2,4-Dicarboxy-pyrroles as selective non-competitive mGluR1 antagonists: Further characterization of 3,5-dimethyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester and structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 13, 2003, Pages 2113-2118

  Micheli, Fabrizio ^a   Di Fabio, Romano ^a   Bordi, Fabio ^a,b   Cavallini, Palmina ^a   Cavanni, Paolo ^a   Donati, Daniele ^a   Faedo, Stefania ^a   Maffeis, Micaela ^a   Sabbatini, Fabio Maria ^a   Tarzia, Giorgio ^a   Tranquillini, Maria Elvira ^a  

^a GSK   (Italy)

^b Sigma Tau SpA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYL GROUP; CYTIDINE DIPHOSPHATE DIGLYCERIDE; METABOTROPIC RECEPTOR AGONIST; PYRROLE DERIVATIVE;

ALKYLATION; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; HYDROPHILICITY; IC 50; LIPID SOLUBILITY; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; RAT; SEDATION; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

EID: 12444256018     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00396-2     Document Type: Article

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