Cancer gene therapy by direct tumor injections of a nonviral T7 vector encoding a thymidine kinase gene

Human Gene Therapy

Volumn 9, Issue 5, 1998, Pages 729-736

  Chen, Xiaozhuo ^a,b   Li, Yunsheng ^b   Xiong, Keyong ^b   Aizicovici, Simona ^b   Xie, Yuefeng ^b   Zhu, Qin ^b   Sturtz, Franck ^a   Shulok, Janine ^a   Snodgrass, Ralph ^a   Wagner, Thomas E ^b   Platika, Doros ^a,c  

^a Progenitor Inc   (United States)

^b OHIO UNIVERSITY   (United States)

^c Ontogeny Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR; PLASMID VECTOR; RNA POLYMERASE; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIOPHAGE T7; CANCER THERAPY; CLONING VECTOR; CONTROLLED STUDY; CYTOPLASM; DNA TRANSFECTION; GENE THERAPY; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRATUMORAL DRUG ADMINISTRATION; NONHUMAN; NUDE MOUSE; OSTEOSARCOMA; RELAPSE; TUMOR GROWTH; TUMOR REGRESSION;

ANIMALIA; HERPES; MUS MUSCULUS; SIMPLEXVIRUS; UNIDENTIFIED BACTERIOPHAGE;

EID: 17344371396     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.5-729     Document Type: Article

References (4)

1. BI, W.L., PARYSEK, L.M., WARNICK, R., and STAMBROOK, P. (1993). In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy. Hum. Gene Then 4, 725-731.
2. BUDZYNSKI, W., and RADZIKOWSKI, C. (1994). Cytotoxic cells in immunodeficient athymic mice. Immunopharmacol. & Immunotoxicol. 16, 319-346.
3. CARUSO, M., PANIS, Y., GAGANDEEP, S., HOUSSIN, D., SALZMANN, J.L., and KLATZMANN, D. (1993). Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. USA 90, 7024-7028.
4. CHEN, S., DHINE, H.D., GOODMAN, J.C., GROSSMAN, R.G., and WOO, S.L. (1994). Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. USA 91, 3054-3057.