Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain

Journal of Biological Chemistry

Volumn 280, Issue 23, 2005, Pages 22205-22211

  Lolkema, Martijn P ^a   Gervais, Michelle L ^b   Snijckers, Cristel M ^a   Hill, Richard P ^b   Giles, Rachel H ^a   Voest, Emile E ^a   Ohh, Michael ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELLS; CHEMICAL REACTIONS; ENZYME KINETICS; GENES; GENETIC ENGINEERING; MUTAGENESIS;

ACIDIC DOMAIN; GENE MUTATIONS; MUTANTS; TUMOR SUPPRESSOR;

TUMORS;

CASEIN KINASE II; FIBRONECTIN; HYPOXIA INDUCIBLE FACTOR 1; VON HIPPEL LINDAU PROTEIN;

ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CARCINOGENESIS; HUMAN; HUMAN CELL; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANOXIA; CELL LINE; CHROMATOGRAPHY, GEL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRONECTINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICE; MICE, SCID; MUTATION; NEOPLASM TRANSPLANTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 20444457555     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M503220200     Document Type: Article

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