Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: Synthesis and activity

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2918-2922

  Li, Qun ^a   Li, Tongmei ^a   Woods, Keith W ^a   Gu, Wen Zhen ^a   Cohen, Jerry ^a   Stoll, Vincent S ^a   Galicia, Tomas ^a   Hutchins, Charles ^a   Frost, David ^a   Rosenberg, Saul H ^a   Sham, Hing L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; FARNESYL TRANS TRANSFERASE; INDOLE DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TIPIFARNIB;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BENZIMIDAZOLES; ENZYME INHIBITORS; FARNESYLTRANSTRANSFERASE; INDOLES; MICE; NIH 3T3 CELLS; QUINOLONES;

EID: 21144450072     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.049     Document Type: Article

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