Ultrasound contrast agents for brain perfusion imaging and ischemic stroke therapy

Journal of Neuroimaging

Volumn 15, Issue 3, 2005, Pages 217-232

  Della Martina, Alberto ^a   Meyer Wiethe, Karsten ^b   Allémann, Eric ^a   Seidel, Günter ^b  

^a Bracco Suisse SA   (Switzerland)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Cerebral perfusion; Review; Stroke; Transcranial ultrasonography; Ultrasound contrast agents

Indexed keywords

CONTRAST MEDIUM;

BLOOD CLOT LYSIS; BOLUS INJECTION; BRAIN PERFUSION; CEREBROVASCULAR ACCIDENT; DOPPLER ECHOGRAPHY; GENE TARGETING; HUMAN; IMAGE ANALYSIS; MICROBUBBLE; NEUROIMAGING; REVIEW; TECHNOLOGY;

BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; CONTRAST MEDIA; ECHOENCEPHALOGRAPHY; HUMANS; MICROBUBBLES; PERFUSION; THROMBOLYTIC THERAPY; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 20844438221     PISSN: 10512284     EISSN: None     Source Type: Journal    
DOI: 10.1177/1051228405277342     Document Type: Review

References (107)

1. Goertler M, Kross R, Baeumer M, et al. Diagnostic impact and prognostic relevance of early contrast-enhanced transcranial color-coded duplex sonography in acute stroke. Stroke 1998;29:955-962.
2. Barbier EL, Lamalle L, Décorps M. Methodology of brain perfusion imaging. J Magn Reson Imaging 2001;13:496-520.
3. Keston P, Murra AD, Jackson A. Cerebral perfusion imaging using contrast-enhanced MRI. Clin Radiol 2003;58:505-513.
4. Ezzeddine MA, Lev MH, McDonald CT, et al. CT angiography with whole brain perfused blood volume imaging: added clinical value in the assessment of acute stroke. Stroke 2002;33:959-966.
5. Meuli RA. Imaging viable brain tissue with CT scan during acute stroke. Cerebrovasc Dis 2004;17(suppl 3):28-34.
6. Alexandrov AV, Masdeu JC, Devous MD, Black SE, Grotta JC. Brain single-photon emission CT with HMPAO and safety of thrombolytic therapy in acute ischemic stroke. Stroke 1997;28:1830-1834.
7. Heiss WD. Imaging the ischemic penumbra and treatment effects by PET. Keio J Med 2001;50:249-256.
8. Guadagno JV, Donnan GA, Markus R, Gillard JH, Baron J-C. Imaging the ischaemic penumbra. Curr Opin Neurol 2004;17:61-67.
9. Ringelstein EB. Echo-enhanced ultrasound for diagnosis and management in stroke patients. Eur J Ultrasound 1998;7(suppl 3):S3-S15.
10. Wiesmann M, Seidel G. Ultrasound perfusion imaging of the human brain. Stroke 2000;31:2421-2425.
11. Seidel G, Meyer K. Harmonic imaging: a new method for the sonographic assessment of cerebral perfusion. Eur J Ultrasound 2001;14:103-113.
12. Gramiak R, Shah PM. Echocardiography of the aortic root. Invest Radiol 1968;3:356-366.
13. Shah PM. Contrast echocardiography: a historical perspective. In: Nanda NC, Schlief R, Goldberg BB, eds. Advances in Echo Imaging Using Contrast Enhancement. Dordrecht, the Netherlands: Kluwer Academic Publishers; 1997:3-9.
14. Kremkau FW, Gramiak R, Carstensen EL, Shah PM, Kramer DH. Ultrasonic detection of cavitation at catheter tips. Am J Roentgenol 1970;110:177-183.
15. Hoff L. Acoustic Characterization of Contrast Agents for Medical Ultrasound Imaging. Boston, MA: Kluwer Academic; 2001.
16. Raisinghani A, DeMaria AN. Physical principles of microbubble ultrasound contrast agents. Am J Cardiol 2002;90(10 suppl 1):3J-7J.
17. Schutt EG, Klein DH, Mattrey RM, Riess JG. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals. Angew Chem Int Ed 2003;42:3218-3235.
18. Bloch SH, Wan M, Dayton PA, Ferrara KW. Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents. Appl Phys Lett 2004;84:631-633.
19. Raisinghani A, Rafter P, Phillips P, Vannan MA, DeMaria AN. Microbubble contrast agents for echocardiography: rationale, composition, ultrasound interactions, and safety. Cardiol Clin 2004;22:171-180.
20. de Jong N, Bouakaz A, Frinking P. Basic acoustic properties of microbubbles. Echocardiography 2002;19:229-240.
21. Bauer A, Schlief R, Zomack M, Urbank A, Niendorf H-P. Acoustically stimulated microbubbles in diagnostic ultrasound: properties and implications for diagnostic use. In: Nanda NC, Schlief R, Goldberg BB, eds. Advances in Echo Imaging Using Contrast Enhancement. Dordrecht, the Netherlands: Kluwer Academic; 1997:669-684.
22. Grayburn PA. Current and future contrast agents. Echocardiography 2002;19:259-265.
23. Grant EG. Sonographic contrast agents in vascular imaging. Semin Ultrasound CT MRI 2001;22(1):25-41.
24. Seidel G, Meyer K. Impact of ultrasound contrast agents in cerebrovascular diagnostics. Eur J Ultrasound 2002;16(1-2):81-90.
25. Riess JG. Fluorocarbon-based injectable gaseous microbubbles for diagnosis and therapy. Curr Opin Colloid Interface Sci 2004;8:259-266.
26. Klibanov AL. Ultrasound contrast agents: development in the field and current status. Top Curr Chem 2002;222:73-106.
27. Miller AP, Nanda NC. Contrast echocardiography: new agents. Ultrasound Med Biol 2004;30:425-434.
28. Serra V, García Fernandez MA, Zamorano JL. Microbubbles: basic principles. In: Zamorano JL, García Fernandez MA, eds. Contrast Echocardiography in Clinical Practice. Milan, Italy: Springer-Verlag; 2004:19-43.
29. Burns PN. Instrumentation for contrast echocardiography. Echocardiography 2002;19:241-258.
30. Frinking PJA, Bouakaz A, Kirkhorn J, ten Gate FJ, de Jong N. Ultrasound contrast imaging: current and new potential methods. Ultrasound Med Biol 2000;26:965-975.
31. Rafter P, Phillips P, Vannan MA. Imaging technologies and techniques. Cardiol Clin 2004;22:181-197.
32. Rim SJ, Leong-Poi H, Lindner JR, et al. Quantification of cerebral perfusion with "real-time" contrast-enhanced ultrasound. Circulation 2001;104:2582-2587.
33. Meyer K, Seidel G, Algermissen C. Harmonic imaging of the brain parenchyma in a dog model following NC100100 (Sonazoid™) bolus injection. J Neuroimaging 2002;12:35-41.
34. Burns PN. Harmonic imaging with ultrasound contrast agents. Clin Radiol 1996;51(suppl 1):50-55.
35. Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 1998;97:473-483.
36. Seidel G, Meyer K, Metzler V, Toth D, Vidal-Langwasser M, Aach T. Human cerebral perfusion analysis with ultrasound contrast agent constant infusion: a pilot study on healthy volunteers. Ultrasound Med Biol 2002;28:183-189.
37. Metzler V, Seidel G, Wiesmann M, Meyer K, Aach T. Perfusion harmonic imaging of the human brain. In: Walker WF, Insana MF, eds. SPIE Symposium on Medical Imaging 2003: Ultrasonic Imaging and Signal Processing. Bellingham, WA: International Society for Optical Engineering; 2003:337-348.
38. Meyer K, Seidel G. Transcranial contrast diminution imaging of the human brain: a pilot study in healthy volunteers. Ultrasound Med Biol 2002;28:1433-1437.
39. Eyding J, Wilkening W, Reckhardt M, et al. Contrast burst depletion imaging (CODIM): a new imaging procedure and analysis method for semiquantitative ultrasonic perfusion imaging. Stroke 2003;34:77-83.
40. Meyer-Wiethe K, Cangür H, Seidel G. Comparison of different mathematical models to analyse diminution kinetics of ultrasound contrast enhancement in a flow phantom. Ultrasound Med Biol In press.
41. Wilkening W, Postert T, Federlein J, Kono Y, Mattrey RM, Ermert H. Ultrasonic assessment of perfusion conditions in the brain and in the liver. Proceedings of the 2000 IEEE Ultrasonics Symposium. New York, NY: IEEE; 2000:1545-1548.
42. Lucidarme O, Kono Y, Corbeil J, Choi S-H, Mattrey RF. Validation of ultrasound contrast destruction imaging for flow quantification. Ultrasound Med Biol 2004;29:1697-1704.
43. Seidel G, Kaps M, Greis C. Second harmonic imaging of a new ultrasound contrast agent (BY963): visualisation of small cerebral arteries and analysis of regional cerebral blood flow [abstract]. J Neuroimaging 1997;7:230.
44. Eyding J, Krogias C, Wilkening W, Meves S, Ermert H, Postert T. Parameters of cerebral perfusion in phase-inversion harmonic imaging (PIHI) ultrasound examinations. Ultrasound Med Biol 2003;29:1379-1385.
45. Harrer JU, Klotzsch C. Second harmonic imaging of the human brain: the practicability of coronal insonation planes and alternative perfusion parameters. Stroke 2002;33:1530-1535.
46. Meves SH, Wilkening W, Thies T, et al. Comparison between echo contrast agent-specific imaging modes and perfusion-weighted magnetic resonance imaging for the assessment of brain perfusion. Stroke 2002;33:2433-2437.
47. Seidel G, Algermissen C, Christoph A, Claassen L, Vidal-Langwasser M, Katzer T. Harmonic imaging of the human brain: visualization of brain perfusion with ultrasound. Stroke 2000;31:151-154.
48. Pohl C, Tiemann K, Schlosser T, Becher H. Stimulated acoustic emission detected by transcranial color Doppler ultrasound: a contrast-specific phenomenon useful for the detection of cerebral tissue perfusion. Stroke 2000;31:1661-1666.
49. Postert T, Hoppe P, Federlein J, et al. Contrast agent specific imaging modes for the ultrasonic assessment of parenchymal cerebral echo contrast enhancement. J Cereb Blood Flow Metab 2000;20:1709-1716.
50. Seidel G, Greis C, Sonne J, Kaps M. Harmonic gray scale imaging of the human brain. J Neuroimaging 1999;9:171-174.
51. Postert T, Muhs A, Meves SH, Federlein J, Przuntek H, Buttner T. Transient response harmonic imaging: an ultrasound technique related to brain perfusion. Stroke 1998;29:1901-1907.
52. Shiogai T, Takayasu N, Mizuno T, Nakagawa M, Furuhata H. Comparison of transcranial brain tissue perfusion images between ultraharmonic, second harmonic, and power harmonic imaging. Stroke 2004;35:687-693.
53. Seidel G, Meyer-Wiethe K, Berdien G, Hollstein D, Toth D, Aach T. Ultrasound perfusion imaging in acute middle cerebral artery infarction predicts outcome. Stroke 2004;35:1107-1111.
54. Wiesmann M, Meyer K, Albers T, Seidel G. Parametric perfusion imaging with contrast-enhanced ultrasound in acute ischemic stroke. Stroke 2004;35:508-513.
55. Seidel G, Albers T, Meyer K, Wiesmann M. Perfusion harmonic imaging in acute middle cerebral artery infarction. Ultrasound Med Biol 2003;29:1245-1251.
56. Federlein J, Postert T, Meves SH, Weber S, Przuntek H, Buttner T. Ultrasonic evaluation of pathological brain perfusion in acute stroke using second harmonic imaging. J Neurol Neurosurg Psychiatry 2000;69:616-622.
57. Meairs S, Daffertshofer M, Neff W, Eschenfleder C, Hennerici M. Pulse-inversion contrast harmonic imaging: ultrasonographic assessment of cerebral perfusion. Lancet 2000;355:550-551.
58. Stolz E, Allendorfer J, Jauss M, Traupe H, Kaps M. Sonographic harmonic grey scale imaging of brain perfusion: scope of a new method demonstrated in selected cases. Ultraschall Med 2003;23:320-324.
59. Meyer K, Wiesmann M, Albers T, Seidel G. Harmonic imaging in acute stroke: detection of a cerebral perfusion deficit with ultrasound and perfusion MRI. J Neuroimaging 2003;13:166-168.
60. Schlachetzki F, Hoelscher T, Dorenbeck U, et al. Sonographic parenchymal and brain perfusion imaging: preliminary results in four patients following decompressive surgery for malignant middle cerebral artery infarct. Ultrasound Med Biol 2001;27:21-31.
61. Postert T, Federlein J, Weber S, Przuntek H, Buttner T. Second harmonic imaging in acute middle cerebral artery infarction: preliminary results. Stroke 1999;30:1702-1706.
62. Eyding J, Krogias C, Wilkening W, Postert T. Detection of cerebral perfusion abnormalities in acute stroke using phase inversion harmonic imaging (PIHI): preliminary results. J Neurol Neurosurg Psychiatry 2004;75:926-929.
63. Mychaskiw G II, Badr AE, Tibbs R, Glower BR, Zhang JH. Optison (FS069) disrupts the blood-brain barrier in rats. Anesth Analg 2000;91:798-803.
64. Hynynen K, McDannold N, Martin H, Jolesz FA, Vykhodtseva N. The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison). Ultrasound Med Biol 2003;29:473-481.
65. Ay T, Havaux X, Van Camp G, et al. Destruction of contrast microbubbles by ultrasound: effects on myocardial function, coronary perfusion pressure, and microvascular integrity. Circulation 2001;104:461-466.
66. Skyba DM, Price RJ, Linka AZ, Skalak TC, Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation 1998;98:290-293.
67. Price RJ, Skyba DM, Kaul S, Skalak TC. Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound. Circulation 1998;98:1264-1267.
68. Klibanov AL, Hughes MS, Villanueva FS, et al. Targeting and ultrasound imaging of microbubble-based contrast agents. MAGMA 1999;8:177-184.
69. Dayton PA, Ferrara KW. Targeted imaging using ultrasound. J Magn Reson Imaging 2002;16:362-377.
70. Nobs L, Buchegger F, Gurny R, Allémann E. Current methods for attaching targeting ligands to liposomes and nanoparticles. J Pharm Sci 2004;93:1980-1982.
71. Lanza GM, Wickline SA. Targeted ultrasonic contrast agents for molecular imaging and therapy. Curr Probl Cardiol 2003;28:625-653.
72. Villanueva FS, Wagner WR, Vannan MA, Narula J. Targeted ultrasound imaging using microbubbles. Cardiol Clin 2004;22:283-298.
73. Lanza GM, Wallace KD, Scott MJ, et al. A novel site-targeted ultrasonic contrast agent with broad biomedical application. Circulation 1996;94:3334-3340.
74. Lanza GM, Wallace KD, Fischer SE, et al. High-frequency ultrasonic detection of thrombi with a targeted contrast system. Ultrasound Med Biol 1997;23:863-870.
75. Unger EC, McCreery TP, Sweitzer RH, DeKang S, Wu GL. In vitro studies of a new thrombus-specific ultrasound contrast agent. Am J Cardiol 1998;81(12 suppl 1):58G-61G.
76. Demos SM, Alkan-Onyuksel H, Kane BJ, et al. In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement. J Am Soc Echocardiogr 1999;33:867-875.
77. Demos SM, Alkan-Onyuksel H, Gilbert J, Roth SI, Kane BJ, Jungblut P, et al. In vitro targeting of antibody-conjugated echogenic liposomes for site-specific ultrasonic image enhancement. J Pharm Sci 1997;86:167-171.
78. Tardy I, Pochon S, Theraulaz M, Nanjappan P, Schneider M. In vivo ultrasound imaging of thrombi using a target-specific contrast agent. Acad Radiol 2002;9(suppl 2):S294-S296.
79. Villanueva FS, Jankowski RJ, Klibanov S, et al. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation 1998;98:1-5.
80. Villanueva FS, Klibanov AL, Wagner WR. Microbubble-endothelial cell interactions as a basis for assessing endothelial function. Echocardiography 2002;19:427-438.
81. Weller GER, Villanueva FS, Klibanov AL, Wagner WR. Modulating targeted adhesion of an ultrasound contrast agent to dysfunctional endothelium. Ann Biomed Eng 2002;30:1012-1019.
82. Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 2001;104:2107-2112.
83. Takalkar AM, Klibanov AL, Rychak JJ, Lindner JR, Ley K. Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release 2004;96:473-482.
84. Putman SS, Hamilton BD, Johnson DB. The use of shock wave lithotripsy for renal calculi. Curr Opin Urol 2004;14:117-121.
85. Culp WC, Porter TR, McCowan TC, et al. Microbubble-augmented ultrasound declotting of thrombosed arteriovenous dialysis grafts in dogs. J Vasc Interv Radiol 2003;14:343-347.
86. Culp WC, Erdem E, Roberson PK, Husain MM. Microbubble potentiated ultrasound as a method of stroke therapy in a pig model: preliminary findings. J Vasc Interv Radiol 2003;14:1433-1436.
87. Nedelmann M, Eicke BM, Nolle F, Lierke EG, Kempski O. Ultraschallkontrastmittel Levovist steigert den thrombolytischen Effekt von niederfrequentem Ultraschall. Med Klin 2002;97:216-220.
88. Viguier A, Rigal M, Petit R, Cintas P, Larrue V. Microbubbles accelerate ultrasound-driven thrombolysis in acute middle cerebral artery stem occlusion [abstract]. Stroke 2004;35:297.
89. Alexandrov AV, Demchuk AM, Burgin WS, Robinson DJ, Grotta JC. Ultrasound-enhanced thrombolysis for acute ischemic stroke: phase I. Findings of the CLOTBUST trial. J Neuroimaging 2004;14:113-117.
90. Garcia MJ. Therapeutic application of ultrasound contrast agents. In: Zamorano JL, García Fernandez MA, eds. Contrast Echocardiography in Clinical Practice. Milan, Italy: Springer-Verlag; 2004:263-286.
91. Unger EC, Matsunaga TO, McCreery T, Schumann P, Sweitzer R, Quigley R. Therapeutic applications of microbubbles. Eur J Radiol 2002;42:160-168.
92. Nelson JL, Roeder BL, Carmen JC, Roloff F, Pitt WG. Ultrasonically activated chemotherapeutic drug delivery in a rat model. Cancer Res 2002;62:7280-7283.
93. Unger EC, Hersh E, Vannan M, McCreery T. Gene delivery using ultrasound contrast agents. Echocardiography 2001;18:355-361.
94. Tachibana K, Tachibana S. Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis. Circulation 1995;92:1148-1150.
95. Porter TR, LeVeen RF, Fox R, Kricsfeld A, Xie F. Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles. Am Heart J 1996;132:964-968.
96. Dhond M, Nguyen T, Dolan C, Pulido G, Bommer W. Ultrasound-enhanced thrombolysis at 20 kHz with air-filled and perfluorocarbon-filled contrast bispheres. J Am Soc Echocardiogr 2000;13:1025-1029.
97. Mizushige K, Kondo I, Ohmori K, Hirao K, Matsuo H. Enhancement of ultrasound-accelerated thrombolysis by echo contrast agents: dependence on microbubble structure. Ultrasound Med Biol 1999;25:1431-1437.
98. Nishioka T, Luo H, Fishbein MC, et al. Dissolution of thrombolytic arterial occlusion by high intensity, low frequency ultrasound and dodecafluoropentane emulsion: an in vitro and in vivo study. J Am Coll Cardiol 1997;30:561-568.
99. Birnbaum Y, Luo H, Nagai T, et al. Noninvasive in vivo clot dissolution without a thrombolytic drug: recanalization of thrombosed iliofemoral arteries by transcutaneous ultrasound combined with intravenous infusion of microbubbles. Circulation 1998;97:130-134.
100. Zarnitsyn VG, Prausnitz MR. Physical parameters influencing optimization of ultrasound-mediated DNA transfection. Ultrasound Med Biol 2004;30:527-538.
101. Tsutsui JM, Grayburn PA, Xie F, Porter TR. Drug and gene delivery and enhancement of thrombolysis using ultrasound and microbubbles. Cardiol Clin 2004;22:299-312.
102. Blomley M. Which US microbubble contrast agent is best for gene therapy? Radiology 2003;229:297-298.
103. Deng CX, Sieling F, Pan H, Cui J. Ultrasound-induced cell membrane porosity. Ultrasound Med Biol 2004;30:519-526.
104. Guzman HR, Nguyen DX, McNamara AJ, Prausnitz MR. Equilibrium loading of cells with macromolecules by ultrasound: effects of molecular size and acoustic energy. J Pharm Sci 2002;91:1693-1701.
105. Shohet RV, Chen S, Zhou YT, et al. Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation 2000;101:2554-2556.
106. Christiansen JP, French BA, Klibanov AL, Kaul S, Lindner JR. Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles. Ultrasound Med Biol 2003;29:1759-1767.
107. Montaldo G, Tanter M, Fink M. Real time inverse filter focusing through iterative time reversal. J Acoust Soc Am 2004;115:768-775.