Improved outcome after severe head injury with a new therapy based on principles for brain volume regulation and preserved microcirculation

Critical Care Medicine

Volumn 26, Issue 11, 1998, Pages 1881-1886

  Eker, Christer ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Blood brain barrier; Cerebral edema; Cerebral microcirculation; Cerebral perfusion pressure; Cerebral vasoconstriction; Head injury; Intracranial pressure; Outcome; 2 agonist; 1 antagonist

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; DIHYDROERGOTAMINE; METOPROLOL; THIOPENTAL; VASOCONSTRICTOR AGENT;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN METABOLISM; BRAIN MICROCIRCULATION; BRAIN WATER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; ENERGY METABOLISM; FLUID BALANCE; HEAD INJURY; HUMAN; HYDROSTATIC PRESSURE; INTRACRANIAL HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; ONCOTIC PRESSURE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0031734201     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199811000-00033     Document Type: Article

References (5)

1. Miller JD, Bccker DP, Ward JD, et al: Significance of intracranial hypertension in severe head injury. J Neurosurg 1977; 47:503-516
2. Marmarou A, Anderson RL, Ward JD, et al: Impact of ICP instability and hypotension on outcome in patients with severe head trauma. Report on The Traumatic Coma Bank Data. J Neurosurg 1991; 75(Suppl):59-66
3. Jennett B, Teasdale G, Galbraith S, et al: Severe head injuries in three countries. J Neural Neurosurg Psychiatry 1977; 40:291-298
4. Miller JD: Significance and management of intracranial hypertension in head injury. In: Intracranial Pressure V. Ishii S, Nagai H, Brock M (Eds.). Berlin, Heidelberg, Springer-Verlag, 1983, pp 44-53
5. Marshall LF, Gautille T, Klauger MR, et al: The outcome of severe closed head injury. J Neurosurg 1991; 75(Suppl):S28-S36