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Volumn 174, Issue 11, 2005, Pages 7160-7171

Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and -resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: Evidence for mixed Th1- and Th2-like responses in visceral leishmaniasis

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMONY DERIVATIVE; DNA VACCINE; GAMMA INTERFERON; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; KINETOPLASTID MEMBRANE PROTEIN 11; MEMBRANE PROTEIN; NITROGEN OXIDE; PENTAVALENT ANTIMONY; STIBOGLUCONATE SODIUM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VIRUS VECTOR;

EID: 18944378937     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.11.7160     Document Type: Article
Times cited : (226)

References (80)
  • 1
    • 0019442454 scopus 로고
    • Cell-mediated immunity in American visceral leishmaniasis: Reversible immunosuppression during acute infection
    • Carvalho, E. M., R. S. Teixeira, and W. D. Johnson, Jr. 1981. Cell-mediated immunity in American visceral leishmaniasis: reversible immunosuppression during acute infection. Infect. Immun. 33: 498-502.
    • (1981) Infect. Immun. , vol.33 , pp. 498-502
    • Carvalho, E.M.1    Teixeira, R.S.2    Johnson Jr., W.D.3
  • 2
    • 0022369062 scopus 로고
    • Absence of γ interferon and interleukin 2 production during active visceral leishmaniasis
    • Carvalho, E. M., R. Badaro, S. G. Reed, T. C. Jones, and W. D. Johnson, Jr. 1985. Absence of γ interferon and interleukin 2 production during active visceral leishmaniasis. J. Clin. Invest. 76: 2066-2069.
    • (1985) J. Clin. Invest. , vol.76 , pp. 2066-2069
    • Carvalho, E.M.1    Badaro, R.2    Reed, S.G.3    Jones, T.C.4    Johnson Jr., W.D.5
  • 3
    • 0035151414 scopus 로고    scopus 로고
    • Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients: A comparative study
    • Pintado, V., P. Martín-Rabadán, M. L. Rivera, S. Moreno, and E. Bouza. 2001. Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients: a comparative study. Medicine (Baltimore) 80: 54-73.
    • (2001) Medicine (Baltimore) , vol.80 , pp. 54-73
    • Pintado, V.1    Martín-Rabadán, P.2    Rivera, M.L.3    Moreno, S.4    Bouza, E.5
  • 5
    • 0033801766 scopus 로고    scopus 로고
    • Identification of vaccine candidates for experimental visceral leishmaniasis by immunization with sequential fractions of a cDNA expression library
    • Melby, P. C., G. B. Ogden, H. A. Flores, W. Zhao, C. Geldmacher, N. M. Biediger, S. K. Ahuja, J. Uranga, and M. Melendez. 2000. Identification of vaccine candidates for experimental visceral leishmaniasis by immunization with sequential fractions of a cDNA expression library. Infect. Immun. 68: 5595-5602.
    • (2000) Infect. Immun. , vol.68 , pp. 5595-5602
    • Melby, P.C.1    Ogden, G.B.2    Flores, H.A.3    Zhao, W.4    Geldmacher, C.5    Biediger, N.M.6    Ahuja, S.K.7    Uranga, J.8    Melendez, M.9
  • 7
    • 0034913328 scopus 로고    scopus 로고
    • Clinical and experimental advances in treatment of visceral leishmaniasis
    • Murray, H. W. 2001. Clinical and experimental advances in treatment of visceral leishmaniasis. Antimicrob. Agents Chemother. 45: 2185-2197.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2185-2197
    • Murray, H.W.1
  • 8
    • 0034451615 scopus 로고    scopus 로고
    • Failure of pentavalent antimony in visceral leishmaniasis in India: Report from the center of the Indian epidemic
    • Sundar, S., D. K. More, M. K. Singh, V. P. Singh, S. Sharma, A. Makharia, P. C. Kumar, and H. W. Murray. 2000. Failure of pentavalent antimony in visceral leishmaniasis in India: report from the center of the Indian epidemic. Clin. Infect. Dis. 31: 1104-1107.
    • (2000) Clin. Infect. Dis. , vol.31 , pp. 1104-1107
    • Sundar, S.1    More, D.K.2    Singh, M.K.3    Singh, V.P.4    Sharma, S.5    Makharia, A.6    Kumar, P.C.7    Murray, H.W.8
  • 10
    • 0027304337 scopus 로고
    • Immunology of leishmaniasis
    • Liew, F. Y., and C. A. O'Donnell. 1993. Immunology of leishmaniasis. Adv. Parasitol. 32: 161-259.
    • (1993) Adv. Parasitol. , vol.32 , pp. 161-259
    • Liew, F.Y.1    O'Donnell, C.A.2
  • 11
    • 0035055496 scopus 로고    scopus 로고
    • Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis
    • Bottrel, R. L., W. O. Dutra, F. A. Martins, B. Gontijo, E. Carvalho, M. Barral-Netto, A. Barral, R. P. Almeida, W. Mayrink, R. Locksley, and K. J. Gollob. 2001. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect. Immun. 69: 3232-3239.
    • (2001) Infect. Immun. , vol.69 , pp. 3232-3239
    • Bottrel, R.L.1    Dutra, W.O.2    Martins, F.A.3    Gontijo, B.4    Carvalho, E.5    Barral-Netto, M.6    Barral, A.7    Almeida, R.P.8    Mayrink, W.9    Locksley, R.10    Gollob, K.J.11
  • 12
    • 0031948654 scopus 로고    scopus 로고
    • Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis
    • Melby, P. C., V. V. Tryon, B. Chandrasekar, and G. L. Freeman. 1998. Cloning of Syrian hamster (Mesocricetus auratus) cytokine cDNAs and analysis of cytokine mRNA expression in experimental visceral leishmaniasis. Infect. Immun. 66: 2135-2142.
    • (1998) Infect. Immun. , vol.66 , pp. 2135-2142
    • Melby, P.C.1    Tryon, V.V.2    Chandrasekar, B.3    Freeman, G.L.4
  • 13
    • 0028874164 scopus 로고
    • Cloning and structure-function analysis of the Leishmania donovani kinetoplastid membrane protein-11
    • Jardim, A., S. Hanson, B. Ullman, W. D. McCubbin, C. M. Kay, and R. W. Olafson. 1995. Cloning and structure-function analysis of the Leishmania donovani kinetoplastid membrane protein-11. Biochem. J. 305: 315-320.
    • (1995) Biochem. J. , vol.305 , pp. 315-320
    • Jardim, A.1    Hanson, S.2    Ullman, B.3    McCubbin, W.D.4    Kay, C.M.5    Olafson, R.W.6
  • 14
    • 0028854812 scopus 로고
    • Isolation and structural characterization of the Leishmania donovani kinetoplastid membrane protein-11, a major immunoreactive membrane glycoprotein
    • Jardim, A., V. Funk, R. M. Caprioli, and R. W. Olafson. 1995. Isolation and structural characterization of the Leishmania donovani kinetoplastid membrane protein-11, a major immunoreactive membrane glycoprotein. Biochem. J. 305: 307-313.
    • (1995) Biochem. J. , vol.305 , pp. 307-313
    • Jardim, A.1    Funk, V.2    Caprioli, R.M.3    Olafson, R.W.4
  • 15
    • 0032497818 scopus 로고    scopus 로고
    • The expression of the Leishmania infantum KMP-11 protein is developmentally regulated and stage specific
    • Berberich, C., G. Machado, G. Morales, G. Carrillo, A. Jimenez-Ruiz, and C. Alonso. 1998. The expression of the Leishmania infantum KMP-11 protein is developmentally regulated and stage specific. Biochim. Biophys. Acta 1442: 230-237.
    • (1998) Biochim. Biophys. Acta , vol.1442 , pp. 230-237
    • Berberich, C.1    Machado, G.2    Morales, G.3    Carrillo, G.4    Jimenez-Ruiz, A.5    Alonso, C.6
  • 16
    • 0345337262 scopus 로고    scopus 로고
    • Immunoprophylaxis and immunotherapy against experimental visceral leishmaniasis
    • Mukhopadhyay, S., P. Sen, S. Bhattacharyya, S. Majumdar, and S. Roy. 1999. Immunoprophylaxis and immunotherapy against experimental visceral leishmaniasis. Vaccine 17: 291-300.
    • (1999) Vaccine , vol.17 , pp. 291-300
    • Mukhopadhyay, S.1    Sen, P.2    Bhattacharyya, S.3    Majumdar, S.4    Roy, S.5
  • 17
    • 0028319021 scopus 로고
    • Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan- associated protein in cells from cured visceral leishmaniasis patients
    • Kurtzhals, J. A., A. S. Hey, A. Jardim, M. Kemp, K. U. Schaefer, E. O. Odera, C. B. Christensen, J. I. Githure, R. W. Olafson, T. G. Theander, et al. 1994. Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan- associated protein in cells from cured visceral leishmaniasis patients. Clin. Exp. Immunol. 96: 416-421.
    • (1994) Clin. Exp. Immunol. , vol.96 , pp. 416-421
    • Kurtzhals, J.A.1    Hey, A.S.2    Jardim, A.3    Kemp, M.4    Schaefer, K.U.5    Odera, E.O.6    Christensen, C.B.7    Githure, J.I.8    Olafson, R.W.9    Theander, T.G.10
  • 18
    • 0034739695 scopus 로고    scopus 로고
    • Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model
    • Requena, J. M., M. Soto, M. D. Doria, and C. Alonso. 2000. Immune and clinical parameters associated with Leishmania infantum infection in the golden hamster model. Vet. Immunol. Immunopathol 76: 269-281.
    • (2000) Vet. Immunol. Immunopathol. , vol.76 , pp. 269-281
    • Requena, J.M.1    Soto, M.2    Doria, M.D.3    Alonso, C.4
  • 19
    • 0028357798 scopus 로고
    • Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis
    • Kemp, M., A. S. Hey, J. A. Kurtzhals, C. B. Christensen, A. Gaafar, M. D. Mustafa, A. A. Kordofani, A. Ismail, A. Kharazmi, and T. G. Theander. 1994. Dichotomy of the human T cell response to Leishmania antigens. I. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis. Clin. Exp. Immunol. 96: 410-415.
    • (1994) Clin. Exp. Immunol. , vol.96 , pp. 410-415
    • Kemp, M.1    Hey, A.S.2    Kurtzhals, J.A.3    Christensen, C.B.4    Gaafar, A.5    Mustafa, M.D.6    Kordofani, A.A.7    Ismail, A.8    Kharazmi, A.9    Theander, T.G.10
  • 22
    • 0030822043 scopus 로고    scopus 로고
    • Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major
    • Gurunathan, S., D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder. 1997. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J. Exp. Med. 186: 1137-1147.
    • (1997) J. Exp. Med. , vol.186 , pp. 1137-1147
    • Gurunathan, S.1    Sacks, D.L.2    Brown, D.R.3    Reiner, S.L.4    Charest, H.5    Glaichenhaus, N.6    Seder, R.A.7
  • 23
    • 0025752328 scopus 로고
    • Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis
    • Kaye, P. M., A. J. Curry, and J. M. Blackwell. 1991. Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis. J. Immunol. 146: 2763-2770.
    • (1991) J. Immunol. , vol.146 , pp. 2763-2770
    • Kaye, P.M.1    Curry, A.J.2    Blackwell, J.M.3
  • 24
    • 0033001096 scopus 로고    scopus 로고
    • Leishmania-specific T cells expressing interferon-γ (IFN-γ) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis
    • Kemp, K., M. Kemp, A. Kharazmi, A. Ismail, J. A. Kurtzhals, L. Hviid, and T. G. Theander. 1999. Leishmania-specific T cells expressing interferon-γ (IFN-γ) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis. Clin. Exp. Immunol. 116: 500-504.
    • (1999) Clin. Exp. Immunol. , vol.116 , pp. 500-504
    • Kemp, K.1    Kemp, M.2    Kharazmi, A.3    Ismail, A.4    Kurtzhals, J.A.5    Hviid, L.6    Theander, T.G.7
  • 25
    • 0033648977 scopus 로고    scopus 로고
    • Cytokine-producing T cell subsets in human leishmaniasis
    • Kemp, K. 2000. Cytokine-producing T cell subsets in human leishmaniasis. Arch. Immunol. Ther. Exp. 48: 173-177.
    • (2000) Arch. Immunol. Ther. Exp. , vol.48 , pp. 173-177
    • Kemp, K.1
  • 26
    • 0023272268 scopus 로고
    • Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF)
    • Kupper, T., P. Flood, D. Coleman, and M. Horowitz. 1987. Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF). J. Immunol. 138: 4288-4292.
    • (1987) J. Immunol. , vol.138 , pp. 4288-4292
    • Kupper, T.1    Flood, P.2    Coleman, D.3    Horowitz, M.4
  • 27
    • 0028011858 scopus 로고
    • Antileishmanial activity and modification of hepatic xenobiotic metabolizing enzymes in golden hamster by 2(3)-tert-butyl-4-hydroxyanisole following infection with Leishmania donovani
    • Mukhopadhyay, R., and R. Madhubala. 1994. Antileishmanial activity and modification of hepatic xenobiotic metabolizing enzymes in golden hamster by 2(3)-tert-butyl-4-hydroxyanisole following infection with Leishmania donovani. Biochem. Pharmacol. 47: 253-256.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 253-256
    • Mukhopadhyay, R.1    Madhubala, R.2
  • 28
    • 0036738070 scopus 로고    scopus 로고
    • Studies on Stibanate unresponsive isolates of Leishmania donovani
    • Bhattacharyya, A., M. Mukherjee, and S. Duttagupta. 2002. Studies on Stibanate unresponsive isolates of Leishmania donovani. J. Biosci. 27: 503-508.
    • (2002) J. Biosci. , vol.27 , pp. 503-508
    • Bhattacharyya, A.1    Mukherjee, M.2    Duttagupta, S.3
  • 29
    • 0023678603 scopus 로고
    • The dynamics of granuloma formation in experimental visceral leishmaniasis
    • McElrath, M. J., H. W. Murray, and Z. A. Cohn. 1988. The dynamics of granuloma formation in experimental visceral leishmaniasis. J. Exp. Med. 167: 1927-1937.
    • (1988) J. Exp. Med. , vol.167 , pp. 1927-1937
    • McElrath, M.J.1    Murray, H.W.2    Cohn, Z.A.3
  • 30
    • 0035253601 scopus 로고    scopus 로고
    • The hamster as a model of human visceral leishmaniasis: Progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response
    • Melby, P. C., B. Chandrasekar, W. Zhao, and J. E. Coe. 2001. The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response. J. Immunol. 166: 1912-1920.
    • (2001) J. Immunol. , vol.166 , pp. 1912-1920
    • Melby, P.C.1    Chandrasekar, B.2    Zhao, W.3    Coe, J.E.4
  • 31
    • 0026586443 scopus 로고
    • Selective inability of spleen antigen presenting cells from Leishmania donovani infected hamsters to mediate specific T cell proliferation to parasite antigens
    • Rodrigues Junior, V., J. S. Da Silva, and A. Campos-Neto. 1992. Selective inability of spleen antigen presenting cells from Leishmania donovani infected hamsters to mediate specific T cell proliferation to parasite antigens. Parasite Immunol. 14: 49-58.
    • (1992) Parasite Immunol. , vol.14 , pp. 49-58
    • Rodrigues Jr., V.1    Da Silva, J.S.2    Campos-Neto, A.3
  • 33
    • 0037024695 scopus 로고    scopus 로고
    • 2+ levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes
    • 2+ levels through the activation of non-selective cation channels induced by oxidative stress causes mitochondrial depolarization leading to apoptosis-like death in Leishmania donovani promastigotes. J. Biol Chem. 277: 24717-24127.
    • (2002) J. Biol Chem. , vol.277 , pp. 24717-24127
    • Mukherjee, S.B.1    Das, M.2    Sudhandiran, G.3    Shaha, C.4
  • 34
    • 0031001121 scopus 로고    scopus 로고
    • Cloning of genes and expression and antigenicity analysis of the Leishmania infantum KMP-11 protein
    • Berberich, C., J. M. Requena, and C. Alonso. 1997. Cloning of genes and expression and antigenicity analysis of the Leishmania infantum KMP-11 protein. Exp. Parasitol. 85: 105-108.
    • (1997) Exp. Parasitol. , vol.85 , pp. 105-108
    • Berberich, C.1    Requena, J.M.2    Alonso, C.3
  • 35
    • 0023145125 scopus 로고
    • Experimental visceral leishmaniasis: Production of interleukin 2 and interferon-γ, tissue immune reaction, and response to treatment with interleukin 2 and interferon-γ
    • Murray, H. W., J. J. Stern, K. Welte, B. Y. Rubin, S. M. Carrier, and C. F. Nathan. 1987. Experimental visceral leishmaniasis: production of interleukin 2 and interferon-γ, tissue immune reaction, and response to treatment with interleukin 2 and interferon-γ. J. Immunol. 138: 2290-2297.
    • (1987) J. Immunol. , vol.138 , pp. 2290-2297
    • Murray, H.W.1    Stern, J.J.2    Welte, K.3    Rubin, B.Y.4    Carrier, S.M.5    Nathan, C.F.6
  • 36
    • 0030932976 scopus 로고    scopus 로고
    • Behavior of visceral Leishmania donovani in an experimentally induced T helper cell 2 (Th2)-associated response model
    • Murray, H. W., J. Hariprashad, and R. L. Coffman. 1997. Behavior of visceral Leishmania donovani in an experimentally induced T helper cell 2 (Th2)-associated response model. J. Exp. Med. 185: 867-874.
    • (1997) J. Exp. Med. , vol.185 , pp. 867-874
    • Murray, H.W.1    Hariprashad, J.2    Coffman, R.L.3
  • 37
    • 0030895747 scopus 로고    scopus 로고
    • Intracellular antimicrobial activity in the absence of interferon-γ: Effect of interleukin-12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice
    • Taylor, A. P., and H. W. Murray. 1997. Intracellular antimicrobial activity in the absence of interferon-γ: effect of interleukin-12 in experimental visceral leishmaniasis in interferon-γ gene-disrupted mice. J. Exp. Med. 185: 1231-1239.
    • (1997) J. Exp. Med. , vol.185 , pp. 1231-1239
    • Taylor, A.P.1    Murray, H.W.2
  • 38
    • 0033785362 scopus 로고    scopus 로고
    • Visceral leishmaniasis in mice devoid of tumor necrosis factor and response to treatment
    • Murray, H. W., A. Jungbluth, E. Ritter, C. Montelibano, and M. W. Marino. 2000. Visceral leishmaniasis in mice devoid of tumor necrosis factor and response to treatment. Infect. Immun. 68: 6289-6293.
    • (2000) Infect. Immun. , vol.68 , pp. 6289-6293
    • Murray, H.W.1    Jungbluth, A.2    Ritter, E.3    Montelibano, C.4    Marino, M.W.5
  • 39
    • 0036839677 scopus 로고    scopus 로고
    • Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy
    • Murray, H. W., C. M. Lu, S. Mauze, S. Freeman, A. L. Moreira, G. Kaplan, and R. L. Coffman. 2002. Interleukin-10 (IL-10) in experimental visceral leishmaniasis and IL-10 receptor blockade as immunotherapy. Infect. Immun. 70: 6284-6293.
    • (2002) Infect. Immun. , vol.70 , pp. 6284-6293
    • Murray, H.W.1    Lu, C.M.2    Mauze, S.3    Freeman, S.4    Moreira, A.L.5    Kaplan, G.6    Coffman, R.L.7
  • 40
    • 0021075679 scopus 로고
    • Cell-mediated immune response in Indian kala-azar and post-kala-azar dermal leishmaniasis
    • Haldar, J. P., S. Ghose, K. C. Sana, and A. C. Ghose. 1983. Cell-mediated immune response in Indian kala-azar and post-kala-azar dermal leishmaniasis. Infect. Immun. 42: 702-707.
    • (1983) Infect. Immun. , vol.42 , pp. 702-707
    • Haldar, J.P.1    Ghose, S.2    Sana, K.C.3    Ghose, A.C.4
  • 41
    • 0028181286 scopus 로고
    • Restoration of IFN-γ production and lymphocyte proliferation in visceral leishmaniasis
    • Carvalho, E. M., O. Bacellar, C. Brownell, T. Regis, R. L. Coffman, and S. G. Reed. 1994. Restoration of IFN-γ production and lymphocyte proliferation in visceral leishmaniasis. J. Immunol. 152: 5949-5956.
    • (1994) J. Immunol. , vol.152 , pp. 5949-5956
    • Carvalho, E.M.1    Bacellar, O.2    Brownell, C.3    Regis, T.4    Coffman, R.L.5    Reed, S.G.6
  • 42
    • 0024442306 scopus 로고
    • Comparison of T-cell responses in self-limiting versus progressive visceral Leishmania donovani infections in golden hamsters
    • Gifawesen, C., and J. P. Farrell. 1989. Comparison of T-cell responses in self-limiting versus progressive visceral Leishmania donovani infections in golden hamsters. Infect. Immun. 57: 3091-3096.
    • (1989) Infect. Immun. , vol.57 , pp. 3091-3096
    • Gifawesen, C.1    Farrell, J.P.2
  • 43
    • 0020544527 scopus 로고
    • Interleukin 2 deficiency in murine Leishmaniasis donovani and its relationship to depressed spleen cell responses to phytohemagglutinin
    • Reiner, N. E., and J. H. Finke. 1983. Interleukin 2 deficiency in murine Leishmaniasis donovani and its relationship to depressed spleen cell responses to phytohemagglutinin. J. Immunol. 131: 1487-1491.
    • (1983) J. Immunol. , vol.131 , pp. 1487-1491
    • Reiner, N.E.1    Finke, J.H.2
  • 44
    • 0031758688 scopus 로고    scopus 로고
    • Modulating the immune response to genetic immunization
    • Cohen, A. D., J. D. Boyer, and D. B. Weiner. 1998. Modulating the immune response to genetic immunization. FASEB J. 12: 1611-1626.
    • (1998) FASEB J. , vol.12 , pp. 1611-1626
    • Cohen, A.D.1    Boyer, J.D.2    Weiner, D.B.3
  • 46
    • 0027522629 scopus 로고
    • Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis
    • Kemp, M., J. A. Kurtzhals, K. Bendtzen, L. K. Poulsen, M. B. Hansen, D. K. Koech, A. Kharazmi, and T. G. Theander. 1993. Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis. Infect. Immun. 61: 1069-1073.
    • (1993) Infect. Immun. , vol.61 , pp. 1069-1073
    • Kemp, M.1    Kurtzhals, J.A.2    Bendtzen, K.3    Poulsen, L.K.4    Hansen, M.B.5    Koech, D.K.6    Kharazmi, A.7    Theander, T.G.8
  • 47
    • 0027175225 scopus 로고
    • Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes
    • Schneemann, M., G. Schoedon, S. Hofer, N. Blau, L. Guerrero, and A. Schaffner. 1993. Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J. Infect. Dis. 167: 1358-1363.
    • (1993) J. Infect. Dis. , vol.167 , pp. 1358-1363
    • Schneemann, M.1    Schoedon, G.2    Hofer, S.3    Blau, N.4    Guerrero, L.5    Schaffner, A.6
  • 48
    • 0032720052 scopus 로고    scopus 로고
    • Immunochemotherapy for Leishmania donovani infection in golden hamsters: Combinatorial action of poly ICLC plus L-arginine and sodium stibogluconate (Stibanate)
    • Bhakuni, V., S. Kulkarni, V. Ali, U. K. Singh, H. B. Levy, and R. K. Maheshwari. 1999. Immunochemotherapy for Leishmania donovani infection in golden hamsters: combinatorial action of poly ICLC plus L-arginine and sodium stibogluconate (Stibanate). J. Interferon Cytokine Res. 19: 1103-1106.
    • (1999) J. Interferon Cytokine Res. , vol.19 , pp. 1103-1106
    • Bhakuni, V.1    Kulkarni, S.2    Ali, V.3    Singh, U.K.4    Levy, H.B.5    Maheshwari, R.K.6
  • 49
    • 0025648446 scopus 로고
    • Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-γ-stimulated macrophages by induction of tumor necrosis factor-α
    • Green, S. J., R. M. Crawford, J. T. Hockmeyer, M. S. Meltzer, and C. A. Nacy. 1990. Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-γ-stimulated macrophages by induction of tumor necrosis factor-α. J. Immunol. 145: 4290-4297.
    • (1990) J. Immunol. , vol.145 , pp. 4290-4297
    • Green, S.J.1    Crawford, R.M.2    Hockmeyer, J.T.3    Meltzer, M.S.4    Nacy, C.A.5
  • 50
    • 0025609915 scopus 로고
    • Tumor necrosis factor-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide
    • Liew, F. Y., Y. Li, and S. Millott. 1990. Tumor necrosis factor-α synergizes with IFN-γ in mediating killing of Leishmania major through the induction of nitric oxide. J. Immunol. 145: 4306-4310.
    • (1990) J. Immunol. , vol.145 , pp. 4306-4310
    • Liew, F.Y.1    Li, Y.2    Millott, S.3
  • 51
    • 0025661887 scopus 로고
    • Tumour necrosis factor (TNF-α) in leishmaniasis. II. TNF-α-induced macrophage leishmanicidal activity is mediated by nitric oxide from L-arginine
    • Liew, F. Y., Y. Li, and S. Millott. 1990. Tumour necrosis factor (TNF-α) in leishmaniasis. II. TNF-α-induced macrophage leishmanicidal activity is mediated by nitric oxide from L-arginine. Immunology 71: 556-559.
    • (1990) Immunology , vol.71 , pp. 556-559
    • Liew, F.Y.1    Li, Y.2    Millott, S.3
  • 54
    • 0031570501 scopus 로고    scopus 로고
    • Perspectives series: Host/pathogen interactions: Mechanisms of nitric oxide-related antimicrobial activity
    • Fang, F. C. 1997. Perspectives series: host/pathogen interactions: mechanisms of nitric oxide-related antimicrobial activity. J. Clin. Invest. 99: 2818-2825.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2818-2825
    • Fang, F.C.1
  • 56
    • 0037424132 scopus 로고    scopus 로고
    • Vaccination with DNA encoding ORFF antigen confers protective immunity in mice infected with Leishmania donovani
    • Sukumaran, B., P. Tewary, S. Saxena, and R. Madhubala. 2003. Vaccination with DNA encoding ORFF antigen confers protective immunity in mice infected with Leishmania donovani. Vaccine 21: 1292-1299.
    • (2003) Vaccine , vol.21 , pp. 1292-1299
    • Sukumaran, B.1    Tewary, P.2    Saxena, S.3    Madhubala, R.4
  • 57
    • 0034911854 scopus 로고    scopus 로고
    • Leishmania donovani p36 (LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis
    • Melby, P. C., J. Yang, W. Zhao, L. E. Perez, and J. Cheng. 2001. Leishmania donovani p36 (LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis. Infect. Immun. 69: 4719-4725.
    • (2001) Infect. Immun. , vol.69 , pp. 4719-4725
    • Melby, P.C.1    Yang, J.2    Zhao, W.3    Perez, L.E.4    Cheng, J.5
  • 58
    • 0035972008 scopus 로고    scopus 로고
    • Protection against Leishmania donovani infection by DNA vaccination: Increased DNA vaccination efficiency through inhibiting the cellular p53 response
    • Ghosh, A., S. Labrecque, and G. Matlashewski. 2001. Protection against Leishmania donovani infection by DNA vaccination: increased DNA vaccination efficiency through inhibiting the cellular p53 response. Vaccine 19: 3169-3178.
    • (2001) Vaccine , vol.19 , pp. 3169-3178
    • Ghosh, A.1    Labrecque, S.2    Matlashewski, G.3
  • 59
    • 0034824676 scopus 로고    scopus 로고
    • DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection
    • Planelles, L., M. C. Thomas, C. Alonso, and M. C. López. 2001. DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection. Infect. Immun. 69: 6558-6563.
    • (2001) Infect. Immun. , vol.69 , pp. 6558-6563
    • Planelles, L.1    Thomas, M.C.2    Alonso, C.3    López, M.C.4
  • 60
    • 0026080768 scopus 로고
    • Immunobiological studies on experimental visceral leishmaniasis. I. Changes in lymphoid organs and their possible role in pathogenesis
    • Saha, B., H. Nanda-Roy, A. Pakrashi, R. N. Chakrabarti, and S. Roy. 1991. Immunobiological studies on experimental visceral leishmaniasis. I. Changes in lymphoid organs and their possible role in pathogenesis. Eur. J. Immunol. 21: 577-581.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 577-581
    • Saha, B.1    Nanda-Roy, H.2    Pakrashi, A.3    Chakrabarti, R.N.4    Roy, S.5
  • 61
    • 0033532294 scopus 로고    scopus 로고
    • Requirement for type 2 NO synthase for IL-12 signaling in innate immunity
    • Diefenbach, A., H. Schindler, M. Röllinghoff, W. M. Yokoyama, and C. Bogdan. 1999. Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Science 284: 951-955.
    • (1999) Science , vol.284 , pp. 951-955
    • Diefenbach, A.1    Schindler, H.2    Röllinghoff, M.3    Yokoyama, W.M.4    Bogdan, C.5
  • 62
    • 0025940127 scopus 로고
    • Role of inorganic nitrogen oxides and tumor necrosis factor α in killing Leishmania donovani amastigotes in γ interferon- lipopolysaccharide-activated macrophages from Lshs and Lshr congenic mouse strains
    • Roach, T. I., A. F. Kiderlen, and J. M. Blackwell. 1991. Role of inorganic nitrogen oxides and tumor necrosis factor α in killing Leishmania donovani amastigotes in γ interferon-lipopolysaccharide- activated macrophages from Lshs and Lshr congenic mouse strains. Infect. Immun. 59: 3935-3944.
    • (1991) Infect. Immun. , vol.59 , pp. 3935-3944
    • Roach, T.I.1    Kiderlen, A.F.2    Blackwell, J.M.3
  • 63
    • 0025266647 scopus 로고
    • Effect of continuous administration of interferon-α in experimental visceral leishmaniasis
    • Murray, H. W. 1990. Effect of continuous administration of interferon-α in experimental visceral leishmaniasis. J. Infect. Dis. 161: 992-994.
    • (1990) J. Infect. Dis. , vol.161 , pp. 992-994
    • Murray, H.W.1
  • 64
    • 0020528710 scopus 로고
    • Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes: Evidence that interferon-γ is the activating lymphokine
    • Murray, H. W., B. Y. Rubin, and C. D. Rothermel. 1983. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes: evidence that interferon-γ is the activating lymphokine. J. Clin. Invest. 72: 1506-1510.
    • (1983) J. Clin. Invest. , vol.72 , pp. 1506-1510
    • Murray, H.W.1    Rubin, B.Y.2    Rothermel, C.D.3
  • 66
  • 67
    • 0025342458 scopus 로고
    • Serum tumor necrosis factor levels and disease dissemination in leprosy and leishmaniasis
    • Pisa, P., M. Gennene, O. Soder, T. Ottenhoff, M. Hansson, and R. Kiessling. 1990. Serum tumor necrosis factor levels and disease dissemination in leprosy and leishmaniasis. J. Infect. Dis. 161: 988-991.
    • (1990) J. Infect. Dis. , vol.161 , pp. 988-991
    • Pisa, P.1    Gennene, M.2    Soder, O.3    Ottenhoff, T.4    Hansson, M.5    Kiessling, R.6
  • 70
    • 0033783387 scopus 로고    scopus 로고
    • Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis
    • Murray, H. W., C. Montelibano, R. Peterson, and J. P. Sypek. 2000. Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis. J. Infect. Dis. 182: 1497-1502.
    • (2000) J. Infect. Dis. , vol.182 , pp. 1497-1502
    • Murray, H.W.1    Montelibano, C.2    Peterson, R.3    Sypek, J.P.4
  • 71
    • 0033788429 scopus 로고    scopus 로고
    • Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis
    • Alexander, J., K. C. Carter, N. Al-Fasi, A. Satoskar, and F. Brombacher. 2000. Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis. Eur. J. Immunol. 30: 2935-2943.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 2935-2943
    • Alexander, J.1    Carter, K.C.2    Al-Fasi, N.3    Satoskar, A.4    Brombacher, F.5
  • 72
    • 0031910758 scopus 로고    scopus 로고
    • Splenic cytokine responses in Indian kala-azar before and after treatment
    • Kenney, R. T., D. L. Sacks, A. A. Gam, H. W. Murray, and S. Sundar. 1998. Splenic cytokine responses in Indian kala-azar before and after treatment. J. Infect. Dis. 177: 815-818.
    • (1998) J. Infect. Dis. , vol.177 , pp. 815-818
    • Kenney, R.T.1    Sacks, D.L.2    Gam, A.A.3    Murray, H.W.4    Sundar, S.5
  • 73
    • 0027788043 scopus 로고
    • The relationship of IL-4- and IFN γ-producing T cells studied by lineage ablation of IL-4-producing cells
    • Kamogawa, Y., L. A. Minasi, S. R. Carding, K. Bottomly, and R. A. Flavell. 1993. The relationship of IL-4- and IFN γ-producing T cells studied by lineage ablation of IL-4-producing cells. Cell 75: 985-995.
    • (1993) Cell , vol.75 , pp. 985-995
    • Kamogawa, Y.1    Minasi, L.A.2    Carding, S.R.3    Bottomly, K.4    Flavell, R.A.5
  • 74
    • 0345628580 scopus 로고    scopus 로고
    • T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice
    • Schuler, T., Z. Qin, S. Ibe, N. Noben-Trauth, and T. Blankenstein. 1999. T helper cell type 1-associated and cytotoxic T lymphocyte-mediated tumor immunity is impaired in interleukin 4-deficient mice. J. Exp. Med. 189: 803-810.
    • (1999) J. Exp. Med. , vol.189 , pp. 803-810
    • Schuler, T.1    Qin, Z.2    Ibe, S.3    Noben-Trauth, N.4    Blankenstein, T.5
  • 75
  • 76
    • 0028911482 scopus 로고
    • Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: Priming for IL-12 and tumor necrosis factor α production
    • D'Andrea, A., X. Ma, M. Aste-Amezaga, C. Paganin, and G. Trinchieri. 1995. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor α production. J. Exp. Med. 181: 537-546.
    • (1995) J. Exp. Med. , vol.181 , pp. 537-546
    • D'Andrea, A.1    Ma, X.2    Aste-Amezaga, M.3    Paganin, C.4    Trinchieri, G.5
  • 77
    • 0028787484 scopus 로고
    • Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection
    • Satoskar, A., H. Bluethmann, and J. Alexander. 1995. Disruption of the murine interleukin-4 gene inhibits disease progression during Leishmania mexicana infection but does not increase control of Leishmania donovani infection. Infect. Immun. 63: 4894-4899.
    • (1995) Infect. Immun. , vol.63 , pp. 4894-4899
    • Satoskar, A.1    Bluethmann, H.2    Alexander, J.3
  • 78
    • 0028360727 scopus 로고
    • Interleukin-4 stimulates cGMP production by IFN-γ-activated human monocytes: Involvement of the nitric oxide synthase pathway
    • Kolb, J. P., N. Paul-Eugene, C. Damais, K. Yamaoka, J. C. Drapier, and B. Dugas. 1994. Interleukin-4 stimulates cGMP production by IFN-γ-activated human monocytes: involvement of the nitric oxide synthase pathway. J. Biol. Chem. 269: 9811-9816.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9811-9816
    • Kolb, J.P.1    Paul-Eugene, N.2    Damais, C.3    Yamaoka, K.4    Drapier, J.C.5    Dugas, B.6
  • 79
    • 0025969044 scopus 로고
    • Cytokine interactions in experimental cutaneous leishmaniasis: Interleukin 4 synergizes with interferon-γ to activate murine macrophages for killing of Leishmania major amastigotes
    • Bogdan, C., S. Stenger, M. Rollinghoff, and W. Solbach. 1991. Cytokine interactions in experimental cutaneous leishmaniasis: interleukin 4 synergizes with interferon-γ to activate murine macrophages for killing of Leishmania major amastigotes. Eur. J. Immunol. 21: 327-333.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 327-333
    • Bogdan, C.1    Stenger, S.2    Rollinghoff, M.3    Solbach, W.4
  • 80
    • 0021995866 scopus 로고
    • Syrian hamster DNA shows limited polymorphism at class I-like loci
    • McGuire, K. L., W. R. Duncan, and P. W. Tucker. 1985. Syrian hamster DNA shows limited polymorphism at class I-like loci. Immunogenetics 22: 257-268.
    • (1985) Immunogenetics , vol.22 , pp. 257-268
    • McGuire, K.L.1    Duncan, W.R.2    Tucker, P.W.3


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