ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells

Leukemia

Volumn 19, Issue 5, 2005, Pages 799-805

  Nigten, J ^a   Breems de Ridder, M C ^b   Erpelinck Verschueren, C A J ^b   Nikoloski, G ^a   van der Reijden, B A ^a   van Wageningen, S ^a   van Hennik, P B ^a,c   de Witte, T ^a   Lowenberg B ^b   Jansen, J H ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c SANQUIN RESEARCH   (Netherlands)

Author keywords

Acute promyelocytic leukemia; Basic helix loop helix; ID proteins; PML RAR ; Transcription factors

Indexed keywords

CELL PROTEIN; HELIX LOOP HELIX PROTEIN; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; LIPOCORTIN 5; RETINOIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GRANULOCYTE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; WESTERN BLOTTING;

EID: 20844446303     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403699     Document Type: Article

References (42)

1. Melnick A, Licht JD. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 1999; 93: 3167-3215.
2. Liu M, Iavarone A, Freedman LP. Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation. J Biol Chem 1996; 271: 31723-31728.
3. Bocchia M, Xu Q, Wesley U, Xu Y, Korontsvit T, Loganzo F et al. Modulation of p53, WAF1/p21 and BCL-2 expression during retinoic acid-induced differentiation of NB4 promyelocytic cells. Leuk Res 1997; 21: 439-447.
4. Wang ZG, Delva L, Gaboli M, Rivi R, Giorgio M, Cordon-Cardo C et al. Role of PML in cell growth and the retinoic acid pathway. Science 1998; 279: 1547-1551.
5. Duprez E, Wagner K, Koch H, Tenen DG. C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells. EMBO J 2003; 22: 5806-5816.
6. Yamanaka R, Kim GD, Radomska HS, Lekstrom-Himes J, Smith LT, Antonson P et al. CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing. Proc Natl Acad Sci USA 1997; 94: 6462-6467.
7. Tenen DG. Disruption of differentiation in human cancer: AML shows the way. Nat Rev Cancer 2003; 3: 89-101.
8. Massari ME, Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 2000; 20: 429-440.
9. Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 2000; 113 (Part 22): 3897-3905.
10. Hasskarl J, Duensing S, Manuel E, Munger K. The helix-loop-helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers. Oncogene 2004; 23: 1930-1938.
11. de Candia P, Solit DB, Giri D, Brogi E, Siegel PM, Olshen AB et al. Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors. Proc Natl Acad Sci USA 2003; 100: 12337-12342.
12. Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Li u Y et al. Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis. Proc Natl Acad Sci USA 2003; 100: 13543-13548.
13. Ruzinova MB, Schoer RA, Gerald W, Egan JE, Pandolfi PP, Rafii S et al. Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. Cancer Cell 2003; 4: 277-289.
14. Sikder H, Huso DL, Zhang H, Wang B, Ryu B, Hwang ST et al. Disruption of Id1 reveals major differences in angiogenesis between transplanted and autochthonous tumors. Cancer Cell 2003; 4: 291-299.
15. Norton JD, Deed RW, Craggs G, Sablitzky F. Id helix-loop-helix proteins in cell growth and differentiation. Trends Cell Biol 1998; 8: 58-65.
16. Begley CG, Aplan PD, Davey MP, Nakahara K, Tchorz K, Kurtzberg J et al. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci USA 1989; 86: 2031-2035.
17. Mellentin JD, Smith SD, Cleary ML. lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 1989; 58: 77-83.
18. Mellentin JD, Murre C, Donlon TA, McCaw PS, Smith SD, Carroll AJ et al. The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias. Science 1989; 246: 379-382.
19. Dyck JA, Maul GG, Miller Jr WH, Chen JD, Kakizuka A, Evans RM. A novel macromolecular structure is a target of the promyelocyteretinoic acid receptor oncoprotein. Cell 1994; 76: 333-343.
20. Koken MH, Puvion-Dutilleul F, Guillemin MC, Viron A, Linares-Cruz G, Stuurman N et al. The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion. EMBO J 1994; 13: 1073-1083.
21. Weis K, Rambaud S, Lavau C, Jansen J, Carvalho T, Carmo-Fonseca M et al. Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells. Cell 1994; 76: 345-356.
22. Lanotte M, Martin-Thouvenin V, Najman S, Balerini P, Valensi F, Berger R. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 1991; 77: 1080-1086.
23. Glasser L, Fiederlein RL. Functional differentiation of normal human neutrophils. Blood 1987; 69: 937-944.
24. Brons PP, Haanen C, Boezeman JB, Muus P, Holdrinet RS, Pennings AH et al. Proliferation patterns in acute myeloid leukemia: leukemic clonogenic growth and in vivo cell cycle kinetics. Ann Hematol 1993; 66: 225-233.
25. Ruzinova MB, Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell Biol 2003; 13: 410-418.
26. Yan W, Young AZ, Soares VC, Kelley R, Benezra R, Zhuang Y. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. Mol Cell Biol 1997; 17: 7317-7327.
27. Yokota Y, Mansouri A, Mori S, Sugawara S, Adachi S, Nishikawa S et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 1999; 397: 702-706.
28. Zhuang Y, Soriano P, Weintraub H. The helix-loop-helix gene E2A is required for B cell formation. Cell 1994; 79: 875-884.
29. Morrow MA, Mayer EW, Perez CA, Adiam M, Siu G. Over-expression of the helix-loop-helix protein Id2 blocks T cell development at multiple stages. Mol Immunol 1999; 36: 491-503.
30. Peverali FA, Ramqvist T, Saffrich R, Pepperkok R, Barone MV, Philipson L. Regulation of G1 progression by E2A and Id helix-loop-helix proteins. EMBO J 1994; 13: 4291-4301.
31. Engel I, Murre C. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J 2004; 23: 202-211.
32. Rutherford MN, LeBrun DP. Restricted expression of E2A protein in primary human tissues correlates with proliferation and differentiation. Am J Pathol 1998; 153: 165-173.
33. Zhao F, Vilardi A, Neely RJ, Choi JK. Promotion of cell cycle progression by basic helix-loop-helix E2A. Mol Cell Biol 2001; 21: 6346-6357.
34. Xin XQ, Nelson C, Collins L, Dorshkind K. Kinetics of E2A basic helix-loop-helix-protein expression during myelopoiesis and primary B cell differentiation. J Immunol 1993; 151: 5398-5407.
35. Voronova AF, Lee F. The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation. Proc Natl Acad Sci USA 1994; 91: 5952-5956.
36. Ishiguro A, Spirin KS, Shiohara M, Tobler A, Gombart AF, Israel MA et al. Id2 expression increases with differentiation of human myeloid cells. Blood 1996; 87: 5225-5231.
37. Cooper CL, Newburger PE. Differential expression of Id genes in multipotent myeloid progenitor cells: Id-1 is induced by early- and late-acting cytokines while Id-2 is selectively induced by cytokines that drive terminal granulocytic differentiation. J Cell Biochem 1998; 71: 277-285.
38. Sikder HA, Devlin MK, Dunlap S, Ryu B, Alani RM. Id proteins in cell growth and tumorigenesis. Cancer Cell 2003; 3: 525-530.
39. Wadman IA, Osada H, Grutz GG, Agulnick AD, Westphal H, Forster A et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J 1997; 16: 3145-3157.
40. Lister JA, Baron MH. Induction of basic helix-loop-helix protein-containing complexes during erythroid differentiation. Gene Exp 1998; 7: 25-38.
41. Cammenga J, Mulloy JC, Berguido FJ, MacGrogan D, Viale A, Nimer SD. Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells. Blood 2003; 101: 2206-2214.
42. Hui EK, Yung BY. Cell cycle phase-dependent effect of retinoic acid on the induction of granulocytic differentiation in HL-60 promyelocytic leukemia cells. Evidence for sphinganine potentiation of retinoic acid-induced differentiation. FEBS Lett 1993; 318: 193-199.