Liver AMP-activated protein kinase and acetyl-CoA carboxylase during and after exercise

Journal of Applied Physiology

Volumn 86, Issue 2, 1999, Pages 669-674

  Carlson, C L ^a   Winder, W W ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

3 hydroxybutyrate; Carnitine palmitoyltransferase 1; Malonyl coenzyme A; Postexercise ketosis

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE; MALONYL COENZYME A;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXERCISE; EXERCISE TEST; HORMONE DETERMINATION; KETOGENESIS; KINETICS; LIVER METABOLISM; METABOLIC PARAMETERS; NONHUMAN; PRIORITY JOURNAL; RAT; TREADMILL EXERCISE;

EID: 0033016641     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1999.86.2.669     Document Type: Article

References (30)

1. Armstrong, R. B., M. H. Laughlin, L. Rome, and C. R. Taylor. Metabolism of rats running up and down an incline. J. Appl. Physiol. 55: 518-521, 1983.
2. Beattie, M. A., and W. W. Winder. Attenuation of postexercise ketosis in fasted endurance-trained rats. Am. J. Physiol. 248 (Regulatory Integrative Comp. Physiol. 17): R63-R67, 1985.
3. Beattie, M. A., and W. W. Winder. Mechanism of training-induced attenuation of postexercise ketosis. Am. J. Physiol. 247 (Regulatory Integrative Comp. Physiol. 16): R780-R785, 1984.
4. Bergmeyer, H. U., E. Bernt, F. Schmidt, and H. Stork. D-Glucose. Determination with hexokinase and glucose-6-phosphate dehydrogenase. In: Methods of Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic, 1974, p. 1196-1201.
5. Davies, S. P., D. Carling, and D. G. Hardie. Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP-dependent protein kinase, studied using a specific and sensitive peptide assay. Eur. J. Biochem. 186: 123-128, 1989.
6. Dohm, G. L., and E. A. Newsholme. Metabolic control of hepatic gluconeogenesis during exercise. Biochem. J. 212: 633-639, 1983.
7. Elayan, I. M., and W. W. Winder. Effect of glucose infusion on muscle malonyl-CoA during exercise. J. Appl. Physiol. 70: 1495-1499, 1991.
8. Hardie, D. G. Regulation of fatty acid synthesis via phosphorylation of acetyl-CoA carboxylase. Prog. Lipid Res. 28: 117-146, 1989.
9. Hardie, D. G., and D. Carling. The AMP-activated protein kinase: fuel gauge of the mammalian cell? Eur. J. Biochem. 246: 259-273, 1997.
10. Hassid, W. Z., and S. Abraham. Chemical procedures for analysis of polysaccharides. Methods Enzymol. 3: 35-36, 1957.
11. Kim, K. H. Regulation of acetyl-CA carboxylase. Curr. Top. Cell. Regul. 22: 143-176, 1983.
12. Kim, K. H., F. Lopez-Casillas, D. H. Bai, X. Luo, and M. E. Pape. Role of reversible phosphorylation of acetyl-CoA carboxylase in long-chain fatty acid synthesis. FASEB J. 3: 2250-2256, 1989.
13. Koeslag, J. H. Post-exercise ketosis and the hormone response to exercise: a review. Med. Sci. Sports Exerc. 14: 327-334, 1982.
14. Kreider, R. B., and W. R. Thompson. Ketone bodies and ketosis in exercise. Ann. Sports Med. 2: 170-174, 1986.
15. Linn, T. C. Purification and crystallization of rat liver fatty acid synthetase. Arch. Biochem. Biophys. 209: 613-619, 1981.
16. Mabrouk, G. M., I. M. Helmy, K. G. Thampy, and S. J. Wakil. Acute hormonal control of acetyl-CoA carboxylase. J. Biol. Chem. 265: 6330-6338, 1990.
17. McGarry, J. D., and N. F. Brown. The mitochondrial carnitine palmitoyltransferase system: from concept to molecular analysis. Eur. J. Biochem. 244: 1-14, 1997.
18. McGarry, J. D., and D. W. Foster. Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem. 49: 395-420, 1980.
19. McGarry, J. D., M. J. Stark, and D. W. Foster. Hepatic malonyl-CoA levels of fed, fasted, and diabetic rats as measured using a simple radioisotopic assay. J. Biol. Chem. 253: 8291-8293, 1978.
20. Novak, M. Colorimetric ultramicromethod for the determination of free fatty acids. J. Lipid Res. 6: 431-433, 1965.
21. Passonneau, J. V., and J. G. Brown. Citrate: fluorimetric determination. In: Methods of Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic, 1974, p. 1561-1569.
22. Sim, A. T. R., and D. G. Hardie. The low activity of acetyl-CoA carboxylase in basal and glucagon-stimulated hepatocytes is due to phosphorylation by the AMP-activated protein kinase and not cyclic AMP-dependent protein kinase. FEBS Lett. 233: 294-298, 1988.
23. Van Schaftingen, E. Role of fructose-2,6-bisphosphate in the regulation of hepatic carbohydrate metabolism. In: Fructose-2,6-Bisphosphate, edited by S. J. Pilkis. Boca Raton, FL: CRC, 1990, p. 65-85.
24. Williamson, D. H., and J. H. Mellanby. D-(-)-3-Hydroxybutyrate. In: Methods of Enzymatic Analysis, edited by H. U. Bergmeyer. New York: Academic, 1974, p. 1836-1839.
25. Winder, W. W. Regulation of hepatic glucose production during exercise. Exerc. Sport Sci. Rev. 13: 1-31, 1985.
26. Winder, W. W., M. A. Beattie, and E. O. Fuller. Glycogenolytic rates and cAMP in livers of rats running at different treadmill speeds. Am. J. Physiol. 245 (Regulatory Integrative Comp. Physiol. 14): R353-R356, 1883.
27. Winder, W. W., S. R. Fisher, S. P. Gygi, J. A. Mitchell, E. Ojuka, and D. A. Weidman. Divergence of muscle and liver fructose 2,6-diphosphate in fasted exercising rats. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E756-E761, 1991.
28. Winder, W. W., and D. G. Hardie. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E299-E304, 1996.
29. Winder, W. W., H. A. Wilson, D. G. Hardie, B. B. Rasmussen, C. A. Hutber, G. B. Call, R. D. Clayton, L. M. Conley, S. Yoon, and B. Zhou. Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A. J. Appl. Physiol. 82: 219-225, 1997.
30. Winder, W. W., H. T. Yang, and J. Arogyasami. Liver fructose 2,6-bisphosphate in rats running at different treadmill speeds. Am. J. Physiol. 255 (Regulatory Integrative Comp. Physiol. 24): R38-R41, 1988.