Xenotransplantation: Reappraising the risk of retroviral zoonosis

Current Opinion in Immunology

Volumn 12, Issue 5, 2000, Pages 504-507

  Takeuchi, Yasuhiro ^a   Weiss, Robin A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; EDITORIAL; HUMAN; MOLECULAR CLONING; NONHUMAN; RETROVIRUS; VIRUS INFECTION; VIRUS PATHOGENESIS; XENOGRAFT; XENOTRANSPLANTATION; ZOONOSIS;

EID: 0033812527     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00128-X     Document Type: Editorial

References (49)

1. Xenotransplantation: Scientific frontiers and public policy
2. Xenotransplantation
3. Baboon-to-human liver transplantation
4. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
5. Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: A pilot study in humans
6. The alpha-galactosyl epitope: A sugar coating that makes viruses and cells unpalatable
7. Sensitization of cells and retroviruses to human serum by (alpha 1-3) galactosyltransferase
8. Anti-Gal alpha1-3Gal antibody levels in organ transplant recipients receiving immunosuppressive therapy
9. Life supporting function for over one month of a transgenic porcine heart in a baboon
10. Liver allotransplantation after extracorporeal hepatic support with transgenic (hCD55/hCD59) porcine livers: Clinical results and lack of pig-to-human transmission of the porcine endogenous retrovirus
11. The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection
12. The fine cytokine line between graft acceptance and rejection
13. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease
14. Transplantation of embryonic porcine mesencephalic tissue in patients with PD
15. Porcine xenografts in Parkinson's disease and Huntington's disease patients: Preliminary results
16. Transplantation of porcine fetal pancreas to diabetic patients
17. Pig-to-human islet transplantation in eight patients
18. Treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation
19. AIDS as a zoonosis: Scientific and public health implications
20. New virus fingered in Malaysian epidemic
21. Outbreak of Nipah-virus infection among abattoir workers in Singapore
22. Transgenic pigs and virus adaptation
23. Genetic and experimental evidence for cross-species infection by swine hepatitis E virus
24. A novel virus in swine is closely related to the human hepatitis E virus
25. The nucleotide sequence of koala (Phascolarctos cinereus) retrovirus: A novel type C endogenous virus related to Gibbon ape leukemia virus
26. C-type virus particles in pig kidney cell lines
27. Evidence for retrovirus in miniature swine with radiation-induced leukemia or metaplasia
28. Infection of human cells by an endogenous retrovirus of pigs
29. Uncertainty in xenotransplantation: Individual benefit versus collective risk
30. Two sets of human-tropic pig retrovirus
31. Retrotransposons, endogenous retroviruses, and the evolution of retroelements
32. Construction of a swine BAC library: Application to the characterization and mapping of porcine type C endoviral elements
33. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells
34. Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells
35. Identification of a full-length cDNA for an endogenous retrovirus of miniature swine
36. Host range and interference studies of three classes of pig endogenous retrovirus
37. Extended analysis of the in vitro tropism of porcine endogenous retrovirus
38. Establishment and characterization of molecular clones of porcine endogenous retroviruses replicating on human cells
39. Infection of nonhuman primate cells by pig endogenous retrovirus
40. Development and validation of a Western immunoblot assay for detection of antibodies to porcine endogenous retrovirus
41. No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts
42. No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys
43. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue
44. No evidence for infection of human cells with porcine endogenous retrovirus (PERV) after exposure to porcine fetal neuronal cells
45. Porcine endogenous retroviruses inhibit human immune cell function: Risk for xenotransplantation?
46. Report of the Food and Drug Administration Subcommittee on Xenotransplantation: Meeting of 3 and 4 June, 1999, Center for Biologics Evaluation and Research
47. Last chance to stop and think on risks of xenotransplants