Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 13, 2005, Pages 4269-4278

  Gu, Ling ^a   Zhuang, Hui ^b   Safina, Brian ^c   Xiao, Xiao Yi ^b   Bradford, Wallace W ^d   Rich, Benjamin E ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b ChemRx   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d SRI INTERNATIONAL   (United States)

Author keywords

IL 7; JAK kinase; Lymphoma; Tyrphostin

Indexed keywords

2 CYANO 3 (3,4 DIHYDROXYPHENYL) N [[3 (TRIFLUOROMETHYL)PHENYL]METHYL] 2 PROPENAMIDE; 2 CYANO 3 (3,4 DIHYDROXYPHENYL) N [[4 (TRIFLUOROMETHYL)PHENYL]METHYL] 2 PROPENAMIDE; CYTOKINE; INTERLEUKIN 7; JANUS KINASE 2; JANUS KINASE 3; JANUS KINASE INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; TYRPHOSTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL LINE; CELL PROLIFERATION; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; LYMPHADENOPATHY; LYMPHOMA; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; INTERLEUKIN-3; INTERLEUKIN-7; JANUS KINASE 3; LYMPHATIC DISEASES; MICE; MICE, TRANSGENIC; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TYRPHOSTINS;

MUS MUSCULUS;

EID: 20344401796     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.022     Document Type: Article

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