Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models

Cancer Research

Volumn 56, Issue 20, 1996, Pages 4614-4619

  Ko, Song Chu ^a   Cheon, Jun ^a   Kao, Chinghai ^a   Gotoh, Akinobu ^a   Shirakawa, Toshiro ^a   Sikes, Robert A ^a   Karsenty, Gerard ^b   Chung, Leland W K ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OSTEOCALCIN;

ANIMAL CELL; ARTICLE; CANCER THERAPY; GENE THERAPY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOSARCOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

3T3 CELLS; ACYCLOVIR; ADENOVIRIDAE; ANIMALS; ANTIVIRAL AGENTS; BONE NEOPLASMS; GANCICLOVIR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE THERAPY; GENETIC VECTORS; HUMANS; MICE; MICE, NUDE; OSTEOCALCIN; OSTEOSARCOMA; RATS; RECOMBINATION, GENETIC; SIMPLEXVIRUS; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

EID: 0029840433     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Boring, C. C., Squires, T S., Tong, T., and Montgomery, S. Cancer statistics, 1994. CA Cancer J Clin , 44: 7-26, 1994.
2. Hudson, M., Jaffe, M R., and Jaffe, N. Pediatric osteosarcoma therapeutic strategies, results, and prognostic factors derived from a 10-year experience. J. Clin. Oncol., 8: 1988-1997, 1990
3. Link, M. P., Goorin, A. M., Miser, A W., Link, M. P., Goorin, A. M., Miser, A W , Green, A. A , Pratt, C. B., Belasco, J. B., Pritchard, J., Malpas, J. S., Baker, A. R., Kirkpatrick, J. A , Ayala, A. G., Schuster, J. J., Abelson, H. T., Simone, J V., and Vietti, T. J. The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity N. Engl J. Med, 314: 1600-1602, 1991.
4. Goorin, A. M. Perez-Atayde, A , Gebbhardt, M , et al. Weekly high-dose methotrexate and doxorubicin for osteosarcoma: the Dana-Farber Cancer Institute/The Children's Hospital-Study III. J. Clin. Oncol., 5: 1178-1184, 1987.
5. Kane, M. J. Chemotherapy of advanced soft tissue and osteosarcoma. Semin. Oncol., 16: 297-304, 1989
6. Kunyama, S., Yoshikawa, M., Ishizaka, S , Tsujii, T., Ikenaka, K , Kagawa, T., Monta, N , and Mikoshiba, K. A potential approach for gene therapy targeting hepatoma using a liver-specific promoter on a retroviral vector. Cell Struct. Funct., 16 503-510, 1991
7. Shimizu, K. Selective gene therapy of malignant glioma using brain-specific promoters its efficacy and basic investigation Nippon Rinsho, 52 3053-3058, 1994.
8. Vile, R. G., Nelson, J. A., Castleden, S , Chong, H., and Hart, I. R. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component. Cancer Res , 54: 6228-6234, 1994.
9. Tanaka, T , Kanai, F , Okabe, S , Yoshida, Y., Wakimoto, H , Hamada, H , Shiraton, Y., Lan, K-H , Ishitobi, M , and Omata, M. Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro Cancer Res , 46: 1341-1345, 1996.
10. Moolten, F. L Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res , 46. 5276-5281, 1986.
11. Chen, S. H., Chen, X H. L., Wang, Y., Kosai, K I , Finegold, M J , Rich, S. S., and Woo, S L C. Combination gene therapy for liver metastasis of colon carcinoma in vivo. Proc. Natl Acad. Sci. USA, 92: 2577-2581, 1995
12. Smythe, W. R., Hwang, B S , Elshami, A. A , Amin, K M , Eck. S., Davidson, B. L . Wilson, J M , Kaiser, L R , and Albelda, S. M. Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene. Ann Surg., 222 78-86, 1995.
13. Price, P. A. Vitamin-K dependent formation of bone GLA protein (osteocalcin) and its function. Vitam. Horm., 42: 65-108, 1985
14. Park, Y K., Yang, M. H., Kim, Y. W , and Park, H. R. Osteocalcin expression in primary bone tumors in situ hybridization and immunohistochemical study J. Korean Med Sci. 10: 268-273, 1995.
15. Gleave, M E , Hsieh, J. T., Wu, H. C , Hong, S. J., Zhau, H E , Guthrie, P D , and Chung, L W. K Epidermal growth factor receptor-mediated autocrine and paracrine stimulation of human transitional cell carcinoma. Cancer Res., 53: 5300-5307, 1993.
16. Donahue, H J , McLeod, K J , Rubin, C T , Andersen, J , Grine, E. A., Hertzberg, E. L , and Brink, P R. Cell-to-cell communication in osteoblastic networks: cell line-dependent hormonal regulation of gap junction function J. Bone Miner Res., 10: 881-889, 1995
17. Clover, J , and Gowen, M. Are MG-63 and HOS TE85 human osteosarcoma cell lines representative models of the osteoblastic phenotype? Bone, 15: 585-591, 1994.
18. Ko, S-C , Gotoh, A , Thalmann, G. N., Zhau, H. E , Johnston, D. A , Zhang, W-W , Kao, C , and Chung, L. W. K. Molecular therapy with recombinant p53 adenovirus in an androgen independent, metastatic human prostate cancer model. Hum. Gene Ther., 7: 1683-1691, 1996.
19. Zhang, W-W , Fang, X., Branch, C. D., Mazur, W., French, B. A., and Roth, J. A. Generation and identification of recombinant adenovirus by liposome-mediated transfection and PCR analysis. Biotechniques, 15: 868-872, 1993.
20. Graham, F. L., and Prevec, L. Manipulation of adenovirus vectors. Vol. 7, pp. 109-128. Clifton, NJ: The Humana Press, Inc., 1991.
21. 3, parathyroid hormone and glucocorticoids. Metab. Bone Dis. Relat. Res , 5. 229-234, 1984
22. Boshart, M., Weber, F., Jahn, G., Dorsch-Hasler, K , Fleckenstein, B., and Schaffner, W. A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell, 41: 521-530, 1985.
23. Fields, B. N. Fields Virology, Ed. 2. New York: Raven Press, 1990.
24. Malawer, M. M., Link, M. P., and Donaldson, S. S Sarcomas of Bone. In V. T DeVita, Jr., S. Hellman, and S.A. Rosenberg (eds.), Cancer Principles and Practice of Oncology, Ed. 4, Vol 2, pp 1509-1566. Philadelphia: J. B Lippincott Company, 1993.
25. Jacobs, S. C. Spread of prostatic cancer to bone. Urology, 21: 337-344, 1983.
26. Koizumi, M., Yamada, Y., Takiguchi, T., Nomura, E., Furukawa, M., Kitahara, T., Yamashita, T., Maeda, H., Takahashi, S , and Aiba, K. E. A. Bone metabolic markers in bone metastasis. J. Cancer Res. Clin. Oncol., 121. 542-548, 1995
27. Gleave, M. E., Hsieh, J. T , Gao, C., Chung, L. W K., and von Eschenbach, A C. Acceleration of human prostate cancer growth in vivo by prostate and bone fibroblasts. Cancer Res., 51. 1910-1916, 1991.
28. Gleave, M. E , Hsieh, J. T., Wu, H C., von Eschenbach, A. C., and Chung, L. W K. Prostate and bone fibroblasts induce human prostate cancer growth in vivo: implications for bidirectional stromal-epithelial interaction in prostate carcinoma growth and metastasis. J Urol., 147: 1151-1159, 1992.
29. Barba, D , Hardin, J., Sadelam, M , and Gage, F H. Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad. Sci. USA, 91: 4348-4352, 1994