 187 : 86-93
19. Poulsen S-A, Quinn RJ (1998) Adenosine receptors: new opportunities for future drugs. Bioorg Med Chem 6 : 619-641
20. 3 adenosine receptor. Proc Natl Acad Sci USA 90 : 10365-10369
21. +-channel-coupled adenosine receptor in guinea pig atria. Naunyn-Schmiedeberg's Arch Pharmacol 340 : 684-688