Role of netrin UNC-6 in patterning the longitudinal nerves of Caenorhabditis elegans

Journal of Neurobiology

Volumn 39, Issue 1, 1999, Pages 107-118

  Ren, Xing Cong ^a   Kim, Seonhee ^a   Fox, Eileen ^a   Hedgecock, Edward M ^b   Wadsworth, William G ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Axon guidance; C. elegans; Netrin; UNC 6

Indexed keywords

NETRIN; PLASMID DNA;

ARTICLE; CAENORHABDITIS ELEGANS; CELL MIGRATION; GENE EXPRESSION; GLIA; NERVE CELL; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; BASEMENT MEMBRANE; BODY PATTERNING; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL MEMBRANE; CELL MOVEMENT; EMBRYO, NONMAMMALIAN; GANGLIA, INVERTEBRATE; HELMINTH PROTEINS; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NERVOUS SYSTEM PHYSIOLOGY; NEUROGLIA; NEURONS;

EID: 0033037921     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(199904)39:1<107::AID-NEU9>3.0.CO;2-7     Document Type: Article

References (40)

1. Bargmann CI, Avery L. 1995. Laser killing of cells in Caenorhabditis elegans. In Epstein H, Shakes D, editors. C. elegans: Modern biological analysis of an organism. San Diego: Academic Press, 225-250.
2. Birchall PS, Fishpool RM, Albertson DG. 1995. Expression patterns of predicted genes from the C. elegans genome sequence visualized by FISH in whole organisms. Nat Genet 11:314-320.
3. Brenner S. 1974. The genetics of Caenorhabditis elegans. Genetics 77:71-94.
4. Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC. 1994. Green fluorescent protein as a marker for gene expression. Science 263:802-805.
5. Chan SS, Zheng H, Su MW, Wilk R, Killeen MT, Hedgecock EM, Culotti JG. 1996. UNC-40, a C. elegans homolog of DCC (deleted in colorectal cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87:187-195.
6. Colamarino SA, Tessier-Lavigne M. 1995a. The axonal chemoattractant Netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81:621-629.
7. Colamarino SA, Tessier-Lavigne M. 1995b. The role of the floor plate in axon guidance. Annu Rev Neurosci 18:497-529.
8. de la Torre JR, Hopker VH, Ming GL, Poo MM, Tessier-Lavigne M, Hemmati-Brivanlou A, Holt CE. 1997. Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. Neuron 19:1211-1224.
9. Durbin R. 1987. Studies on the development and organisation of the nervous system of Caenorhabditis elegans. PhD thesis, University of Cambridge, England.
10. Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne M, Weinberg RA. 1997. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386:796-804.
11. Fire A. 1986. Integrative transformation of Caenorhabditis elegans. EMBO J 5:2673-2680.
12. Hamelin M, Scott IM, Way JC, Culotti JG. 1992. The mec-7 β-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons. EMBO J 11: 2885-2893.
13. Hamelin M, Zhou Y, Su MW, Scott IM, Culotti JG. 1993. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 364:327-330.
14. Harris R, Sabatelli LM, Seeger MA. 1996. Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila Netrin/UNC-6 homologs. Neuron 17:217-228.
15. Hedgecock E, Hall D. 1990. Homologies in the neurogenesis of nematodes, arthropods and chordates. Semin Neurosci 2:159-172.
16. Hedgecock EM, Culotti JG, Hall DH. 1990. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4:61-85.
17. Ishii N, Wadsworth WG, Stern BD, Culotti JG, Hedgecock EM. 1992. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9:873-881.
18. Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SSY, Culotti JG, Tessier-Lavigne M. 1996. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87:175-185.
19. Kennedy TE, Serafini T, de la Torre J, Tessier-Lavigne M. 1994. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78: 425-435.
20. Keynes R, Cook GMW. 1995. Axon guidance molecules. Cell 83:161-169.
21. Kolodziej PA. 1996. frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87:197-204.
22. Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M. 1997. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386:833-838.
23. Leung-Hagesteijn C, Spence AM, Stern BD, Zhou Y, Su MW, Hedgecock EM, Culotti JG. 1992. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 71:289-299.
24. Maduro M, Pilgrim D. 1995. Identification and cloning of une-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141:977-988.
25. McIntire SL, Garriga G, White J, Jacobson D, Horvitz HR. 1992. Genes necessary for directed axonal elongation or fasciculation in C. elegans. Neuron 8:307-322.
26. Mello C, Fire A. 1995. DNA Transformation. In. Epstein H, Shakes DC, editors. Caenorhabditis elegans: Modern biological analysis of an organism. San Diego: Academic Press, 451-482.
27. Mello CC, Kramer JM, Stinchcomb D, Ambros V. 1991. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10:3959-3970.
28. Mitchell KJ, Doyle JL, Serafini T, Kennedy TE, Tessier-Lavigne M, Goodman CS, Dickson BJ. 1996. Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons. Neuron 17:203-215.
29. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular cloning: A laboratory manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
30. Savage C, Hamelin M, Culotti JG, Coulson A, Albertson DG, Chalfie M. 1989. mec-7 is a beta-tubulin gene required for the production of the 15-protofilament microtubules in Caenorhabditis elegans. Genes Dev 3:870-881.
31. Savage C, Xue YZ, Mitani S, Hall D, Zakhary R, Chalfie M. 1994. Mutations in the Caenorhabditis elegans β-tubulin gene mec-7: effects on microtubule assembly and stability and on tubulin autoregulation. J Cell Sci 107:2165-2175.
32. Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Shames WC, Tessier-Lavigne M. 1996. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87: 1001-1014.
33. Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M. 1994. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78:409-424.
34. Seydoux G, Fire A. 1994. Soma-germline asymmetry in the distribution of embryonic RNAs in Caenorhabditis elegans. Development 120:2823-2834.
35. Seydoux G, Fire A. 1995. Whole-mount in situ hybridization for the detection of RNA in C. elegans embryos. In: Epstein H, Shakes D, editors. C. elegans: Modern biological analysis of an organism. San Diego: Academic Press, 323-337.
36. Sulston J, Hodgkin J. 1988. Methods. In: Wood WB, editor. The nematode Caenorhabditis elegans. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 587-606.
37. Sulston J, Horvitz R. 1977. Postembryonic cell lineages of the nematode Caenorhabditis elegans. Dev Bio 56:110-156.
38. Tessier-Lavigne M, Goodman CS. 1996. The molecular biology of axon guidance. Science 274:1123-1133.
39. Wadsworth WG, Bhatt H, Hedgecock EM. 1996. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron 16:35-46.
40. White J, Southgate E, Thompson J, Brenner S. 1986. The structure of the nervous system of the nematode Caenorhabditis elegans. Phil Trans R Soc Lond B 314:1-340.