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Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5371-5376

Synthesis and activity of 1-aryl-1′-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors

(14) Li, Qun a Wang, Gary T a Li, Tongmei a Gwaltney II, Stephen L a Woods, Keith W a Claiborne, Akiyo a Wang, Xilu a Gu, Wendy a Cohen, Jerry a Stoll, Vincent S a Hutchins, Charles a Frost, David a Rosenberg, Saul H a Sham, Hing L a

a ABBOTT LABORATORIES (United States)

Author keywords

Anticancer; Farnesyltransferase inhibitors; Tipifarnib

Indexed keywords

ETHER DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TIPIFARNIB;

ARTICLE; CELL ACTIVITY; CHIRALITY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50;

ALKYL AND ARYL TRANSFERASES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TRANSFORMED; CRYSTALLOGRAPHY, X-RAY; ETHERS; FARNESYLTRANSTRANSFERASE; GENES, RAS; HUMANS; IMIDAZOLES; MICE; MODELS, MOLECULAR; NIH 3T3 CELLS; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5344258229 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2004.08.011 Document Type: Article

Times cited : (13)

References (22)

1
- 0034788453
- P. Traxler, G. Bold, E. Buchdunger, G. Caravatti, P. Furet, P. Manley, T. O'Reilly, J. Wood, and J. Zimmermann Med. Res. Rev. 21 2001 499 512
- (2001) Med. Res. Rev. , vol.21 , pp. 499-512
- Traxler, P.¹ Bold, G.² Buchdunger, E.³ Caravatti, G.⁴ Furet, P.⁵ Manley, P.⁶ O'reilly, T.⁷ Wood, J.⁸ Zimmermann, J.⁹

2
- 0033763084
- J. Baselga, and S.D. Averbuch Drugs 60 suppl. 1 2000 33 40
- (2000) Drugs , vol.60 , Issue.1 , pp. 33-40
- Baselga, J.¹ Averbuch, S.D.²

3
- 0024376173
- J.L. Bos Cancer Res. 49 1998 4682 4689
- (1998) Cancer Res. , vol.49 , pp. 4682-4689
- Bos, J.L.¹

4
- 0037264633
- J. Downward Nat. Rev. Cancer 3 2003 11 22
- (2003) Nat. Rev. Cancer , vol.3 , pp. 11-22
- Downward, J.¹

5
- 33646014197
- H.I. Hurwitz, and P.J. Casey Curr. Top. Membr. 52 2002 531 550
- (2002) Curr. Top. Membr. , vol.52 , pp. 531-550
- Hurwitz, H.I.¹ Casey, P.J.²

6
- 0036114003
- S. Ayral-Kaloustian, and E. Salaski J. Curr. Med. Chem. 9 2002 1003 1032
- (2002) J. Curr. Med. Chem. , vol.9 , pp. 1003-1032
- Ayral-Kaloustian, S.¹ Salaski, E.²

7
- 0036489947
- S.B. Singh, and R.B. Lingham Curr. Opin. Drug Dis. Dev. 5 2002 225 244
- (2002) Curr. Opin. Drug Dis. Dev. , vol.5 , pp. 225-244
- Singh, S.B.¹ Lingham, R.B.²

8
- 0038685910
- F. Caponigro, M. Casale, and J. Bryce Expert Opin. Investig. Drugs 12 2003 943 954
- (2003) Expert Opin. Investig. Drugs , vol.12 , pp. 943-954
- Caponigro, F.¹ Casale, M.² Bryce, J.³

9
- 0036399117
- J.E. Dancey Curr. Pharm. Des. 8 2002 2259 2267
- (2002) Curr. Pharm. Des. , vol.8 , pp. 2259-2267
- Dancey, J.E.¹

10
- 0036134355
- W.T. Purcell, and R.C. Donehower Curr. Oncol. Rep. 4 2002 29 36
- (2002) Curr. Oncol. Rep. , vol.4 , pp. 29-36
- Purcell, W.T.¹ Donehower, R.C.²

11
- 0038621230
- M. Venet, D. End, and P. Angibaud Curr. Top. Med. Chem. 3 2003 1095 1102
- (2003) Curr. Top. Med. Chem. , vol.3 , pp. 1095-1102
- Venet, M.¹ End, D.² Angibaud, P.³

12
- 0036239527
- P. Norman Curr. Opin. Invest. Drugs 3 2002 313 319
- (2002) Curr. Opin. Invest. Drugs , vol.3 , pp. 313-319
- Norman, P.¹

13
- 5344263089
- doi:10.1016/j.bmcl.2004.08.012
- Q. Li, A. Claiborne, T. Li, L. Hasvold, S.V. Stoll, S. Muchmore, C.G. Jakob, W. Gu, J. Cohen, C. Hutchins, D. Frost, S.H. Rosenberg, and H.L. Sham Bioorg. Med. Chem. Lett. 14 2004 preceding paper. doi:10.1016/j.bmcl.2004.08.012
- (2004) Bioorg. Med. Chem. Lett. , vol.14
- Li, Q.¹ Claiborne, A.² Li, T.³ Hasvold, L.⁴ Stoll, S.V.⁵ Muchmore, S.⁶ Jakob, C.G.⁷ Gu, W.⁸ Cohen, J.⁹ Hutchins, C.¹⁰ Frost, D.¹¹ Rosenberg, S.H.¹² Sham, H.L.¹³

14
- 10744220773
- L.A. Hasvold, W. Wang, S.L. Gwaltney, T.W. Rockway II, L.T.J. Nelson, R. Mantei, S. Fakhoury, G. Sullivan, Q. Li, N.-H. Lin, L. Wang, H. Zhang, J. Cohen, W.-Z. Gu, K. Marsh, J. Bauch, S. Rosenberg, and H. Sham Bioorg. Med. Chem. Lett. 13 2003 4001 4005
- (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 4001-4005
- Hasvold, L.A.¹ Wang, W.² Gwaltney, S.L.³ Rockway II, T.W.⁴ Nelson, L.T.J.⁵ Mantei, R.⁶ Fakhoury, S.⁷ Sullivan, G.⁸ Li, Q.⁹ Lin, N.-H.¹⁰ Wang, L.¹¹ Zhang, H.¹² Cohen, J.¹³ Gu, W.-Z.¹⁴ Marsh, K.¹⁵ Bauch, J.¹⁶ Rosenberg, S.¹⁷ Sham, H.¹⁸

15
- 9144261574
- L. Wang, G.T. Wang, X. Wang, Y. Tong, G. Sullivan, D. Park, N. Leonard, Q. Li, J. Cohen, W.-Z. Gu, H. Zhang, J. Bauch, C.G. Jacob, C.W. Hutchins, S.V. Stoll, K. Marsh, S.H. Rosenberg, H. Sham, and N.-H. Lin J. Med. Chem. 47 2004 612 626
- (2004) J. Med. Chem. , vol.47 , pp. 612-626
- Wang, L.¹ Wang, G.T.² Wang, X.³ Tong, Y.⁴ Sullivan, G.⁵ Park, D.⁶ Leonard, N.⁷ Li, Q.⁸ Cohen, J.⁹ Gu, W.-Z.¹⁰ Zhang, H.¹¹ Bauch, J.¹² Jacob, C.G.¹³ Hutchins, C.W.¹⁴ Stoll, S.V.¹⁵ Marsh, K.¹⁶ Rosenberg, S.H.¹⁷ Sham, H.¹⁸ Lin, N.-H.¹⁹

16
- 0033530870
- C.J. Dinsmore, T.M. Williams, T.J. O'Neill, D. Liu, E. Rands, J.C. Culberson, R.B. Lobell, K.S. Koblan, N.E. Kohl, J.B. Gibbs, A.I. Oliff, S.L. Graham, and G.D. Hartman Bioorg. Med. Chem. Lett. 9 1999 3301 3306
- (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 3301-3306
- Dinsmore, C.J.¹ Williams, T.M.² O'neill, T.J.³ Liu, D.⁴ Rands, E.⁵ Culberson, J.C.⁶ Lobell, R.B.⁷ Koblan, K.S.⁸ Kohl, N.E.⁹ Gibbs, J.B.¹⁰ Oliff, A.I.¹¹ Graham, S.L.¹² Hartman, G.D.¹³

17
- 12444299958
- Y. Tong, N.-H. Lin, L. Wang, L. Hasvold, W. Wang, N. Leonard, T. Li, Q. Li, J. Cohen, W.-Z. Gu, H. Zhang, V. Stoll, J. Bauch, K. Marsh, S.H. Rosenberg, and H.L. Sham Bioorg. Med. Chem. Lett. 13 2003 1571 1574
- (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 1571-1574
- Tong, Y.¹ Lin, N.-H.² Wang, L.³ Hasvold, L.⁴ Wang, W.⁵ Leonard, N.⁶ Li, T.⁷ Li, Q.⁸ Cohen, J.⁹ Gu, W.-Z.¹⁰ Zhang, H.¹¹ Stoll, V.¹² Bauch, J.¹³ Marsh, K.¹⁴ Rosenberg, S.H.¹⁵ Sham, H.L.¹⁶

18
- 84862437087
- WO02074747, 2002
- Claiborne, A. K.; Gwaltney, S. L., II; Hasvold, L. A.; Li, Q.; Li, T.; Lin, N.-H.; Mantei, R. A.; Rockway, T. W.; Sham, H. L.; Sullivan, G. M.; Tong, Y.; Wang, G.; Wang, L.; Wang, X.; Wang, W. WO02074747, 2002
- Claiborne, A.K.¹ Gwaltney II, S.L.² Hasvold, L.A.³ Li, Q.⁴ Li, T.⁵ Lin, N.-H.⁶ Mantei, R.A.⁷ Rockway, T.W.⁸ Sham, H.L.⁹ Sullivan, G.M.¹⁰ Tong, Y.¹¹ Wang, G.¹² Wang, L.¹³ Wang, X.¹⁴ Wang, W.¹⁵

19
- 13044300878
- N.J. Anthony, R.P. Gomez, M.D. Schaber, S.D. Mosser, K.A. Hamilton, T.J. O'Neil, K.S. Koblan, S.L. Graham, G.D. Hartman, D. Shah, E. Rands, N.E. Kohl, J.B. Gibbs, and A.I. Oliff J. Med. Chem. 42 1999 3356 3368
- (1999) J. Med. Chem. , vol.42 , pp. 3356-3368
- Anthony, N.J.¹ Gomez, R.P.² Schaber, M.D.³ Mosser, S.D.⁴ Hamilton, K.A.⁵ O'neil, T.J.⁶ Koblan, K.S.⁷ Graham, S.L.⁸ Hartman, G.D.⁹ Shah, D.¹⁰ Rands, E.¹¹ Kohl, N.E.¹² Gibbs, J.B.¹³ Oliff, A.I.¹⁴

20
- 0035802995
- H. Lee, J. Lee, S. Lee, Y. Shin, W. Jung, J.H. Kim, K. Park, K. Kim, H.S. Cho, S. Ro, S. Lee, S.W. Jeong, T. Choi, H.H. Chung, and J.S. Koh Bioorg. Med. Chem. Lett. 11 2001 3069 3072
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 3069-3072
- Lee, H.¹ Lee, J.² Lee, S.³ Shin, Y.⁴ Jung, W.⁵ Kim, J.H.⁶ Park, K.⁷ Kim, K.⁸ Cho, H.S.⁹ Ro, S.¹⁰ Lee, S.¹¹ Jeong, S.W.¹² Choi, T.¹³ Chung, H.H.¹⁴ Koh, J.S.¹⁵

21
- 0037424681
- S.L. Gwaltney II, S.J. O'Connor, L.T.J. Nelson, G.M. Sullivan, H. Imade, W. Wang, L. Hasvold, Q. Li, J. Cohen, W.-Z. Gu, S.K. Tahir, J. Bauch, K. Marsh, S.-C. Ng, D.J. Frost, H. Zhang, S. Muchmore, C.G. Jacob, V. Stoll, C. Hutchins, S.H. Rosenberg, and H.L. Sham Bioorg. Med. Chem. Lett. 16 2003 1363 1366
- (2003) Bioorg. Med. Chem. Lett. , vol.16 , pp. 1363-1366
- Gwaltney II, S.L.¹ O'Connor, S.J.² Nelson, L.T.J.³ Sullivan, G.M.⁴ Imade, H.⁵ Wang, W.⁶ Hasvold, L.⁷ Li, Q.⁸ Cohen, J.⁹ Gu, W.-Z.¹⁰ Tahir, S.K.¹¹ Bauch, J.¹² Marsh, K.¹³ Ng, S.-C.¹⁴ Frost, D.J.¹⁵ Zhang, H.¹⁶ Muchmore, S.¹⁷ Jacob, C.G.¹⁸ Stoll, V.¹⁹ Hutchins, C.²⁰ Rosenberg, S.H.²¹ Sham, H.L.²² more..

22
- 0028912593
- Assay methods described in: A. Vogt, Y. Qian, M.A. Blaskovich, R.D. Fossum, A.D. Hamilton, and S.M. Sebti J. Biol. Chem. 270 1995 660 664
- (1995) J. Biol. Chem. , vol.270 , pp. 660-664
- Vogt, A.¹ Qian, Y.² Blaskovich, M.A.³ Fossum, R.D.⁴ Hamilton, A.D.⁵ Sebti, S.M.⁶

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