Identification of vaccine candidates for experimental visceral leishmaniasis by immunization with sequential fractions of a cDNA expression library

Infection and Immunity

Volumn 68, Issue 10, 2000, Pages 5595-5602

  Melby, P C ^a   Ogden, G B ^a   Flores, H A ^a   Zhao, W ^a   Geldmacher, C ^a   Biediger, N M ^a   Ahuja, S K ^a   Uranga, J ^a   Melendez, M ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; DNA VACCINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; PLASMID DNA; PROTOZOAL DNA;

ANIMAL MODEL; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNE RESPONSE; IMMUNIZATION; LEISHMANIA DONOVANI; LEISHMANIASIS; MOUSE; NONHUMAN; PARASITE; PRIORITY JOURNAL; VACCINATION;

ANIMAL; DNA, COMPLEMENTARY; DNA, PROTOZOAN; GENE LIBRARY; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MICE; MICE, INBRED BALB C; PLASMIDS; PROTOZOAN VACCINES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; VACCINATION; VACCINES, DNA;

EID: 0033801766     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.10.5595-5602.2000     Document Type: Article

References (34)

1. Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection
2. Basic local alignment search tool
3. Leishmania and human immunodeficiency virus coinfection: The first 10 years
4. New perspectives on a subclinical form of visceral leishmaniasis
5. Protection against mycoplasma infection using expression-library immunization
6. Routes of plasmid DNA vaccination that prime murine humoral and cellular immune responses
7. Modulation of host immune responses by prolozoal DNA
8. Antigen-specific immunosuppression in visceral leishmaniasis is cell mediated
9. Cell-mediated immunity in American visceral leishmaniasis: Reversible immunosuppression during acute infection
10. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
11. DNA vaccines
12. + cell-, interferon gamma-, and nitric oxide-dependent immunity
13. Characterization of two proteins from Leishmania donovani and their use for vaccination against visceral leishmaniasis
14. Differential production of Th1- and Th2-derived cytokines does not determine the genetically controlled or vaccine-induced rate of cure in murine visceral leishmaniasis
15. Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells
16. Translation and the stability of mRNAs encoding the transferrin receptor and c-fos
17. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells
18. Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates
19. Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani
20. Cell-mediated immune response in experimental visceral leishmaniasis. I. Correlation between resistance to Leishmania donovani and lymphokine-generating capacity
21. Histone H1 expression varies during the Leishmania major life cycle
22. Plasmid DNA malaria vaccine: Tissue distribution and safety studies in mice and rabbits
23. Protective immune responses induced by vaccination with an expression genomic library of Leishmania major
24. Pure protein from Leishmania donovani protects mice against both cutaneous and visceral leishmaniasis
25. Animal models for the analysis of immune responses to leishmahiasis
26. Mapping of the linear antigenic determinants from the Leishmania infantum histone H2A recognized by sera from dogs with leishmaniasis
27. Characterization of the antigenic determinants of the Leishmania infantum histone H3 recognized by antibodies elicited during canine visceral leishmaniasis
28. Growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed in mouse liver and placenta
29. Studies in the epidemiology of East African leish-maniasis. 5. Leishmania adleri and natural immunity
30. + cells in experimental visceral leishmaniasis
31. Gene vaccination: Plasmid DNA is more than just a blueprint
32. DNA immunization targeting the skin: Molecular control of adaptive immunity
33. Nucleotide sequence of the Leishmania donovani medRNA gene
34. Local suppression of IFN-gamma in hepatic granulomas correlates with tissue-specific replication of Leishmania chagasi