Leishmania-specific T cells expressing interferon-gamma (IFN-γ) and IL- 10 upon activation are expanded in individuals cured of visceral leishmaniasis

Clinical and Experimental Immunology

Volumn 116, Issue 3, 1999, Pages 500-504

  Kemp, Kåre ^a   Kemp, M ^a   Kharazmi, A ^a   Ismail, A ^a,c   Kurtzhals, J A L ^b   Hviid, L ^a   Theander, T G ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF KHARTOUM   (Sudan)

Author keywords

Cytokines; Flow cytometry; Leishmaniasis

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4;

ARTICLE; CELL ACTIVATION; CELLULAR DISTRIBUTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; VISCERAL LEISHMANIASIS;

ANIMALS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-4; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 0033001096     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00918.x     Document Type: Article

References (30)

1. Badaró R, Jones TC, Carvalho EM et al. New perspectives on a subclinical form of visceral leishmaniasis. J Infect Dis 1986; 154:207-14.
2. Mosmann TR, Cherwinsky H, Bond MW et al. Two types of murine helper T cell clone. 1. Definition according to profiles of lymphokinc activities and secreted proteins. J Immunol 1986; 136:2348-57.
3. Noben-Trauth N, Shultz LD, Brombacher F. An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci USA 1997; 94: 10838-43.
4. Kaye PM, Curry AJ, Blackwell JM. Differential production of Th1 - and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis. J Immunol 1991; 146:2763-70.
5. + T cells in intracellular infections in humans: leishmaniasis as an example. Immunol Today 1996;17:13-16.
6. Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today 1995; 12:256-7.
7. Allen JE, Maizels RM. Th1-Th2: reliable paradigm or dangerous dogma? Immunol Today 1997; 18:387-97.
8. Kelso A. TH1 and TH2 subsets: paradigms lost. Immunol Today 1995; 16:374-9.
9. Carvalho EM, Badaro R, Reed SG et al. Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis. J Clin Invest 1985; 76:2066-9.
10. Ghalib HW, Whittle JA, Kubin M et al. IL-12 enhances Th1-type responses in human Leishmania donovani infections. J Immunol 1995; 154:4623-9.
11. Kurtzhals JAL, Hey AS, Jardim A et al. Dichotomy of the human T-cell response to Leishmania antigens. II. Absent or Th2 like response to gp63 and Th1 like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients. Clin Exp Immunol 1994; 96:416-21.
12. Kemp M, Kurtzhals JAL, Christensen CBV et al. Production of interferon-gamma and interleukin-4 by human T cells recognising Leishmania lipophosphoglycan-associated protein. Immunol Letters 1993; 38:137-44.
13. Bahrenscheer J, Kemp M, Kurtzhals JAL et al. Interferon-γ and interleukin-4 production by human T cells recognising Leishmania donovani antigens separated by SDS PAGE. APMIS 1995; 103:131-9.
14. Hviid L, Albeck G, Hansen B et al. A new portable device for automatic controlled-gradient cryopreservation of blood mononuclear cells. J Immunol Methods 1993; 157:135-42.
15. Kurtzhals JAL, Kemp M, Poulsen LK et al. Interleukin-4 and interferon-gamma production by Leishmania stimulated peripheral blood mononuclear cells from nonexposed individuals, Scand J Immunol 1995; 41:343-9.
16. Jung T, Schauer U, Hausser C et al. Detection of intracellular cytokines by flow cytometry. J Immunol Methods 1993; 159:197-207.
17. Prussin C, Metcalfe DD. Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. J Immunol Methods 1995; 188:117-28.
18. Schauer U, Jung T, Krug N et al. Measurement of intracellular cytokines. Immunol Today 1996; 17:305-7.
19. Kemp M, Hansen MB, Theander TG. Recognition of Leishmania antigens by T cells from non-exposed individuals. Infect Immun 1992; 60:2246-51.
20. Kemp K, Hviid L, Kharazmi A et al. IFN-γ production by human T cells and NK cells in vitro in response to antigens from two intracellular pathogens Mycobacterium tuberculosis and Leishmania major. Scand J Immunol 1997; 46:495-500.
21. Gaafar A, Kharazmi A, Ismail A et al. Dichotomy of the T cell response to Leishmania antigens in patients suffering from cutaneous leishmaniasis; absence or scarcity of Th1 activity is associated with severe infections. Clin Exp Immunol 1995; 100:239-45.
22. Kemp M, Hey AS, Kurtzhals JAL et al. Dichotomy of the human T cell response to Leishmania antigens. 1. Th1-like response to Leishmania major promastigole antigens in individuals recovered from cutaneous leishmaniasis. Clin Exp Immunol 1994; 96:410-5.
23. Windhagen A, Anderson DE, Carrizosa A et al. IL-12 induces human T cells secreting IL 10 with IFN-γ. J Immunol 1996; 157; 1127-31.
24. Gerosa F, Paganin C, Peritt D et al. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med 1996; 183:2559-69.
25. Pohl-Koppe A, Balshov KE, Steere AC et al. Identification of a T cell subset capable of both IFN-γ and IL 10 secretion in patients with chronic Borrelia burgdorferi infection. J Immunol 1998; 160:1804-18.
26. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389:737-42.
27. Karp CL., El-safi SH, Wynn TA et al. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. J Clin Invest 1993; 91:1644-8.
28. Holaday B, Pompeu ML, Jeronim S et al. Potential role for interleukin-10 in the immunosuppression associated with Kala Azar. J Clin Invest 1993; 92:2626-32.
29. Cillari E, Vitale G, Arcoleo F et al. In vivo and in vitro cytokine profiles and mononuclear subsets in Sicilian patients with active visceral leishmaniasis. Cytokine 1995; 7:740-5.
30. Ghalib HW, Piuvezam MR, Skeiky YA et al. Interleukin 10 production correlates with pathology in human Leishmania donovani infections. J Clin Invest 1993; 92:324-9.