Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK

Journal of Biological Chemistry

Volumn 280, Issue 22, 2005, Pages 21237-21245

  Kim, Ho ^a   Rhee, Sang Hoon ^a   Kokkotou, Efi ^a   Na, Xi ^a   Savidge, Tor ^b   Moyer, Mary P ^c   Pothoulakis, Charalabos ^a   LaMont, J Thomas ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Dana 501 ^*  (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ENZYME INHIBITION; HUMAN ENGINEERING; MICROORGANISMS; PROTEINS; SIGNALING; TOXIC MATERIALS;

INFLAMMATION; NEUTROPHIL INFILTRATION; SIGNALING PATHWAY; UPREGULATIONS;

ENZYME KINETICS;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; CLOSTRIDIUM DIFFICILE TOXIN A; COMPLEMENTARY DNA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN AND STRESS ACTIVATED PROTEIN KINASE 1; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; CLOSTRIDIUM DIFFICILE; COLITIS; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOXIN ANALYSIS;

ANIMALS; BACTERIAL TOXINS; CELL LINE; COLON; CYCLIC AMP; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENTEROTOXINS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; ILEUM; IMIDAZOLES; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTRAMOLECULAR OXIDOREDUCTASES; LUCIFERASES; MEMBRANE PROTEINS; MICE; MICE, SCID; MODELS, BIOLOGICAL; NITROBENZENES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PYRIDINES; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONAMIDES; TIME FACTORS; TISSUE TRANSPLANTATION; TRANSFECTION;

CLOSTRIDIUM DIFFICILE;

EID: 20444395071     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413842200     Document Type: Article

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