Cytokine-producing T cell subsets in human leishmaniasis

Archivum Immunologiae et Therapiae Experimentalis

Volumn 48, Issue 3, 2000, Pages 173-176

  Kemp, Kar̊e ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

Author keywords

Cytokines; Human leishmaniasis; T cells

Indexed keywords

CYTOKINE;

ANIMAL; BIOSYNTHESIS; DISEASE MODEL; HUMAN; IMMUNOLOGY; LEISHMANIASIS; LYMPHOCYTE ACTIVATION; MOUSE; REVIEW; SKIN LEISHMANIASIS; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; VISCERAL LEISHMANIASIS;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; LEISHMANIASIS; LEISHMANIASIS, CUTANEOUS; LEISHMANIASIS, VISCERAL; LYMPHOCYTE ACTIVATION; MICE; T-LYMPHOCYTE SUBSETS; TH1 CELLS; TH2 CELLS;

EID: 0033648977     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. AKUFFO H., MAASHO K. and HOWE R. (1993): Natural and acquired resistance to Leishmania: cellular activation by Leishmania aehiopica of mononuclear cells from unexposed individuals is through the stimulation of natural killer (NK) cells. Clin. Exp. Immunol., 94, 516-521.
2. CARVALHO E. M., BADARO R., REED S. G. et al. (1990): Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis. J. Clin. Invest., 76, 2066-2069.
3. CILLARI E., VITALE G., ARCOLEO F. et al. (1995): In vivo and in vitro cytckine profiles and mononuclear subsets in Sicilian patients with active visceral leishmaniasis. Cytokine, 7, 740-745.
4. GHALIB H. W., PIUVEZAM M. R., SKEIKY Y. A. et al. (1993): Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J. Clin. Invest., 92, 324-329.
5. GROUX H., GARRA A. O., BIGLER M. et al. (1997): CD4+ T-cell subset inhibits antigen specific T cell responses and prevents colitis. Nature, 389, 737-742.
6. GAAFAR A., KHARAZMI A., ISMAIL A. et al. (1995): Dichotomy of the T cell response to Leishmania antigens in patients suffering from cutaneous leishmaniasis; absence or scarcity of Th1 activity is associated with severe infections. Clin. Exp. Immunol., 100, 239-245.
7. HOLADAY B., POMPEU M. L., JERONIM S. et al. (1993): Potential role for interleukin-10 in the immunosuppression associated with kala azar. J. Clin. Invest., 92, 2626-2632.
8. HOWARD J. G., HALE C. and LIEW F. Y. (1981): Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic regulation effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to Leishmania tropica. J. Exp. Med., 153, 557-568.
9. HVIID L., KURTZHALS J. A. L., GOKA B. Q. et al. (1997): Rapid re-emergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria. Infect. Immun., 65, 1090-1093.
10. ISMAIL A., EL HASSAN A. M., KEMP K. et al. (1999): Immunopathology of post-kala-azar dermal leishmaniasis (PKDL) T cell phenotypes and cytokine profile. J. Pathol. (in press).
11. JUNG T., SCHAUER U., HEUSSER C. et al. (1993): Detection of intracellular cytokines by flow cytometry. J. Immunol. Methods, 159, 197-207.
12. KARP C. L., EL-SAFI S. H., WYNN T. A. et al. (1993): In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J. Clin. Invest., 91, 1644-1648.
13. KEMP K., HVIID L., KHARAZMI A. et al. (1997): Interferon-γ production by human T cells and natural killer cells in vitro response to antigens from two intracellular pathogens Mycobacteriuin tuberculosis and Leishmania major. Scand. J. Immunol., 46, 495-499.
14. KEMP K., KEMP M., KHARAZMI A. et al. (1999): Leishmania-specific T cells expressing interferon-gamma (IFN-γ) and IL10 upon activation are expanded in individuals cured of visceral leishmaniasis. Clin. Exp. Immunol., 116, 500-504.
15. KEMP K., THEANDER T. G., HVIID L. et al. (1999): Interferon-γ and tumour necrosis factor-α-producing cells in humans who are immune to cutaneous leishmaniasis. Scand. J. Immunol., 49, 655-659.
16. KEMP M., HANDMAN E., KEMP K. et al. (1998): The Leishmania promastigote surface antigen-2 (PSA-2) is specifically recognised by Th1 cells in humans with naturally acquired immunity to L. major. FEMS Immunol. Med. Microbiol., 3, 209-218.
17. KEMP M., HANSEN M. B. and THEANDER T. G. (1992): Recognition of Leishmania antigens by T cells from non-exposed individuals. Infect. Immun., 22, 2246-2251.
18. KEMP M., HEY A. S., BENDTZEN K. et al. (1994): Th1-like human T-cell clones recognising Leishmania gp63 inhibit Leishmania major in human macrophages. Scand. J. Immunol., 40, 629-635.
19. KEMP M., HEY A. S., KURTZHALS J. A. et al. (1994): Dichotomy of the human T cell response to Leishmania antigens. Th1-like response to Leishmania major promastigote antigens in individuals recovered from cutaneous leishmaniasis. Clin. Exp. Immunol., 96, 410-415.
20. KEMP M., THEANDER T. G. and KHARAZMI A (1996): The contrasting roles of CD4+ T cells in intracellular infections in hu-mans: leishmaniasis as an example. Immunol. Today, 17, 13-16.
21. KURTZHALS J. A. L., HEY A. S., JARDIM A. et al. (1994): Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2 like response to gp63 and Th1 like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. Clin. Exp. Immunol., 96, 137-144.
22. KURTZHALS J. A. L., KEMP M., POULSEN L. K. et al. (1995): Interlukin-4 and interferon-gamma production by Leishmania stimulated peripheral blood mononuclear cells from nonexposed individuals. Scand. J. Immunol., 41, 343-349.
23. LEI F. Y., WEI X. Q. and PROUDFOOT L. (1997): Cytokines and nitric oxide as effector molecules against parasitic infections. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 352, 1311-1315.
24. LOCKSLEY R. M. and SCOTT P. (1991): Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function. Immunol. Today, 12, 58-61.
25. MELBY P. C. (1991): Experimental leishmaniasis in humans: Review. Rev. Infect. Dis., 13, 1009-1017.
26. PRUSSIN C. and METCALFE D. D. (1995): Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J. Immunol. Methods, 188, 117-128.
27. SCHAUER U., JUNG T. KRUG N. et al. (1996): Measurement of intracellular cytokines. Immunol. Today, 17, 305-307.
28. SCOTT O., NATOVITZ P., COFFMAN R. L. et al. (1988): Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J. Exp. Med., 168, 1675-1684.
29. SCOTT P. (1996): Th cell development and regulation in experimental cutaneous leishmaniasis. Chem. Immunol., 63, 98-114.
30. THICKER C. P. and KUMAR K. (1992): Post-kala-azar dermal leishmaniasis: a neglected aspect of kala-azar control programmes. Ann. Trop. Med. Parasitol., 86, 355-359.
31. WANG Z. E., REINER S. L., ZHENG S. et al. (1994): CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J. Exp. Med., 179, 1367-1371.
32. ZULSTRA E. E., EL HASSAN A. M. and ISMAEL A. (1995): Endemic kala-azar in eastern Sudan: Post-kala-azar dermal leishmaniasis. Am. J. Trop. Med. Hyg., 52, 299-305.
33. ZWINGENBERGER K., HARMS G., PEDROSA J. et al. (1990): Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin-4 over interferon-gamma production. Clin. Immunol. Immunopathol., 51, 242-249.