-
1
-
-
12644277043
-
A prevalent amino acid polymorphism at codon 326 met-ile in the gene encoding the phosphatidylinositol 3-kinase p85a regulatory subunit is associated with decreased glucose tolerance and glucose effectiveness
-
Andersen CB, Hansen T, Escwald SM, Urhammer SA, Clausen JO & Pedersen O 1996 A prevalent amino acid polymorphism at codon 326 met-ile in the gene encoding the phosphatidylinositol 3-kinase p85a regulatory subunit is associated with decreased glucose tolerance and glucose effectiveness. Experimental and Clinical Endocrinology and Diabetes 101 Suppl 2 60-61.
-
(1996)
Experimental and Clinical Endocrinology and Diabetes
, vol.101
, Issue.2 SUPPL.
, pp. 60-61
-
-
Andersen, C.B.1
Hansen, T.2
Escwald, S.M.3
Urhammer, S.A.4
Clausen, J.O.5
Pedersen, O.6
-
2
-
-
0025911310
-
Decreased insulin stimulated 3-o-methylglucose transport in in vitro incubated muscle strips from type2 diabetic subjects
-
Andreasson K, Galuska D, Thorne A, Sonnenfeld T & Wallberg-Henriksson H 1991 Decreased insulin stimulated 3-o-methylglucose transport in in vitro incubated muscle strips from type2 diabetic subjects. Acta Medico Scandinavica 142 255-260.
-
(1991)
Acta Medico Scandinavica
, vol.142
, pp. 255-260
-
-
Andreasson, K.1
Galuska, D.2
Thorne, A.3
Sonnenfeld, T.4
Wallberg-Henriksson, H.5
-
3
-
-
0029913340
-
IRS-1 binds two novel splice variants of the regulatory subunit of PI 3-kinase in muscle and brain
-
Antonetti D, Algenstaed P & Kahn CR 1996 IRS-1 binds two novel splice variants of the regulatory subunit of PI 3-kinase in muscle and brain. Molecular and Cellular Biology 16 2195-2203.
-
(1996)
Molecular and Cellular Biology
, vol.16
, pp. 2195-2203
-
-
Antonetti, D.1
Algenstaed, P.2
Kahn, C.R.3
-
4
-
-
0027432424
-
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidyl 3,4,5 triphosphate in neutrophil responses
-
Arcaro A & Wymann MP 1993 Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidyl 3,4,5 triphosphate in neutrophil responses. Biochemical Journal 296 297-301.
-
(1993)
Biochemical Journal
, vol.296
, pp. 297-301
-
-
Arcaro, A.1
Wymann, M.P.2
-
5
-
-
0026660653
-
Phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation
-
Backer JM, Myers MG, Shoelson SE, Chin DJ, Sun X, Miralpeix M, Hu P, Margolis B, Skolink EY, Schlessinger J & White MF 1992 Phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation. EMBO Journal 11 3469-3479.
-
(1992)
EMBO Journal
, vol.11
, pp. 3469-3479
-
-
Backer, J.M.1
Myers, M.G.2
Shoelson, S.E.3
Chin, D.J.4
Sun, X.5
Miralpeix, M.6
Hu, P.7
Margolis, B.8
Skolink, E.Y.9
Schlessinger, J.10
White, M.F.11
-
6
-
-
0021258643
-
Correlation between muscle glycogen synthase activity and in vivo insulin action in man
-
Bogardus C, Lillioja S, Stone K & Mott D 1984 Correlation between muscle glycogen synthase activity and in vivo insulin action in man Journal of Clinical Investigation 73 1185-1190.
-
(1984)
Journal of Clinical Investigation
, vol.73
, pp. 1185-1190
-
-
Bogardus, C.1
Lillioja, S.2
Stone, K.3
Mott, D.4
-
7
-
-
0028812255
-
The sequence of PI 4P 5-kinase defines a novel family of lipid kinases
-
Boronenkov IV & Anderson RA 1995 The sequence of PI 4P 5-kinase defines a novel family of lipid kinases. Journal of Biological Chemistry 270 2881-2884.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 2881-2884
-
-
Boronenkov, I.V.1
Anderson, R.A.2
-
8
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering BMT & Coffer PJ 1995 Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376 599-602.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.T.1
Coffer, P.J.2
-
9
-
-
0026757162
-
Human GLUT4 muscle/fat glucose transporter gene: Sequence, promoter characterization and genetic variations
-
Buse JB, Yasuda K, Lay TP, Seo TS, Karam JH, Seino S & Bell GI 1992 Human GLUT4 muscle/fat glucose transporter gene: sequence, promoter characterization and genetic variations. Diabetes 41 1436-1446.
-
(1992)
Diabetes
, vol.41
, pp. 1436-1446
-
-
Buse, J.B.1
Yasuda, K.2
Lay, T.P.3
Seo, T.S.4
Karam, J.H.5
Seino, S.6
Bell, G.I.7
-
10
-
-
0025175753
-
Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM - Evidence for primary defect in glucose transport and/or phosphorylation but not oxidation
-
Butler PC, Kryshak EJ, Marsh M & Rizza RA 1990 Effect of insulin on oxidation of intracellularly and extracellularly derived glucose in patients with NIDDM - Evidence for primary defect in glucose transport and/or phosphorylation but not oxidation. Diabetes 39 1373-1380.
-
(1990)
Diabetes
, vol.39
, pp. 1373-1380
-
-
Butler, P.C.1
Kryshak, E.J.2
Marsh, M.3
Rizza, R.A.4
-
11
-
-
0028308412
-
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of p70s6-kinase, DNA synthesis and glucose transporter translocation
-
Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J & Kahn CR 1994 Phosphatidylinositol 3-kinase activation is required for insulin stimulation of p70s6-kinase, DNA synthesis and glucose transporter translocation. Molecular and Cellular Biology 14 4902-4911.
-
(1994)
Molecular and Cellular Biology
, vol.14
, pp. 4902-4911
-
-
Cheatham, B.1
Vlahos, C.J.2
Cheatham, L.3
Wang, L.4
Blenis, J.5
Kahn, C.R.6
-
12
-
-
0028178928
-
PDGF and insulin dependent p70s6-kinase activation mediated by phosphatidylinositol-3-OH kinase
-
Chung J, Grammer TC, Lemon KP, Kazlauskas A & Blenis J 1994 PDGF and insulin dependent p70s6-kinase activation mediated by phosphatidylinositol-3-OH kinase, Nature 370 71-75.
-
(1994)
Nature
, vol.370
, pp. 71-75
-
-
Chung, J.1
Grammer, T.C.2
Lemon, K.P.3
Kazlauskas, A.4
Blenis, J.5
-
13
-
-
0028260280
-
Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor wortmannin
-
Clarke JF, Young PW, Yonezawa K, Kasuga M & Holman GD 1994 Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor wortmannin. Biochemical Journal 300 631-635.
-
(1994)
Biochemical Journal
, vol.300
, pp. 631-635
-
-
Clarke, J.F.1
Young, P.W.2
Yonezawa, K.3
Kasuga, M.4
Holman, G.D.5
-
14
-
-
0029587224
-
Inhibition of glycogen synthase kinase 3 by insulin mediated by protein kinase B
-
Cross DAE, Alessi DR, Cohen P, Andjelkovich M & Hemmings BA 1995a Inhibition of glycogen synthase kinase 3 by insulin mediated by protein kinase B. Nature 378 785-789
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
15
-
-
0028850452
-
Wortmannin and demethoxyviridin inhibit insulin stimulated phospholipase A2 activity in Swiss 3T3 cells
-
Cross MJ, Stewart A, Hodgkin MN, Kerr DJ & Wakelam MJ 1995b Wortmannin and demethoxyviridin inhibit insulin stimulated phospholipase A2 activity in Swiss 3T3 cells. Journal of Biological Chemistry 270 25352-25355.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 25352-25355
-
-
Cross, M.J.1
Stewart, A.2
Hodgkin, M.N.3
Kerr, D.J.4
Wakelam, M.J.5
-
17
-
-
0028891049
-
Does MAP kinase have a role in insulin action: The case for and against
-
Denton RM & Tavare JM 1995 Does MAP kinase have a role in insulin action: the case for and against. European Journal of Biochemistry 227 597-611.
-
(1995)
European Journal of Biochemistry
, vol.227
, pp. 597-611
-
-
Denton, R.M.1
Tavare, J.M.2
-
18
-
-
0028157767
-
PI 3-kinase: Structural and functional analysis of intersubunit interactions
-
Dhand R, Hara K, Hiles I, Bax B, Gout I, Panayatou G, Fry MJ, Yonezawa K, Kasuga M & Waterfield MD 1994a PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO Journal 13 511-521.
-
(1994)
EMBO Journal
, vol.13
, pp. 511-521
-
-
Dhand, R.1
Hara, K.2
Hiles, I.3
Bax, B.4
Gout, I.5
Panayatou, G.6
Fry, M.J.7
Yonezawa, K.8
Kasuga, M.9
Waterfield, M.D.10
-
19
-
-
0027953284
-
PI 3-kinase is a dual specificity enzyme: Autoregulation by an intrinsic protein-serine kinase activity
-
Dhand R, Hiles I, Panayotou G, Roche S, Fry MJ, Gout I, Totty NF, Truong O, Vicendo P, Yonezawa K, Kasuga M, Courtneidge SA & Waterfield MD 1994e PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity. EMBO Journal 13 522-533.
-
(1994)
EMBO Journal
, vol.13
, pp. 522-533
-
-
Dhand, R.1
Hiles, I.2
Panayotou, G.3
Roche, S.4
Fry, M.J.5
Gout, I.6
Totty, N.F.7
Truong, O.8
Vicendo, P.9
Yonezawa, K.10
Kasuga, M.11
Courtneidge, S.A.12
Waterfield, M.D.13
-
20
-
-
0023683874
-
An in vitro human muscle preparation suitable for metabolic studies: Decreased insulin stimulation of glucose transport in muscle from morbidly obese diabetic subjects
-
Dohm GL, Tapscott EB, Pories WJ, Dabbs DJ, Flickinger EG, Meelheim D, Fushiki T, Atkinson SM, Elton CW & Caro JF 1988 An in vitro human muscle preparation suitable for metabolic studies: Decreased insulin stimulation of glucose transport in muscle from morbidly obese diabetic subjects. Journal of Clinical Investigation 82 486-494.
-
(1988)
Journal of Clinical Investigation
, vol.82
, pp. 486-494
-
-
Dohm, G.L.1
Tapscott, E.B.2
Pories, W.J.3
Dabbs, D.J.4
Flickinger, E.G.5
Meelheim, D.6
Fushiki, T.7
Atkinson, S.M.8
Elton, C.W.9
Caro, J.F.10
-
21
-
-
0026539998
-
Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle in intact rat
-
Folli F, Saad MJ, Backer JM & Kahn CR 1992 Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle in intact rat. Journal of Biological Chemistry 267 22171-22177.
-
(1992)
Journal of Biological Chemistry
, vol.267
, pp. 22171-22177
-
-
Folli, F.1
Saad, M.J.2
Backer, J.M.3
Kahn, C.R.4
-
22
-
-
0027484001
-
Regulation of phosphatidyl inositol 3-kinase activity in liver and muscle of animal models of insulin resistant and insulin deficient diabetes mellitus
-
Folli F, Saad MJA, Backer JM & Kahn CR 1993 Regulation of phosphatidyl inositol 3-kinase activity in liver and muscle of animal models of insulin resistant and insulin deficient diabetes mellitus. Journal of Clinical Investigation 92 1787-1794.
-
(1993)
Journal of Clinical Investigation
, vol.92
, pp. 1787-1794
-
-
Folli, F.1
Saad, M.J.A.2
Backer, J.M.3
Kahn, C.R.4
-
23
-
-
0026483185
-
Purification and characterization of a phosphatidyl-inositol 3-kinase complex from bovine brain using phosphoaffinity peptide columns
-
Fry MJ, Panayotou G, Dhand R, Ruiz-Larrea F, Gout I, Nguyen O, Courtneidge SA & Waterfield MD 1992 Purification and characterization of a phosphatidyl-inositol 3-kinase complex from bovine brain using phosphoaffinity peptide columns. Biochemical Journal 288 383-393.
-
(1992)
Biochemical Journal
, vol.288
, pp. 383-393
-
-
Fry, M.J.1
Panayotou, G.2
Dhand, R.3
Ruiz-Larrea, F.4
Gout, I.5
Nguyen, O.6
Courtneidge, S.A.7
Waterfield, M.D.8
-
24
-
-
0028237314
-
PIK1 is an essential P1 4-kinase required in the yeast nucleus
-
Garcia-Bustos JF, Marini F, Stevenson I, Frei C & Hall MN 1994 PIK1 is an essential P1 4-kinase required in the yeast nucleus. EMBO Journal 13 2352-2361.
-
(1994)
EMBO Journal
, vol.13
, pp. 2352-2361
-
-
Garcia-Bustos, J.F.1
Marini, F.2
Stevenson, I.3
Frei, C.4
Hall, M.N.5
-
25
-
-
0026683018
-
Insulin stimulates phosphatidyl inositol 3-kinase activity in rat adipocytes
-
Giorgetti S, Ballotti R, Kowalski-Chauval A, Cormont M & Obberghen EV 1992 Insulin stimulates phosphatidyl inositol 3-kinase activity in rat adipocytes. European Journal of Biochemistry 207 599-606.
-
(1992)
European Journal of Biochemistry
, vol.207
, pp. 599-606
-
-
Giorgetti, S.1
Ballotti, R.2
Kowalski-Chauval, A.3
Cormont, M.4
Obberghen, E.V.5
-
26
-
-
0027512244
-
The insulin and insulin like growth factor-1 receptor substrate IRS-1 associates with and activates phophatidylinositol 3-kinase in vitro
-
Giorgetti S, Ballotto R, Kowalski-Chauvel A, Tartare S & Van-Obberghen E 1993 The insulin and insulin like growth factor-1 receptor substrate IRS-1 associates with and activates phophatidylinositol 3-kinase in vitro. Journal of Biological Chemistry 268 7358-7364.
-
(1993)
Journal of Biological Chemistry
, vol.268
, pp. 7358-7364
-
-
Giorgetti, S.1
Ballotto, R.2
Kowalski-Chauvel, A.3
Tartare, S.4
Van-Obberghen, E.5
-
27
-
-
12644288951
-
Insulin receptor signalling is impaired in skeletal muscle from obese patients
-
Goodyear LJ, Sherman LA, Giorgino F, Carey J, Smith RJ & Dohm GL 1994 Insulin receptor signalling is impaired in skeletal muscle from obese patients. Diabetes 43 (Suppl) 455.
-
(1994)
Diabetes
, vol.43
, Issue.SUPPL.
, pp. 455
-
-
Goodyear, L.J.1
Sherman, L.A.2
Giorgino, F.3
Carey, J.4
Smith, R.J.5
Dohm, G.L.6
-
28
-
-
0026486879
-
Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85b protein using the baculovirus expression system
-
Gout I, Dhand R, Panayatou G, Fry MJ, Hiles I, Otsu M & Waterfield MD 1992 Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85b protein using the baculovirus expression system. Biochemical Journal 288 395-405.
-
(1992)
Biochemical Journal
, vol.288
, pp. 395-405
-
-
Gout, I.1
Dhand, R.2
Panayatou, G.3
Fry, M.J.4
Hiles, I.5
Otsu, M.6
Waterfield, M.D.7
-
29
-
-
0025147293
-
Expression of insulin regulatable glucose transporter in skeletal muscle from type 2 (non insulin dependent) diabetic patients
-
Handberg A, Vaag A, Dambso P, Beck-Nielsen H & Vinten J 1990 Expression of insulin regulatable glucose transporter in skeletal muscle from type 2 (non insulin dependent) diabetic patients. Diabetologia 33 625-627.
-
(1990)
Diabetologia
, vol.33
, pp. 625-627
-
-
Handberg, A.1
Vaag, A.2
Dambso, P.3
Beck-Nielsen, H.4
Vinten, J.5
-
30
-
-
0027981333
-
1-Phosphatidylinositol 3-kinase activity is required for insulin stimulated glucose transport but not for Ras activation on CHO cells
-
Hara K, Yonezawa K, Sakaue H, Ando A, Kotani K, Kitamura T, Kitamura Y, Ueda Y, Stephens L, Jackson TR, Hawkins PT, Dhand R, Clark AE, Holman GD, Waterfield MD & Kasuga M 1994 1-Phosphatidylinositol 3-kinase activity is required for insulin stimulated glucose transport but not for Ras activation on CHO cells Proceedings of the National Academy of Sciences of the USA 91 7415-7419.
-
(1994)
Proceedings of the National Academy of Sciences of the USA
, vol.91
, pp. 7415-7419
-
-
Hara, K.1
Yonezawa, K.2
Sakaue, H.3
Ando, A.4
Kotani, K.5
Kitamura, T.6
Kitamura, Y.7
Ueda, Y.8
Stephens, L.9
Jackson, T.R.10
Hawkins, P.T.11
Dhand, R.12
Clark, A.E.13
Holman, G.D.14
Waterfield, M.D.15
Kasuga, M.16
-
31
-
-
0028986738
-
Normal activation of p70s6 kinase by insulin in cells overexpressing dominant negative 85 kDa subunit of phosphoinositide 3-kinase
-
Hara K, Yonezawa K, Sakaue H, Kotani K, Kojima A, Waterfield MD & Kasuga M 1995 Normal activation of p70s6 kinase by insulin in cells overexpressing dominant negative 85 kDa subunit of phosphoinositide 3-kinase. Biochemical and Biophysical Research Communications 208 735-741.
-
(1995)
Biochemical and Biophysical Research Communications
, vol.208
, pp. 735-741
-
-
Hara, K.1
Yonezawa, K.2
Sakaue, H.3
Kotani, K.4
Kojima, A.5
Waterfield, M.D.6
Kasuga, M.7
-
32
-
-
0029156599
-
DNA dependent protein kinase catalytic subunit: A relative of PI 3-kinase and ataxia telangectasia gene product
-
Hartley KO, Gell D & Smith GCM 1995 DNA dependent protein kinase catalytic subunit: a relative of PI 3-kinase and ataxia telangectasia gene product. Cell 82 849-856.
-
(1995)
Cell
, vol.82
, pp. 849-856
-
-
Hartley, K.O.1
Gell, D.2
Smith, G.C.M.3
-
33
-
-
0028875678
-
Insulin stimulated glucose transport is mediated by a divergent signalling pathway
-
Haruta T, Morris AJ, Rose DW, Nelson JG, Mueckler M & Olefsky JM 1995 Insulin stimulated glucose transport is mediated by a divergent signalling pathway. Journal of Biological Chemistry 270 27991-27994.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 27991-27994
-
-
Haruta, T.1
Morris, A.J.2
Rose, D.W.3
Nelson, J.G.4
Mueckler, M.5
Olefsky, J.M.6
-
34
-
-
0028137771
-
TORI and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast
-
Heluwell S, Wagner P, Kunz J, Deuter-Reinhard M, Henriquez R & Hall MN 1994 TORI and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Molecular Biology of the Cell 5 105-118.
-
(1994)
Molecular Biology of the Cell
, vol.5
, pp. 105-118
-
-
Heluwell, S.1
Wagner, P.2
Kunz, J.3
Deuter-Reinhard, M.4
Henriquez, R.5
Hall, M.N.6
-
35
-
-
0028142414
-
Potent activation of phosphatidylinositol 3-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains
-
Herbst JL, Andrews G, Contillo L, Lamphere L, Gardner J, Lienhard GE & Gibbs EM 1994 Potent activation of phosphatidylinositol 3-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains. Biochemistry 33 9376-9381.
-
(1994)
Biochemistry
, vol.33
, pp. 9376-9381
-
-
Herbst, J.L.1
Andrews, G.2
Contillo, L.3
Lamphere, L.4
Gardner, J.5
Lienhard, G.E.6
Gibbs, E.M.7
-
36
-
-
0028789628
-
Effect of the activation of phosphatidylinositol 3-kinase by a thiphosphotyrosine peptide on glucose transport in 3T3-L1 adipocytes
-
Herbst JL, Andrews GC, Contillo LC, Singleton DH, Genereux PE, Gibbs EM & Lienhard GE 1995 Effect of the activation of phosphatidylinositol 3-kinase by a thiphosphotyrosine peptide on glucose transport in 3T3-L1 adipocytes. Journal of Biological Chemistry 270 26000-26005.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 26000-26005
-
-
Herbst, J.L.1
Andrews, G.C.2
Contillo, L.C.3
Singleton, D.H.4
Genereux, P.E.5
Gibbs, E.M.6
Lienhard, G.E.7
-
37
-
-
0027190677
-
Defect in skeletal muscle phosphatidyl inositol 3-kinase in obese insulin resistant mice
-
Heydrick SJ, Jullien D, Gautier N, Tanti J, Giorgetti S, Obberghen EV & Marchand-Brustel YL 1993 Defect in skeletal muscle phosphatidyl inositol 3-kinase in obese insulin resistant mice. Journal of Clinical Investigation 91 1358-1366.
-
(1993)
Journal of Clinical Investigation
, vol.91
, pp. 1358-1366
-
-
Heydrick, S.J.1
Jullien, D.2
Gautier, N.3
Tanti, J.4
Giorgetti, S.5
Obberghen, E.V.6
Marchand-Brustel, Y.L.7
-
38
-
-
0026720350
-
Phosphatidylinositol 3-kinase: Structure and expression of the 110 kD catalytic subunit
-
Hiles ID, Otsu M, Volinia S, Fry MJ, Gout I, Dhand R, Panayotou G, Ruiz-Larrea F, Thompson A, Totty N, Hsuan JJ, Courtneidge SA, Parker PJ & Waterfield M D 1992 Phosphatidylinositol 3-kinase: Structure and expression of the 110 kD catalytic subunit. Cell 70 419-429.
-
(1992)
Cell
, vol.70
, pp. 419-429
-
-
Hiles, I.D.1
Otsu, M.2
Volinia, S.3
Fry, M.J.4
Gout, I.5
Dhand, R.6
Panayotou, G.7
Ruiz-Larrea, F.8
Thompson, A.9
Totty, N.10
Hsuan, J.J.11
Courtneidge, S.A.12
Parker, P.J.13
Waterfield, M.D.14
-
39
-
-
0027361002
-
Cloning of a novel, ubiquitously expressed human phosphatidyl inositol 3-kinase and identification of binding site to p85
-
Hu P, Mondino A, Skolnik EY & Schlessinger J 1993 Cloning of a novel, ubiquitously expressed human phosphatidyl inositol 3-kinase and identification of binding site to p85. Molecular and Cellular Biology 13 7677-7688.
-
(1993)
Molecular and Cellular Biology
, vol.13
, pp. 7677-7688
-
-
Hu, P.1
Mondino, A.2
Skolnik, E.Y.3
Schlessinger, J.4
-
40
-
-
0028865424
-
The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin stimulated glucose uptake
-
Isakoff SJ, Taha C, Rose E, Marcusohn J, Klip A & Skolnik EY 1995 The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin stimulated glucose uptake. Proceedings of the National Academy of Sciences of the USA 92 10247-10251.
-
(1995)
Proceedings of the National Academy of Sciences of the USA
, vol.92
, pp. 10247-10251
-
-
Isakoff, S.J.1
Taha, C.2
Rose, E.3
Marcusohn, J.4
Klip, A.5
Skolnik, E.Y.6
-
41
-
-
0029615497
-
Disruption of GLUT1 glucose carrier trafficking in 16E9 and So18 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin
-
Kaliman P, Vinalis F, Testar X, Palacin M & Zorzano A 1995 Disruption of GLUT1 glucose carrier trafficking in 16E9 and So18 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin. Biochemical Journal 312 471-477.
-
(1995)
Biochemical Journal
, vol.312
, pp. 471-477
-
-
Kaliman, P.1
Vinalis, F.2
Testar, X.3
Palacin, M.4
Zorzano, A.5
-
42
-
-
0028269980
-
Insulin signalling: The role of insulin receptor substrate-1
-
Keller SR & Lienhard GE 1994 Insulin signalling: the role of insulin receptor substrate-1. Trends in Cell Biology 4 115-119.
-
(1994)
Trends in Cell Biology
, vol.4
, pp. 115-119
-
-
Keller, S.R.1
Lienhard, G.E.2
-
43
-
-
0027412618
-
Insulin stimulated phosphatidylinositol 3-kinase: Association with a 185 kDa tyrosine phosphorylated protein (IRS-1) and localization in a low density microsome vesicle
-
Kelly KL & Ruderman NB 1993 Insulin stimulated phosphatidylinositol 3-kinase: Association with a 185 kDa tyrosine phosphorylated protein (IRS-1) and localization in a low density microsome vesicle. Journal of Biological Chemistry 268 4391-4398.
-
(1993)
Journal of Biological Chemistry
, vol.268
, pp. 4391-4398
-
-
Kelly, K.L.1
Ruderman, N.B.2
-
44
-
-
0026640730
-
Phosphatidyl inositol 3-kinase in isolated rat adipocytes: Activation by insulin and subcellular distribution
-
Kelly KL, Ruderman NB & Chen KS 1992 Phosphatidyl inositol 3-kinase in isolated rat adipocytes: Activation by insulin and subcellular distribution. Journal of Biological Chemistry 267 3423-3428.
-
(1992)
Journal of Biological Chemistry
, vol.267
, pp. 3423-3428
-
-
Kelly, K.L.1
Ruderman, N.B.2
Chen, K.S.3
-
45
-
-
0029143388
-
Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase
-
Kohn AD, Kovacina KS & Roth RA 1995 Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase. EMBO Journal 14 4288-4295.
-
(1995)
EMBO Journal
, vol.14
, pp. 4288-4295
-
-
Kohn, A.D.1
Kovacina, K.S.2
Roth, R.A.3
-
46
-
-
0028264058
-
Involvement of phosphoinositide 3-kinase in insulin/IGF-1 induced membrane ruffling
-
Kotani K, Yonezawa K, Hara K, Veda H, Kitamura Y, Sakaue H, Ando A, Chavanieu A, Cala B, Grigoresceu F, Nishiyema M, Waterfield MD & Kasuga M 1994 Involvement of phosphoinositide 3-kinase in insulin/IGF-1 induced membrane ruffling. EMBO Journal 13 2313-2319.
-
(1994)
EMBO Journal
, vol.13
, pp. 2313-2319
-
-
Kotani, K.1
Yonezawa, K.2
Hara, K.3
Veda, H.4
Kitamura, Y.5
Sakaue, H.6
Ando, A.7
Chavanieu, A.8
Cala, B.9
Grigoresceu, F.10
Nishiyema, M.11
Waterfield, M.D.12
Kasuga, M.13
-
47
-
-
0028903554
-
Requirement for phophoinositide 3-kinase in insulin stimulated GLUT4 translocation in 3T3-L1 adipocytes
-
Kotani K, Carozzi A, Sakaue H, Hara K, Robinson LJ, Clark SF, Yonezawa K, James DE & Kasuga M 1995 Requirement for phophoinositide 3-kinase in insulin stimulated GLUT4 translocation in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 209 343-348.
-
(1995)
Biochemical and Biophysical Research Communications
, vol.209
, pp. 343-348
-
-
Kotani, K.1
Carozzi, A.2
Sakaue, H.3
Hara, K.4
Robinson, L.J.5
Clark, S.F.6
Yonezawa, K.7
James, D.E.8
Kasuga, M.9
-
48
-
-
0026668515
-
The association of insulin elicited phosphotyrosine proteins with src homology 2 domains
-
Lavan BE, Kuhne MR, Garner CW, Anderson D, Reedijk M, Pawson T & Lienhard GE 1992 The association of insulin elicited phosphotyrosine proteins with src homology 2 domains. Journal of Biological Chemistry 267 11631-11636.
-
(1992)
Journal of Biological Chemistry
, vol.267
, pp. 11631-11636
-
-
Lavan, B.E.1
Kuhne, M.R.2
Garner, C.W.3
Anderson, D.4
Reedijk, M.5
Pawson, T.6
Lienhard, G.E.7
-
49
-
-
0029149712
-
Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: Comparison with fat cells
-
LeMarchand-Brustel Y, Gautier N, Cormont M & VanObberghen E 1995 Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: Comparison with fat cells. Endocrinology 136 3564-3570.
-
(1995)
Endocrinology
, vol.136
, pp. 3564-3570
-
-
Lemarchand-Brustel, Y.1
Gautier, N.2
Cormont, M.3
Vanobberghen, E.4
-
50
-
-
0029012980
-
Studies with wortmannin indicate insulin stimulation of lipogenesis involves multiple signalling pathways
-
Moule SK, Edgell XJ, Welsh GI, Diggle TA, Proud CG & Denton RM 1995 Studies with wortmannin indicate insulin stimulation of lipogenesis involves multiple signalling pathways. Biochemical Society Transactions 23 206S.
-
(1995)
Biochemical Society Transactions
, vol.23
-
-
Moule, S.K.1
Edgell, X.J.2
Welsh, G.I.3
Diggle, T.A.4
Proud, C.G.5
Denton, R.M.6
-
51
-
-
0027535742
-
Activation of the zeta isoform of protein kinase C by phosphatidyl inositol 3,4,5 trisphosphate
-
Nakanishi H, Brewer KA & Exton JH 1993 Activation of the zeta isoform of protein kinase C by phosphatidyl inositol 3,4,5 trisphosphate Journal of Biological Chemistry 268 13-16.
-
(1993)
Journal of Biological Chemistry
, vol.268
, pp. 13-16
-
-
Nakanishi, H.1
Brewer, K.A.2
Exton, J.H.3
-
52
-
-
0029015694
-
A wortmannin sensitive phosphatidylinositol 4-kinase that regulates hormone sensitive pools of inositolphospholipids
-
Nakanishi S, Catt KJ & Balla T 1995 A wortmannin sensitive phosphatidylinositol 4-kinase that regulates hormone sensitive pools of inositolphospholipids Proceedings of the National Academy of Sciences of the USA 92 5317-5321.
-
(1995)
Proceedings of the National Academy of Sciences of the USA
, vol.92
, pp. 5317-5321
-
-
Nakanishi, S.1
Catt, K.J.2
Balla, T.3
-
53
-
-
0029788522
-
Phorbol esters stimulate phosphatidylinositol 3,4,5 tris phosphate production in 3T3-L1 adipocytes: Implications for stimulation of glucose transport
-
Navé BT, Siddle S & Shepherd PR 1996a Phorbol esters stimulate phosphatidylinositol 3,4,5 tris phosphate production in 3T3-L1 adipocytes: Implications for stimulation of glucose transport. Biochemical Journal 318 203-205
-
(1996)
Biochemical Journal
, vol.318
, pp. 203-205
-
-
Navé, B.T.1
Siddle, S.2
Shepherd, P.R.3
-
54
-
-
0029811141
-
Compartment specific regulation of phosphoinositide 3-kinase by PDGF and insulin in 3T3-L1 adipocytes
-
Navé BT, Haigh R, Hayward AC, Siddle S & Shepherd PR 1996b Compartment specific regulation of phosphoinositide 3-kinase by PDGF and insulin in 3T3-L1 adipocytes. Biochemical Journal 318 55-60.
-
(1996)
Biochemical Journal
, vol.318
, pp. 55-60
-
-
Navé, B.T.1
Haigh, R.2
Hayward, A.C.3
Siddle, S.4
Shepherd, P.R.5
-
55
-
-
0028124189
-
Essential role of phosphatidylinositol 3-kinase in insulin induced glucose transport and antilipolysis in rat adipocytes
-
Okada T, Kawano Y, Sakakibara T, Hazeki O & Ui M 1994 Essential role of phosphatidylinositol 3-kinase in insulin induced glucose transport and antilipolysis in rat adipocytes. Journal of Biological Chemistry 269 3568-3573.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 3568-3573
-
-
Okada, T.1
Kawano, Y.2
Sakakibara, T.3
Hazeki, O.4
Ui, M.5
-
56
-
-
0026578215
-
Insulin receptor and insulin responsive glucose transporter (GLUT4) mutations and polymorphisms in a Welsh type 2 (non insulin dependent) diabetic population
-
O'Rahilly S, Rook A, Morgan R, Rees A, Flier JS & Moller DE 1992 Insulin receptor and insulin responsive glucose transporter (GLUT4) mutations and polymorphisms in a Welsh type 2 (non insulin dependent) diabetic population. Diabetologia 35 486-489.
-
(1992)
Diabetologia
, vol.35
, pp. 486-489
-
-
O'Rahilly, S.1
Rook, A.2
Morgan, R.3
Rees, A.4
Flier, J.S.5
Moller, D.E.6
-
57
-
-
0029091623
-
Activation of PRK1 by phosphatidylinositol 4,5 bisphosphate and phosphatidyl 3,4,5 tris phosphate
-
Palmer RH, Dekker LV, Woscholski R, LeGood JA, Gigg R & Parker PJ 1995 Activation of PRK1 by phosphatidylinositol 4,5 bisphosphate and phosphatidyl 3,4,5 tris phosphate. Journal of Biological Chemistry 270 22412-22416.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 22412-22416
-
-
Palmer, R.H.1
Dekker, L.V.2
Woscholski, R.3
Legood, J.A.4
Gigg, R.5
Parker, P.J.6
-
58
-
-
0028810236
-
4PS/insulin receptor substrate 2 (IRS-2) is the alternative substrate of the insulin receptor in IRS-1 deficient mice
-
Patti M, Sun X, Breuning JC, Araki E, Lipes MA, White MF & Kahn CR 1995 4PS/insulin receptor substrate 2 (IRS-2) is the alternative substrate of the insulin receptor in IRS-1 deficient mice. Journal of Biological Chemistry 270 24670-24673.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 24670-24673
-
-
Patti, M.1
Sun, X.2
Breuning, J.C.3
Araki, E.4
Lipes, M.A.5
White, M.F.6
Kahn, C.R.7
-
59
-
-
0025302915
-
Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM
-
Pedersen O, Bak JF, Andersen PH, Lund S, Moller DE, Flier JS & Kahn BB 1990 Evidence against altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Diabetes 39 865-870.
-
(1990)
Diabetes
, vol.39
, pp. 865-870
-
-
Pedersen, O.1
Bak, J.F.2
Andersen, P.H.3
Lund, S.4
Moller, D.E.5
Flier, J.S.6
Kahn, B.B.7
-
60
-
-
0028982198
-
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase
-
Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, Fisher TL, Myers MG, Sun XJ & White MF 1995 The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Molecular and Cellular Biology 15 4453-4465.
-
(1995)
Molecular and Cellular Biology
, vol.15
, pp. 4453-4465
-
-
Pons, S.1
Asano, T.2
Glasheen, E.3
Miralpeix, M.4
Zhang, Y.5
Fisher, T.L.6
Myers, M.G.7
Sun, X.J.8
White, M.F.9
-
61
-
-
0028018097
-
Essential role of phosphatidylinositol 3-kinase in insulin induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes
-
Rahn T, Ridderstrale M, Tornqvist H, Manganiello V, Fredrikson G, Belfrage P & Degerman E 1994 Essential role of phosphatidylinositol 3-kinase in insulin induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. FEBS Letters 350 314-318.
-
(1994)
FEBS Letters
, vol.350
, pp. 314-318
-
-
Rahn, T.1
Ridderstrale, M.2
Tornqvist, H.3
Manganiello, V.4
Fredrikson, G.5
Belfrage, P.6
Degerman, E.7
-
62
-
-
0029990003
-
Activation of PI 3-kinase by interaction with ras and by point mutation
-
Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD & Downward J 1996 Activation of PI 3-kinase by interaction with ras and by point mutation. EMBO Journal 15 2442-2451.
-
(1996)
EMBO Journal
, vol.15
, pp. 2442-2451
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Vanhaesebroeck, B.3
Waterfield, M.D.4
Downward, J.5
-
64
-
-
0027489828
-
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone treated rats
-
Saad MJA, Kahn FFA & Kahn CR 1993 Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone treated rats Journal of Clinical Investigation 92 2065-2072.
-
(1993)
Journal of Clinical Investigation
, vol.92
, pp. 2065-2072
-
-
Saad, M.J.A.1
Kahn, F.F.A.2
Kahn, C.R.3
-
65
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP-12 in a rapamycin dependent fashion and is homologous to yeast TORs
-
Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P & Snyder SH 1994 RAFT1: a mammalian protein that binds to FKBP-12 in a rapamycin dependent fashion and is homologous to yeast TORs. Cell 78 35-43.
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
66
-
-
0029009331
-
Ras independent and wortmannin sensitive activation of glycogen synthase by insulin in CHO cells
-
Sakaue H, Hara K, Noguchi T, Matozaki T, Kotani K, Ogawa W, Yonezawa K, Waterfield MD & Kasuga M 1995 Ras independent and wortmannin sensitive activation of glycogen synthase by insulin in CHO cells. Journal of Biological Chemistry 270 11304-11309.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 11304-11309
-
-
Sakaue, H.1
Hara, K.2
Noguchi, T.3
Matozaki, T.4
Kotani, K.5
Ogawa, W.6
Yonezawa, K.7
Waterfield, M.D.8
Kasuga, M.9
-
67
-
-
0027290847
-
Use of bismannose photolabel to elucidate insulin regulated GLUT4 subcellular trafficking kinetics in rat adipose cells
-
Satoh S, Nishimura H, Clark AE, Kozka IJ, Vannucci SJ, Simpson IA, Quon MJ, Cushman SW & Holman GD 1993 Use of bismannose photolabel to elucidate insulin regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Journal of Biological Chemistry 268 37820-17829.
-
(1993)
Journal of Biological Chemistry
, vol.268
, pp. 37820-117829
-
-
Satoh, S.1
Nishimura, H.2
Clark, A.E.3
Kozka, I.J.4
Vannucci, S.J.5
Simpson, I.A.6
Quon, M.J.7
Cushman, S.W.8
Holman, G.D.9
-
68
-
-
0029057336
-
A single ataxia telangectasia gene with a product similar to PI 3-kinase
-
Savitsky K, Bar-Shira A & Gilad S 1995 A single ataxia telangectasia gene with a product similar to PI 3-kinase. Science 268 1749-1752
-
(1995)
Science
, vol.268
, pp. 1749-1752
-
-
Savitsky, K.1
Bar-Shira, A.2
Gilad, S.3
-
69
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
Schu PY, Takegawa K, Fry MJ, Stack JH, Waterfield MD & Emr SD 1993 Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260 88-91.
-
(1993)
Science
, vol.260
, pp. 88-91
-
-
Schu, P.Y.1
Takegawa, K.2
Fry, M.J.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
70
-
-
0029011643
-
Insulin activates glycogen synthase by a novel PI 3-kinase/p70 s6-kinase dependent pathway in 3T3-L1 adipocytes
-
Shepherd PR, Navé BT & Siddle K 1995a Insulin activates glycogen synthase by a novel PI 3-kinase/p70 s6-kinase dependent pathway in 3T3-L1 adipocytes. Biochemical Society Transactions 23 202S
-
(1995)
Biochemical Society Transactions
, vol.23
-
-
Shepherd, P.R.1
Navé, B.T.2
Siddle, K.3
-
71
-
-
0028797745
-
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: Evidence for the involvement of phosphoinositide 3-kinase and p-70 ribosomal protein-S6 kinase
-
Shepherd PR, Nave BT & Siddle K 1995b Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: Evidence for the involvement of phosphoinositide 3-kinase and p-70 ribosomal protein-S6 kinase. Biochemical Journal 305 25-28.
-
(1995)
Biochemical Journal
, vol.305
, pp. 25-28
-
-
Shepherd, P.R.1
Nave, B.T.2
Siddle, K.3
-
72
-
-
0027288587
-
The SH2/SH3 domain containing protein Grb-2 interacts with tyrosine phosphorylated IRS-1 and She - Implications for insulin control of ras signalling
-
Skolnik EY, Lee CH, Batzer A, Vicenti LM, Zhou M, Daly R, Myers MG, Backer JM, Ullrich A, White MF & Schlessinger J 1993 The SH2/SH3 domain containing protein Grb-2 interacts with tyrosine phosphorylated IRS-1 and She - Implications for insulin control of ras signalling. EMBO Journal 12 1929-1936.
-
(1993)
EMBO Journal
, vol.12
, pp. 1929-1936
-
-
Skolnik, E.Y.1
Lee, C.H.2
Batzer, A.3
Vicenti, L.M.4
Zhou, M.5
Daly, R.6
Myers, M.G.7
Backer, J.M.8
Ullrich, A.9
White, M.F.10
Schlessinger, J.11
-
73
-
-
0027366440
-
Agonist stimulated synthesis of phosphatidylinositol (3,4,5) trisphosphate: A new signalling system?
-
Stephens LR, Jackson TR & Hawkins PT 1993 Agonist stimulated synthesis of phosphatidylinositol (3,4,5) trisphosphate: a new signalling system? Biochimica et Biophysica Acta 1179 27-75.
-
(1993)
Biochimica et Biophysica Acta
, vol.1179
, pp. 27-75
-
-
Stephens, L.R.1
Jackson, T.R.2
Hawkins, P.T.3
-
74
-
-
0028388146
-
Characterization of a phosphatidyl inositol specific 3 kinase from mammalian cells
-
Stephens L, Cooke FT, Walters R, Jackson T, Volinia S, Gout I, Waterfield MD & Hawkins PT 1994a Characterization of a phosphatidyl inositol specific 3 kinase from mammalian cells. Current Biology 4 203-214.
-
(1994)
Current Biology
, vol.4
, pp. 203-214
-
-
Stephens, L.1
Cooke, F.T.2
Walters, R.3
Jackson, T.4
Volinia, S.5
Gout, I.6
Waterfield, M.D.7
Hawkins, P.T.8
-
75
-
-
0028334738
-
A novel phosphoinositide 3 kinase activity in myeloid derived cells is activated by G protein βγ subunits
-
Stephens L, Smrcks A, Cooke FT, Jackson TR, Sternweis PC & Hawkins PT 1994b A novel phosphoinositide 3 kinase activity in myeloid derived cells is activated by G protein βγ subunits. Cell 77 83-93
-
(1994)
Cell
, vol.77
, pp. 83-93
-
-
Stephens, L.1
Smrcks, A.2
Cooke, F.T.3
Jackson, T.R.4
Sternweis, P.C.5
Hawkins, P.T.6
-
76
-
-
0029090212
-
Cloning and characterization of a G-protein activated human phosphoinositide 3-kinase
-
Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesenbroeck B, Dhand R, Nurnberg B, Gierschik P, Seedorf K, Hsuan JJ, Waterfield MD & Wetzker R 1995 Cloning and characterization of a G-protein activated human phosphoinositide 3-kinase Science 269 690-693.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
Rubio, I.4
Loubtchenkov, M.5
Malek, D.6
Stoyanova, S.7
Vanhaesenbroeck, B.8
Dhand, R.9
Nurnberg, B.10
Gierschik, P.11
Seedorf, K.12
Hsuan, J.J.13
Waterfield, M.D.14
Wetzker, R.15
-
77
-
-
12644295652
-
Overexpression of a constitutively active form of PI 3-kinase is sufficient to promote GLUT4 translocation in transfected rat adipocytes
-
Tanti JF, Gremeaux T, Ricort J, Van Obberghen E & LeMarchand Brustel Y 1996 Overexpression of a constitutively active form of PI 3-kinase is sufficient to promote GLUT4 translocation in transfected rat adipocytes. Experimental and Clinical Endocrinology and Diabetes 101 (Suppl 2) 25-26.
-
(1996)
Experimental and Clinical Endocrinology and Diabetes
, vol.101
, Issue.2 SUPPL.
, pp. 25-26
-
-
Tanti, J.F.1
Gremeaux, T.2
Ricort, J.3
Van Obberghen, E.4
Lemarchand Brustel, Y.5
-
78
-
-
0025979358
-
Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non insulin dependent diabetes mellitus
-
Thorburn AW, Gumbiner B, Bulacan F, Brechtel G & Henry RR 1991 Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non insulin dependent diabetes mellitus. Journal of Clinical Investigation 87 489-495.
-
(1991)
Journal of Clinical Investigation
, vol.87
, pp. 489-495
-
-
Thorburn, A.W.1
Gumbiner, B.2
Bulacan, F.3
Brechtel, G.4
Henry, R.R.5
-
79
-
-
0028560447
-
Activation of protein kinase C family members by the novel phosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3
-
Toker A, Meyer M, Reddy KK, Flack JR, Aneda R, Aneda S, Parra A, Burns DJ, Ballas LM & Cantley LC 1994 Activation of protein kinase C family members by the novel phosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. Journal of Biological Chemistry 269 32358-32367.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 32358-32367
-
-
Toker, A.1
Meyer, M.2
Reddy, K.K.3
Flack, J.R.4
Aneda, R.5
Aneda, S.6
Parra, A.7
Burns, D.J.8
Ballas, L.M.9
Cantley, L.C.10
-
80
-
-
0029122720
-
Multiple roles of PI 3-kinase in regulation of glucose transport, amino acid transport and glucose transporters in L6 skeletal muscle cells
-
Tsakiridis T, McDowell HE, Walker T, Downes CP, Hundal HS, Vranic M & Klip A 1995 Multiple roles of PI 3-kinase in regulation of glucose transport, amino acid transport and glucose transporters in L6 skeletal muscle cells. Endocrinology 136 4315-4322.
-
(1995)
Endocrinology
, vol.136
, pp. 4315-4322
-
-
Tsakiridis, T.1
McDowell, H.E.2
Walker, T.3
Downes, C.P.4
Hundal, H.S.5
Vranic, M.6
Klip, A.7
-
81
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morphinyl)-8-phenyl-4H-1-benzopyranol-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY & Brown RF 1994 A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morphinyl)-8-phenyl-4H-1-benzopyranol-one (LY294002). Journal of Biological Chemistry 269 5241-5248
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
82
-
-
0028981018
-
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p/Vps15p protein sorting system
-
Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil M, Domin J, Panareto C & Waterfield MD 1995 A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p/Vps15p protein sorting system. EMBO Journal 14 3339-3348.
-
(1995)
EMBO Journal
, vol.14
, pp. 3339-3348
-
-
Volinia, S.1
Dhand, R.2
Vanhaesebroeck, B.3
MacDougall, L.K.4
Stein, R.5
Zvelebil, M.6
Domin, J.7
Panareto, C.8
Waterfield, M.D.9
-
84
-
-
0028032480
-
Cloning and characterization of a human phosphatidylinositol 4-kinase
-
Wong K & Cantley L 1994 Cloning and characterization of a human phosphatidylinositol 4-kinase. Journal of Biological Chemistry 269 28878-28884.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 28878-28884
-
-
Wong, K.1
Cantley, L.2
-
85
-
-
0028815153
-
Upstream mechanisms of glycogen synthase activation by insulin and insulin like growth factor
-
Yamamoto-Honda R, Tobe K, Kaburagi Y, Ueki K, Asai S, Yachi M, Shirozou M, Yodoi J, Akanuma Y, Yokoyama S, Yazaki Y & Kadowaki T 1995 Upstream mechanisms of glycogen synthase activation by insulin and insulin like growth factor Journal of Biological Chemistry 270 2729-2734.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 2729-2734
-
-
Yamamoto-Honda, R.1
Tobe, K.2
Kaburagi, Y.3
Ueki, K.4
Asai, S.5
Yachi, M.6
Shirozou, M.7
Yodoi, J.8
Akanuma, Y.9
Yokoyama, S.10
Yazaki, Y.11
Kadowaki, T.12
-
86
-
-
0030059569
-
Phosphatidylinositol 3-kinase acts at an intracellular site to enhance GLUT4 exocytocis in 3T3-LI cells
-
Yang J, Clarke JF, Ester CJ, Young PW, Kasuga M & Holman GD 1996 Phosphatidylinositol 3-kinase acts at an intracellular site to enhance GLUT4 exocytocis in 3T3-LI cells. Biochemical Journal 313 125-131.
-
(1996)
Biochemical Journal
, vol.313
, pp. 125-131
-
-
Yang, J.1
Clarke, J.F.2
Ester, C.J.3
Young, P.W.4
Kasuga, M.5
Holman, G.D.6
-
88
-
-
0023251849
-
Regulation of glycogen synthase and phophorylase activities by glucose and insulin in human skeletal muscle
-
Yki-Jarvinen H, Mort D, Young A, Stone K & Bogardus C 1987 Regulation of glycogen synthase and phophorylase activities by glucose and insulin in human skeletal muscle. Journal of Clinical Investigation 80 95-100.
-
(1987)
Journal of Clinical Investigation
, vol.80
, pp. 95-100
-
-
Yki-Jarvinen, H.1
Mort, D.2
Young, A.3
Stone, K.4
Bogardus, C.5
-
89
-
-
0025138242
-
Localization of rate limiting defect for glucose disposal in skeletal muscle of insulin resistant type 1 diabetic patients
-
Yki-Jarvinen H, Sahlin K, Ren JM & Koivisto VA 1990 Localization of rate limiting defect for glucose disposal in skeletal muscle of insulin resistant type 1 diabetic patients. Diabetes 39 157-167.
-
(1990)
Diabetes
, vol.39
, pp. 157-167
-
-
Yki-Jarvinen, H.1
Sahlin, K.2
Ren, J.M.3
Koivisto, V.A.4
-
90
-
-
0027979837
-
A novel gene, STT 4 encodes a phosphatidylinositol 4-kinase in the PKC-1 protein kinase pathway of Saccharomyces cerevisiae
-
Yoshida S, Ohya Y, Goebl M, Nakano A & Anraku Y 1994 A novel gene, STT 4 encodes a phosphatidylinositol 4-kinase in the PKC-1 protein kinase pathway of Saccharomyces cerevisiae. Journal of Biological Chemistry 269 1166-1172.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 1166-1172
-
-
Yoshida, S.1
Ohya, Y.2
Goebl, M.3
Nakano, A.4
Anraku, Y.5
-
91
-
-
0028032417
-
Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione derived antidiabetic agents in Chinese hamster ovary cells expressing insulin receptors and L6 myotubes
-
Zhang B, Szalkowkski D, Diaz E, Hayes N, Smit R & Berger J 1994 Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione derived antidiabetic agents in Chinese hamster ovary cells expressing insulin receptors and L6 myotubes, Journal of Biological Chemistry 269 25735-25741.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 25735-25741
-
-
Zhang, B.1
Szalkowkski, D.2
Diaz, E.3
Hayes, N.4
Smit, R.5
Berger, J.6
-
92
-
-
0030605392
-
Structural and functional diversity of phosphoinositide 3-kinases
-
Zvelebil MJ, Macdougall L, Leevers S, Volinia S, Vanhaesebroeck B, Gout I, Panayatou G, Domin J, Stein R, Koga H, Pages F, Salim K, Linacre J, Das P, Panaretou C, Wetzker R & Waterfield M 1996 Structural and functional diversity of phosphoinositide 3-kinases, Proceedings of the Royal Society Series B 351 217-223
-
(1996)
Proceedings of the Royal Society Series B
, vol.351
, pp. 217-223
-
-
Zvelebil, M.J.1
Macdougall, L.2
Leevers, S.3
Volinia, S.4
Vanhaesebroeck, B.5
Gout, I.6
Panayatou, G.7
Domin, J.8
Stein, R.9
Koga, H.10
Pages, F.11
Salim, K.12
Linacre, J.13
Das, P.14
Panaretou, C.15
Wetzker, R.16
Waterfield, M.17
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