Synthesis and Biological Evaluation of Iodinated and Fluorinated 9-(2-Hydroxypropyl) and 9-(2-Hydroxyethoxy)methyl Purine Nucleoside Analogues

Journal of Medicinal Chemistry

Volumn 46, Issue 26, 2003, Pages 5763-5772

  Prekupec, Svjetlana ^a   Svedružić, Draženka ^a   Gazivoda, Tatjana ^a   Mrvoš Sermek, Draginja ^b   Nagl, Ante ^c   Grdiša, Mira ^d   Pavelić, Krešimir ^d   Balzarini, Jan ^e   De Clercq, Erik ^e   Folkers, Gerd ^f   Scapozza, Leonardo ^f   Mintas, Mladen ^a   Raić Malić, Silvana ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c UNIVERSITY OF ZAGREB   (Croatia)

^d RUDER BO KOVI INSTITUTE   (Croatia)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^f ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPURINE 6 THIONE DERIVATIVE; 9 (2 ACETOXYPROPYL) 2 AMINO 1,9 DIHYDRO 6H PURINE 6 THIONE; 9 (2 HYDROXYETHOXY)METHYL PURINE NUCLEOSIDE DERIVATIVE; 9 (2 HYDROXYPROPYL)METHYL PURINE NUCLEOSIDE DERIVATIVE; 9 [(2 ACETOXYETHOXY)METHYL] 2 AMINO 1,9 DIHYDRO 6H PURINE 6 THIONE; CYTOSTATIC AGENT; NUCLEOSIDE ANALOG; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOSTASIS; DRUG SCREENING; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; IODINATION; REACTION ANALYSIS; X RAY ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL LINE; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORINE; GUANINE; HUMANS; IODINE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR STRUCTURE; PURINE NUCLEOSIDES; THIONES;

EID: 10744232495     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0308747     Document Type: Article

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