Reporter gene imaging: effects of ganciclovir treatment on nucleoside uptake, hypoxia and perfusion in a murine gene therapy tumour model that expresses herpes simplex type-1 thymidine kinase

Nuclear Medicine Communications

Volumn 21, Issue 2, 2000, Pages 129-137

  Morin, K W ^a   Knaus, E E ^a   Wiebe, L I ^a   Xia, H ^a   McEWAN, A JB ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 (2 IODOVINYL) 1 (2' FLUORO 2' DEOXYURIDINE); 5-(2-IODOVINYL)-1-(2'-FLUORO-2'-DEOXYURIDINE); ANTIVIRUS AGENT; DRUG DERIVATIVE; FLOXURIDINE; GANCICLOVIR; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; RADIOACTIVE IODINE; THYMIDINE KINASE;

ANIMAL; ARTICLE; CELL CULTURE; CELL HYPOXIA; DRUG EFFECT; GENE THERAPY; GENETICS; HERPES SIMPLEX VIRUS 1; MOUSE; REPORTER GENE; SARCOMA; SCINTISCANNING;

ANIMALS; ANTIVIRAL AGENTS; CELL HYPOXIA; FLOXURIDINE; GANCICLOVIR; GENE THERAPY; GENES, REPORTER; HERPESVIRUS 1, HUMAN; IODINE RADIOISOTOPES; MICE; SARCOMA, EXPERIMENTAL; TECHNETIUM TC 99M EXAMETAZIME; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

EID: 0034137990     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/00006231-200002000-00002     Document Type: Article

References (32)

1. Mullen CA. Metabolic suicide genes in gene therapy. Pharmac Ther 1994; 63: 199-207.
2. Culver KW, Ram Z, Walbridge S et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-1552.
3. Tjuvajev JG, Stockhammer G, Desai R et al. Imaging the expression of transfected genes in vivo. Cancer Res 1995: 55: 6126-6132.
4. Tjuvajev JG, Finn R, Watanabe K et al. Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: A potential method for monitoring clinical gene therapy. Cancer Res 1996: 65: 4087-4095.
5. Moolten F. Tumor sensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res 1986; 46: 5276-5281.
6. Iwashina T, Tovell DR, Xu L et al. Synthesis and antiviral activity of IVFRU, a potential probe for the non-invasive diagnosis of herpes simplex encephalitis. Drug Des Del 1988; 3: 309-321.
7. 125I]iodovinyl)-2′-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene: Evaluation as probes for monitoring gene therapy. J Med Chem 1997; 40: 2184-2190.
8. Morin KW, Knaus EE, Wiebe LI. Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy model. Nucl Med Commun 1997; 18: 599-605.
9. m-HMPAO as a tumour blood flow agent. Eur J Nucl Med 1987; 13: 90-94.
10. Chapman JD. The detection and measurement of hypoxic cells in solid tumors. Cancer 1984; 54: 2441-2449.
11. Aaronson SA, Weaver CA. Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells. J Gen Virol 1971; 13: 245-252.
12. Freeman SM, Abboud CN, Whartenby KA et al. The ‘bystander effect’: Tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-5283.
13. Moolten FL, Wells JM. Curability of tumors bearing herpes thymidine kinase genes transferred by retrovirus vectors. J Natl Cancer Inst 1990; 82: 297-300.
14. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 1993; 15: 532-537.
15. Milanesi G, Barbanti-Brodano G, Negrini M et al. BK virus-plasmid expression vector that persists episomally in human cells and shuttles into Escherichia coli. Mol Cell Biol 1984; 4: 1551-1560.
16. m-HMPAO (abstract). J Nucl Med 1988; 29: 572.
17. Born JL, Smith BR. The synthesis of tritium-labelled mis-onidazole. J Labelled Cmpds Radiopharm 1983; 20: 429-432.
18. Moore RB, Chapman JD, Mercer JR et al. Measurement of PDT-induced hypoxia in Dunning prostate tumors by iodine-123-iodoazomycin arabinoside. J Nucl Med 1993; 34: 405-411.
19. Groshar D, McEwan AJ, Parliament MB et al. Imaging tumor hypoxia and tumor perfusion. J Nucl Med 1993; 34: 885-888.
20. Freeman SM, Ramesh R, Shastri M et al. The role of cytokines in mediating the bystander effect using HSV-TK xenogeneic cells. Cancer Lett 1995; 92: 167-174.
21. Ramesh R, Marrogi AJ, Munshi A et al. In vivo analysis of the bystander effect: A cytokine cascade. Exp Hematol 1996; 24: 829-838.
22. Vile RG, Castleden S, Marshall J et al. Generation of an anti-tumour immune response in a non-immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1-like profile of intratumoural cytokine expression. Int J Cancer 1997; 71: 267-274.
23. Caruso M, Panis Y, Gagandeep S et al. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA 1993; 90: 7024-7028
24. Barba D, Hardin J, Sadelain M, Gage FH. Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci USA 1994; 91: 4348-4352.
25. Ram Z, Walbridge S, Shawker T et al. The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J Neurosurg 1994; 81: 256-260.
26. Haberkorn U, Altmann A, Morr I et al. Multitracer studies during gene therapy of hepatoma cells with herpes simplex virus thymidine kinase and ganciclovir. J Nucl Med 1997; 38: 1048-1054.
27. Wertheimer E, Sasson S, Cersai E, Ben-Neriah Y. The ubiquitous glucose transporter GLUT-1 belongs to the glucose-regulated protein family of stress-inducible proteins. Proc Natl Acad Sci USA 1991; 88: 2525-2529.
28. Taylor DJ, Faragher EB, Evanson JM. Inflammatory cytokines stimulate glucose uptake and glycolysis but reduce glucose oxidation in human dermal fibroblasts in vitro. Circ Shock 1992; 37: 105-110.
29. Taylor DJ, Whitehead RJ, Evanson JM et al. Effect of recombinant cytokines on glycolysis and fructose 2,6 bisphosphate in rheumatoid synovial cells in vitro. Biochem J 1988; 250: 111-115.
30. Field AK, Davies ME, De Witt C et al. 9-[2-Hydroxy-1-(hydroxymethyl)ethoxymethyl] guanine: A selective inhibitor of herpes group virus replication. Proc Natl Acad Sci USA 1983; 80: 4139-4143.
31. Balzarini J, Morin KW, Knaus EE et al. Novel (E)-5-(2-iodovinyl)-2′-deoxyuridine derivatives as potential cytostatic agents against herpes simplex virus thymidine kinase gene transfected tumors. Gene Therapy 1995; 2: 317-322.
32. St. Clair MH, Lambe CU, Furman PA. Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpes virus genetic information. Antimicrob Agents Chemother 1987; 31: 844-849.