A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: Studies with radiolabeled (E)-5-(2-iodovinyl)-2′-fluoro-2′- deoxyuridine

Nuclear Medicine and Biology

Volumn 32, Issue 5, 2005, Pages 459-464

  Morin, Kevin W ^a   Duan, Weili ^a   Knaus, Edward E ^a   McEwan, Alexander J B ^a   Wiebe, Leonard I ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Gene expression; Gene therapy; IVFRU; Nude mice; Osteosarcoma; Reporter gene; Thymidine kinase

Indexed keywords

5 (2 IODOVINYL) 2' FLUORO 2' DEOXYURIDINE; GANCICLOVIR; RADIOPHARMACEUTICAL AGENT; RETROVIRUS VECTOR; THYMIDINE KINASE 1; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL LINE; CELL LINEAGE; CELL TYPE; CELLULAR DISTRIBUTION; CYTOTOXICITY; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; NUDE MOUSE; OSTEOSARCOMA CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BONE NEOPLASMS; CELL LINE, TUMOR; FLOXURIDINE; HERPESVIRUS 1, HUMAN; HUMANS; IODINE RADIOISOTOPES; OSTEOSARCOMA; THYMIDINE KINASE; TISSUE DISTRIBUTION;

EID: 20744460086     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2005.03.006     Document Type: Article

References (33)

1. K.W. Morin, L.I. Wiebe, E.E. Knaus, J. Balzarini, and E. De Clercq Metabolic imaging in gene therapy of cancer (abstract) Eur J Nucl Med 21 1994 S-125
2. Wiebe LI, Knaus EE, Morin KW. Tissue imaging in gene therapy. United Kingdom provisional patent application; 1994. [9421223.0].
3. J.G. Tjuvajev, G. Stockhammer, R. Desai, H. Uehara, K. Watanabe, and B. Gansbacher Imaging the expression of transfected genes in vivo Cancer Res 55 1995 6126 6132
4. L.I. Wiebe, K.W. Morin, and E.E. Knaus Radiopharmaceuticals to monitor gene transfer Q J Nucl Med 41 1997 79 89
5. S.S. Gambhir Molecular imaging of cancer with positron emission tomography Nat Rev Cancer 2 2002 683 693
6. J.J. Min, and S.S. Gambhir Gene therapy progress and prospects: noninvasive imaging of gene therapy in living subjects Gene Ther 11 2004 115 125
7. J.G. Tjuvajev, N. Avril, T. Oku, T. Sasajima, T. Miyagawa, and R. Joshi Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography Cancer Res 58 1998 4333 4341
8. 14C]FIAU for imaging of HSV1-tk reporter gene expression: adenoviral infection vs. stable transfection Eur J Nucl Med Mol Imaging 30 2003 1547 1560
9. K.W. Morin, W. Duan, L. Xu, A. Zhou, S. Moharram, and E.E. Knaus Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells Nucl Med Biol 31 2004 623 630
10. A. De, X.Z. Lewis, and S.S. Gambhir Noninvasive imaging of lentiviral-mediated reporter gene expression in living mice Mol Ther 7 2003 681 691
11. G. Sundaresan, R. Paulmurugan, F. Berger, B. Stiles, Y. Nagayama, and H. Wu MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene Gene Ther 11 2004 609 618 [Jan 15 electronic publication ahead of print]
12. S.C. Ko, J. Cheon, C. Kao, A. Gotoh, T. Shirakawa, and R.A. Sikes Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models Cancer Res 56 1996 4614 4619
13. J. Cheon, S.C. Ko, T.A. Gardner, T. Shirakawa, A. Gotoh, and C. Kao Chemogene therapy: osteocalcin promoter-based suicide gene therapy in combination with methotrexate in a murine osteosarcoma model Cancer Gene Therapy 4 1997 359 365
14. T. Shirakawa, S.C. Ko, T.A. Gardner, J. Cheon, T. Miyamoto, and A. Gotoh In vivo suppression of osteosarcoma pulmonary metastasis with intravenous osteocalcin promoter-based toxic gene therapy Cancer Gene Therapy 5 1998 274 280
15. X. Chen, Y. Li, K. Xiong, S. Aizicovici, Y. Xie, and Q. Zhu Cancer gene therapy by direct tumor injection of a nonviral T7 vector encoding a thymidine kinase gene Hum Gene Ther 9 1998 729 736
16. V.M. Brown, A. Ossadtchi, A.H. Khan, S.S. Gambhir, S.R. Cherry, and R.M. Leahy Gene expression tomography Physiol Genomics 8 2002 159 167
17. P. Leyssen, N. Charlier, J. Paeshuyse, E. De Clercq, and J. Neyts Prospects for antiviral therapy Adv Virus Res 61 2003 511 553
18. S. Prekupec, D. Svedruzic, T. Gazivoda, D. Mrvos-Sermek, A. Nagl, and M. Grdisa Synthesis and biological evaluation of iodinated and fluorinated 9-(2-hydroxypropyl) and 9-(2-hydroxyethoxy)methyl purine nucleoside analogues J Med Chem 46 2003 5763 5772
19. K.W. Morin, E.E. Knaus, and L.I. Wiebe Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model Nucl Med Commun 18 1997 599 605
20. 125I]iodovinyl)-2′-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy J Med Chem 40 1997 2184 2190
21. J. Balzarini, K.W. Morin, E.E. Knaus, L.I. Wiebe, and E. De Clercq Novel (E)-5-(2-iodovinyl)-2′-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors Gene Therapy 2 1995 317 322
22. B. Degreve, G. Andrei, M. Izquierdo, J. Piette, K. Morin, and E.E. Knaus Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer Gene Therapy 4 1997 1107 1114
23. J.S. Rhim, H.Y. Cho, and R.J. Huebner Non-producer human cells induced by murine sarcoma virus Int J Cancer 15 1975 23 29
24. S. Bacchetti, and F.L. Graham Transfer of the gene for thymidine kinase to thymidine kinase-deficient human cells by purified herpes simplex viral DNA Proc Natl Acad Sci U S A 74 1977 1590 1594
25. C.M. Croce, J. Barrick, A. Linnenbach, and H. Koprowski Expression of malignancy in hybrids between normal and malignant cells J Cell Physiol 99 1979 279 286
26. G. Milanesi, G. Barbanti-Brodano, M. Negrini, D. Lee, A. Corallini, and A. Caputo BK virus-plasmid expression vector that persists episomally in human cells and shuttles into Escherichia coli Mol Cell Biol 4 1984 1551 1560
27. S.M. Freeman, C.N. Abboud, K.A. Whartenby, C.H. Packman, D.S. Koeplin, and F.L. Moolten The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified Cancer Res 53 1993 5274 5283
28. A.K. Field, M.E. Davies, C. De Witt, H.C. Perry, R. Liou, and J. Germershausen 9-[2-Hydroxy-1-(hydroxymethyl)ethoxymethyl] guanine: a selective inhibitor of herpes group virus replication Proc Natl Acad Sci U S A 80 1983 4139 4143
29. K.W. Morin, E.E. Knaus, L.I. Wiebe, H. Xia, and A.J. McEwan Reporter gene imaging: effects of ganciclovir on nucleoside uptake, hypoxia and perfusion in a murine gene therapy model that expresses herpes simplex type-1 thymidine kinase Nucl Med Commun 21 2000 129 137
30. M.H. St Clair, C.U. Lambe, and P.A. Furman Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information Antimicrob Agents Chemother 31 1987 844 849
31. T. Iwashina, D.R. Tovell, L. Xu, D.L. Tyrrell, E.E. Knaus, and L.I. Wiebe Synthesis and antiviral activity of IVFRU, a potential probe for the non-invasive diagnosis of herpes simplex encephalitis Drug Des Deliv 3 1988 309 321
32. T.H. Choi, S.H. Ahn, H.C. Kwon, C.W. Choi, O.D. Awh, and S.M. Lim In vivo comparison of IVDU and IVFRU in HSV1-TK gene expressing tumor bearing rats Appl Radiat Isot 60 2004 15 21
33. 131I](E)-5-(2-iodovinyl)- 2′-deoxyuridine in dogs Antimicrob Agents Chemother 29 1986 320 324