Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 13, 2005, Pages 4291-4299

  Sondhi, Sham M ^a   Singh, Nirupma ^a   Lahoti, Anand M ^a   Bajaj, Kiran ^b   Kumar, Ashok ^b   Lozach, Olivier ^c   Meijer, Laurent ^c  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b LLRM MEDICAL COLLEGE   (India)

^c STATION BIOLOGIQUE   (France)

Author keywords

Acridinyl thiazolino derivatives; Analgesic; Anti inflammatory; CDK1 inhibitor; Synthesis

Indexed keywords

1 [(2 METHYLACRIDIN 9 YL) 3 [4 PHENYL 3 [4 PHENYL 3 (4' METHYLPHENYL)THIAZOL 2(3H) YLIDENE]]]ISOTHIOUREA; 1 [(4 METHOXYACRIDIN 9 YL) 3 (3,4 DIPHENYL)THIAZOL 2(3H) YLIDENE]ISOTHIOUREA; 1 [(4 METHYLACRIDIN 9 YL) 3 (3,4 DIPHENYL)THIAZOL 2(3H) YLIDENE]ISOTHIOUREA; 1 [(4 METHYLACRIDIN 9 YL) 3 [4 PHENYL 3 (4' METHOXYPHENYL)THIAZOL 2(3H) YLIDENE]]ISOTHIOUREA; 1 [(4 METHYLACRIDIN 9 YL) 3 [4 PHENYL 3 (4' METHYLPHENYL)THIAZOL 2(3H) YLIDENE]]ISOTHIOUREA; 1 [(ACRIDIN 9 YL) 3 (3,4 DIPHENYL)THIAZOL 2(3H) YLIDENE]ISOTHIOUREA; 1 [(ACRIDIN 9 YL) 3 [4 PHENYL 3 (2' METHYLPHENYL)THIAZOL 2(3H) YLIDENE]]ISOTHIOUREA; ACRIDINE DERIVATIVE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; ENZYME INHIBITOR; N [4 PHENYL 3 (2' DIMETHOXYPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (2' METHOXYPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHYLACRIDIN 9 AMINE; N [4 PHENYL 3 (2' NITROPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (2',3' DIMETHYLPHENYL)THIAZOL 2(3H) YLIDENE] 2 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (2',3' DIMETHYLPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (2',3' DIMETHYLPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHYLACRIDIN 9 AMINE; N [4 PHENYL 3 (3' NITROPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (4' CHLOROPHENYL)THIAZOL 2(3H) YLIDENE] 2 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (4' CHLOROPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (4' CHLOROPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHYLACRIDIN 9 AMINE; N [4 PHENYL 3 (4' METHOXYPHENYL)THIAZOL 2(3H) YLIDENE] 2 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (4' METHOXYPHENYL)THIAZOL 2(3H) YLIDENE] 2 METHYLACRIDIN 9 AMINE; N [4 PHENYL 3 (4' METHOXYPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (4' METHYLPHENYL)THIAZOL 2(3H) YLIDENE] 2 METHOXYACRIDIN 9 AMINE; N [4 PHENYL 3 (4' METHYLPHENYL)THIAZOL 2(3H) YLIDENE] 4 METHYLACRIDIN 9 AMINE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; IC 50; INFRARED RADIATION; MASS SPECTROMETRY; MOUSE; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE;

ACRIDINES; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZOQUINONES; BRAIN; CARRAGEENAN; CDC2 PROTEIN KINASE; CYCLIN-DEPENDENT KINASE 5; CYCLIN-DEPENDENT KINASES; EDEMA; ENZYME INHIBITORS; FEMALE; GLYCOGEN SYNTHASE KINASE 3; MICE; PAIN MEASUREMENT; RATS; SWINE; THIAZOLES;

PUFFINUS AURICULARIS;

EID: 20344377156     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.017     Document Type: Article

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