Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 21, 2004, Pages 5367-5370

  Li, Qun ^a   Claiborne, Akiyo ^a   Li, Tongmei ^a   Hasvold, Lisa ^a   Stoll, Vincent S ^a   Muchmore, Steven ^a   Jakob, Clarissa G ^a   Gu, Wendy ^a   Cohen, Jerry ^a   Hutchins, Charles ^a   Frost, David ^a   Rosenberg, Saul H ^a   Sham, Hing L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Anticancer; Farnesyltransferase inhibitors; Pyridone; Quinolone; Tipifarnib

Indexed keywords

2 QUINOLONE; 4 QUINOLONE DERIVATIVE; IMIDAZOLE; LONAFARNIB; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PYRIDONE DERIVATIVE; QUINOLONE DERIVATIVE; TIPIFARNIB; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; IC 50; SUBSTITUTION REACTION; X RAY ANALYSIS;

4-QUINOLONES; ALKYL AND ARYL TRANSFERASES; CRYSTALLOGRAPHY, X-RAY; FARNESYLTRANSTRANSFERASE; MODELS, MOLECULAR; PYRIDONES; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 5344263089     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.08.012     Document Type: Article

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