Modulation of p53, WAF1/p21 and BCL-2 expression during retinoic acid-induced differentiation of NB4 promyelocytic cells

Leukemia Research

Volumn 21, Issue 5, 1997, Pages 439-447

  Bocchia, Monica ^a   Xu, Qin ^a   Wesley, Umadevi ^a   Xu, Yang ^a   Korontsvit, Tatyana ^a   Loganzo, Frank ^a   Albino, Anthony P ^a   Scheinberg, David A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Apoptosis; BCL 2; NB4 cells; p53; Retinoic acid; WAF1 p21

Indexed keywords

CD11B ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; PROTEIN BCL 2; PROTEIN P53; RETINOIC ACID;

ACUTE MYELOBLASTIC LEUKEMIA; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CHROMOSOME TRANSLOCATION 15; CHROMOSOME TRANSLOCATION 17; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GRANULOPOIESIS; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROMYELOCYTE; PROTEIN SYNTHESIS REGULATION; TUMOR SUPPRESSOR GENE;

ANTIGENS, CD; APOPTOSIS; BURKITT LYMPHOMA; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; GENES, P53; HUMANS; KINETICS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MACROPHAGE-1 ANTIGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; TRETINOIN; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030852977     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(96)00085-9     Document Type: Article

References (31)

1. Lanotte M., Martin-Thouvenin V., Najman S., Balerini P., Valensi F. & Berger R. (1992) NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3). Blood 77, 1080.
2. Avarachan P. J. & Dharam P. C. (1993) Retinoic acid and calcium regulation of p53, transforming growth factor-β1, and transforming growth factor-α gene expression and growth in adenovirus 12-SV40-transformed human tracheal gland epithelial cells. Am. J. Respir. Cell Mol. Biol. 8, 408.
3. Nigro J. M., Baker S. J., Preisinger A. C., Jessup J. M., Hostetter R., Cleary K., Bigner S. H., Davidson N., Baylin S., Devilee P., Glover T., Collins F. S., Weston A., Modali R., Harris C. & Vogelstein B. (1989) Mutations in the p53 gene occur in diverse human tumor types. Nature 342, 705.
4. Hollstein M., Sidranskz D., Vogelstein B. & Harris C. C. (1991) p53 mutations in human cancers. Science 253, 49.
5. Levine A. J. (1993) The tumor suppressor genes. Ann. Rev. Biochem. 62, 623.
6. Kastan M. B., Radin A. L., Kuerbitz S. J., Onyekwere O., Wolkow C. A., Civin C. I., Stone K. D., Woo T., Ravindranath Y. & Craig R. W. (1991) Levels of p53 protein increase with maturation in human haematopoietic cells. Cancer Res. 51, 4279.
7. Soddu S., Blandino G., Citro G., Scardigli R., Piaggio G., Ferber A., Calabretta B. & Sacchi A. (1994) Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells. Blood 83, 2230.
8. El-Deiry W. S., Tokino T., Velculescu V. E., Levy D. B., Parsons R., Trent J. M., Lin D., Mercer W. E., Kinzler K. W. & Vogelstein B. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817.
9. Michiele P., Chedid M., Lin D., Mercer W. E. & Givol D. (1994) Induction of WAF1/CIP1 by a p53 independent pathway. Cancer Res. 54, 3391.
10. Hockenbery D., Nunez G., Milliman C., Schreiber R. D. & Korsmeyer S. J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348, 334.
11. Kane D. J., Sarafion T. A., Anton R., Hahn H., Gralla E., Valentine J. S., Ord T. & Bredesen D. E. (1993) Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262, 1274.
12. Hockenbery D. M., Zutter M., Hickey W., Nahm M. & Korsmeyer S. J. (1991) Protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. natn. Acad. Sci. U.S.A. 88, 6961.
13. Brady-Kalnay S. M., Rimm D. L. & Tonks N. K. (1995) Receptor protein tyrosine phosphatase PTPmu associates with cadherins and catenins in vivo. J. Cell. Biol. 130, 977.
14. Chirwin J. M., Przybyla A. E., Macdonald R. J. & Rutter W. J. (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294.
15. Rosmarin A. G., Weil S. C., Rosner G. L., Griffin J. D., Arnaout M. A. & Tenen D. G. (1989) Differential expression of CD11b/CD18 (Mol) and myeloperoxidase genes during myeloid differentiation. Blood 10, 131.
16. Peacock J. W., Chung S., Bristow R. G., Hill R. P. & Benchimol S. (1995) The p53-mediated G1 checkpoint is retained in tumorigenic rat embryo fibroblast clones transformed by the human papillomavirus type 16 E7 gene and EJ-ras. Mol. Cell. Biol. 15, 1446.
17. Calabresse C., Venturini L., Barbey S., Dubois C., Degos L. & Chomienne C. (1994) Molecular features of apoptosis during APL differentiation therapy. Blood 84, 600a.
18. Harper J. W., Adami G. R., Wei N., Keuomarsi K. & Elledge S. J. (1993) The p21 Cdk-interacting protein CIP1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805.
19. Waga S., Hannon G. J., Beach D. & Stillman B. (1994) The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369, 574.
20. El-Deiry W. S., Harper J. W., O'Connor P. M., Velculescu V. E., Canman C. E., Jackman J., Pietenpol J. A., Burrell M., Hill D. E., Wang Y. S., Wiman K. G., Mercer W. E., Kastan M. B., Kohn K. W., Elledge S. J., Kinzler K. W. & Vogelstein B. (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54, 1169.
21. Steinman R. A., Hoffman B., Iro A., Guillouf C., Liebermann D. A. & el-Houseini M. E. (1994) Induction of p21 (WAF1/CIP1) during differentiation. Oncogene 9(11), 3389.
22. Thompson C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456.
23. Kaufmann S. H. (1989) Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res. 49, 5870.
24. Savill J. S., Wyllie A. H., Henson J. E., Walport M. J., Henson P. M. & Haslett C. (1989) Macrophage phagocytosis of aging neutrophils in inflammation - Programmed cell death in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 83, 865.
25. Park J. R., Robertson K., Hickstein D. D., Tsai S., Hockenbery D. M. & Collins S. J. (1994) Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes. Blood 84, 440.
26. Calabresse C., Venturini L., Ronco G., Villa P., Degos L., Belpomme D. & Chomienne C. (1994) Selective induction of apoptosis in myeloid leukemic cell lines by monoacetone glucose-3 butyrate. Biochem. Biophys. Res. Commun. 201, 266.
27. Naumovski L. & Cleary M. L. (1994) Bcl 2 inhibits apoptosis associated with terminal differentiation of HL-60 myeloid leukemia cells. Blood 83, 2261.
28. Reed J. C. (1994) Cell death and the bcl-2 gene. Contemporary Oncology 4(10), 29.
29. Jiang H. P., Lin J., Su Z. Z., Collart F. R., Huberman E. & Fisher P. B. (1994) Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/ CIP1 expression in the absence of p53. Oncogene 9, 3397.
30. Cip/Waf1 proteins following γ-irradiation of human lymphoma cells. Cancer Res. 55, 2387.
31. Grignani F., Ferrucci P. F., Testa U., Talamo G., Fagioli M., Alcalay M., Mencarelli A., Grignani F., Peschle C., Nicoletti I. & Pelicci P. G. (1993) The acute promyelocytic leukemia specific PML/RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell 74, 423.