Slit-roundabout signaling neutralizes netrin-frazzled-mediated attractant cue to specify the lateral positioning of longitudinal axon pathways

Genetics

Volumn 170, Issue 1, 2005, Pages 149-159

  Bhat, Krishna Moorthi ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NETRIN; NETRIN FRAZZLED SIGNALING PROTEIN; SLIT PROTEIN; SLIT ROUNDABOUT SIGNALING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DROSOPHILA; GENE MUTATION; MOLECULAR CLONING; NERVE CORD; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL;

ANIMALS; AXONS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EPISTASIS, GENETIC; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 20444387267     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: 10.1534/genetics.104.036863     Document Type: Article

References (34)

1. BA-CHARVET, N. K. T., K. BROSE, V. MARILLAT, T. KIDD, C. S. GOODMAN et al., 1999 Slit2-mediated chemorepulsion and collapse of developing forebrain axons. Neuron 22: 463-473.
2. BASHAW, G. J., and C. S. GOODMAN, 1999 Chimeric axon guidance receptors: the cytoplasmic domains of Slit and Netrin receptrs specify attraction versus repulsion. Cell 97: 917-926.
3. BASHAW, G. J., T. KIDD, D. MURRAY, T. PAWSON and C. S. GOODMAN, 2000 Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor. Cell 101: 703-715.
4. BHAT, K. M., 1996 The patched signaling pathway mediates repression of gooseberry allowing neuroblast specification by wingless during Drosophila neurogenesis. Development 122: 2921-2932.
5. BHAT, K. M., and P. SCHEDL, 1997 Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis. Development 124: 1675-1688.
6. BHAT, K. M., E. H. VAN BEERS and P. BHAT, 2000 Sloppy paired acts as the downstream target of wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis. Development 127: 655-665.
7. BROSE, K., K. S. BLAND, K. H. WANG, D. ARNOTT, W. HENZEL et al., 1999 Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 9: 795-806.
8. CHAN, S. S., H. ZHENG, M. W. SU, R. WILK, M. T. KILLEEN et al., 1996 UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87: 187-195.
9. GOODMAN, C. S., 1996 Mechanisms and molecules that control growth cone guidance. Annu. Rev. Neurosci. 19: 341-377.
10. HARRIS, R., L. M. SABATELLI and M. A. SEEGER, 1996 Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs. Neuron 17: 217-228.
11. HARRIS, W. A., and C. E. HOLT, 1999 Slit, the midline repellent. Nature 398: 462-463.
12. HASSAN, B. A., N. A. BERMINGHAM, Y. HE, Y. SUN, Y. N. JAN et al., 2000 atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25: 549-561.
13. HEDGECOCK, E. M., J. G. CULOTTI and D. H. HALL, 1990 The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4: 61-85.
14. ISHII, N., W. G. WADSWORTH, B. D. STERN, J. G. CULOTTI and E. M. HEDGECOCK, 1992 UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9: 873-881.
15. KELEMAN, K., and B. J. DICKSON, 2001 Short- and long-range repulsion by the Drosophila Unc5 netrin receptor. Neuron 32: 605-617.
16. KIDD, T., K. S. BLAND and C. S. GOODMAN, 1999 Slit is the midline repellent for the robo receptor in Drosophila. Cell 96: 785-794.
17. KOLODZIEJ, P. A., L. C. TIMPE, K. J. MITCHELL, S. R. FRIED, C. S. GOODMAN et al., 1996 frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87: 197-204.
18. LI, H. S., J. H. CHEN, W. WU, T. FAGALY, T. L. ZHOU et al., 1999 Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96: 807-818.
19. MITCHELL, K. J., J. L. DOYLE, T. SERAFINI, T. E. KENNEDY, M. TESSIER-LAVIGNE et al., 1996 Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Neuron 17: 203-215.
20. NOORDERMEER, J., J. KLINGENSMITH, N. PERRIMON and R. NUSSE, 1994 dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature 367: 80-83.
21. RAJAGOPALAN, S., V. VIVANCOS, E. NICOLAS and B. J. DICKSON, 2000 Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS. Cell 103: 1033-1045.
22. REN, X. C., S. KIM, E. FOX, E. M. HEDGECOCK and W. G. WADSWORTH, 1999 Role of netrin UNC-6 in patterning the longitudinal nerves of Caenorhabditis elegans. J. Neurobiol. 39: 107-118.
23. ROTHBERG, J. M., J. R. JACOBS, C. S. GOODMAN and S. ARTAVANIS-TSAKONAS, 1990 slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev. 4: 2169-2187.
24. SCHINDELHOLZ, B., M. KNIRR, R. WARRIOR and K. ZINN, 2001 Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F. Development 128: 4371-4378.
25. SEEGER, M., G. TEAR, M. D. FERRES and C. S. GOODMAN, 1993 Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline. Neuron 10: 409-426.
26. SEEGER, M. A., and C. BEATTIE, 1999 Attraction versus repulsion: modular receptors make the difference in axon guidance. Cell 97: 821-824.
27. SIEGFRIED, E., E. L. WILDER and N. PERRIMON, 1994 Components of wingless signalling in Drosophila. Nature 367: 76-80.
28. SIMPSON, J. H., T. KIDD, K. S. BLAND and C. S. GOODMAN, 2000 Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance. Neuron 28: 753-766.
29. STEIN, E., and M. TESSIER-LAVIGNE, 2001 Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science 291: 1928-1938.
30. TEAR, G., R. HARRIS, S. SUTARIA, K. KILOMANSKI, C. S. GOODMAN et al., 1996 commissureless controls growth cone guidance across the CNS midline in Drosophila and encodes a novel membrane protein. Neuron 16: 501-514.
31. TESSIER-LAVIGNE, M., 1994 Axon guidance by diffusible repellants and attractants. Curr. Opin. Genet. Dev. 4: 596-601.
32. VAN VACTOR, D., and J. G. FLANAGAN, 1999 The middle and the end: slit brings guidance and branching together in axon pathway selection. Neuron 2: 649-652.
33. WANG, K. H., K. BROSE, D. ARNOTT, T. KIDD, C. S. GOODMAN et al., 1999 Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching. Cell 96: 771-784.
34. WOLF, B. D., and A. CHIBA, 2000 Axon pathfinding proceeds normally despite disrupted growth cone decisions at CNS midline. Development 127: 2001-2009.