Association analysis of the variant in the regulatory subunit of phosphoinositide 3-kinase (p85α) with Type 2 diabetes mellitus and hypertension in the Chinese Han population

Diabetic Medicine

Volumn 22, Issue 6, 2005, Pages 737-743

  Chen, S ^a,b   Yan, W ^a   Huang, J ^a   Ge, D ^a   Yao, Z ^b   Gu, Dongfeng ^a,b  

^a FUWAI HOSPITAL   (China)

^b CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

Hypertension; Phosphoinositide 3 kinase; Regulatory subunit; Type 2 diabetes mellitus

Indexed keywords

GLUCOSE; LIPID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85ALPHA; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY MASS; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; LIPID BLOOD LEVEL; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGED; CASE-CONTROL STUDIES; CHINA; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 20444418183     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2005.01490.x     Document Type: Article

References (25)

1. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-1607.
2. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus, provisional report of a WHO consultation. Diabet Med 1998; 15: 539-553.
3. Zavaroni I, Mazza S, Dall'Aglio E, Gasparini P, Passeri M, Reaven GM. Prevalence of hyperinsulinaemia in patients with high blood pressure. J Intern Med 1992; 231: 235-240.
4. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism 1990; 39: 167-174.
5. Shepherd PR, Nave BT, O'Rahilly S. The role of phosphoinositide 3-kinase in the insulin signalling. J Mol Endocrinol 1996; 17: 175-184.
6. Krook A, Roth RA, Jiang XJ, Zierath JR, Wallberg-Henriksson H. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 1998; 47: 1281-1286.
7. Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T et al. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest 2000; 105: 311-320.
8. Fruman DA, Meyers RE, Cantley LC. Phosphoinositide kinases. Ann Rev Biochem 1998; 67: 481-507.
9. Cannizzaro LA, Skolnik EY, Margolis B, Croce CM, Schlesinger J, Huebner K. The human gene encoding phosphatidylinositol-3 kinase associated p85α is at chromosome region 5q12-13. Cancer Res 1991; 51: 3818-3820.
10. Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ et al. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest 2002; 109: 141-149.
11. Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3-kinase. Nat Genet 1999; 21: 230-235.
12. Hansen T, Andersen CB, Echwald SM, Urhammer SA, Clausen JO, Vestergaard H et al. Identification of a common amino acid polymorphism in the p85α regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. Diabetes 1997; 46: 494-501.
13. Almind K, Delahaye L, Hansen T, Van Obbetghen E, Pedersen O, Kahn CR. Characterization of the Met326Ile variant of phosphatidylinositol 3-kinase p85α. Proc Natl Acad Sci USA 2002; 99: 2124-2128.
14. Baier LJ, Wiedrich C, Hanson RL, Bogatdus C. Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85α): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. Diabetes 1998; 47: 973-975.
15. Kawanishi M, Tamori Y, Masugi J, Mori H, Ito C, Hansen T et al. Prevalence of a polymorphism of the phosphatidylinositol 3-kinase p85α regulatory subunit (codon 326 Met → Ile) in Japanese NIDDM patients. Diabetes Care 1997; 20: 1043.
16. Hansen L, Zethelius B, Berglund L, Reneland R, Hansen T, Berne C et al. in vitro and in vivo studies of a naturally occurring variant of the human p85α regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity. Diabetes 2001; 50: 690-693.
17. Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW et al. Candidate gene association study in type 2 diabetes indicates a role for genes involved in β-cell function as well as insulin action. PLoS Biol 2003; 1: E20.
18. Perloff D, Grim C, Flack J, Frohlich ED, Hill M, McDonald M et al. Human blood pressure determination by sphygmomanometry. Circulation 1993; 88: 2460-2470.
19. Zhou BF, Cooperative Meta-Analysis Group of Working Group on Obesity in China. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults: study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Asia Pac J Clin Nutr 2002; 11: S685-693.
20. Gu D, Huang G, Wu X, Duan X. Relationship between body mass index and major cardiovascular diseases in Chinese population. Zhonghua Yi Xue Za Zhi 2002; 82: 1018-1021.
21. Zhou BF, Effect of body mass index on all-cause mortality and incidence of cardiovascular diseases-report for meta-analysis of prospective studies open optimal cut-off points of body mass index in Chinese adults. Biomed Environ Sci 2002; 15: 245-252.
22. Shepherd PR, Withers DJ, Siddle K. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 1998; 333: 471-490.
23. Cheatham B, Kahn CR. Insulin action and the insulin signaling network. Endocr Rev 1995; 16: 117-142.
24. Velloso LA, Folli F, Sun XJ, White MF, Saad MJ, Kahn CR. Crosstalk between the insulin and angiotensin signaling systems. Proc Natl Acad Sci USA 1996; 93: 12490-12495.
25. Ogihara T, Asano T, Ando K, Chiba Y, Sakoda H, Anai M et al. Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension 2002; 40: 872-879.