Deletions within the mouse β-globin locus control region preferentially reduce β(min) globin gene expression

Genomics

Volumn 63, Issue 3, 2000, Pages 417-424

  Alami, Raouf ^a   Bender, M A ^b,c   Feng, Yong Qing ^a   Fiering, Steven N ^d   Hug, Bruce A ^e   Ley, Timothy J ^e   Groudine, Mark ^b,c   Bouhassira, Eric E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN;

ARTICLE; CONTROLLED STUDY; GENE CLUSTER; GENE CONTROL; GENE DELETION; GENE EXPRESSION SYSTEM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; RETICULOCYTE;

RODENTIA;

EID: 0034144045     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1999.6104     Document Type: Article

References (45)

1. Alter B. P. Fetal erythropoiesis in stress hematopoiesis. Exp. Hematol. 7:1979;200-209.
2. Alter B. P., Goff S. C. A murine model for the switch from fetal to adult hemoglobin during ontogeny. Blood. 56:1980;1100-1105.
3. Alter B. P., Wagner C. K. A murine model for hemoglobin regulation: Hydroxyurea increases mouse minor hemoglobin in vivo. Prog. Clin. Biol. Res. 251:1987;479-485.
4. Alter B. P., Wagner C. K., Susser L. S., Weinberg R. S. Modulation of mouse hemoglobin expression by hydroxyurea and erythropoietin in vivo. Prog. Clin. Biol. Res. 316B:1989;317-325.
5. Bender M. A., Reik A., Close J., Telling A., Epner E., Fiering S., Hardison R., Groudine M. Description and targeted deletion of 5′ hypersensitive site 5 and 6 of the mouse beta-globin locus control region. Blood. 92:1998;4394-4403.
6. Bouhassira E. E., Kielman M. F., Gilman J. G., Fabry M. F., Suzuka S., Leone O., Gikas E., Bernini L. F., Nagel R. L. Properties of the mouse alpha-globin HS-26: Relationship to HS-40, the major enhancer of human alpha-globin gene expression. Am. J. Hematol. 54:1997;30-39.
7. Bresnick E. H., Felsenfeld G. Dual promoter activation by the human beta-globin locus control region. Proc. Natl. Acad. Sci. USA. 91:1994;1314-1317.
8. Bungert J., Tanimoto K., Patel S., Liu Q., Fear M., Engel J. D. Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription. Mol. Cell. Biol. 19:1999;3062-3072.
9. Clegg J. B., Naughton M. A., Weatherball D. J. Abnormal human haemoglobins. Separation and characterization of the alpha and beta chains by chromatography, and the determination of two new variants, hb Chesapeake and hb J (Bangkok). J. Mol. Biol. 19:1966;91-108.
10. Dillon N., Trimborn T., Strouboulis J., Fraser P., Grosveld F. The effect of distance on long-range chromatin interactions. Mol. Cell. 1:1997;131-139.
11. Driscoll M. C., Dobkin C. S., Alter B. P. Gamma delta beta-thalassemia due to a de novo mutation deleting the 5′ beta-globin gene activation-region hypersensitive sites. Proc. Natl. Acad. Sci. USA. 86:1989;7470-7474.
12. Epner E., Reik A., Cimbora D., Telling A., Bender M. A., Fiering S., Enver T., Martin D. I., Kennedy M., Keller G., Groudine M. The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus. Mol. Cell. 2:1998;447-455.
13. Fabry M. E., Nagel R. L., Pachnis A., Suzuka S. M., Costantini F. High expression of human beta S- and alpha-globins in transgenic mice: Hemoglobin composition and hematological consequences. Proc. Natl. Acad. Sci. USA. 89:1992;12150-12154.
14. Fiering S., Epner E., Robinson K., Zhuang Y., Telling A., Hu M., Martin D. I. K., Enver T., Ley T. T., Groudine M. Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev. 9:1995;2203-2213.
15. Forget B. G., Pearson H. A. Hemoglobin synthesis and the thalassemias. Handin R. I., Lux S. E., Stoye J. P. Blood Principles and Practice of Hematology. 1995;1525-1590 Lippincott, Philadelphia.
16. Forrester W. C., Epner E., Driscoll M. C., Enver T., Brice M., Papayannopoulou T., Groudine M. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus. Genes Dev. 4:1990;1637-1649.
17. Fraser P., Grosveld F. Locus control regions, chromatin activation and transcription. Curr. Opin. Cell Biol. 10:1998;361-365.
18. Gilman J. G. Rodent hemoglobin structure: A comparison of several species of mice. Ann. N. Y. Acad. Sci. 241:1974;416-433.
19. Gribnau J., Deboer E., Trimborn T., Wijgerde M., Milot E., Grosveld F., Fraser P. Chromatin interaction mechanism of transcriptional control in vivo. EMBO J. 17:1998;6020-6027.
20. Groudine M., Forrester W. C., Novak U., Epner E. Replication and activation of the human beta-globin gene domain. Prog. Clin. Biol. Res. 316A:1989;15-35.
21. Hanscombe O., Whyatt D., Fraser P., Yannoutsos N., Greaves D., Dillon N., Grosveld F. Importance of globin gene order for correct developmental expression. Genes Dev. 5:1991;1387-1394.
22. Hug B. A., Moon A. M., Ley T. J. Structure and function of the murine beta-globin locus control region 5′ HS-3. Nucleic Acids Res. 20:1992;5771-5778.
23. Hug B. A., Wesselschmidt R. L., Fiering S., Bender M. A., Epner E., Groudine M., Ley T. J. Analysis of mice containing a targeted deletion of beta-globin locus control region 5′ hypersensitive site 3. Mol. Cell. Biol. 16:1996;2906-2912.
24. Hughes T. A., Pombo A., McManus J., Hozak P., Jackson D. A., Cook P. R. On the structure of replication and transcription factories. J. Cell. Sci. 1995;59-65.
25. Iborra F. J., Pombo A., Jackson D. A., Cook P. R. Active RNA polymerases are localized within discrete transcription 'factories' in human nuclei. J. Cell. Sci. 109:1996a;1427-1436.
26. Iborra F. J., Pombo A., McManus J., Jackson D. A., Cook P. R. The topology of transcription by immobilized polymerases. Exp. Cell Res. 229:1996b;167-173.
27. Lyon M. F., Barker J. E., Popp R. A. Mouse globin gene nomenclature. J. Hered. 79:1988;93-95.
28. Martin D. I. K., Fiering S., Groudine M. Regulation of beta-globin gene expression: Straightening out the locus. Curr. Opin. Genet. Dev. 6:1996;488-495.
29. Mirkovitch J., Mirault M. E., Laemmli U. K. Organization of the higher-order chromatin loop: Specific DNA attachment sites on nuclear scaffold. Cell. 39:1984;223-232.
30. Moon A. M., Ley T. J. Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions. Proc. Natl. Acad. Sci. USA. 87:1990;7693-7697.
31. Nienhuis A. W., Falwey A. K., Anderson F. W. Preparation of globin messenger RNA. Methods Enzymol. 30:1974;621.
32. Pappas S., Cauchi M. N. Factors affecting hemoglobin synthesis in the mouse. Exp. Hematol. 10:1982;761-767.
33. Peterson K. R., Navas P. A., Stamatoyannopoulos G. beta-YAC transgenic mice for studying LCR function. Ann N. Y. Acad. Sci. 850:1998;28-37.
34. Peterson K. R., Zitnik G., Huxley C., Lowrey C. H., Gnirke A., Leppig K. A., Papayannopoulou T., Stamatoyannopoulos G. Use of yeast artificial chromosomes (YACs) for studying control of gene expression: Correct regulation of the genes of a human beta-globin locus YAC following transfer to mouse erythroleukemia cell lines. Proc. Natl. Acad. Sci. USA. 90:1993;11207-11211.
35. Ranney H. M., Gluckson-Waelsh S. Filter paper electrophoresis of mouse hemoglobin: Preliminary note. Ann. Hum. Genet. 19:1955;269-272.
36. Reik A., Telling A., Zitnik G., Cimbora D., Epner E., Groudine M. The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells. Mol. Cell. Biol. 18:1998;5992-6000.
37. Russell E. S., McFarland E. C. Genetics of mouse hemoglobins. Ann. N. Y. Acad. Sci. 241:1974;25-38.
38. Shehee W. R., Oliver P., Smithies O. Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. Proc. Natl. Acad. Sci. USA. 90:1993;3177-3181.
39. Travers A. Chromatin modification by DNA tracking. Proc. Natl. Acad. Sci. USA. 96:1999;13634-13637.
40. Trimborn T., Gribnau J., Grosveld F., Fraser P. Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Genes Dev. 13:1999;112-124.
41. Tuan D., Kong S., Hu K. Transcription of the hypersensitive site HS2 enhancer in erythroid cells. Proc. Natl. Acad. Sci. USA. 89:1992;11219-11223.
42. Weintraub H., Groudine M. Chromosomal subunits in active genes have an altered conformation. Science. 193:1976;848-856.
43. Whitelaw E., Lamb P., Hogben P., Proudfoot N. J. The globin switch at the level of mRNA in the developing mouse. Prog. Clin. Biol. Res. 316A:1989;323-333.
44. Whitney J. B. Differential control of the synthesis of two hemoglobin beta chains in normal mice. Cell. 12:1977;863-871.
45. Whitney J. B. Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine. Biochem. Genet. 16:1978;667-672.