The immunological barrier to xenotransplantation

Immunity

Volumn 14, Issue 4, 2001, Pages 437-446

  Cascalho, M ^a,b   Platt, J L ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN; THROMBIN;

GRAFT REJECTION; HISTOPATHOLOGY; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; THROMBOCYTE; XENOTRANSPLANTATION;

EID: 0035034212     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00124-8     Document Type: Review

References (64)

1. Al-Mohanna F., Collison K., Parhar R., Kwaasi A., Meyer B., Saleh S., Allen S., Al-Sedairy S., Stern D., Yacoub M. Activation of naive xenogeneic but not allogeneic endothelial cells by human naive neutrophils. a potential occult barrier to xenotransplantation Am. J. Pathol. 151:1997;111-120.
2. Alter B.J., Bach F.H. Cellular basis of the proliferative response of human T cells to mouse xenoantigens. J. Exp. Med. 191:1990;333-338.
3. Artrip J.H., Kwiatkowski P., Michler R.E., Wang S.F., Tugulea S., Ankersmit J., Chisholm L., McKenzie I.F., Sandrin M.S., Itescu S. Target cell susceptibility to lysis by human natural killer cells is augmented by alpha(1,3)-galactosyltransferase and reduced by alpha(1,2)-fucosyltransferase. J. Biol. Chem. 274:1999;10717-10722.
4. Atkinson J.P., Oglesby T.J., White D., Adams E.A., Liszewski M.K. Separation of self from non-self in the complement system. a role for membrane cofactor protein and decay accelerating factor Clin. Exp. Immunol. Suppl. 86:1991;27-30.
5. Auchincloss H. Jr., Sachs D.H. Xenogeneic transplantation. Annu. Rev. Immunol. 16:1998;433-470.
6. Bach F.H., Winkler H., Ferran C., Hancock W.W., Robson S.C. Delayed xenograft rejection. Immunol. Today. 17:1996;379-384.
7. Bach F.H., Ferran C., Hechenleitner P., Mark W., Koyamada N., Miyatake T., Winkler H., Badrichani A., Cardinas D., Hancock W.H. Accommodation of vascularized xenografts. expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment Nat. Med. 3:1997;196-204.
8. Benzaquen L.R., Nicholson-Weller A., Halperin J.A. Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells. J. Exp. Med. 179:1994;985-992.
9. Bracy J.L., Sachs D.H., Iacomini J. Inhibition of xenoreactive natural antibody production by retroviral gene therapy. Science. 281:1998;1845-1847.
10. Brauer R.B., Baldwin W.M. III, Daha M.R., Pruitt S.K., Sanfilippo F. Use of C6-deficient rats to evaluate the mechanism of hyperacute rejection of discordant cardiac xenografts. J. Immunol. 151:1993;7240-7248.
11. Bustos M., Platt J.L. Platelet-endothelial cell interactions in a xenograft model. Transplant. Proc. 29:1997;886.
12. Bustos M., Saadi S., Platt J.L. Platelet-mediated activation of endothelial cells. implications for the pathogenesis of transplant rejection Transplantation. in press:2001.
13. Cozzi E., Bhatti F., Schmoeckel M., Chavez G., Smith K.G., Zaidi A., Bradley J.R., Thiru S., Goddard M., Vial C.et al. Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts. Transplantation. 70:2000;15-21.
14. Diamond L.E., McCurry K.R., Oldham E.R., McClellan S.B., Martin M.J., Platt J.L., Logan J.S. Characterization of transgenic pigs expressing functionally active human CD59 on cardiac endothelium. Transplantation. 61:1996;1241-1249.
15. Dorling A., Lombardi G., Binns R., Lechler R.I. Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur. J. Immunol. 26:1996;1378-1387.
16. Fearon D.T., Locksley R.M. The instructive role of innate immunity in the acquired immune response. Science. 272:1996;50-54.
17. Galili U. Interaction of the natural anti-Gal antibody with α-galactosyl epitopes. a major obstacle for xenotransplantation in humans Immunol. Today. 14:1993;480-482.
18. Galili U., Shohet S.B., Kobrin E., Stults C.L.M., Macher B.A. Man, apes, and old world monkeys differ from other mammals in the expression of α-Galactosyl epitopes on nucleated cells. J. Biol. Chem. 263:1988;17755-17762.
19. Geller R.L., Bach F.H., Turman M.A., Casali P., Platt J.L. Evidence that polyreactive antibodies are deposited in rejected discordant xenografts. Transplantation. 55:1993;168-172.
20. Good A.H., Cooper D.K.C., Malcolm A.J., Ippolito R.M., Koren E., Neethling F.A., Ye Y., Zuhdi N., Lamontagne L.R. Identification of carbohydrate structures that bind human antiporcine antibodies. implications for discordant xenografting in humans Transplant. Proc. 24:1992;559-562.
21. Gritsch H.A., Glaser R.M., Emery D.W., Lee L.A., Smith C.V., Sablinski T., Arn J.S., Sachs D.H., Sykes M. The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells. Transplantation. 57:1994;906-917.
22. Gunsalus J.R., Brady D.A., Coulter S.M., Gray B.M., Edge A. Reduction of serum cholesterol in watanabe rabbits by xenogeneic hepatocellular transplantation. Nat. Med. 3:1997;48-53.
23. Hancock W.W., Buelow R., Sayegh M.H., Turka L.A. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat. Med. 4:1998;1392-1396.
24. Holzknecht Z.E., Platt J.L. Identification of porcine endothelial cell membrane antigens recognized by human xenoreactive antibodies. J. Immunol. 154:1995;4565-4575.
25. Holzknecht Z.E., Platt J.L. The fine cytokine line between graft acceptance and rejection. Nat. Med. 6:2000;497-498.
26. Holzknecht Z.E., Coombes S., Blocher B.A., Plummer T.B., Bustos M., Lau C.L., Davis R.D., Platt J.L. Immune complex formation after xenotransplantation. evidence of type III as well as type II immune reactions provides clues to pathophysiology Am. J. Pathol. 158:2001;627-637.
27. Humphreys T., Reinherz E.L. Invertebrate immune recognition, natural immunity and the evolution of positive selection. Immunol. Today. 15:1994;316-320.
28. Ierino F.L., Kozlowski T., Siegel J.B., Shimizu A., Colvin R.B., Banerjee P.T., Cooper D.K., Cosimi A.B., Bach F.H., Sachs D.H.et al. Disseminated intravascular coagulation in association with the delayed rejection of pig-to-baboon renal xenografts. Transplantation. 66:1998;1439-1450.
29. Inverardi L., Samaja M., Motterlini R., Mangili F., Bender J.R., Pardi R. Early recognition of a discordant xenogeneic organ by human circulating lymphocytes. J. Immunol. 149:1992;1416-1423.
30. Inverardi L., Clissi B., Stolzer A.L., Bender J.R., Sandrin M.S., Pardi R. Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues. Transplantation. 63:1997;1318-1330.
31. Jurd K.M., Gibbs R.V., Hunt B.J. Activation of human prothrombin by porcine aortic endothelial cells - a potential barrier to pig to human xenotransplantation. Blood Coagul. Fibrinolysis. 7:1996;336-343.
32. Lawson J.H., Platt J.L. Molecular barriers to xenotransplantation. Transplantation. 62:1996;303-310.
33. Lin S.S., Weidner B.C., Byrne G.W., Diamond L.E., Lawson J.H., Hoopes C.W., Daniels L.J., Daggett C.W., Parker W., Harland R.C.et al. The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J. Clin. Invest. 101:1998;1745-1756. a.
34. Lin Y., Vandeputte M., Waer M. Accommodation and T-independent B cell tolerance in rats with long term surviving hamster heart xenografts. J. Immunol. 160:1998;369-375. b.
35. Lin Y., Soares M.P., Sato K., Takigami K., Csizmadia E., Smith N., Bach F.H. Accommodated xenografts survive in the presence of anti-donor antibodies and complement that precipitate rejection of naive xenografts. J. Immunol. 163:1999;2850-2857.
36. Lin S.S., Hanaway M.J., Gonzalez-Stawinski G.V., Lau C.L., Parker W., Davis R.D., Byrne G.W., Diamond L.E., Logan J.S., Platt J.L. The role of anti-Galα1-3Gal antibodies in acute vascular rejection of xenotransplants and accommodation of xenografts. Transplantation. 70:2000;1667-1674.
37. Lindahl K.F., Bach F.H. Genetic and cellular aspects of xenogeneic mixed leukocyte culture reaction. J. Exp. Med. 144:1976;305-318.
38. McCurry K.R., Kooyman D.L., Alvarado C.G., Cotterell A.H., Martin M.J., Logan J.S., Platt J.L. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat. Med. 1:1995;423-427.
39. Medzhitov R., Janeway C.A. Innate immunity. impact on the adaptive immune response Curr. Opin. Immunol. 9:1997;4-9.
40. Moses R.D., Winn H.J., Auchincloss H. Jr. Multiple defects in cell surface molecule interactions across species differences are responsible for diminished xenogeneic T cell responses. Transplantation. 53:1992;203-209.
41. Muller W.E., Blumbach B., Muller I.M. Evolution of the innate and adaptive immune systems. relationships between potential immune molecules in the lowest metazoan phylum (Porifera) and those in vertebrates Transplantation. 68:1999;1215-1227.
42. Murray A.G., Khodadoust M.M., Pober J.S., Bothwell A.L.M. Porcine aortic endothelial cells activate human T cells. direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28 Immunity. 1:1994;57-63.
43. Nagayasu T., Saadi S., Holzknecht R.A., Patte C.A., Plummer T.B., Platt J.L. Expression of tissue factor mRNA in cardiac xenografts. clues to the pathogenesis of acute vascular rejection Transplantation. 69:2000;475-482.
44. Ohdan H., Yang Y.-G., Shimizu A., Swenson K.G., Sykes M. Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Galα1,3Gal-mediated graft rejection. J. Clin. Invest. 104:1999;281-290.
45. Palmetshofer A., Galili U., Dalmasso A.P., Robson S.C., Bach F.H. Alpha-galactosyl epitope-mediated activation of porcine aortic endothelial cells. type I activation Transplantation. 65:1998;844.
46. Parker W., Saadi S., Lin S.S., Holzknecht Z.E., Bustos M., Platt J.L. Transplantation of discordant xenografts. a challenge revisited Immunol. Today. 17:1996;373-378.
47. Pierson R.N., Winn H.J., Russell P.S., Auchincloss H. Xenogeneic skin graft rejection is especially dependent on CD4+ T cells. J. Exp. Med. 170:1989;991-996.
48. Platt J.L. New directions for organ transplantation. Nature Suppl. 392:1998;11-17.
49. Platt J.L., Vercellotti G.M., Dalmasso A.P., Matas A.J., Bolman R.M., Najarian J.S., Bach F.H. Transplantation of discordant xenografts. a review of progress Immunol. Today. 11:1990;450-456.
50. Platt J.L., Lin S.S., McGregor C.G.A. Acute vascular rejection. Xenotransplantation. 5:1998;169-175.
51. Polejaeva I.A., Chen S., Vaught T.D., Page R.L., Mullins J., Ball S., Dai Y., Boone J., Walker S., Ayares D.L.et al. Cloned piglets produced by nuclear transfer from adult somatic cells. Nature. 407:2000;86-90.
52. Pratt J.R., Hibbs M.J., Laver A.J., Smith R.A.G., Sacks S.H. Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat. Am. J. Pathol. 149:1996;2055-2066.
53. Read M.A., Whitley M.Z., Williams A.J., Collins T. NF-kB and IkBα an inducible regulatory system in endothelial activation J. Exp. Med. 179:1994;503-512.
54. Rollins S.A., Kennedy S.P., Chodera A.J., Elliott E.A., Zavoico G.B., Matis L.A. Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2. Transplantation. 57:1994;1709-1716.
55. Saadi S., Platt J.L. Transient perturbation of endothelial integrity induced by antibodies and complement. J. Exp. Med. 181:1995;21-31.
56. Saadi S., Holzknecht R.A., Patte C.P., Stern D.M., Platt J.L. Complement-mediated regulation of tissue factor activity in endothelium. J. Exp. Med. 182:1995;1807-1814.
57. Saadi S., Holzknecht R.A., Patte C.P., Platt J.L. Endothelial cell activation by pore forming structures. pivotal role for IL-1α Circulation. 101:2000;1867-1873.
58. Sachs D.H., Sablinski T. Tolerance across discordant xenogeneic barriers. Xenotransplantation. 2:1995;234-239.
59. Sandrin M.S., Vaughan H.A., Dabkowski P.L., McKenzie I.F.C. Anti-pig IgM antibodies in human serum react predominantly with Galα(1,3)Gal epitopes. Proc. Natl. Acad. Sci. USA. 90:1993;11391-11395.
60. Sibley D.R., Lefkowitz R.J. Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. Nature. 317:1985;124-129.
61. Smyth M.J., Taniguchi M., Kawano T., Kelly J.M. Accessory function for NK1.1+ NK cells producing interferon-γ in xenospecific CTL differentiation. Transplantation. 68:1999;840-843.
62. Thall A.D., Malý P., Lowe J.B. Oocyte Galα1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse. J. Biol. Chem. 270:1995;21437-21440.
63. Yang Y.-G., deGoma E., Ohdan H., Bracy J.L., Xu Y., Iacomini J., Thall A.D., Sykes M. Tolerization of anti-Galα1-3Gal natural antibody-forming B cells by induction of mixed chimerism. J. Exp. Med. 187:1998;1335-1342.
64. Yuzawa Y., Brett J., Fukatsu A., Matsuo S., Caldwell P., Niesen N., Milgrom F., Godman G., Stern D., Andres G. Interaction of antibody with forssman antigen in guinea pigs. Am. J. Pathol. 146:1995;1260-1272.