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Volumn 20, Issue 3, 2005, Pages 165-171

DNA damage induced by a quinoxaline 1,4-di-Af-oxide derivative (hypoxic selective agent) in Caco-2 cells evaluated by the comet assay

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 3 [[(N,N DIMETHYLAMINO)PROPYL]AMINO] 2 QUINOXALINECARBONITRILE 1,4 DI N OXIDE HYDROCHLORIDE; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 19544376104     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/gei023     Document Type: Article
Times cited : (22)

References (46)
  • 1
    • 0034285733 scopus 로고    scopus 로고
    • The role of hypoxia-activated prodrugs in cancer therapy
    • Denny,W.A. (2000) The role of hypoxia-activated prodrugs in cancer therapy. Oncology, 1, 25-29.
    • (2000) Oncology , vol.1 , pp. 25-29
    • Denny, W.A.1
  • 2
    • 0035415493 scopus 로고    scopus 로고
    • Prodrug strategies in cancer therapy
    • Denny,W.A. (2001) Prodrug strategies in cancer therapy, Eur. J. Med. Chem., 36, 577-595.
    • (2001) Eur. J. Med. Chem. , vol.36 , pp. 577-595
    • Denny, W.A.1
  • 5
    • 0036910635 scopus 로고    scopus 로고
    • The hypoxic core: A possible answer to the cancer paradox
    • Guppy,M, (2002) The hypoxic core: a possible answer to the cancer paradox. Biochem. Biophys. Res. Commun., 299, 676-680.
    • (2002) Biochem. Biophys. Res. Commun. , vol.299 , pp. 676-680
    • Guppy, M.1
  • 6
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
    • Brown,J.M. and Giaccia,AJ. (1998) The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res., 58, 1408-1416.
    • (1998) Cancer Res. , vol.58 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 7
    • 0033405294 scopus 로고    scopus 로고
    • The hypoxic cell: A target for selective cancer therapy-eighteenth Bruce F.Cain memorial award lecture
    • Brown,J.M. (1999) The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F.Cain memorial award lecture, Cancer Res., 59, 5863-5870.
    • (1999) Cancer Res. , vol.59 , pp. 5863-5870
    • Brown, J.M.1
  • 8
    • 0034176782 scopus 로고    scopus 로고
    • Exploiting the hypoxic cancer cell: Mechanisms and therapeutic strategies
    • Brown,J.M. (2000) Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies. Mol. Med. Today, 6, 157-161.
    • (2000) Mol. Med. Today , vol.6 , pp. 157-161
    • Brown, J.M.1
  • 9
    • 16244365120 scopus 로고    scopus 로고
    • La radioterapia en relación con la hipoxia tumoral y la anemia
    • Villa,M.A. (2001) La radioterapia en relación con la hipoxia tumoral y la anemia. Radiobiología, 1, 7-8
    • (2001) Radiobiología , vol.1 , pp. 7-8
    • Villa, M.A.1
  • 11
  • 12
    • 0037480606 scopus 로고    scopus 로고
    • Hypoxie cervical cancers with low apoptotic index are highly aggressive
    • Hockel,M., Schlenger,K., Hockel,S. and Vaupel,P. (1999) Hypoxie cervical cancers with low apoptotic index are highly aggressive. Cancer Res., 59, 4525-4528.
    • (1999) Cancer Res. , vol.59 , pp. 4525-4528
    • Hockel, M.1    Schlenger, K.2    Hockel, S.3    Vaupel, P.4
  • 13
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel,M., Schlenger,K., Aral,B., Mitze,M., Schaffer,U. and Vaupel,P. (1996) Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res., 56, 4509-4515.
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 14
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark,M., Overgaard,M. and Overgaard,J. (1996) Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol., 41, 31-39.
    • (1996) Radiother. Oncol. , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 15
    • 0032708195 scopus 로고    scopus 로고
    • Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
    • Brizel,D.M., Dodge,R.K., Clough,R.W. and Dewhirst,M.W. (1999) Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome, Radiother. Oncol., 53, 113-117.
    • (1999) Radiother. Oncol. , vol.53 , pp. 113-117
    • Brizel, D.M.1    Dodge, R.K.2    Clough, R.W.3    Dewhirst, M.W.4
  • 16
    • 0031716020 scopus 로고    scopus 로고
    • Oxygenation predicts radiation response and survival in patients with cervix cancer
    • Fyles,A.W., Milosevic,M., Wong,R. et al. (1998) Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother. Oncol., 48, 149-156.
    • (1998) Radiother. Oncol. , vol.48 , pp. 149-156
    • Fyles, A.W.1    Milosevic, M.2    Wong, R.3
  • 18
    • 0034823234 scopus 로고    scopus 로고
    • Oxygenation of human tumors-implications for combined therapy
    • Feldmann,H.J. (2001) Oxygenation of human tumors-implications for combined therapy. Lung Cancer, Suppl. 1, S77-S83.
    • (2001) Lung Cancer , Issue.1 SUPPL.
    • Feldmann, H.J.1
  • 19
    • 0038293080 scopus 로고    scopus 로고
    • Prognostic significance of tumor oxygenation in humans
    • Evans,S.M. and Koch,C.J. (2003) Prognostic significance of tumor oxygenation in humans. Cancer Lett., 195, 1-16.
    • (2003) Cancer Lett. , vol.195 , pp. 1-16
    • Evans, S.M.1    Koch, C.J.2
  • 20
    • 0015451983 scopus 로고
    • Potential bioreductive alkylating agents. 1. Benzoquinone derivatives
    • Lin,A.J., Cosby,L.A., Shansky,C.W. and Sartorelli,A.C. (1972) Potential bioreductive alkylating agents. 1. Benzoquinone derivatives. J. Med. Chem., 15, 1247-1252.
    • (1972) J. Med. Chem. , vol.15 , pp. 1247-1252
    • Lin, A.J.1    Cosby, L.A.2    Shansky, C.W.3    Sartorelli, A.C.4
  • 21
    • 0031742631 scopus 로고    scopus 로고
    • Bioreductive therapies: An overview of drags and their mechanisms of action
    • Rauth,A.M., Melo,T. and Misra,V. (1998) Bioreductive therapies: an overview of drags and their mechanisms of action. Int. J. Radiat. Oncol., Biol. Phys., 42, 755-762.
    • (1998) Int. J. Radiat. Oncol., Biol. Phys. , vol.42 , pp. 755-762
    • Rauth, A.M.1    Melo, T.2    Misra, V.3
  • 22
    • 0026417645 scopus 로고
    • Therapeutic advantage of hypoxic cells in tumors: A theoretical study
    • Brown,J.M. and Koong,A.J. (1991) Therapeutic advantage of hypoxic cells in tumors: a theoretical study. J. Natl Cancer Inst., 83, 178-185.
    • (1991) J. Natl Cancer Inst. , vol.83 , pp. 178-185
    • Brown, J.M.1    Koong, A.J.2
  • 23
    • 0033063810 scopus 로고    scopus 로고
    • Cisplatin anti-tumor potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin
    • Kovacs,M.S., Hocking,D.J., Evans,J.W., Siim,B.G., Wouters,B.G. and Brown,J.M. (1999) Cisplatin anti-tumor potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin, Br. J. Cancer, 80, 1245-1251.
    • (1999) Br. J. Cancer , vol.80 , pp. 1245-1251
    • Kovacs, M.S.1    Hocking, D.J.2    Evans, J.W.3    Siim, B.G.4    Wouters, B.G.5    Brown, J.M.6
  • 25
    • 0030738399 scopus 로고    scopus 로고
    • Adaptation of human tumour cells to tirapazamine under aerobic conditions-implications of increased antioxidant enzyme activity to mechanism of aerobic toxicity
    • Elwell,J.H., Siim,B.G., Evans,J.W. and Brown,J.M, (1997) Adaptation of human tumour cells to tirapazamine under aerobic conditions-implications of increased antioxidant enzyme activity to mechanism of aerobic toxicity. Biochem. Pharmacol., 54, 249-257.
    • (1997) Biochem. Pharmacol. , vol.54 , pp. 249-257
    • Elwell, J.H.1    Siim, B.G.2    Evans, J.W.3    Brown, J.M.4
  • 26
    • 0026073332 scopus 로고
    • SR4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures
    • Biedermann,K.A., Wang,J., Graham,R.P. and Brown,J.M. (1991) SR4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures. Br. J. Cancer, 63, 358-362.
    • (1991) Br. J. Cancer , vol.63 , pp. 358-362
    • Biedermann, K.A.1    Wang, J.2    Graham, R.P.3    Brown, J.M.4
  • 27
    • 0030009223 scopus 로고    scopus 로고
    • Tirapazamine-induced DNA damage measured using the comet assay correlates with toxicity towards hypoxic tumour cells in vitro
    • Siim,B.G., van Zijl,P.L. and Brown,J.M. (1996) Tirapazamine-induced DNA damage measured using the comet assay correlates with toxicity towards hypoxic tumour cells in vitro. Br. J. Cancer, 73, 952-960.
    • (1996) Br. J. Cancer , vol.73 , pp. 952-960
    • Siim, B.G.1    Van Zijl, P.L.2    Brown, J.M.3
  • 28
    • 0037009278 scopus 로고    scopus 로고
    • Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4- benzotriazine 1,4-dioxide (tirapazamine)
    • Kotandeniya,D., Ganley,B. and Gates,K.S. (2002) Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine). Bioorg. Med. Chem. Lett., 12, 2325-2329.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 2325-2329
    • Kotandeniya, D.1    Ganley, B.2    Gates, K.S.3
  • 29
    • 0026802366 scopus 로고
    • Repair of DNA and chromosome breaks in cells exposed to SR-4233 under hypoxia or to ionizing radiation
    • Wang,J., Biedermann,K.A. and Brown,J.M. (1992) Repair of DNA and chromosome breaks in cells exposed to SR-4233 under hypoxia or to ionizing radiation. Cancer Res., 52, 4473-4477.
    • (1992) Cancer Res. , vol.52 , pp. 4473-4477
    • Wang, J.1    Biedermann, K.A.2    Brown, J.M.3
  • 30
    • 3643111389 scopus 로고    scopus 로고
    • Direct evidence for bimodal DNA damage induced by tirapazamine
    • Daniels,J.S. and Gates,K.S. (1998) Direct evidence for bimodal DNA damage induced by tirapazamine. Chem. Res. Toxicol., 11, 1254-1257.
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 1254-1257
    • Daniels, J.S.1    Gates, K.S.2
  • 32
    • 0028877272 scopus 로고
    • Hypoxia-selective agents derived from 2-quinoxalinecarbonitrile 1,4-di-N-oxides
    • Monge,A., Martinez-Crespo,F.J., López de Cerain,A. et al. (1995) Hypoxia-selective agents derived from 2-quinoxalinecarbonitrile 1,4-di-N-oxides, J. Med. Chem., 38, 4488-4494.
    • (1995) J. Med. Chem. , vol.38 , pp. 4488-4494
    • Monge, A.1    Martinez-Crespo, F.J.2    López De Cerain, A.3
  • 34
    • 0015503670 scopus 로고
    • Antibacterial properties of quindoxin. New growth-promoting agent
    • Henessey,T.D. and Edwards,J.R. (1972) Antibacterial properties of quindoxin. New growth-promoting agent. Vet. Rec., 90, 187-191.
    • (1972) Vet. Rec. , vol.90 , pp. 187-191
    • Henessey, T.D.1    Edwards, J.R.2
  • 35
    • 0018086175 scopus 로고
    • Mode of action of quindoxin and substituted quinoxaline-di-N-oxides on Escherichia coli
    • Suter,W., Rosselet,A. and Knüsel,F. (1978) Mode of action of quindoxin and substituted quinoxaline-di-N-oxides on Escherichia coli. Antimicrob. Agents Chemother., 13, 770-783.
    • (1978) Antimicrob. Agents Chemother. , vol.13 , pp. 770-783
    • Suter, W.1    Rosselet, A.2    Knüsel, F.3
  • 36
    • 0018827966 scopus 로고
    • The mutagenic action of quindoxin, carbadox, olaquindox and some other N-oxides on bacteria and yeast
    • Voogd,C.E., Van der Stel,J.J. and Jacobs,J.J. (1980) The mutagenic action of quindoxin, carbadox, olaquindox and some other N-oxides on bacteria and yeast. Mutat. Res., 78, 233-242.
    • (1980) Mutat. Res. , vol.78 , pp. 233-242
    • Voogd, C.E.1    Van Der Stel, J.J.2    Jacobs, J.J.3
  • 37
    • 0024563459 scopus 로고
    • Genotoxicity of quinoxaline 1,4-dioxide derivatives in Escherichia coli and Salmonella typhimurium
    • Nunoshiba,T. and Nishioka,H. (1989) Genotoxicity of quinoxaline 1,4-dioxide derivatives in Escherichia coli and Salmonella typhimurium. Mutat. Res., 217, 203-209.
    • (1989) Mutat. Res. , vol.217 , pp. 203-209
    • Nunoshiba, T.1    Nishioka, H.2
  • 38
    • 0016773826 scopus 로고
    • Carcinogenic action of quinoxaline 1,4-dioxide in rats
    • Tucker, M.J. (1975) Carcinogenic action of quinoxaline 1,4-dioxide in rats. J. Natl Cancer Inst., 55, 137-146.
    • (1975) J. Natl Cancer Inst. , vol.55 , pp. 137-146
    • Tucker, M.J.1
  • 39
    • 0034830902 scopus 로고    scopus 로고
    • Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxides
    • Ganley,B., Chowdhury,G., Bhansali,J., Daniels,J.S. and Gates,K.S. (2001) Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1,4-di-N-oxides. Bioorg. Med. Chem., 9, 2395-2401.
    • (2001) Bioorg. Med. Chem. , vol.9 , pp. 2395-2401
    • Ganley, B.1    Chowdhury, G.2    Bhansali, J.3    Daniels, J.S.4    Gates, K.S.5
  • 40
    • 0030794153 scopus 로고    scopus 로고
    • Physicochemical properties and stability of the new hypoxia-selective agent 7-chloro-3-[[(N,N,-dimethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydrochloride
    • Zamalloa,E., Aldana,I., Bachiller,C.M. and Monge,A. (1997) Physicochemical properties and stability of the new hypoxia-selective agent 7-chloro-3-[[(N,N,-dimethylamino)propyl]amino]-2-quinoxalinecarbonitrile 1,4-di-N-oxide hydrochloride. Arzneim. Forsch./Drug Res., 47, 873-878.
    • (1997) Arzneim. Forsch./Drug Res. , vol.47 , pp. 873-878
    • Zamalloa, E.1    Aldana, I.2    Bachiller, C.M.3    Monge, A.4
  • 41
    • 84988130977 scopus 로고
    • Experimental studies upon lymphocytes: I. The reactions of lymphocytes under various experimental conditions
    • Pappenheimer,A.M. (1917) Experimental studies upon lymphocytes: I. The reactions of lymphocytes under various experimental conditions, J. Exp. Med., 25, 633-650.
    • (1917) J. Exp. Med. , vol.25 , pp. 633-650
    • Pappenheimer, A.M.1
  • 42
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh,N.P., McCoy,M.T., Tice,R.R. and Schneider,E.L. (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res., 175, 184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 44
    • 0024358607 scopus 로고
    • Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation
    • Frankenberg-Schwager,M, (1989) Review of repair kinetics for DNA damage induced in eukaryotic cells in vitro by ionizing radiation. Radiother. Oncol., 14, 307-320.
    • (1989) Radiother. Oncol. , vol.14 , pp. 307-320
    • Frankenberg-Schwager, M.1
  • 45
    • 0028833163 scopus 로고
    • The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells
    • Collins,A.R., Al-guo,M. and Duthie,S.J. (1995) The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells. Mutat. Res., 336, 69-77.
    • (1995) Mutat. Res. , vol.336 , pp. 69-77
    • Collins, A.R.1    Al-Guo, M.2    Duthie, S.J.3
  • 46
    • 0000711137 scopus 로고
    • A comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay
    • Kobayashi,H., Sugiyama,C., Morikawa,Y., Hayashi,M. and Sofuni,T. (1995) A comparison between manual microscopic analysis and computerized image analysis in the single cell gel electrophoresis assay. MMS Commun., 3, 103-115.
    • (1995) MMS Commun. , vol.3 , pp. 103-115
    • Kobayashi, H.1    Sugiyama, C.2    Morikawa, Y.3    Hayashi, M.4    Sofuni, T.5


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