Blood-brain barrier transport of morphine in patients with severe brain trauma

British Journal of Clinical Pharmacology

Volumn 57, Issue 4, 2004, Pages 427-435

  Ederoth, Per ^a   Tunblad, Karin ^b   Bouw, René ^b   Lundberg, C Johan F ^a   Ungerstedt, Urban ^c   Nordström, Carl Henrik ^a   Hammarlund Udenaes, Margareta ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Blood brain barrier; Brain injury; Human; Microdialysis; Morphine; Pharmacokinetics

Indexed keywords

MORPHINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INJURY; BRAIN TISSUE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG MONITORING; DRUG PENETRATION; DRUG PROTEIN BINDING; EFFUSION; FEMALE; HUMAN; MALE; MICRODIALYSIS; PRIORITY JOURNAL; SUBCUTANEOUS FAT;

ADULT; ANALGESICS, OPIOID; AREA UNDER CURVE; BLOOD-BRAIN BARRIER; BRAIN INJURIES; FEMALE; HALF-LIFE; HUMANS; MALE; MIDDLE AGED; MORPHINE;

EID: 1942519818     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.2003.02032.x     Document Type: Article

References (25)

1. Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 1999; 39: 361-98.
2. Taylor JC, Horvath AR, Higgins CF, Begley GS. The multidrug resistance P-glycoprotein. Oligomeric state and intramolecular interactions. J Biol Chem 2001; 276: 36075-8.
3. Xie R, Hammarlund-Udenaes M, de Boer AG, de Lange EC. The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice. Br J Pharmacol 1999; 128: 563-8.
4. King M, Su W, Chang A, Zuckerman A, Pasternak GW. Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs. Nat Neurosci 2001; 4: 268-74.
5. Tunblad K, Jonsson EN, Hammralund-Udenaes M. Morphine blood-brain barrier transport is influenced by probenecid co-administration. Pharm Res 2003; 20: 618-23.
6. Letrent SP, Pollack GM, Brouwer KR, Brouwer KL. Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat. Drug Metab Dispos 1999; 27: 827-34.
7. Sisodiya SM, Lin WR, Harding BN, Squier MV, Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 2002; 125: 22-31.
8. Sadeque AJ, Wandel C, He H, Shah S, Wood AJ. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther 2000; 68: 231-7.
9. Ståhl N, Mellergård P, Hallström A, Ungerstedt U, Nordström CH. Intracerebral microdialysis and bedside biochemical analysis in patients with fatal traumatic brain lesions. Acta Anaesthesiol Scand 2001; 45: 977-85.
10. Stahl N, Ungerstedt U, Nordström CH. Brain energy metabolism during controlled reduction of cerebral perfusion pressure in severe head injuries. Intensive Care Med 2001; 27: 1215-23.
11. Eker C, Asgeirsson B, Grande PO, Schalen W, Nordstrom CH. Improved outcome after severe head injury with a new therapy based on principles for brain volume regulation and preserved microcirculation. Crit Care Med 1998; 26: 1881-6.
12. Bouw MR, Hammarlund-Udenaes M. Methodological aspects of the use of a calibrator in in vivo microdialysis -further development of the retrodialysis method. Pharm Res 1998; 15: 1673-9.
13. Joel SP, Osborne RJ, Slevin ML. An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites. J Chromatogr 1988; 430: 394-9.
14. Hillered L, Valtysson J, Enblad P, Persson L. Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain. J Neurol Neurosurg Psychiatry 1998; 64: 486-91.
15. Reinstrup P, Ståhl N, Mellergård P, Uski T, Ungerstedt U, Nordström CH. Intracerebral microdialysis in clinical practice: baseline values for chemical markers during wakefulness, anesthesia, and neurosurgery. Neurosurgery 2000; 47: 701-9 discussion 709.
16. Ungerstedt U, Bäckström T, Hallström Å, Grände PO, Mellergård P, Nordström CH. Microdialysis in normal and injured brain. In Physiology, Stress and Malnutrition: Functional Correlates, Nutritional Intervention, eds Kinney JM, Tucker HN. Philadelphia: Lippincott-Raven, 1997, 361-74.
17. Stain-Texier F, Boschi G, Sandouk P, Scherrmann JM. Elevated concentrations of morphine 6-beta-D-glucuronide in brain extracellular fluid despite low blood-brain barrier permeability. Br J Pharmacol 1999; 128: 917-24.
18. Bouw MR, Gårdmark M, Hammarlund-Udenaes M. Pharmacokinetic- pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats - a microdialysis study. Pharm Res 2000; 17: 1220-7.
19. Wandel C, Kim R, Wood M, Wood A. Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein. Anesthesiology 2002; 96: 913-20.
20. Bungay PM, Morrison PF, Dedrick RL. Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro. Life Sci 1990; 46: 105-19.
21. Chen KC, Hoistad M, Kehr J, Fuxe K, Nicholson C. Theory relating in vitro and in vivo microdialysis with one or two probes. J Neurochem 2002; 81: 108-21.
22. Osborne R, Joel S, Trew D, Slevin M. Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin Pharmacol Ther 1990; 47: 12-19.
23. Stoelting RK. Opioid agonists and antagonists. In Pharmacology and Physiology in Anesthetic Practice, ed Stoelting RK. Philadelphia: Lippincott-Raven, 1999, 77-113.
24. Bonica JJ, Teitz CC. Pain due to musculoskeletal injuries. In The Management of Pain, 2nd edn, ed Bonica JJ. London: Lea & Febiger, 1990, 368-87.
25. van den Nieuwenhuyzen MC, Engbers FH, Vuyk J, Burm AG. Target-controlled infusion systems: role in anaesthesia and analgesia. Clin Pharmacokinet 2000; 38: 181-90.