Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors

Transplantation

Volumn 67, Issue 7, 1999, Pages 972-977

  Sablinski, Tomasz ^a,b   Emery, David W ^b   Monroy, Rod ^c   Hawley, Robert J ^c   Xu, Yuanxin ^c   Gianello, Pierre ^b   Lorf, Thomas ^b   Kozlowski, Tomasz ^b   Bailin, Michael ^b   Cooper, David K C ^b   Cosimi, A Benedict ^b   Sachs, David H ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BioTransplant Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXYSPERGUALIN; CYCLOSPORIN; CYCLOSPORIN A; GROWTH FACTOR; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; METHYLCELLULOSE; RECOMBINANT INTERLEUKIN 3; RECOMBINANT STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; CHIMERA; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY TRANSPLANTATION; MALE; MIXED LYMPHOCYTE REACTION; MONKEY; NONHUMAN; PANCYTOPENIA; PRIMATE; PRIORITY JOURNAL; SWINE; WHOLE BODY RADIATION; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES; BONE MARROW TRANSPLANTATION; CHIMERA; GROWTH SUBSTANCES; LYMPHOCYTE CULTURE TEST, MIXED; MACACA FASCICULARIS; MALE; SPECIES SPECIFICITY; SWINE; SWINE, MINIATURE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033561172     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199904150-00007     Document Type: Article

References (32)

1. Sachs DH. The pig as a potential xenograft donor. Vet Immunol Immunopathol 1994; 43: 185.
2. Kirkman RL. Of swine and men: organ physiology in different species. In: Hardy MA, ed. Xenograft 25. Amsterdam: Excerpta Medica, 1989: 125.
3. Sachs DH, Sablinski T. Tolerance across discordant xenogeneic barriers. Xenotransplantation 1995; 2: 234.
4. Zinkernagel RM, Althage A, Callahan G, Welsh RM Jr. On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras. J Immunol 1980; 124: 2356.
5. Ildstad ST, Sachs DH. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 1984; 307: 168.
6. Sharabi Y, Sachs DH. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 1989; 169: 493.
7. Kawai T, Cosimi AB, Colvin RB, et al. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation 1995; 59: 256.
8. Sharabi Y, Asksentijevich I, Sundt TM III, Sachs DH, Sykes M. Specific tolerance induction across a xenogeneic barrier: production of mixed rat/mouse lymphohematopoietic chimeras using a nonlethal preparative regimen. J Exp Med 1990; 172: 195.
9. Lee LA, Gritsch HA, Sergio JJ, Arn JS, et al. Xenogeneic swine thymus grafts generate functional murine T cells that are tolerant of pig antigens. Proc Natl Acad Sci USA 1994; 91: 10864.
10. Gritsch HA, Glaser RM, Emery DW, et al. The importance of non-immune factors in reconstitution by discordant xenogeneic hematopoietic cells. Transplantation 1994; 57: 906.
11. Sachs DH. MHC homozygous miniature swine. In: Swindle MM, Moody DC, Philips LD, eds. Swine as models in biomedical research. Ames: Iowa State University Press, 1992: 3.
12. Sablinski T, Latinne D, Gianello P, et al. Xenotransplantation of pig kidneys to nonhuman primates. I. Development of the model. Xenotransplantation 1995; 2: 264.
13. Pennington LR, Sakamoto K, Popitz-Bergez FA, et al. Bone marrow transplantation in miniature swine. I. Development of the model. Transplantation 1988; 45: 21.
14. Hawley RJ, Abraham S, Akiyoshi DE, et al. Xenogeneic bone marrow transplantation. I. Cloning, expression, and species specificity of porcine IL-3 and granulocyte-macrophage colony stimulating factor. Xenotransplantation 1997; 4: 103.
15. Giovino MA, Hawley RJ, Dickerson MW, et al. Xenogeneic bone marrow transplantation. II. Porcine-specific growth factors enhance porcine bone marrow engraftment in an in vitro primate microenvironment. Xenotransplantation 1997; 4: 112.
16. Emery DW, Shafer GE, Karson EM, Sachs DH, LeGuern C. Retrovirus-mediated transfer and expression of an allogeneic major histocompatibility complex class II DRB cDNA in swine bone marrow cultures. Blood 1993; 81: 2460.
17. Emery DW, Sablinski T, Shimada H, et al. Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity. Transplantation 1997; 64: 1414.
18. Ramshaw HS, Rao SS, Crittenden RB, Peters SO, Weier HU, Quesenberry PJ. Engraftment of bone marrow cells into normal unprepared hosts: effects of 5-fluorouracil and cell cycle status. Blood 1995; 86: 294.
19. Sykes M, Szot GL, Swenson K, Pearson DA. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat Med 1997; 3: 783.
20. Norman JC, Brown ME, Saravis CA, Ackyroyd FW, McDermott WV. Perfusion techniques in temporary human-isolated ex vivo porcine liver cross circulation: possible adjunct in the treatment of hepatic failure. Surgery 1966; 6: 121.
21. Collins BH, Chari RS, Magee JC, et al. Mechanisms of injury in porcine livers perfused with blood of patients with fulminant hepatic failure. Transplantation 1994; 58: 1162.
22. Xu Y, Lorf T, Sablinski T, et al. Removal of anti-porcine natural antibodies from human and non-human primate plasma in vitro and in vivo by a Galα 1-3Gal β1-4 βGlc-X immunoaffinity column. Transplantation 1998; 65: 172.
23. Kozlowski T, Ierino FL, Fuchimoto Y, et al. Depletion of anti-Gal α1-3Gal antibody in baboons by specific αGal immunoaffinity columns. Xenotransplantation 1998; 5: 122.
24. Aksentijevich I, Sachs DH, Sykes M. Humoral tolerance in xenogeneic BMT recipients conditioned with a non-myeloablative regimen. Transplantation 1992; 53: 1108.
25. Takahashi K, Tanabe K, Ooba S, et al. Prophylactic use of a new immunosuppressive agent, deoxyspergualin, in patients with kidney transplantation from ABO-incompatible or preformed antibody-positive donors. Transplant Proc 1991; 23: 1078.
26. Leventhal JR, Flores HC, Gruber SA, et al. Evidence that 15-deoxyspergualin inhibits natural antibody production but fails to prevent hyperacute rejection in a discordant xenograft model. Transplantation 1992; 54: 26.
27. Foster PN, Trejdosiewicz LK. Impaired proliferative response of peripheral blood B cells from splenectomized subjects to phorbol ester and ionophore. Clin Exp Immunol 1992; 89: 369.
28. Alexandre GPJ, Squifflet JP, De Bruyere M, et al. Present experiences in a series of 26 ABO-incompatible living donor renal allografts. Transplant Proc 1987; 19: 4538.
29. Kamel-Reid S, Dick JE. Engraftment of immune-deficient mice with human hematopoietic stem cells. Science 1988; 242: 1706.
30. Fabre JW, Morris PJ. The effect of donor strain blood pretreatment on renal allograft rejection in rats. Transplantation 1972; 14: 634.
31. Alter BI, Bach FH. Cellular basis of the proliferative response of human T cells to mouse xenoantigens. J Exp Med 1990; 171: 333.
32. Yamada K, Sachs DH, DerSimonian H. The human anti-porcine xenogeneic T-cell response: evidence for allelic specificity of MLR and for both direct and indirect pathways of recognition. J Immunol 1995; 155: 5249.