Allogeneic Stem Cell-Derived "Repair Unit" Therapy and the Barriers to Clinical Deployment

Journal of the American Society of Nephrology

Volumn 15, Issue 5, 2004, Pages 1133-1139

  Strom, Terry B ^a   Field, Loren J ^b   Ruediger, Manfred ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Cardion AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE IMMUNOTHERAPY; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOTRANSPLANTATION; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; CADAVER DONOR; GRAFT REJECTION; HEALTH CARE NEED; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; HUMAN; IMMUNOGENICITY; IMMUNOREACTIVITY; IMMUNOREGULATION; KIDNEY TRANSPLANTATION; LIVING DONOR; MEDICAL ETHICS; PATIENT CARE; PLURIPOTENT STEM CELL; PRACTICE GUIDELINE; PRIORITY JOURNAL; REVIEW; STEM CELL TRANSPLANTATION; TREATMENT CONTRAINDICATION; TREATMENT INDICATION;

EID: 1942538568     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000119682.89273.02     Document Type: Review

References (29)

1. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM: Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147, 1998
2. Amit M, Carpenter MK, Inokuma MS, Chiu CP, Harris CP, Waknitz MA, Itskovitz-Eldor J, Thomson JA: Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev Biol 27: 271-278, 2000
3. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41-49, 2002
4. Lagasse E, Shizuru JA, Uchida N, Taukamoto A, Weissman IL: Toward regenerative medicine. Immunity 14: 425-236, 2001
5. Weissman IL: Stem cells-Scientific, medical and political issues. N Engl J Med 346: 1576-1579, 2002
6. Wurmser AE, Gage FH: Cell fusion causes confusion. Nature 416: 485-547, 2002
7. Solter D, Gearhart J: Putting stem cells to work. Science 283: 1468-1470, 1999
8. Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R: Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292: 1389-1394, 2001
9. Klug MD, Soonpaa MH, Koh GY, Field LJ: Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 98: 216-224, 1996
10. Reinlib L, Field LJ: Cell transplantation as future therapy for cardiovascular disease: A workshop of the National Heart, Lung, and Blood Institute. Circulation 101: E182-187, 2000
11. Minamino T, Yujiri T, Papst PJ, Chan ED, Johnson GL, Terada N: MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. Proc Natl Acad Sci U S A 96: 15127-15132, 1999
12. Li M, Pevny L, Lovell-Badge R: Generation of purified neural precursors from embryonic stem cells by lineage selection. Current Biol 8: 971-974, 1998
13. Soria B, Roche E, Bema G, Leon-Quinto T, Reig JA, Martin F: Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 40: 157, 2000
14. Wells AD, Li XC, Li Y, Walsh MC, Zheng XX, Wu Z, Nunez G, Tang A, Sayegh M, Hancock WW, Strom TB, Turka LA: Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 5: 1303-1307, 1999
15. Li Y, Li XC, Zheng XX: Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and inudction of peripheral allograft tolerance. Nat Med 5: 1298, 1999
16. Li XC, Strom TB, Turka LA, Wells AD: T cell death and transplantation tolerance. Immunity 14: 407-416, 2001
17. Li XC, Zand MS, Li Y, Zheng XX, Strom TB: On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. J Immunol 161: 2241-2247, 1998
18. Lakkis FG: Role of cytokines in transplantation tolerance: Lessons learned from gene-knockout mice. J Am Soc Nephrol 9: 2361-2367, 1998
19. Dai Z, Konieczny BT, Baddoura FK, Lakkis FG: Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice. J Immunol 161: 1659-1663, 1998
20. Konieczny BT, Dai Z, Elwood ET, Saleem S, Linsley PS, Baddoura FK, Larsen CP, Pearson TC, Lakkis FG: IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways. J Immunol 160: 2059-2064, 1998
21. Bradley JA, Bolton EM, Pedersen RA: Stem cell medicine encounters the immune system. Nat Rev Immunol 2: 859-871, 2002
22. Kim YS, Maslinski W, Zheng XX, Stevens AC, Li XC, Tesch GH, Kelley VR, Strom TB: Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity. J Immunol 160: 5742-5748, 1998
23. Ferrari-Lacraz S, Zheng XX, Kim YS, Li Y, Maslinski W, Li XC, Strom TB: An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection. J Immunol 167: 3478-3485, 2001
24. Chae DW, Nosaka Y, Strom TB, Maslinski W: Distribution of IL-15 receptor alpha-chains on human peripheral blood mononuclear cells and effect of immunosuppressive drugs on receptor expression. J Immunol 157: 2813-2819, 1996
25. + T cells. Nat Immunol 1: 107-111, 2000
26. Waldmann TA, Dubois S, Tagaya Y: Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy. Immunity 14: 105-110, 2001
27. Li XC, Demirci G, Ferrari-Lacraz S, Groves C, Coyle A, Malek TR, Strom TB: IL-15 and IL-2: A matter of life and death for T cells in vivo. Nat Med 7: 114-118, 2001
28. Zheng XX, Sanchez-Fueyo A, Sho M, Domenig C, Sayegh MH, Strom TB: Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 19: 503-514, 2003
29. Hochedlinger K, Jaenisch R: Nuclear transplantation, embryonic stem cells and the potential for cell therapy. N Engl J Med 349: 275-286, 2003