β-Minor globin gene expression is preferentially reduced in EKLF Knock-Out mice

Gene

Volumn 351, Issue , 2005, Pages 11-17

  Porcu, Susanna ^a   Poddie, Daniela ^a   Melis, Marco ^b   Cao, Antonio ^a,b   Ristaldi, Maria Serafina ^a  

^a CNR   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Globin gene activation; CACCC boxes; EKLF; LCR

Indexed keywords

BETA GLOBIN; DNA BINDING PROTEIN; ERYTHROID KRUPPEL LIKE FACTOR; MESSENGER RNA;

ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA BINDING MOTIF; FETUS; FETUS DEVELOPMENT; FETUS LIVER; GENE ACTIVATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; MODEL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SPECIES COMPARISON; TERMINAL SEQUENCE; WILD TYPE; ZINC FINGER MOTIF;

ANIMALS; BASE SEQUENCE; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENOTYPE; GLOBINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, KNOCKOUT; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTION FACTORS;

EID: 19544380228     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2005.03.005     Document Type: Article

References (37)

1. R. Alami Deletions within the mouse β-globin locus control region preferentially reduce β min globin gene expression Genomics 63 2000 417 424
2. B.P. Alter, and S.C. Goff A murine model for the switch from fetal to adult hemoglobin during ontogeny Blood 56 1980 1100 1105
3. J.A. Armstrong, J.J. Bieker, and B.M. Emerson A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue specific transcriptional regulation by EKLF in vitro Cell 95 1998 93 104
4. H. Asano, and G. Stamatoyannopoulos Activation of beta-globin promoter by erythroid Kruppel-like factor Mol. Cell. Biol. 18 1998 102 109
5. E. Baysal, M.L. Ribeiro, and T.H. Huisman Binding of nuclear factors to the proximal and distal CACCC motifs of the beta-globin gene promoter: implications for the -101 (C>T) 'silent' beta-thalassemia mutation Acta Haematol. 91 1994 16 20
6. D. Carter, L. Chakalova, C.S. Osborne, Y. Dai, and P. Fraser Long-range chromatin regulatory interactions in vivo Nat. Genet. 32 2002 623 626
7. R. Clark Brown Distinct domains of erythroid Kruppel-like factor modulate chromatin remodeling and transactivation at the endogenous b-globin gene promoter Mol. Cell. Biol. 22 2002 161 170
8. M.A. Erhart, S.S. Kimberlee, and S. Weaver Evolution of the mouse b-globin genes: a recent gene conversion in the HbbS haplotype Mol. Biol. Evol. 2 1995 304 320
9. R. Festenstein Locus control region function and heterochromatin-induced position effect variegation Science 271 1996 1123 1125
10. P. Fraser, and F. Grosveld Locus control region, chromatin activation and transcription Curr. Opin. Cell Biol. 10 1998 361 365
11. N. Gillemans Altered DNA-binding specificity mutants of EKLF and SP1 show that EKLF is an activator of the β-globin locus control region in vivo Genes Dev. 12 1998 2863 2873
12. A.J. Goodwin, J.M. McInerney, M.A. Glande, O. Pomerantz, and C.H. Lowrey In vivo formation of a human β-globin locus control region core element requires binding sites for multiple factors including GATA-1, NF-E2, erythroid Kruppel-like factor, and SP1 J. Biol. Chem. 276 2001 26883 26892
13. L.G. Guy, N. Delvoye, and L. Wall Expression of a human β-globin transgene in mice with the CACCC motif and upstream sequence deleted from the promoter still depends on erythroid Kruppel-like factor J. Biol. Chem. 275 2000 3675 3680
14. B.A. Hug Analysis of mice containing a targeted deletion of β-globin Locus Control Region 5′ Hypersensitive site 3 Mol. Cell. Biol. 16 1996 2906 2912
15. C.L. Jahn DNA sequence organization of the beta-globin complex in the BALB/c mouse Cell 21 1980 159 168
16. J.S. Lee, C.H. Lee, and J.H. Chung The β-globin promoter is important for recruitment of erythroid Kruppel-like factor to the locus control region in erythroid cells Proc. Natl. Acad. Sci. U. S. A. 96 1999 10051 10055
17. M.G. Marini The distal beta-globin CACCC box is required for maximal stimulation of the beta-globin gene by EKLF Br. J. Haematol. 127 2004 114 117
18. T. McMorrow Activation of the beta globin locus by transcription factors and chromatin modifiers EMBO J. 19 2000 4986 4996
19. I.J. Miller, and I.J. Bieker A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear protein Mol. Cell. Biol. 13 1993 2776 2786
20. E. Milot Heterochromatic effects on the frequency and duration of LCR-mediated gene transcription Cell 87 1996 105 114
21. P. Moi A novel silent beta-thalassemia mutation in the distal CACCC box affects the binding and responsiveness to EKLF Br. J. Haematol. 126 2004 881 884
22. B. Nuez, D. Michalovich, A. Byagrave, R. Ploemacher, and F. Grosveld Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene Nature 25 1995 316 318
23. A.C. Perkins, A.H. Scarpe, and S.H. Orkin Lethal beta-thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF Nature 375 1995 318 322
24. A.C. Perkins, K.R. Peterson, G. Stamatoyannopoulos, H.E. Witowska, and S.H. Orkin Fetal expression of a human A gamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos Blood 95 2000 1827 1833
25. D. Poddie, M.F. Marongiu, S. Cigliuti Ferrari, S. Porcu, and M.S. Ristaldi Delta globin gene structure and expression in K562 cell line Hemoglobin 27 2003 219 228
26. M.S. Ristaldi The C-T substitution in the distal CACCC box of the beta-globin gene promoter is a common cause of silent beta thalassemia in the Italian population Br. J. Haematol. 74 1990 480 486
27. M.S. Ristaldi The role of the -50 region of the human gamma-globin gene switching EMBO J. 20 2001 5242 5249
28. C.M. Southwood, K.M. Downs, and J.J. Bieker Erythroid Kruppel-like factor exhibits a nearly and sequentially localized pattern of expression during mammalian ontogeny Dev. Dyn. 206 1996 248 259
29. R. Tewari Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5′HS3 of the β-globin locus control region EMBO J. 17 1998 2334 2341
30. B. Tolhuis, R.J. Palstra, E. Splinter, F. Grosveld, and W. De Laat Looping and interaction between hypersensitive sites in the active beta-globin locus Mol. Cell 10 2002 1453 1465
31. T. Trimborn, J. Gribnau, F. Grosveld, and P. Fraser Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci Genes Dev. 13 1999 112 124
32. R. Vestri, E. Pieragostini, and M.S. Ristaldi Expression gradient in sheep alpha alpha and alpha alpha alpha globin gene haplotypes: mRNA levels Blood 83 1994 2317 2322
33. C.J. Wawrzyniak, S.E. Lewis, and R.A. Popp Differential expression of murine adult hemoglobins in early ontogeny G. Stamatoyannopoulos A.W. Nienhuis Experimental Approaches for the Study of Hemoglobin Switching 1985 Alan R Liss INC. New York 421 431
34. J.B. Whitney III Differential control of the synthesis of two hemoglobin beta chains in normal mice Cell 12 1977 863 871
35. M. Wijgerde, F. Grosveld, and P. Fraser Transcription complex stability and chromatin dynamics in vivo Nature 377 1995 209 213
36. M. Wijgerde The role of EKLF in human beta-globin gene competition Genes Dev. 10 1996 2894 2902
37. W. Zhang, S. Kadam, B.M. Emerson, and J.J. Bieker Site-specific acetylation by p300 or CREB binding protein regulates erythroid Kruppel-like factor transcriptional activity via its interaction with the SWI-SNF complex Mol. Cell. Biol. 21 2001 2413 2422